Ryan S Senger

Summary

Affiliation: University of Delaware
Country: USA

Publications

  1. pmc The transcriptional program underlying the physiology of clostridial sporulation
    Shawn W Jones
    Department of Chemical and Biological Engineering, Northwestern University, Sheridan Road, Evanston, IL 60208 3120, USA
    Genome Biol 9:R114. 2008
  2. ncbi request reprint Prediction of N-linked glycan branching patterns using artificial neural networks
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA
    Math Biosci 211:89-104. 2008
  3. pmc Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1053-71. 2008
  4. pmc Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1036-52. 2008
  5. ncbi request reprint Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1199-209. 2003
  6. ncbi request reprint Neural-network-based identification of tissue-type plasminogen activator protein production and glycosylation in CHO cell culture under shear environment
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1828-36. 2003
  7. ncbi request reprint Variable site-occupancy classification of N-linked glycosylation using artificial neural networks
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, MS 43121, Lubbock, 79409 3121, USA
    Biotechnol Prog 21:1653-62. 2005
  8. ncbi request reprint Optimization of fed-batch parameters and harvest time of CHO cell cultures for a glycosylated product with multiple mechanisms of inactivation
    Ryan S Senger
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Biotechnol Bioeng 98:378-90. 2007
  9. ncbi request reprint Development of a culture sub-population induction model: signaling pathways synergy and taxanes production by Taxus canadensis
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, USA
    Biotechnol Prog 22:1671-82. 2006

Collaborators

Detail Information

Publications9

  1. pmc The transcriptional program underlying the physiology of clostridial sporulation
    Shawn W Jones
    Department of Chemical and Biological Engineering, Northwestern University, Sheridan Road, Evanston, IL 60208 3120, USA
    Genome Biol 9:R114. 2008
    ..Elucidation of their sporulation program is critical for understanding important clostridial programs pertaining to their physiology and their industrial or environmental applications...
  2. ncbi request reprint Prediction of N-linked glycan branching patterns using artificial neural networks
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA
    Math Biosci 211:89-104. 2008
    ..G. Lee, N.K. Kalyan, S.M. Cheng, F. Wiener, W. Pierzchala, P.P. Hung, Alterations in the domain structure of tissue-type plasminogen activator change the nature of asparagine glycosylation. Biotechnology (N.Y.) 8 (1990) 321-325]...
  3. pmc Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1053-71. 2008
    ..These results were then used to establish additional constraints for the genome-scale model...
  4. pmc Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
    Ryan S Senger
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way Newark, Delaware 19711, USA
    Biotechnol Bioeng 101:1036-52. 2008
    ..Systematic gene knock-out simulations were performed to identify a set of genes encoding clostridial enzymes essential for growth in silico...
  5. ncbi request reprint Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1199-209. 2003
    ..Decreased residence time of r-tPA in the ER as a result of increased protein synthesis related to shear protection mechanisms is proposed to limit contact of site Asn184 with the membrane-bound oligosaccharyltransferase enzyme in the ER...
  6. ncbi request reprint Neural-network-based identification of tissue-type plasminogen activator protein production and glycosylation in CHO cell culture under shear environment
    Ryan S Senger
    Department of Chemical Engineering, Colorado State University, Fort Collins, Colorado 80523, USA
    Biotechnol Prog 19:1828-36. 2003
    ..945, 0.943, 0.956, and 0.990 were calculated to validate individual ANN prediction accuracy for total ammonia, apparent viable cell density, total r-tPA, and Type II glycoform concentrations, respectively...
  7. ncbi request reprint Variable site-occupancy classification of N-linked glycosylation using artificial neural networks
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, MS 43121, Lubbock, 79409 3121, USA
    Biotechnol Prog 21:1653-62. 2005
    ..Biochemistry 1998, 37, 6833-6837). Further simulations on purely theoretical sequences suggested that influences of charged residues were a subset of multiple mechanisms in the determination of glycosylation site-occupancy...
  8. ncbi request reprint Optimization of fed-batch parameters and harvest time of CHO cell cultures for a glycosylated product with multiple mechanisms of inactivation
    Ryan S Senger
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Biotechnol Bioeng 98:378-90. 2007
    ..15 of glucose to amino acids. Comparison of the two feeding strategies showed a slight advantage of rapid feeding at a fixed flow rate as opposed to metabolite control for a product with multiple mechanisms of inactivation...
  9. ncbi request reprint Development of a culture sub-population induction model: signaling pathways synergy and taxanes production by Taxus canadensis
    Ryan S Senger
    Department of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, USA
    Biotechnol Prog 22:1671-82. 2006
    ..When coupled with simple non-growth product models, levels of all extracellular taxanes were effectively predicted using the culture sub-population induction model...