Research Topics
Species | Barbara SenninoSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitorsBarbara Sennino
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
Cancer Res 69:4527-36. 2009..The findings emphasize the interdependence of pericytes and endothelial cells in tumors and the importance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor vessels...- Rapid vascular regrowth in tumors after reversal of VEGF inhibitionMichael R Mancuso
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143-0452, USA
J Clin Invest 116:2610-21. 2006.... 
Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic miceBarbara Sennino
Department of Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California, USA
Magn Reson Med 62:616-25. 2009..356 mL/min/100 cm(3). Dynamic MMCM-enhanced MRI is feasible in RIP-Tag2 pancreatic tumors, yielding estimates of vascular permeability and microscopically validated measurements of vascular richness...- Magnetic resonance imaging for monitoring the effects of thalidomide on experimental human breast cancersClemens C Cyran
Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Eur Radiol 19:121-31. 2009..The significant correlation between MRI and fluorescence microscopic measures of MMCM extravasation supports the utility of the non-invasive MRI approach for assessing the action of thalidomide on tumor blood vessels... - Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculatureClemens C Cyran
Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Invest Radiol 43:298-305. 2008.... 
Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102Barbara Sennino
Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California 94080, USA
Cancer Res 67:7358-67. 2007..Loss of pericytes in tumors is an expected direct consequence of PDGF-B blockade, but reduced tumor vascularity is likely to be secondary to pericyte regression...- Labeling human mesenchymal stem cells with fluorescent contrast agents: the biological impactSophie E Boddington
Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
Mol Imaging Biol 13:3-9. 2011..This study aims to determine the effect of human mesenchymal stem cell (hMSC) labeling with the fluorescent dye DiD and the iron oxide nanoparticle ferucarbotran on chondrogenesis... - Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cellsTobias D Henning
Department of Radiology, University of California, San Francisco UCSF Medical Center, UCSF, San Francisco, CA 94143 0628, USA
Magn Reson Med 62:325-32. 2009..These results show that viable cells with compartmentalized iron oxides may-in principle-be distinguished from lysed cells or released iron oxides... - VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculatureTomomi Kamba
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H560-76. 2006..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature... - Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumorsBarbara Sennino
Comprehensive Cancer Center, Department of Anatomy, University of California San Francisco UCSF, San Francisco, CA 94143 0452, USA
Cancer Discov 2:270-87. 2012..The results show that simultaneous inhibition of c-Met and VEGF signaling not only slows tumor growth but also reduces invasion and metastasis... - An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritisElizabeth J Sutton
Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
Opt Express 17:24403-13. 2009..The experimental results indicate that DiD integrated into the cell membrane. DiD-labeled MSC localization in the arthritic ankle joints was observed with OI indicating that this method can be applied to monitor MSC in arthritic joints... - Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-BBeverly L Falcon
Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA
Am J Pathol 178:2920-30. 2011..Together, these findings indicate that inhibition of PDGF-B signaling promotes the delivery and efficacy of chemotherapeutic agents by increasing the efficiency of tumor blood vessels... - VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancerWeon Kyoo You
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143, USA
Cancer Res 71:4758-68. 2011.... - Controlling escape from angiogenesis inhibitorsBarbara Sennino
the UCSF Helen Diller Family Comprehensive Cancer Center, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, San Francisco, California 94143 0452, USA
Nat Rev Cancer 12:699-709. 2012..New therapeutic approaches that target pathways that are involved in the escape mechanisms add the benefits of blocking tumour progression to those of slowing tumour growth by inhibiting angiogenesis... - MR signal characteristics of viable and apoptotic human mesenchymal stem cells in matrix-associated stem cell implants for treatment of osteoarthritisAlexander Nedopil
Department of Radiology and Biomedical Imaging, UCSF Medical Center, University of California, San Francisco, CA 94143, USA
Invest Radiol 45:634-40. 2010..To compare magnetic resonance (MR) signal characteristics of contrast agent-labeled apoptotic and viable human mesenchymal stem cells (hMSCs) in matrix-associated stem cell implants... - Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signalingFabienne Baffert
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H547-59. 2006.... - Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in ratsHans Juergen Raatschen
Department of Radiology, Center for Pharmaceutical and Molecular Imaging, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, CA, USA
Radiology 247:391-9. 2008.... - The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cellsTobias D Henning
Department of Radiology, UCSF Medical Center, University of California, San Francisco, CA 94143 0628, USA
Contrast Media Mol Imaging 4:165-73. 2009..Magnetic labeling of hMSC with ferucarbotran inhibits chondrogenesis in a dose-dependent manner when using simple incubation techniques. When decreasing the incubation time to 4 h, inhibition of chondrogenesis was not significant...