Krishanu Sengupta

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Lesional T cells and dermal dendrocytes in psoriasis plaque express increased levels of granulysin
    Siba P Raychaudhuri
    Psoriasis Research Institute, Palo Alto and Stanford University School of Medicine, Palo Alto, California, USA
    J Am Acad Dermatol 51:1006-8. 2004
  2. ncbi Role of IL-17 in psoriasis and psoriatic arthritis
    Siba P Raychaudhuri
    VA Sacramento Medical Centre, 10535, Hospital Way, Mather, CA 95655, USA
    Clin Rev Allergy Immunol 44:183-93. 2013
  3. ncbi A cutting edge overview: psoriatic disease
    Siba P Raychaudhuri
    Department of Medicine, VA Sacramento Medical Centre, 10535 Hospital Way, Mather, CA 95655, USA
    Clin Rev Allergy Immunol 44:109-13. 2013
  4. ncbi Functional role of IL-22 in psoriatic arthritis
    Anupam Mitra
    University of California, Davis, School of Medicine, Dermatology, Davis and VA Medical Center Sacramento, Mather, CA, USA
    Arthritis Res Ther 14:R65. 2012
  5. ncbi Comorbidities of psoriatic arthritis -- metabolic syndrome and prevention: a report from the GRAPPA 2010 annual meeting
    Siba P Raychaudhuri
    Veterans Affairs Sacramento Medical Center, University of California Davis, School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, Davis, California, USA
    J Rheumatol 39:437-40. 2012
  6. ncbi A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee
    Krishanu Sengupta
    Cellular and Molecular Biology Division, Laila Impex R and D Center, Jawahar Autonagar, Vijayawada, India
    Arthritis Res Ther 10:R85. 2008
  7. ncbi IL-17 receptor and its functional significance in psoriatic arthritis
    Siba P Raychaudhuri
    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis School of Medicine and VA Medical Center Sacramento, 1911 Geneva Place, Davis, CA 95618, USA
    Mol Cell Biochem 359:419-29. 2012
  8. ncbi NGF and its receptor system: a new dimension in the pathogenesis of psoriasis and psoriatic arthritis
    Smriti K Raychaudhuri
    VA Medical Center Sacramento and UC Davis School of Medicine, Department of Medicine Division of Rheumatology, Allergy and Clinical Immunology, Sacramento, CA 95655, USA
    Ann N Y Acad Sci 1173:470-7. 2009
  9. ncbi Incidence and nature of infectious disease in patients treated with anti-TNF agents
    Siba P Raychaudhuri
    VA Medical Center, Sacramento, USA
    Autoimmun Rev 9:67-81. 2009
  10. ncbi The regulatory role of nerve growth factor and its receptor system in fibroblast-like synovial cells
    S P Raychaudhuri
    VA Medical Center Sacramento, Clinical Immunology Laboratory, Davis, CA, USA
    Scand J Rheumatol 38:207-15. 2009

