Michael Seldin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis
    Victoria E H Carlton
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 77:567-81. 2005
  2. pmc Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    BMC Proc 3:S2. 2009
  3. pmc Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
  4. pmc An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels
    Rami Nassir
    Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
    BMC Genet 10:39. 2009
  5. pmc Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, Davis, California 95616 8669, USA
    Genome Res 14:1076-84. 2004
  6. pmc Argentine population genetic structure: large variance in Amerindian contribution
    Michael F Seldin
    Rowe Program in Human Genetics, Department of Biological Chemistry, University of California Davis, Davis, CA 95616, USA
    Am J Phys Anthropol 132:455-62. 2007
  7. pmc European population substructure: clustering of northern and southern populations
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, California, United States of America
    PLoS Genet 2:e143. 2006
  8. pmc Admixture mapping as a tool in gene discovery
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, Room 4453, Tupper Hall Department of Biological Chemistry, One Shields Avenue, University of California, Davis, CA 95616, USA
    Curr Opin Genet Dev 17:177-81. 2007
  9. pmc New approaches to disease mapping in admixed populations
    Michael F Seldin
    Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA
    Nat Rev Genet 12:523-8. 2011
  10. pmc Application of ancestry informative markers to association studies in European Americans
    Michael F Seldin
    Department of Biochemistry, University of California Davis, Davis, California, United States of America
    PLoS Genet 4:e5. 2008

Research Grants

Detail Information

Publications59

  1. pmc PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis
    Victoria E H Carlton
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 77:567-81. 2005
    ..Additional analyses identified two SNPs on a single common haplotype that are associated with RA independent of R620W, suggesting that R620W and at least one additional variant in the PTPN22 gene region influence RA susceptibility...
  2. pmc Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    BMC Proc 3:S2. 2009
    ..Several questions could be addressed using the data, including analysis of genetic associations using single SNPs or haplotypes, as well as gene-gene and genetic analysis of SNPs for qualitative and quantitative factors...
  3. pmc Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
    ....
  4. pmc An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels
    Rami Nassir
    Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
    BMC Genet 10:39. 2009
    ..Previously, we described a panel of 128 SNP AIMs that were designed as a tool for ascertaining the origins of subjects from Europe, Sub-Saharan Africa, Americas, and East Asia...
  5. pmc Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, Davis, California 95616 8669, USA
    Genome Res 14:1076-84. 2004
    ..These studies suggest that admixture mapping in the African American population can provide a powerful approach to defining genetic factors for some disease phenotypes...
  6. pmc Argentine population genetic structure: large variance in Amerindian contribution
    Michael F Seldin
    Rowe Program in Human Genetics, Department of Biological Chemistry, University of California Davis, Davis, CA 95616, USA
    Am J Phys Anthropol 132:455-62. 2007
    ..In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies...
  7. pmc European population substructure: clustering of northern and southern populations
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, California, United States of America
    PLoS Genet 2:e143. 2006
    ..Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies...
  8. pmc Admixture mapping as a tool in gene discovery
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, Room 4453, Tupper Hall Department of Biological Chemistry, One Shields Avenue, University of California, Davis, CA 95616, USA
    Curr Opin Genet Dev 17:177-81. 2007
    ....
  9. pmc New approaches to disease mapping in admixed populations
    Michael F Seldin
    Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA
    Nat Rev Genet 12:523-8. 2011
    ....
  10. pmc Application of ancestry informative markers to association studies in European Americans
    Michael F Seldin
    Department of Biochemistry, University of California Davis, Davis, California, United States of America
    PLoS Genet 4:e5. 2008
  11. ncbi request reprint Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine
    Nan Yang
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California, One Shields Avenue, Davis, CA, 95616 8669, USA
    Hum Genet 118:382-92. 2005
    ..99). Overall, the study demonstrates that AIMs can provide a useful adjunct to forensic medicine, pharmacogenomics and disease studies in which major ancestry or ethnic affiliation might be linked to specific outcomes...
