Barbara Sennino

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Cancer Res 69:4527-36. 2009
  2. pmc Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    Michael R Mancuso
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143 0452, USA
    J Clin Invest 116:2610-21. 2006
  3. doi request reprint Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice
    Barbara Sennino
    Department of Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Magn Reson Med 62:616-25. 2009
  4. pmc Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cells
    Tobias D Henning
    Department of Radiology, University of California, San Francisco UCSF Medical Center, UCSF, San Francisco, CA 94143 0628, USA
    Magn Reson Med 62:325-32. 2009
  5. ncbi request reprint Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California 94080, USA
    Cancer Res 67:7358-67. 2007
  6. pmc Labeling human mesenchymal stem cells with fluorescent contrast agents: the biological impact
    Sophie E Boddington
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Mol Imaging Biol 13:3-9. 2011
  7. doi request reprint Magnetic resonance imaging for monitoring the effects of thalidomide on experimental human breast cancers
    Clemens C Cyran
    Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Eur Radiol 19:121-31. 2009
  8. doi request reprint Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature
    Clemens C Cyran
    Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Invest Radiol 43:298-305. 2008
  9. ncbi request reprint VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    Tomomi Kamba
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H560-76. 2006
  10. pmc Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B
    Beverly L Falcon
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA
    Am J Pathol 178:2920-30. 2011

