Chantelle F Sephton

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration
    Chantelle F Sephton
    Deparment of Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9111, USA
    Biol Chem 393:589-94. 2012
  2. pmc TDP-43 aggregation in neurodegeneration: are stress granules the key?
    Colleen M Dewey
    Department of Neuroscience, The University of Texas Southwestern Medical Center at Dallas, USA
    Brain Res 1462:16-25. 2012
  3. pmc Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration
    Basar Cenik
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 287:32298-306. 2012
  4. pmc TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor
    Colleen M Dewey
    Department of Neuroscience, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Mol Cell Biol 31:1098-108. 2011
  5. pmc Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes
    Chantelle F Sephton
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 286:1204-15. 2011
  6. pmc Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase
    Sheu Fen Lee
    Department of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 286:27447-53. 2011
  7. pmc TDP-43 is a developmentally regulated protein essential for early embryonic development
    Chantelle F Sephton
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:6826-34. 2010
  8. pmc Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia
    Basar Cenik
    Department of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9111, USA
    J Biol Chem 286:16101-8. 2011

Collaborators

Detail Information

Publications8

  1. pmc TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration
    Chantelle F Sephton
    Deparment of Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9111, USA
    Biol Chem 393:589-94. 2012
    ..TDP-43 RNA targets and protein interactions have now been identified, and in vivo evidence shows that TDP-43 is essential in CNS development and function. This review will highlight aspects of these findings...
  2. pmc TDP-43 aggregation in neurodegeneration: are stress granules the key?
    Colleen M Dewey
    Department of Neuroscience, The University of Texas Southwestern Medical Center at Dallas, USA
    Brain Res 1462:16-25. 2012
    ..This article is part of a Special Issue entitled: RNA-Binding Proteins...
  3. pmc Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration
    Basar Cenik
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 287:32298-306. 2012
    ..Revealing the cell surface receptors and the intracellular functions of granulins and progranulin is crucial for understanding their contributions to neurodegeneration...
  4. pmc TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor
    Colleen M Dewey
    Department of Neuroscience, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Mol Cell Biol 31:1098-108. 2011
    ..We propose that mutant TDP-43 alters stress granule dynamics, which may contribute to the progression of TDP-43 proteinopathies...
  5. pmc Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes
    Chantelle F Sephton
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 286:1204-15. 2011
    ..This work thus reveals the protein and RNA components of the TDP-43-containing ribonucleoprotein complexes and provides a framework for understanding how dysregulation of TDP-43 in RNA metabolism contributes to neurodegeneration...
  6. pmc Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase
    Sheu Fen Lee
    Department of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 286:27447-53. 2011
    ..The sequential and regulated proteolysis by γ-secretase and MIPEP suggests a new means by which Notch function can be modulated...
  7. pmc TDP-43 is a developmentally regulated protein essential for early embryonic development
    Chantelle F Sephton
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:6826-34. 2010
    ..These results indicate that TDP-43 is developmentally regulated and indispensible for early embryonic development...
  8. pmc Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia
    Basar Cenik
    Department of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9111, USA
    J Biol Chem 286:16101-8. 2011
    ..SAHA has demonstrated therapeutic potential in other neurodegenerative diseases and thus holds promise as a first generation drug for the prevention and treatment of frontotemporal dementia...