Katherine L Seley-Radtke

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Carbocyclic isoadenosine analogues of neplanocin A
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Org Lett 5:4401-3. 2003
  2. doi request reprint Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
    Mikhail S Novikov
    Department of Pharmaceutical and Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq, 1, Volgograd 400131, Russia
    Bioorg Med Chem 21:4151-7. 2013
  3. ncbi request reprint N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase
    Mikhail S Novikov
    Department of Pharmaceutical and Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq, 1, Volgograd 400131, Russia
    Bioorg Med Chem 21:1150-8. 2013
  4. pmc Carbocyclic thymidine analogues for use as potential therapeutic agents
    Katherine L Seley-Radtke
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland, USA
    Nucleosides Nucleotides Nucleic Acids 28:633-41. 2009
  5. ncbi request reprint Design and synthesis of a series of chlorinated 3-deazaadenine analogues
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Nucleosides Nucleotides Nucleic Acids 22:2133-44. 2003
  6. ncbi request reprint "Molecular chameleons". Design and synthesis of a second series of flexible nucleosides
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    J Org Chem 70:1612-9. 2005
  7. ncbi request reprint "Molecular chameleons". Design and synthesis of C-4-substituted imidazole fleximers
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    Org Lett 7:63-6. 2005
  8. pmc Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides
    Joshua M Sadler
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 17:5520-5. 2009
  9. pmc Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues
    Orrette R Wauchope
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 20:3009-15. 2012
  10. pmc "Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors
    Sarah C Zimmermann
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore, Maryland 21250, USA
    Nucleosides Nucleotides Nucleic Acids 32:137-54. 2013

Research Grants

  1. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2009
  2. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2002
  3. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2007
  4. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2005
  5. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2005
  6. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2006
  7. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2006
  8. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2005
  9. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2004
  10. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2005

Collaborators

  • Jan Balzarini
  • Liang Zhang
  • Robert Snoeck
  • Brent E Korba
  • Olaf Wiest
  • KATHERINE RADTKE
  • Katherine L Seley
  • Mikhail S Novikov
  • Peter I O'Daniel
  • Orrette R Wauchope
  • Joshua M Sadler
  • Sarah C Zimmermann
  • Graciela Andrei
  • Sylvester L Mosley
  • Kartik W Temburnikar
  • Nathaniel T Kim
  • Denis A Babkov
  • Kartik Temburnikar
  • Maria P Paramonova
  • Anastasia L Khandazhinskaya
  • Samer Salim
  • Zhaohui Sunny Zhou
  • Kathleen M Dorgan
  • Christopher Gelbmann
  • Christina R Ross
  • Christine E Salomon
  • Gerald M Wilson
  • Sergey A Gavryushov
  • Vladimir T Valuev-Elliston
  • Alexander V Ivanov
  • Kelin Brace
  • Alexander A Ozerov
  • Alexander O Chizhov
  • Sergey N Kochetkov
  • Christophe Pannecouque
  • Cameron Johnson
  • Pasupathy Krishnamoorthy
  • Matthew J Tomney
  • Joseph L Pepper
  • Malcolm Jefferson
  • Naresh K Sunkara
  • Brian A Bakke
  • Fanxing Zeng

Detail Information

Publications15

  1. ncbi request reprint Carbocyclic isoadenosine analogues of neplanocin A
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Org Lett 5:4401-3. 2003
    ..Their design, synthesis, and structural elucidation is reported...
  2. doi request reprint Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
    Mikhail S Novikov
    Department of Pharmaceutical and Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq, 1, Volgograd 400131, Russia
    Bioorg Med Chem 21:4151-7. 2013
    ..5-12μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region...
  3. ncbi request reprint N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase
    Mikhail S Novikov
    Department of Pharmaceutical and Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq, 1, Volgograd 400131, Russia
    Bioorg Med Chem 21:1150-8. 2013
    ..27 μM) thus confirming that the 3-benzyluracil fragment in the NNRTI structure can be regarded as a functional analogue of the benzophenone pharmacophore typically found in NNRTIs...
  4. pmc Carbocyclic thymidine analogues for use as potential therapeutic agents
    Katherine L Seley-Radtke
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland, USA
    Nucleosides Nucleotides Nucleic Acids 28:633-41. 2009
    ..In that regard, the synthesis and preliminary biological results for two truncated carbocyclic thymidine analogues are presented herein...
  5. ncbi request reprint Design and synthesis of a series of chlorinated 3-deazaadenine analogues
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Nucleosides Nucleotides Nucleic Acids 22:2133-44. 2003
    ..During the synthetic efforts, two unexpected compounds were identified. Their synthesis, along with synthesis of the chlorinated targets is presented herein...
  6. ncbi request reprint "Molecular chameleons". Design and synthesis of a second series of flexible nucleosides
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    J Org Chem 70:1612-9. 2005
    ..Their design and synthesis is described...
  7. ncbi request reprint "Molecular chameleons". Design and synthesis of C-4-substituted imidazole fleximers
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    Org Lett 7:63-6. 2005
    ..As a result, these structurally innovative nucleosides can more readily adapt to capricious binding sites and, as such, should find use for investigating enzyme-coenzyme as well as nucleic acid-protein interactions...
  8. pmc Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides
    Joshua M Sadler
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 17:5520-5. 2009
    ..In that regard, the design, synthesis and results of preliminary biological activity for a series of carbocyclic uracil derivatives with either a fused imidazole or thiazole ring are presented herein...
  9. pmc Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues
    Orrette R Wauchope
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 20:3009-15. 2012
    ..The synthetic efforts towards realizing the expanded 2'-deoxy-guanosine and -adenosine tricyclic analogues as well as the preliminary biological results are presented herein...
  10. pmc "Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors
    Sarah C Zimmermann
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore, Maryland 21250, USA
    Nucleosides Nucleotides Nucleic Acids 32:137-54. 2013
    ..Preliminary biological screening has revealed surprising inhibition of adenosine deaminase, despite their lack of resemblance to adenosine...
  11. ncbi request reprint Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines
    Kartik W Temburnikar
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 22:2113-22. 2014
    ..Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein. ..
  12. pmc Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics
    Orrette R Wauchope
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    Org Lett 12:4466-9. 2010
    ..Details of the synthesis, structural characterization, and preliminary biological results are reported...
  13. pmc A computational study of expanded heterocyclic nucleosides in DNA
    Peter I O'Daniel
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    J Biomol Struct Dyn 26:283-92. 2008
    ..MD simulations of 10-mers suggest that the balance between base pairing vs. base stacking and intercalation can be shifted towards the latter due to the increased surface area and polarizability of the expanded bases...
  14. pmc Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
    Sylvester L Mosley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    Bioorg Med Chem 14:7967-71. 2006
    ..3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a Ki value of 5.0 microM against SAHase...
  15. doi request reprint Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology
    Kartik Temburnikar
    University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, United States
    J Org Chem 78:7305-11. 2013
    ..The results of this brief study revealed that the benzyloxymethyl (BOM) group proved optimal, and Heck coupling using Jeffery conditions increased the coupling yield significantly. The results are reported herein. ..

Research Grants16

  1. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2009
    ..abstract_text> ..
  2. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2002
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  3. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2007
    ..abstract_text> ..
  4. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2005
    ..abstract_text> ..
  5. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2005
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  6. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2006
    ..abstract_text> ..
  7. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2006
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  8. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2005
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  9. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2004
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  10. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2005
    ..abstract_text> ..
  11. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2003
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  12. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2004
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  13. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2003
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..
  14. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2002
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..