Jeremy D Semrau

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. Farhan Ul Haque M, Kalidass B, Bandow N, Turpin E, DiSpirito A, Semrau J. Cerium regulates expression of alternative methanol dehydrogenases in Methylosinus trichosporium OB3b. Appl Environ Microbiol. 2015;81:7546-52 pubmed publisher
    ..As a result, it appears Mxa-MeDH can be uncoupled from methane oxidation by sMMO in M. trichosporium OB3b but not from pMMO. ..
  2. Kalidass B, Ul Haque M, Baral B, DiSpirito A, Semrau J. Competition between metals for binding to methanobactin enables expression of soluble methane monooxygenase in the presence of copper. Appl Environ Microbiol. 2015;81:1024-31 pubmed publisher
    ..Finally, these findings also suggest strategies whereby field sites can be manipulated to enhance sMMO expression, i.e., through the addition of a metal that can compete with copper for binding to methanobactin. ..
  3. Farhan Ul Haque M, Kalidass B, Vorobev A, Baral B, DiSpirito A, Semrau J. Methanobactin from Methylocystis sp. strain SB2 affects gene expression and methane monooxygenase activity in Methylosinus trichosporium OB3b. Appl Environ Microbiol. 2015;81:2466-73 pubmed publisher
    ..These data suggest that methanobactin acts as a general signaling molecule in methanotrophs and that methanobactin "piracy" may be commonplace. ..
  4. Gu W, Baral B, DiSpirito A, Semrau J. An Aminotransferase Is Responsible for the Deamination of the N-Terminal Leucine and Required for Formation of Oxazolone Ring A in Methanobactin of Methylosinus trichosporium OB3b. Appl Environ Microbiol. 2017;83: pubmed
  5. Farhan Ul Haque M, Gu W, Baral B, DiSpirito A, Semrau J. Carbon source regulation of gene expression in Methylosinus trichosporium OB3b. Appl Microbiol Biotechnol. 2017;101:3871-3879 pubmed publisher
    ..trichosporium OB3b even though methane was not provided. Such findings indicate that methanotrophs can sense and respond to multiple environmental parameters simultaneously. ..
  6. Semrau J, DiSpirito A, Gu W, Yoon S. Metals and Methanotrophy. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..Here, we review recent findings on methanotrophic interactions with metals, with a particular focus on these metal switches and the mechanisms used by methanotrophs to bind and sequester metals. ..
  7. Farhan Ul Haque M, Gu W, DiSpirito A, Semrau J. Marker Exchange Mutagenesis of mxaF, Encoding the Large Subunit of the Mxa Methanol Dehydrogenase, in Methylosinus trichosporium OB3b. Appl Environ Microbiol. 2015;82:1549-1555 pubmed publisher
    ..Interestingly, growth of this mutant occurred in both the presence and the absence of copper, suggesting that Xox MeDH can replace Mxa MeDH regardless of the form of MMO expressed. ..
  8. Semrau J, DiSpirito A, Vuilleumier S. Facultative methanotrophy: false leads, true results, and suggestions for future research. FEMS Microbiol Lett. 2011;323:1-12 pubmed publisher
    ..In this review, we summarize the history of facultative methanotrophy, describe scenarios for the basis of facultative methanotrophy, and pose several topics for future research in this area...
  9. Gu W, Semrau J. Copper and cerium-regulated gene expression in Methylosinus trichosporium OB3b. Appl Microbiol Biotechnol. 2017;101:8499-8516 pubmed publisher
    ..Collectively, these data suggest that copper plays a larger role in regulating gene expression in methanotrophs, but that significant changes occur when both copper and cerium are present. ..

More Information

Publications11

  1. Gu W, Farhan Ul Haque M, Baral B, Turpin E, Bandow N, Kremmer E, et al. A TonB-Dependent Transporter Is Responsible for Methanobactin Uptake by Methylosinus trichosporium OB3b. Appl Environ Microbiol. 2016;82:1917-1923 pubmed publisher
    ..trichosporium OB3b, indicating that this methanotroph has multiple mechanisms for copper uptake. ..
  2. Gu W, Farhan Ul Haque M, DiSpirito A, Semrau J. Uptake and effect of rare earth elements on gene expression in Methylosinus trichosporium OB3b. FEMS Microbiol Lett. 2016;363: pubmed publisher
    ..Collectively, these data suggest that multiple levels of gene regulation by metals exist in M. trichosporium OB3b, but that copper overrides the effect of other metals by an as yet unknown mechanism. ..