Collaborators

Detail Information

Publications29

  1. ncbi Lesional T cells and dermal dendrocytes in psoriasis plaque express increased levels of granulysin
    Siba P Raychaudhuri
    Psoriasis Research Institute, Palo Alto and Stanford University School of Medicine, Palo Alto, California, USA
    J Am Acad Dermatol 51:1006-8. 2004
    ..Increased levels of granulysin provide an explanation for relative immunity of psoriatic plaques against both gram-positive and gram-negative bacterial infections...
  2. ncbi Role of IL-17 in psoriasis and psoriatic arthritis
    Siba P Raychaudhuri
    VA Sacramento Medical Centre, 10535, Hospital Way, Mather, CA 95655, USA
    Clin Rev Allergy Immunol 44:183-93. 2013
    ..In this review article, we have discussed the role of IL-17 in psoriatic disease and have narrated about the novel IL17/IL-17R antibodies currently in preparation for its therapeutic uses in autoimmune diseases...
  3. ncbi A cutting edge overview: psoriatic disease
    Siba P Raychaudhuri
    Department of Medicine, VA Sacramento Medical Centre, 10535 Hospital Way, Mather, CA 95655, USA
    Clin Rev Allergy Immunol 44:109-13. 2013
    ..In this thematic review, we have attempted to provide summaries of not only basic science and clinical research, but also an overview of future research directions...
  4. ncbi Functional role of IL-22 in psoriatic arthritis
    Anupam Mitra
    University of California, Davis, School of Medicine, Dermatology, Davis and VA Medical Center Sacramento, Mather, CA, USA
    Arthritis Res Ther 14:R65. 2012
    ..Immunopathological role of IL-22 has been studied in rheumatoid arthritis (RA) and psoriasis. Here we are reporting the functional role of IL-22 in the inflammatory and proliferative cascades of psoriatic arthritis (PsA)...
  5. ncbi Comorbidities of psoriatic arthritis -- metabolic syndrome and prevention: a report from the GRAPPA 2010 annual meeting
    Siba P Raychaudhuri
    Veterans Affairs Sacramento Medical Center, University of California Davis, School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, Davis, California, USA
    J Rheumatol 39:437-40. 2012
    ..The review summarizes a presentation at the 2010 annual meeting of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis)...
  6. ncbi A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee
    Krishanu Sengupta
    Cellular and Molecular Biology Division, Laila Impex R and D Center, Jawahar Autonagar, Vijayawada, India
    Arthritis Res Ther 10:R85. 2008
    ..A 90-day, double-blind, randomized, placebo-controlled study was conducted to evaluate the efficacy and safety of 5-Loxin in the treatment of osteoarthritis (OA) of the knee...
  7. ncbi IL-17 receptor and its functional significance in psoriatic arthritis
    Siba P Raychaudhuri
    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis School of Medicine and VA Medical Center Sacramento, 1911 Geneva Place, Davis, CA 95618, USA
    Mol Cell Biochem 359:419-29. 2012
    ..This is the first report to demonstrate the functional significance of IL-17RA in PsA. Results of this study support the hypothesis that IL-17RA blocking antibodies have the potential to be a therapeutic option for psoriatic arthritis...
  8. ncbi NGF and its receptor system: a new dimension in the pathogenesis of psoriasis and psoriatic arthritis
    Smriti K Raychaudhuri
    VA Medical Center Sacramento and UC Davis School of Medicine, Department of Medicine Division of Rheumatology, Allergy and Clinical Immunology, Sacramento, CA 95655, USA
    Ann N Y Acad Sci 1173:470-7. 2009
    ..In this chapter we will discuss the role of NGF and its receptor system in psoriatic disease, inflammatory arthritis, and arthritic pain of osteoarthritis...
  9. ncbi Incidence and nature of infectious disease in patients treated with anti-TNF agents
    Siba P Raychaudhuri
    VA Medical Center, Sacramento, USA
    Autoimmun Rev 9:67-81. 2009
    ..This review provides the incidence and nature of infections in patients treated with TNF-alpha inhibitor agents and reminds the clinician of the required vigilance in monitoring patients...
  10. ncbi The regulatory role of nerve growth factor and its receptor system in fibroblast-like synovial cells
    S P Raychaudhuri
    VA Medical Center Sacramento, Clinical Immunology Laboratory, Davis, CA, USA
    Scand J Rheumatol 38:207-15. 2009
    ..Here we have studied NGF/NGF-R and their functional significance on cultured fibroblast-like synovial cells (FLS) collected from the synovial tissue of five healthy subjects...
  11. ncbi Nerve growth factor: A key local regulator in the pathogenesis of inflammatory arthritis
    Siba P Raychaudhuri
    University of California School of Medicine, Davis, VA Medical Center, Sacramento, California, USA
    Arthritis Rheum 63:3243-52. 2011
    ....
  12. ncbi Revisiting the Koebner phenomenon: role of NGF and its receptor system in the pathogenesis of psoriasis
    Siba P Raychaudhuri
    Veterans Administration Medical Center and Division of Rheumatology, Allergy, and Clinical Immunology, School of Medicine, University of California Davis, Sacramento, CA, USA
    Am J Pathol 172:961-71. 2008
    ....
  13. ncbi FR255734, a humanized, Fc-Silent, Anti-CD28 antibody, improves psoriasis in the SCID mouse-psoriasis xenograft model
    Siba P Raychaudhuri
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    J Invest Dermatol 128:1969-76. 2008
    ..In vitro studies have shown that FR255734 effectively blocked T-cell proliferation and proinflammatory cytokine production. These observations warrant studies to evaluate the efficacy of FR255734 in human autoimmune diseases...
  14. ncbi Insulin-like growth factor-1 (IGF-1) induces WISP-2/CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen receptor-positive breast tumor cells
    Kakali Dhar
    Cancer Research Unit, VA Medical Center, Kansas City, MO 64128, USA
    Cancer Res 67:1520-6. 2007
