L Sen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Differences in mechanisms of SR dysfunction in ischemic vs. idiopathic dilated cardiomyopathy
    L Sen
    Division of Cardiology, Department of Medicine, Department of Surgery, University of California Los Angeles Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Am J Physiol Heart Circ Physiol 279:H709-18. 2000
  2. ncbi Efficiency, efficacy, and adverse effects of adenovirus vs. liposome-mediated gene therapy in cardiac allografts
    L Sen
    Division of Cardiothoracic Surgery, Department of Surgery, University of California Medical Center and University of California School of Medicine, Los Angeles, California 90095, USA
    Am J Physiol Heart Circ Physiol 281:H1433-41. 2001
  3. ncbi Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heart
    Luyi Sen
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Mol Ther 12:49-57. 2005
  4. ncbi G protein modulates thyroid hormone-induced Na(+) channel activation in ventricular myocytes
    Luyi Sen
    Division of Cardiology, Department of Medicine, The David Geffen School of Medicine, 47 123 CHS, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    Am J Physiol Heart Circ Physiol 283:H2119-29. 2002
  5. ncbi Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation
    Jun Xu
    Division of Cardiology, UCLA Medical Center, 10833 Le Conte Ave, 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Circulation 109:363-8. 2004
  6. ncbi Effects of human tissue plasminogen gene transfer on allograft coronary atherosclerosis
    F G Scholl
    Division of Cardiothoracic Surgery, UCLA Medical Center, Los Angeles, California, USA
    J Heart Lung Transplant 20:322-9. 2001
  7. ncbi Increased incidence of atrial flutter associated with the rejection of heart transplantation
    G Cui
    Division of Cardiology, Department of Medicine, UCLA Medical Center, UCLA School of Medicine, Los Angeles, California 90095-1679, USA
    Am J Cardiol 88:280-4. 2001
  8. ncbi Localized immunosuppression in the cardiac allograft induced by a new liposome-mediated IL-10 gene therapy
    Yoo Sun Hong
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center and UCLA School of Medicine, Los Angeles, California 90095, USA
    J Heart Lung Transplant 21:1188-200. 2002
  9. ncbi Liposome-mediated combinatorial cytokine gene therapy induces localized synergistic immunosuppression and promotes long-term survival of cardiac allografts
    Hiroshi Furukawa
    Division of Cardiothoracic Surgery, Department of Surgery, University of California, Los Angeles, 90095, USA
    J Immunol 174:6983-92. 2005
  10. ncbi Overexpressed exogenous IL-4 And IL-10 paradoxically regulate allogenic T-cell and cardiac myocytes apoptosis through FAS/FASL pathway
    Hiroshi Furukawa
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Transplantation 85:437-46. 2008

