Svetlana Semenova

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
  2. doi request reprint Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 219:433-42. 2012
  3. pmc The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Eur Neuropsychopharmacol 20:731-46. 2010
  4. pmc The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
  5. pmc Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
  6. doi request reprint Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Eur J Pharmacol 602:78-84. 2009
  7. pmc The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 52:863-72. 2007
  8. ncbi request reprint Mild anxiogenic effects of nicotine withdrawal in mice
    Sietse Jonkman
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 516:40-5. 2005
  9. pmc The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat
    Neil E Paterson
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 198:351-62. 2008
  10. pmc Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice
    Astrid K Stoker
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 54:1223-32. 2008

Collaborators

  • Nicholas D P Cosford
  • Li Yang
  • Sietse Jonkman
  • Ian P Stolerman
  • Fabrizio Gasparini
  • Anton Bespalov
  • Neil E Paterson
  • Martin Paulus
  • Athina Markou
  • Nurith Amitai
  • Shyama Sidique
  • Russell Dahl
  • P Jeffrey Conn
  • Brook L Henry
  • Douglas J Sheffler
  • Xinchun Jin
  • Astrid K Stoker
  • Manoranjan S D'Souza
  • Hilary Highfield Nickols
  • Arianna Mangravita-Novo
  • Raveendra Panickar Dhanya
  • Layton H Smith
  • Ian Abramson
  • AMANDA GRETHE
  • Ronald Ellis
  • Michael Potter
  • J Hampton Atkinson
  • Sarah Archibald
  • Reena Deutsch
  • Mili Parikh
  • Terence Hendrix
  • Eliezer Masliah
  • Florin Vaida
  • Thomas Marcotte
  • C Fenema-Notestine
  • Ronald J Ellis
  • Will Toperoff
  • Mariana Cherner
  • Virawudh Soontornniyomkij
  • Robert Heaton
  • Clint Cushman
  • Amir Sabouri
  • Dexter Walpole
  • Mark Geyer
  • ADAM ARON
  • Miriam Scadeng
  • Alana Talob
  • Rachel Meyer
  • Edmund Capparelli
  • Sheldon Morris
  • Jared W Young
  • Gregory Brown
  • Igor Grant
  • Stuart Lipton
  • Michael Mante
  • DeeDee Pacheco
  • Terry Alexander
  • Teresa Oyos
  • William Perry
  • Terry Jernigan
  • Melanie Sherman
  • Thomas Liu
  • Erick Tatro
  • RACHEL SCHRIER
  • Dongxian Zhang
  • Jose Mendez
  • Michael Repinski
  • Mandy van Rhenen
  • Nichole Duarte
  • Rodney von Jaeger
  • Sara Ortiz
  • Mark A Geyer
  • Anders Dale
  • David Smith
  • Brook Henry
  • Mahalah Buell
  • Christopher Ake
  • Arpi Minassian
  • Jennifer Marquie-Beck
  • Anthony C Gamst
  • Steven Woods
  • Ian Everall
  • Scott Letendre
  • Brad Beyenhof
  • Richard Seghers
  • Marcus Kaul
  • Matthew Dawson
  • Christian Achim
  • Robert Ardecky

Detail Information

Publications19

  1. pmc Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
    ....
  2. doi request reprint Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 219:433-42. 2012
    ..Alcohol abuse is prevalent in adolescent humans, but the long-term behavioral consequences of binge alcohol drinking are unknown...
  3. pmc The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Eur Neuropsychopharmacol 20:731-46. 2010
    ....
  4. pmc The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
    ..The higher selectivity of BINA compared with an mGluR2/3 agonist for drug- vs food-motivated behaviors suggests a therapeutic role for mGluR2 PAMs for the treatment of cocaine addiction and possibly other drugs of abuse...
  5. pmc Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
    ..Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT(7) receptor...
  6. doi request reprint Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Eur J Pharmacol 602:78-84. 2009
    ....
  7. pmc The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 52:863-72. 2007
    ..Thus, blockade of mGluR5, but not mGluR2/3, decreased overall responding without affecting accuracy in the 5CSRTT...
  8. ncbi request reprint Mild anxiogenic effects of nicotine withdrawal in mice
    Sietse Jonkman
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 516:40-5. 2005
    ..In conclusion, the present data show that nicotine withdrawal is mildly anxiogenic in C57BL/6J mice under the conditions used in the present experiments...
  9. pmc The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat
    Neil E Paterson
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 198:351-62. 2008
    ..These aversive aspects of nicotine withdrawal and the rewarding effects of nicotine play major roles in maintaining nicotine dependence...
  10. pmc Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice
    Astrid K Stoker
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 54:1223-32. 2008
    ..The current study is one of the first to demonstrate reward deficits associated with both spontaneous and nAChR antagonist-precipitated nicotine withdrawal in C57BL/6J mice...
  11. pmc Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 14:1346-55. 2012
    ..The role of β4-containing nicotinic acetylcholine receptors (nAChRs) in cognition, anxiety, depression, and analgesia in the absence of nicotine is unclear...
  12. ncbi request reprint Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, Mail Code 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 193:521-37. 2007
    ..The development and validation of animal models of cognitive deficits characterizing schizophrenia are crucial for clarifying the underlying neuropathology and discovery of improved treatments for such deficits...
  13. pmc Chronic nicotine administration improves attention while nicotine withdrawal induces performance deficits in the 5-choice serial reaction time task in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603 La Jolla, California 92093, USA
    Pharmacol Biochem Behav 87:360-8. 2007
    ..These results provide evidence that chronic, but not acute, nicotine administration induced accuracy improvement under baseline conditions, while nicotine withdrawal produced some limited performance deficits...
  14. ncbi request reprint Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1025:491-503. 2004
    ..Thus, compounds that increase GABAergic neurotransmission and antagonists at mGluR5 have potential as anti-smoking medications for humans...
  15. pmc Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence
    Shyama Sidique
    Apoptosis and Cell Death Research Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 55:9434-45. 2012
    ..Our data, showing for the first time efficacy of an mGlu(2) receptor PAM in this in vivo model, suggest potential utility for the treatment of nicotine dependence in humans...
  16. ncbi request reprint Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine
    Svetlana Semenova
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:1249-64. 2003
    ..g., anhedonia), we hypothesized that treatment with clozapine may be effective against nicotine and amphetamine withdrawal...
  17. ncbi request reprint Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration
    Svetlana Semenova
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Eur J Pharmacol 472:99-110. 2003
    ..Thus, nicotine withdrawal results in modest, but yet detectable, changes in the behavior of mice...
  18. pmc Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Psychopharmacology (Berl) 215:697-707. 2011
    ..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions...
  19. ncbi request reprint The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    Neil E Paterson
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 167:257-64. 2003
    ..Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbens and may play a role in modulating the post-synaptic response to both glutamate and dopamine...