    ..Collectively, these studies propose for the first time that WISP-2/CCN5 is an integral signaling molecule in mitogenic action of IGF-1 axis in ER-positive human breast tumor cells...
  15. ncbi VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis
    Snigdha Banerjee
    Stem Cell Research Laboratory, Cancer Research Unit, VA Medical Center, Kansas City, Missouri 64128, USA
    Biochemistry 47:3345-51. 2008
    ....
  16. ncbi Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks
    Snigdha Banerjee
    Cancer Research Unit, Research Division 151, VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA
    Mol Cancer Res 3:151-62. 2005
    ..Finally, regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells...
  17. ncbi K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model
    Siba P Raychaudhuri
    Psoriasis Research Institute, Palo Alto, California, USA
    J Invest Dermatol 122:812-9. 2004
    ..5+/-42.69 to 150.52+/-32.93 microm (p<0.05, Student's t test). This study provides evidence for the role of NGF and its high-affinity receptor in the pathogenesis of psoriasis and insights to develop novel therapeutic modalities...
  18. ncbi Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract
    Krishanu Sengupta
    Cellular and Molecular Biology Division, Laila Impex R and D Center, Jawahar Autonagar, Vijayawada 520 007, India
    Mol Cell Biochem 354:189-97. 2011
    ....
  19. ncbi Breast cancer cells secreted platelet-derived growth factor-induced motility of vascular smooth muscle cells is mediated through neuropilin-1
    Snigdha Banerjee
    Cancer Research Unit, VA Medical Center, Kansas City, Missouri 64128, USA
    Mol Carcinog 45:871-80. 2006
    ..Moreover, we demonstrate that PDGF physically interacts with NRP-1. We propose that tumor-derived PDGF and NRP-1 of AOSMCs function as a relay system that promotes motility of vascular SMCs...
  20. ncbi Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study
    Krishanu Sengupta
    Laila Impex R and D Center, Jawahar Autonagar, Vijayawada 520 007, India
    Int J Med Sci 7:366-77. 2010
    ..Aflapin exhibited better efficacy compared to 5-Loxin(®). In comparison with placebo, the safety parameters were almost unchanged in the treatment groups. Hence both 5-Loxin(®) and Aflapin(®) are safe for human consumption...
  21. ncbi Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis
    Siba P Raychaudhuri
    Psoriasis Research Institute, Stanford University School of Medicine, 510 Ashton Avenue, Palo Alto, CA 94306, USA
    Prog Brain Res 146:433-7. 2004
    ..Currently, we are evaluating antagonists to selected neuropeptides and NGF/receptors, with the expectation of identifying pharmacological agents to counter neurogenic inflammation in psoriasis...
  22. ncbi Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis
    Smriti K Raychaudhuri
    VA Medical Center, Mather, California, USA
    Metab Syndr Relat Disord 8:331-4. 2010
    ..The aim of this study was to determine the prevalence of metabolic syndrome in PsA...
  23. ncbi Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol
    Krishanu Sengupta
    Cancer Research Unit, VA Medical Center, Kansas City, MO 64128, USA
    Mol Cancer Res 2:150-8. 2004
    ..Together, these studies suggest that TSP-1 can be considered an important negative factor in understanding the increased angiogenesis in response to estrogens...
  24. ncbi SCEDOSPORIUM INFECTION IN A PATIENT WITH ANTI-TNFα THERAPY
    Caroline T Nguyen
    Department of Medicine, VA Medical Center Sacramento and UC Davis School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, Hospital Way, Mather, CA 95655, USA
    Indian J Dermatol 56:82-3. 2011
    ..Patients on anti-TNFα need close follow-up and clinicians should be suspicious for atypical infections in these immunocompromised hosts...
  25. ncbi Current controversies in spondyloarthritis: SPARTAN
    Michael Weisman
    Cedars Sinai Medical Center, Los Angeles, California, USA
    J Rheumatol 37:2617-23. 2010
    ..Presentations also were made on psoriasis in the SCID mouse model; the challenges and opportunities of SpA in China; a discussion of the special needs in managing SpA in Ibero-America, and the SPARK Survey in Europe and North America...
  26. ncbi Golimumab and certolizumab: the two new anti-tumor necrosis factor kids on the block
    Mohit Mittal
    Department of Medicine, Division of Rheumatology, VA Medical Center Sacramento and UC Davis School of Medicine, Allergy and Clinical Immunology, 105 35 Hospital Way, Mather, CA 95655, USA
    Indian J Dermatol Venereol Leprol 76:602-8; quiz 609. 2010
    ..Here, we are providing a brief description about these two drugs and their uses...
  27. ncbi Scid mouse model of psoriasis: a unique tool for drug development of autoreactive T-cell and th-17 cell-mediated autoimmune diseases
    Smriti K Raychaudhuri
    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, School of Medicine and VA Sacramento Medical Center, CA 95618, USA
    Indian J Dermatol 55:157-60. 2010
    ..Here we will share our experience of the SCID mouse model of psoriasis in respect to its use in investigating psoriatic diseases and development of immune-based drugs for psoriasis, psoriatic arthritis, and other autoimmune diseases...
  28. ncbi Biologics: target-specific treatment of systemic and cutaneous autoimmune diseases
    Siba P Raychaudhuri
    Department of Immunology and Rheumatology, VA Medical Center, Sacramento Graduate Group Immunology, University of California Davis, USA
    Indian J Dermatol 54:100-9. 2009
    ..Consensus needs be formed to further categorize the clinical profiles of the patients in whom biologics are to be used in the future, given that the long-term safety profiles of these agents are very much unknown at present...
  29. ncbi Clinical course of psoriasis during pregnancy
    Siba P Raychaudhuri
    Psoriasis Research Institute, Palo Alto, CA 94306, USA
    Int J Dermatol 42:518-20. 2003
    ..In this study we investigated the clinical course of psoriasis during pregnancy...