Collaborators

Detail Information

Publications14

  1. ncbi Differences in mechanisms of SR dysfunction in ischemic vs. idiopathic dilated cardiomyopathy
    L Sen
    Division of Cardiology, Department of Medicine, Department of Surgery, University of California Los Angeles Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Am J Physiol Heart Circ Physiol 279:H709-18. 2000
    ..DCM. The SR Ca(2+) release dysfunction may play an important pathogenetic role in the abnormal Ca(2+) homeostasis in DCM, and the SR Ca(2+) uptake dysfunction may be responsible for the contractile dysfunction in ICM...
  2. ncbi Efficiency, efficacy, and adverse effects of adenovirus vs. liposome-mediated gene therapy in cardiac allografts
    L Sen
    Division of Cardiothoracic Surgery, Department of Surgery, University of California Medical Center and University of California School of Medicine, Los Angeles, California 90095, USA
    Am J Physiol Heart Circ Physiol 281:H1433-41. 2001
    ....
  3. ncbi Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heart
    Luyi Sen
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Mol Ther 12:49-57. 2005
    ..Our results demonstrate for the first time that PET reporter-therapeutic linked gene imaging is applicable for noninvasively monitoring ex vivo intracoronarily delivered therapeutic transgene expression in the whole heart...
  4. ncbi G protein modulates thyroid hormone-induced Na(+) channel activation in ventricular myocytes
    Luyi Sen
    Division of Cardiology, Department of Medicine, The David Geffen School of Medicine, 47 123 CHS, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    Am J Physiol Heart Circ Physiol 283:H2119-29. 2002
    ..Pertussis toxin-sensitive G protein modulation greatly magnifies the T(3) effects on the channel kinetics and null probability, thereby increasing the channel open probability...
  5. ncbi Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation
    Jun Xu
    Division of Cardiology, UCLA Medical Center, 10833 Le Conte Ave, 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Circulation 109:363-8. 2004
    ..However, the alteration of atrial extracellular matrix components during remodeling and its effect on the electrical remodeling and atrial arrhythmia have never been explored...
  6. ncbi Effects of human tissue plasminogen gene transfer on allograft coronary atherosclerosis
    F G Scholl
    Division of Cardiothoracic Surgery, UCLA Medical Center, Los Angeles, California, USA
    J Heart Lung Transplant 20:322-9. 2001
    ....
  7. ncbi Increased incidence of atrial flutter associated with the rejection of heart transplantation
    G Cui
    Division of Cardiology, Department of Medicine, UCLA Medical Center, UCLA School of Medicine, Los Angeles, California 90095-1679, USA
    Am J Cardiol 88:280-4. 2001
    ..These results demonstrate that the incidence of Afl increased after OHT, which might be a consequence of cellular and humoral rejection, and coronary vasculopathy of the transplanted hearts...
  8. ncbi Localized immunosuppression in the cardiac allograft induced by a new liposome-mediated IL-10 gene therapy
    Yoo Sun Hong
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center and UCLA School of Medicine, Los Angeles, California 90095, USA
    J Heart Lung Transplant 21:1188-200. 2002
    ..Interleukin-10 has many immunosuppressive effects; however, the mechanism(s) of its protective effect on allograft rejection remains unknown...
  9. ncbi Liposome-mediated combinatorial cytokine gene therapy induces localized synergistic immunosuppression and promotes long-term survival of cardiac allografts
    Hiroshi Furukawa
    Division of Cardiothoracic Surgery, Department of Surgery, University of California, Los Angeles, 90095, USA
    J Immunol 174:6983-92. 2005
    ..Synergism of overexpressed IL-4 and IL-10 in the inhibition of T lymphocyte infiltration and cytoxicity, and modulation of Th1/Th2 cytokine production promote long-term survival of cardiac allografts...
  10. ncbi Overexpressed exogenous IL-4 And IL-10 paradoxically regulate allogenic T-cell and cardiac myocytes apoptosis through FAS/FASL pathway
    Hiroshi Furukawa
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Transplantation 85:437-46. 2008
    ..However, the mechanism for promoting long-term allograft survival remains unknown...
  11. ncbi Localized interleukin-10 gene transfer induces apoptosis of alloreactive T cells via FAS/FASL pathway, improves function, and prolongs survival of cardiac allograft
    Kiyohiro Oshima
    Division of Cardiothoracic Surgery, Department of Surgery, University of California Los Angeles, School of Medicine, Los Angeles, CA 90095 1679, USA
    Transplantation 73:1019-26. 2002
    ....
  12. ncbi Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8+ cells and prolongs cardiac allograft survival
    Kiyohiro Oshima
    Division of Cardiothoracic Surgery, Dept of Surgery, UCLA Medical Center, David Geffen School of Medicine in UCLA, 10833 Le Conte Ave, 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Am J Physiol Heart Circ Physiol 292:H277-84. 2007
    ..Reduction of cytolytic function of cytotoxic effector cells prevents the apoptosis of cardiac myocytes...
  13. ncbi Dual upregulation of Fas and Bax promotes alloreactive T cell apoptosis in IL-10 gene targeting of cardiac allografts
    Thomas C Tung
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center, David Geffen School of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
    Am J Physiol Heart Circ Physiol 285:H964-73. 2003
    ....
  14. ncbi Preclinical safety evaluation of 18F-FHBG: a PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk's expression
    Shahriar S Yaghoubi
    Department of Radiology, Molecular Imaging Program at Stanford, Bio X Program, Stanford University School of Medicine, California, USA
    J Nucl Med 47:706-15. 2006
    ..18)F-FHBG has suitable pharmacokinetics and dosimetry for clinical applications and imaging of HSV1-TK has been demonstrated in the livers of hepatocellular cancer patients...