LIISA SELIN

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Plasticity of T cell memory responses to viruses
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Immunity 20:5-16. 2004
  2. pmc Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis
    Shalyn C Clute
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 115:3602-12. 2005
  3. ncbi request reprint Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 211:164-81. 2006
  4. pmc Heterologous immunity: immunopathology, autoimmunity and protection during viral infections
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Autoimmunity 44:328-47. 2011
  5. ncbi request reprint Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Am Soc Nephrol 18:2268-77. 2007
  6. ncbi request reprint CD8 memory T cells: cross-reactivity and heterologous immunity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Semin Immunol 16:335-47. 2004
  7. ncbi request reprint A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses
    Yuri N Naumov
    Department of Pathology, University of Massachusetts Medical School, Worchester, MA 01655, USA
    J Immunol 170:3994-4001. 2003
  8. ncbi request reprint T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
    Michael A Brehm
    Department of Pathology and Progranm in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nat Immunol 3:627-34. 2002
  9. pmc Heterologous immunity between viruses
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 235:244-66. 2010
  10. pmc Attrition of memory CD8 T cells
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 459:E3-4; discussion E4. 2009

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Plasticity of T cell memory responses to viruses
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Immunity 20:5-16. 2004
    ..This is in part accounted for by crossreactive memory T cells, which can be employed in immune responses and mediate protective immunity or life-threatening immunopathology...
  2. pmc Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis
    Shalyn C Clute
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 115:3602-12. 2005
    ..Our results support the concept that cross-reactive memory CD8+ T cells activated by EBV contribute to the characteristic lymphoproliferation of IM...
  3. ncbi request reprint Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 211:164-81. 2006
    ....
  4. pmc Heterologous immunity: immunopathology, autoimmunity and protection during viral infections
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Autoimmunity 44:328-47. 2011
    ....
  5. ncbi request reprint Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Am Soc Nephrol 18:2268-77. 2007
    ....
  6. ncbi request reprint CD8 memory T cells: cross-reactivity and heterologous immunity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Semin Immunol 16:335-47. 2004
    ..Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells...
  7. ncbi request reprint A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses
    Yuri N Naumov
    Department of Pathology, University of Massachusetts Medical School, Worchester, MA 01655, USA
    J Immunol 170:3994-4001. 2003
    ..Self similarity, power laws, and recursive mapping algorithms are associated with fractal systems. Thus, Ag-specific memory CD8 T cell repertoires can be considered as fractal, which could indicate optimized flexibility and robustness...
  8. ncbi request reprint T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
    Michael A Brehm
    Department of Pathology and Progranm in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nat Immunol 3:627-34. 2002
    ..Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology...
  9. pmc Heterologous immunity between viruses
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 235:244-66. 2010
    ..We propose that heterologous immunity is an important factor in resistance to and variations of human viral infections and that issues of heterologous immunity should be considered in the design of vaccines...
  10. pmc Attrition of memory CD8 T cells
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 459:E3-4; discussion E4. 2009
    ..We show here in Fig. 1 that a series of infections can indeed reduce the total number of memory cells, indicating that vaccination strategies need to consider this issue...
  11. pmc Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus
    Yuri N Naumov
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 181:7407-19. 2008
    ....
  12. pmc Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry
    Markus Cornberg
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:934-44. 2007
    ....
  13. ncbi request reprint Complex T cell memory repertoires participate in recall responses at extremes of antigenic load
    Yuri N Naumov
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:2006-14. 2006
    ....
  14. ncbi request reprint Immunological memory to viral infections
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Annu Rev Immunol 22:711-43. 2004
