Ryan S Senger

Summary

Affiliation: University of Delaware
Country: USA

Publications

  1. pmc The transcriptional program underlying the physiology of clostridial sporulation
    Shawn W Jones
    Department of Chemical and Biological Engineering, Northwestern University, Sheridan Road, Evanston, IL 60208 3120, USA
    Genome Biol 9:R114. 2008
  2. ncbi request reprint Prediction of N-linked glycan branching patterns using artificial neural networks
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA
    Math Biosci 211:89-104. 2008
  3. pmc Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1053-71. 2008
  4. pmc Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1036-52. 2008
  5. ncbi request reprint Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1199-209. 2003
  6. ncbi request reprint Neural-network-based identification of tissue-type plasminogen activator protein production and glycosylation in CHO cell culture under shear environment
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1828-36. 2003
  7. ncbi request reprint Variable site-occupancy classification of N-linked glycosylation using artificial neural networks
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, MS 43121, Lubbock, 79409 3121, USA
    Biotechnol Prog 21:1653-62. 2005
  8. ncbi request reprint Optimization of fed-batch parameters and harvest time of CHO cell cultures for a glycosylated product with multiple mechanisms of inactivation
    Ryan S Senger
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Biotechnol Bioeng 98:378-90. 2007
  9. ncbi request reprint Development of a culture sub-population induction model: signaling pathways synergy and taxanes production by Taxus canadensis
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, USA
    Biotechnol Prog 22:1671-82. 2006

Collaborators

Detail Information

Publications9

  1. pmc The transcriptional program underlying the physiology of clostridial sporulation
    Shawn W Jones
    Department of Chemical and Biological Engineering, Northwestern University, Sheridan Road, Evanston, IL 60208 3120, USA
    Genome Biol 9:R114. 2008
    ..Elucidation of their sporulation program is critical for understanding important clostridial programs pertaining to their physiology and their industrial or environmental applications...
  2. ncbi request reprint Prediction of N-linked glycan branching patterns using artificial neural networks
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA
    Math Biosci 211:89-104. 2008
    ..G. Lee, N.K. Kalyan, S.M. Cheng, F. Wiener, W. Pierzchala, P.P. Hung, Alterations in the domain structure of tissue-type plasminogen activator change the nature of asparagine glycosylation. Biotechnology (N.Y.) 8 (1990) 321-325]...
  3. pmc Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1053-71. 2008
    ..These results were then used to establish additional constraints for the genome-scale model...
  4. pmc Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1036-52. 2008
    ..Systematic gene knock-out simulations were performed to identify a set of genes encoding clostridial enzymes essential for growth in silico...
  5. ncbi request reprint Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1199-209. 2003
    ..Decreased residence time of r-tPA in the ER as a result of increased protein synthesis related to shear protection mechanisms is proposed to limit contact of site Asn184 with the membrane-bound oligosaccharyltransferase enzyme in the ER...
  6. ncbi request reprint Neural-network-based identification of tissue-type plasminogen activator protein production and glycosylation in CHO cell culture under shear environment
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1828-36. 2003
    ..945, 0.943, 0.956, and 0.990 were calculated to validate individual ANN prediction accuracy for total ammonia, apparent viable cell density, total r-tPA, and Type II glycoform concentrations, respectively...
  7. ncbi request reprint Variable site-occupancy classification of N-linked glycosylation using artificial neural networks
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, MS 43121, Lubbock, 79409 3121, USA
    Biotechnol Prog 21:1653-62. 2005
    ..Biochemistry 1998, 37, 6833-6837). Further simulations on purely theoretical sequences suggested that influences of charged residues were a subset of multiple mechanisms in the determination of glycosylation site-occupancy...
  8. ncbi request reprint Optimization of fed-batch parameters and harvest time of CHO cell cultures for a glycosylated product with multiple mechanisms of inactivation
    Ryan S Senger
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Biotechnol Bioeng 98:378-90. 2007
    ..15 of glucose to amino acids. Comparison of the two feeding strategies showed a slight advantage of rapid feeding at a fixed flow rate as opposed to metabolite control for a product with multiple mechanisms of inactivation...
  9. ncbi request reprint Development of a culture sub-population induction model: signaling pathways synergy and taxanes production by Taxus canadensis
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, USA
    Biotechnol Prog 22:1671-82. 2006
    ..When coupled with simple non-growth product models, levels of all extracellular taxanes were effectively predicted using the culture sub-population induction model...

Research Grants2

  1. Clostridial genome-scale metabolic and regulatory model of differentiation
    RYAN SENGER; Fiscal Year: 2007
    ..In the case of certain clostridia, this model will also be used to identify targets of metabolic engineering that result in increased production of biofuels (ethanol and butanol) and renewable energy (hydrogen). ..