Katherine L Seley-Radtke

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Carbocyclic isoadenosine analogues of neplanocin A
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Org Lett 5:4401-3. 2003
  2. ncbi Design and synthesis of a series of chlorinated 3-deazaadenine analogues
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Nucleosides Nucleotides Nucleic Acids 22:2133-44. 2003
  3. ncbi "Molecular chameleons". Design and synthesis of C-4-substituted imidazole fleximers
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    Org Lett 7:63-6. 2005
  4. ncbi "Molecular chameleons". Design and synthesis of a second series of flexible nucleosides
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    J Org Chem 70:1612-9. 2005
  5. ncbi Carbocyclic thymidine analogues for use as potential therapeutic agents
    Katherine L Seley-Radtke
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland, USA
    Nucleosides Nucleotides Nucleic Acids 28:633-41. 2009
  6. ncbi Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides
    Joshua M Sadler
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 17:5520-5. 2009
  7. ncbi Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues
    Orrette R Wauchope
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 20:3009-15. 2012
  8. ncbi Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics
    Orrette R Wauchope
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    Org Lett 12:4466-9. 2010
  9. ncbi A computational study of expanded heterocyclic nucleosides in DNA
    Peter I O'Daniel
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    J Biomol Struct Dyn 26:283-92. 2008
  10. ncbi Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
    Sylvester L Mosley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    Bioorg Med Chem 14:7967-71. 2006

Research Grants

  1. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2009
  2. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2007
  3. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2006

Collaborators

  • Jan Balzarini
  • Brent E Korba
  • Olaf Wiest
  • KATHERINE RADTKE
  • Katherine L Seley
  • Orrette R Wauchope
  • Peter I O'Daniel
  • Sylvester L Mosley
  • Joshua M Sadler
  • Samer Salim
  • Kathleen M Dorgan
  • Zhaohui Sunny Zhou
  • Liang Zhang
  • Graciela Andrei
  • Robert Snoeck
  • Cameron Johnson
  • Pasupathy Krishnamoorthy
  • Matthew J Tomney
  • Joseph L Pepper
  • Malcolm Jefferson
  • Naresh K Sunkara
  • Brian A Bakke
  • Fanxing Zeng

Detail Information

Publications10

  1. ncbi Carbocyclic isoadenosine analogues of neplanocin A
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Org Lett 5:4401-3. 2003
    ..Their design, synthesis, and structural elucidation is reported...
  2. ncbi Design and synthesis of a series of chlorinated 3-deazaadenine analogues
    Katherine L Seley
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA
    Nucleosides Nucleotides Nucleic Acids 22:2133-44. 2003
    ..During the synthetic efforts, two unexpected compounds were identified. Their synthesis, along with synthesis of the chlorinated targets is presented herein...
  3. ncbi "Molecular chameleons". Design and synthesis of C-4-substituted imidazole fleximers
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    Org Lett 7:63-6. 2005
    ..As a result, these structurally innovative nucleosides can more readily adapt to capricious binding sites and, as such, should find use for investigating enzyme-coenzyme as well as nucleic acid-protein interactions...
  4. ncbi "Molecular chameleons". Design and synthesis of a second series of flexible nucleosides
    Katherine L Seley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    J Org Chem 70:1612-9. 2005
    ..Their design and synthesis is described...
  5. ncbi Carbocyclic thymidine analogues for use as potential therapeutic agents
    Katherine L Seley-Radtke
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland, USA
    Nucleosides Nucleotides Nucleic Acids 28:633-41. 2009
    ..In that regard, the synthesis and preliminary biological results for two truncated carbocyclic thymidine analogues are presented herein...
  6. ncbi Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides
    Joshua M Sadler
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 17:5520-5. 2009
    ..In that regard, the design, synthesis and results of preliminary biological activity for a series of carbocyclic uracil derivatives with either a fused imidazole or thiazole ring are presented herein...
  7. ncbi Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues
    Orrette R Wauchope
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem 20:3009-15. 2012
    ..The synthetic efforts towards realizing the expanded 2'-deoxy-guanosine and -adenosine tricyclic analogues as well as the preliminary biological results are presented herein...
  8. ncbi Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics
    Orrette R Wauchope
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    Org Lett 12:4466-9. 2010
    ..Details of the synthesis, structural characterization, and preliminary biological results are reported...
  9. ncbi A computational study of expanded heterocyclic nucleosides in DNA
    Peter I O'Daniel
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    J Biomol Struct Dyn 26:283-92. 2008
    ..MD simulations of 10-mers suggest that the balance between base pairing vs. base stacking and intercalation can be shifted towards the latter due to the increased surface area and polarizability of the expanded bases...
  10. ncbi Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
    Sylvester L Mosley
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    Bioorg Med Chem 14:7967-71. 2006
    ..3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a Ki value of 5.0 microM against SAHase...

Research Grants16

  1. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2009
    ..abstract_text> ..
  2. Unnatural Base Pairs as DNA Bioprobes
    KATHERINE RADTKE; Fiscal Year: 2007
    ..abstract_text> ..
  3. Fused Pyrimidine (IsoA) Nucleosides:Design and Synthesis
    KATHERINE RADTKE; Fiscal Year: 2006
    ..We believe this inhibition will result in meaningful biological activity, as well as to induce cell differentiation. ..