  12. doi request reprint Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus
    M F Seldin
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, CA, USA
    Genes Immun 9:389-93. 2008
    ..These studies suggest that populations with Amerindian admixture, like those with West African admixture, should be considered in future studies to identify additional allelic variants that predispose to SLE...
  13. ncbi request reprint Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis
    M F Seldin
    Rowe Program in Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA, USA
    Genes Immun 6:720-2. 2005
    ..27-1.70, P=3 x 10(-7)) and in family studies (P<10(-6)). In contrast, no allelic association was seen with JIA (230 probands) and only weak evidence for a genotypic effect of 1858T homozygotes was observed in this population...
  14. ncbi request reprint Analysis of MHC region genetics in Finnish patients with juvenile idiopathic arthritis: evidence for different locus-specific effects in polyarticular vs pauciarticular subsets and a shared DRB1 epitope
    J A Runstadler
    Rowe Program in Human Genetics and Molecular Medicine, Department of Biological Chemistry, University of California, Davis, USA
    Genes Immun 4:326-35. 2003
    ..00001). Analysis strongly suggests that the difference is because of additional JIA susceptibility loci within the MHC being present in polyarticular RF negative patients...
  15. ncbi request reprint Primary biliary cirrhosis and autoimmunity: evaluating the genetic risk
    M E Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California at Davis, Davis, CA, USA
    Isr Med Assoc J 2:7-10. 2000
    ..In this review we place these concepts in perspective and highlight in particular the genetic associations in primary biliary cirrhosis...
  16. ncbi request reprint HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC
    J A Runstadler
    Rowe Program in Human Genetics and Molecular Medicine, Department of Biological Chemistry, University of California, Davis 95616, USA
    Genes Immun 5:562-71. 2004
    ..This observation may have implications for functional etiological differences between the pauciarticular and polyarticular JIA patients...
  17. ncbi request reprint Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes
    A P Spicer
    Rowe Program in Human Genetics and Molecular Medicine, Department of Biological Chemistry, School of Medicine, Tupper Hall, University of California, Davis, California 95616, USA
    J Biol Chem 273:25117-24. 1998
    ....
  18. pmc Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women
    L A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA
    Ann Rheum Dis 65:1163-7. 2006
    ..To determine whether the impact of tobacco exposure on rheumatoid arthritis (RA) risk is influenced by polymorphisms at the HLA-DRB1 and glutathione S-transferase M1 (GSTM1) loci...
  19. pmc Telomere length regulation in mice is linked to a novel chromosome locus
    L Zhu
    Rowe Program in Genetics, Departments of Biological Chemistry and Medicine University of California, Davis, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 95:8648-53. 1998
    ..This locus is distinct from candidate genes encoding known telomere-binding proteins or telomerase components. These results demonstrate that an unidentified gene(s) mapped to distal chromosome 2 regulates telomere length in the mouse...
  20. ncbi request reprint Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families
    A Parsa
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
    Genes Immun 3:S42-6. 2002
    ..010). Due to the choice of study design and analytic method these results are unlikely to be due to population admixture. Our findings suggest that DNA sequence variation in the ACE gene influences the risk of developing SLE and LN...
  21. pmc Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis
    F B S Briggs
    University of California, Berkeley, 94720, USA
    Genes Immun 11:199-208. 2010
    ..A total of seven replicating epistatic interactions were identified. SNP variants within CDH13, MYO3A, CEP72 and near WFDC1 showed significant evidence for interaction with PTPN22, affecting susceptibility to RA...
  22. ncbi request reprint Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase beta-subunit gene in mouse and human: tight linkage to the Huntington disease region (4p16.3)
    M R Altherr
    Department of Biological Chemistry, University of California, Irvine 92717
    Genomics 12:750-4. 1992
    ..Linkage of the mouse Pdeb locus with other homologues in the human 4p16.3 region is maintained but gene order is not, suggesting at least three possible sites for the corresponding mouse HD gene...
