Svetlana Semenova

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
  2. ncbi Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 219:433-42. 2012
  3. ncbi The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Eur Neuropsychopharmacol 20:731-46. 2010
  4. ncbi The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
  5. ncbi Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
  6. ncbi Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Eur J Pharmacol 602:78-84. 2009
  7. ncbi The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 52:863-72. 2007
  8. ncbi The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat
    Neil E Paterson
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 198:351-62. 2008
  9. ncbi Mild anxiogenic effects of nicotine withdrawal in mice
    Sietse Jonkman
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 516:40-5. 2005
  10. ncbi Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice
    Astrid K Stoker
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 54:1223-32. 2008

Collaborators

  • Neil E Paterson
  • Nicholas D P Cosford
  • Li Yang
  • Sietse Jonkman
  • Ian P Stolerman
  • Fabrizio Gasparini
  • Anton Bespalov
  • Martin Paulus
  • Athina Markou
  • Nurith Amitai
  • Shyama Sidique
  • Russell Dahl
  • P Jeffrey Conn
  • Douglas J Sheffler
  • Brook L Henry
  • Xinchun Jin
  • Astrid K Stoker
  • Arianna Mangravita-Novo
  • Manoranjan S D'Souza
  • Layton H Smith
  • Hilary Highfield Nickols
  • Raveendra Panickar Dhanya
  • Reena Deutsch
  • Mark Geyer
  • Stuart Lipton
  • Nichole Duarte
  • William Perry
  • Eliezer Masliah
  • Arpi Minassian
  • Mariana Cherner
  • Steven Woods
  • Melanie Sherman
  • Robert Heaton
  • Mandy van Rhenen
  • Thomas Marcotte
  • Alana Talob
  • Sara Ortiz
  • Christopher Ake
  • Scott Letendre
  • Clint Cushman
  • Sheldon Morris
  • Richard Seghers
  • Ronald J Ellis
  • Teresa Oyos
  • Anders Dale
  • Virawudh Soontornniyomkij
  • Dongxian Zhang
  • Ronald Ellis
  • Rachel Meyer
  • Matthew Dawson
  • Jennifer Marquie-Beck
  • Jose Mendez
  • Mili Parikh
  • Edmund Capparelli
  • Brook Henry
  • David Smith
  • Michael Potter
  • Terry Jernigan
  • Marcus Kaul
  • J Hampton Atkinson
  • Will Toperoff
  • Erick Tatro
  • Mahalah Buell
  • Christian Achim
  • Anthony C Gamst
  • Amir Sabouri
  • Jared W Young
  • Miriam Scadeng
  • Ian Abramson
  • Michael Mante
  • Gregory Brown
  • Florin Vaida
  • ADAM ARON
  • Igor Grant
  • Ian Everall
  • Terence Hendrix
  • Brad Beyenhof
  • Mark A Geyer
  • C Fenema-Notestine
  • Thomas Liu
  • Rodney von Jaeger
  • RACHEL SCHRIER
  • Dexter Walpole
  • DeeDee Pacheco
  • Sarah Archibald
  • AMANDA GRETHE
  • Terry Alexander
  • Michael Repinski
  • Robert Ardecky

Detail Information

Publications19

  1. ncbi Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
    ....
  2. ncbi Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 219:433-42. 2012
    ..Alcohol abuse is prevalent in adolescent humans, but the long-term behavioral consequences of binge alcohol drinking are unknown...
  3. ncbi The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Eur Neuropsychopharmacol 20:731-46. 2010
    ....
  4. ncbi The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
    ..The higher selectivity of BINA compared with an mGluR2/3 agonist for drug- vs food-motivated behaviors suggests a therapeutic role for mGluR2 PAMs for the treatment of cocaine addiction and possibly other drugs of abuse...
  5. ncbi Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
    ..Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT(7) receptor...
  6. ncbi Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Eur J Pharmacol 602:78-84. 2009
    ....
  7. ncbi The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 52:863-72. 2007
    ..Thus, blockade of mGluR5, but not mGluR2/3, decreased overall responding without affecting accuracy in the 5CSRTT...
  8. ncbi The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat
    Neil E Paterson
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 198:351-62. 2008
    ..These aversive aspects of nicotine withdrawal and the rewarding effects of nicotine play major roles in maintaining nicotine dependence...
  9. ncbi Mild anxiogenic effects of nicotine withdrawal in mice
    Sietse Jonkman
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 516:40-5. 2005
    ..In conclusion, the present data show that nicotine withdrawal is mildly anxiogenic in C57BL/6J mice under the conditions used in the present experiments...
  10. ncbi Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice
    Astrid K Stoker
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 54:1223-32. 2008
    ..The current study is one of the first to demonstrate reward deficits associated with both spontaneous and nAChR antagonist-precipitated nicotine withdrawal in C57BL/6J mice...
  11. ncbi Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, Mail Code 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 193:521-37. 2007
    ..The development and validation of animal models of cognitive deficits characterizing schizophrenia are crucial for clarifying the underlying neuropathology and discovery of improved treatments for such deficits...
  12. ncbi Chronic nicotine administration improves attention while nicotine withdrawal induces performance deficits in the 5-choice serial reaction time task in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603 La Jolla, California 92093, USA
    Pharmacol Biochem Behav 87:360-8. 2007
    ..These results provide evidence that chronic, but not acute, nicotine administration induced accuracy improvement under baseline conditions, while nicotine withdrawal produced some limited performance deficits...
  13. ncbi Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1025:491-503. 2004
    ..Thus, compounds that increase GABAergic neurotransmission and antagonists at mGluR5 have potential as anti-smoking medications for humans...
  14. ncbi Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence
    Shyama Sidique
    Apoptosis and Cell Death Research Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 55:9434-45. 2012
    ..Our data, showing for the first time efficacy of an mGlu(2) receptor PAM in this in vivo model, suggest potential utility for the treatment of nicotine dependence in humans...
  15. ncbi Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine
    Svetlana Semenova
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:1249-64. 2003
    ..Finally, the data suggest that there may be commonalities in the neurosubstrates mediating affective aspects of drug withdrawal and the negative symptoms of schizophrenia...
  16. ncbi Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration
    Svetlana Semenova
    Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Eur J Pharmacol 472:99-110. 2003
    ..Thus, nicotine withdrawal results in modest, but yet detectable, changes in the behavior of mice...
  17. ncbi Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Psychopharmacology (Berl) 215:697-707. 2011
    ..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions...
  18. ncbi The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    Neil E Paterson
    Department of Neuropharmacology, CVN-7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 167:257-64. 2003
    ..It is postulated that mGluR5 plays an essential role in mediating the reinforcing effects of nicotine, possibly but not exclusively, via modulation of mesolimbic dopaminergic neurotransmission...
  19. ncbi Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 14:1346-55. 2012
    ..The role of β4-containing nicotinic acetylcholine receptors (nAChRs) in cognition, anxiety, depression, and analgesia in the absence of nicotine is unclear...