    ..Here we describe how T and B cell memory is generated in response to virus infections and how these cells respond when the host is infected again by similar or different viruses...
  15. ncbi request reprint CD8 T cell responses to viral infections in sequence
    Michael A Brehm
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell Microbiol 6:411-21. 2004
    ..Here we will describe the characteristics of CD8 T cells and the dynamics of their response to heterologous viral infections in sequence...
  16. ncbi request reprint Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation
    Sung Kwon Kim
    Department of Pathology, University of Massachusetts, Worcester, MA 01655, USA
    J Immunol 169:90-8. 2002
    ..Thus, depending on the pathogen and the sequence of infection, a heterologous agent may selectively stimulate the memory pool in patterns consistent with heterologous immunity...
  17. ncbi request reprint IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections
    Kapil Bahl
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, 01655, USA
    J Immunol 176:4284-95. 2006
    ..In addition, computer models indicated that early depletion of memory T cells may allow for the generation for a more diverse T cell response to infection by reducing the immunodomination caused by cross-reactive T cells...
  18. pmc Private specificities of CD8 T cell responses control patterns of heterologous immunity
    Sung Kwon Kim
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 201:523-33. 2005
    ..This variability in cross-reactive T cell expansion that is unique to the individual may underlie variation in the pathogenesis of infectious diseases...
  19. ncbi request reprint No one is naive: the significance of heterologous T-cell immunity
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Nat Rev Immunol 2:417-26. 2002
    ..Here, we discuss evidence from studies in mice and humans that shows the importance of this phenomenon in determining the outcome of infection...
  20. ncbi request reprint Heterologous immunity and the CD8 T cell network
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Springer Semin Immunopathol 24:149-68. 2002
  21. pmc Bi-specific MHC heterodimers for characterization of cross-reactive T cells
    Zu T Shen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 285:33144-53. 2010
    ..A similar strategy could be used to develop reagents to analyze cross-reactive T cell responses in humans...
  22. pmc CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections
    Markus Cornberg
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:2825-38. 2010
    ..Defining such cross-reactive networks between commonly encountered human pathogens may facilitate the design of vaccines...
  23. pmc Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire
    Siwei Nie
    Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Pathol 176:2107-12. 2010
    ..This indicates that virus-induced immunopathology under conditions of heterologous immunity is a function of the private specificity of the immune repertoire...
  24. pmc Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity
    Siwei Nie
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:6554-60. 2009
    ..Thus, heterologous immunity may help explain why treatment of patients with anti-TNF compounds is reasonably well tolerated with relatively few infectious complications...
  25. ncbi request reprint Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs
    Xiaoting Z Wang
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 18:631-42. 2003
    ..This may contribute to the survival of nondividing peripheral memory T cells, enabling them to efficiently function without being driven into apoptosis...
  26. pmc Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung
    Hong D Chen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Pathol 163:1341-55. 2003
    ..Heterologous immunity thus occurs between many viruses, resulting in altered protective immunity and lung immunopathology, and this is influenced by the specific virus infection sequence...
  27. pmc Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity
    Markus Cornberg
    Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School UMMS, Worcester, Massachusetts 01655, USA
    J Clin Invest 116:1443-56. 2006
    ..This has implications for the design of peptide-based vaccines, which might unintentionally prime for skewed TCR responses to cross-reactive epitopes...
  28. ncbi request reprint Embedding T cells in the matrix
    Liisa K Selin
    Nat Med 10:343-5. 2004

Research Grants9

  1. IMMUNITY IN SYSTEMIC AND MUCOSAL VIRUS INFECTIONS
    LIISA SELIN; Fiscal Year: 2004
    DESCRIPTION: (Adapted from the Investigator's abstract): This is a revised application from Dr. Liisa Selin to study cross-reactive immunity to systemic and mucosal viral infections...
  2. IMMUNITY IN SYSTEMIC AND MUCOSAL VIRUS INFECTIONS
    LIISA SELIN; Fiscal Year: 2009
    ..Examine the mechanisms involved in augmented viral replication and immunopathology during LCMV or MCMV infection of influenza-immune mice. Specific Aim #4. Define the role of cytokines in mediating heterologous immunity. ..