Collaborators

Detail Information

Publications21

  1. pmc Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Cancer Res 69:4527-36. 2009
    ..The findings emphasize the interdependence of pericytes and endothelial cells in tumors and the importance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor vessels...
  2. pmc Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    Michael R Mancuso
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143 0452, USA
    J Clin Invest 116:2610-21. 2006
    ....
  3. doi request reprint Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice
    Barbara Sennino
    Department of Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Magn Reson Med 62:616-25. 2009
    ..356 mL/min/100 cm(3). Dynamic MMCM-enhanced MRI is feasible in RIP-Tag2 pancreatic tumors, yielding estimates of vascular permeability and microscopically validated measurements of vascular richness...
  4. pmc Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cells
    Tobias D Henning
    Department of Radiology, University of California, San Francisco UCSF Medical Center, UCSF, San Francisco, CA 94143 0628, USA
    Magn Reson Med 62:325-32. 2009
    ..These results show that viable cells with compartmentalized iron oxides may-in principle-be distinguished from lysed cells or released iron oxides...
  5. ncbi request reprint Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California 94080, USA
    Cancer Res 67:7358-67. 2007
    ..Loss of pericytes in tumors is an expected direct consequence of PDGF-B blockade, but reduced tumor vascularity is likely to be secondary to pericyte regression...
  6. pmc Labeling human mesenchymal stem cells with fluorescent contrast agents: the biological impact
    Sophie E Boddington
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Mol Imaging Biol 13:3-9. 2011
    ..This study aims to determine the effect of human mesenchymal stem cell (hMSC) labeling with the fluorescent dye DiD and the iron oxide nanoparticle ferucarbotran on chondrogenesis...
  7. doi request reprint Magnetic resonance imaging for monitoring the effects of thalidomide on experimental human breast cancers
    Clemens C Cyran
    Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Eur Radiol 19:121-31. 2009
    ..The significant correlation between MRI and fluorescence microscopic measures of MMCM extravasation supports the utility of the non-invasive MRI approach for assessing the action of thalidomide on tumor blood vessels...
  8. doi request reprint Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature
    Clemens C Cyran
    Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Invest Radiol 43:298-305. 2008
    ....
  9. ncbi request reprint VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    Tomomi Kamba
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H560-76. 2006
    ..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature...
  10. pmc Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B
    Beverly L Falcon
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA
    Am J Pathol 178:2920-30. 2011
    ..Together, these findings indicate that inhibition of PDGF-B signaling promotes the delivery and efficacy of chemotherapeutic agents by increasing the efficiency of tumor blood vessels...
  11. pmc Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
    Barbara Sennino
    Comprehensive Cancer Center, Department of Anatomy, University of California San Francisco UCSF, San Francisco, CA 94143 0452, USA
    Cancer Discov 2:270-87. 2012
    ..These findings document that invasion and metastasis are promoted by selective inhibition of VEGF signaling and can be reduced by the concurrent inhibition of c-Met...
  12. pmc An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritis
    Elizabeth J Sutton
    Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
    Opt Express 17:24403-13. 2009
    ..The experimental results indicate that DiD integrated into the cell membrane. DiD-labeled MSC localization in the arthritic ankle joints was observed with OI indicating that this method can be applied to monitor MSC in arthritic joints...
  13. doi request reprint Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats
    Hans Juergen Raatschen
    Department of Radiology, Center for Pharmaceutical and Molecular Imaging, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, CA, USA
    Radiology 247:391-9. 2008
    ....
  14. pmc Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice
    Barbara Sennino
    Department of Anatomy, Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Cancer Res 73:3692-703. 2013
    ..Prevention of lymph node metastasis by PF-04217903 in this setting implicates c-Met signaling in tumor cell spread to lymph nodes...
  15. pmc VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer
    Weon Kyoo You
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Cancer Res 71:4758-68. 2011
    ....
  16. pmc Controlling escape from angiogenesis inhibitors
    Barbara Sennino
    the UCSF Helen Diller Family Comprehensive Cancer Center, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, San Francisco, California 94143 0452, USA
    Nat Rev Cancer 12:699-709. 2012
    ..New therapeutic approaches that target pathways that are involved in the escape mechanisms add the benefits of blocking tumour progression to those of slowing tumour growth by inhibiting angiogenesis...
  17. pmc MR signal characteristics of viable and apoptotic human mesenchymal stem cells in matrix-associated stem cell implants for treatment of osteoarthritis
    Alexander Nedopil
    Department of Radiology and Biomedical Imaging, UCSF Medical Center, University of California, San Francisco, CA 94143, USA
    Invest Radiol 45:634-40. 2010
    ..To compare magnetic resonance (MR) signal characteristics of contrast agent-labeled apoptotic and viable human mesenchymal stem cells (hMSCs) in matrix-associated stem cell implants...
  18. ncbi request reprint Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
    Fabienne Baffert
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H547-59. 2006
    ....
  19. pmc The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells
    Tobias D Henning
    Department of Radiology, UCSF Medical Center, University of California, San Francisco, CA 94143 0628, USA
    Contrast Media Mol Imaging 4:165-73. 2009
    ..Magnetic labeling of hMSC with ferucarbotran inhibits chondrogenesis in a dose-dependent manner when using simple incubation techniques. When decreasing the incubation time to 4 h, inhibition of chondrogenesis was not significant...
  20. ncbi request reprint Cell labeling with the positive MR contrast agent Gadofluorine M
    Tobias D Henning
    Department of Radiology, University of California in San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143, USA
    Eur Radiol 17:1226-34. 2007
    ..Potential in vivo cell-tracking applications include targeting of inflammatory processes with Gadofluorine-labeled leukocytes or monitoring of stem cell therapies for the treatment of arthritis...
  21. pmc Iron administration before stem cell harvest enables MR imaging tracking after transplantation
    Aman Khurana
    Department of Radiology and Molecular Imaging Program at Stanford, Stanford University School of Medicine, 725 Welch Rd, Room 1665, Stanford, CA 94305 5654 Department of Communication and Statistics and Department of Materials Science and Engineering, Stanford University, Stanford, Calif Department of Neurology, Comprehensive Cancer Center, Cardiovascular Research Institute and Department of Anatomy, University of California San Francisco, San Francisco, Calif
    Radiology 269:186-97. 2013
    ..To determine whether intravenous ferumoxytol can be used to effectively label mesenchymal stem cells (MSCs) in vivo and can be used for tracking of stem cell transplants...