  23. ncbi request reprint The Fcgamma receptor IIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians but not non-Caucasians
    V A Seligman
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, USA
    Arthritis Rheum 44:618-25. 2001
    ..To determine whether inheritance of Fcgamma receptor (FcgammaR) alleles conferring lower affinity for IgG binding increases the risk of developing lupus nephritis...
  24. ncbi request reprint Mapping of two mouse membrane-type matrix metalloproteinase (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4, respectively
    M F Seldin
    Department of Biological Chemistry, University of California, Davis, USA
    Genomics 50:295-7. 1998
  25. ncbi request reprint Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis
    A Parsa
    Division of Nephrology, University of California, San Francisco, CA 94143 0500, USA
    Genes Immun 6:217-24. 2005
    ..005) and Atg M235T (P=0.04) polymorphisms, and GFR analyzed as a continuous variable among Asians. These findings suggest a significant role for ACE and Atg gene sequence variation and severity of LN among Asians with SLE...
  26. ncbi request reprint Chromosomal mapping of Adam9, Adam15 and Adam21
    M F Seldin
    Rowe Program in Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, 956161, USA
    Matrix Biol 19:185-7. 2000
    ..The mapping of these mouse loci and the extrapolated loci for their human orthologs may facilitate the mapping of diseases involving these genes...
  27. ncbi request reprint Chromosomal mapping of the tankyrase gene in human and mouse
    L Zhu
    Rowe Program in Genetics, Department of Biological Chemistry and Department of Medicine, University of California at Davis, Davis, California 95616, USA
    Genomics 57:320-1. 1999
  28. pmc STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    N Engl J Med 357:977-86. 2007
    ..Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q...
  29. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  30. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  31. pmc Ethnic-difference markers for use in mapping by admixture linkage disequilibrium
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Department of Biological Chemistry and Medicine, University of California at Davis, Davis, CA 95616 8669, USA
    Am J Hum Genet 70:737-50. 2002
    ..Taken together, these data suggest that EDMs with large interpopulation and small intrapopulation differences can be readily identified for MALD studies in both AA and MA populations...
  32. pmc Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus
    Hye Soon Lee
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, United States of America
    Mol Med 14:293-300. 2008
    ..These data emphasize that further analysis of the MHC is likely to reveal genetic risk factors for rheumatoid arthritis that are independent of the DRB1 shared epitope alleles...
  33. pmc A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    Ann B Begovich
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 75:330-7. 2004
    ..The minor allele of this SNP recently was implicated in type 1 diabetes, suggesting that the variant phosphatase may increase overall reactivity of the immune system and may heighten an individual carrier's risk for autoimmune disease...
  34. pmc The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis
    Monica Chang
    Celera, Alameda, CA, USA
    Arthritis Rheum 58:1877-81. 2008
  35. pmc Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus
    Kimberly E Taylor
    Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, California, USA
    PLoS Genet 4:e1000084. 2008
    ..We conclude that this common polymorphism of STAT4 contributes to the phenotypic heterogeneity of SLE, predisposing specifically to more severe disease...
  36. pmc A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2
    Monica Chang
    Celera, Alameda, California, United States of America
    PLoS Genet 4:e1000107. 2008
    ..Lastly, in combination with the other two known genetic risk factors, HLA-DRB1 and PTPN22, the variants reported here generate more than a 45-fold RA-risk differential...
  37. pmc Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
    Int J Cancer 123:2095-104. 2008
    ..61; 95% CI: 0.42-0.88). Our study suggests different elements of the NER pathway may be important in the different ethnic groups resulting either from different linkage relationship, genetic backgrounds and/or exposure histories...
  38. pmc Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and Latinos
    Melinda C Aldrich
    University of California, San Francisco, Box 2911 Rock Hall, Mission Bay 582, 1550 4th Street, San Francisco, CA 94143 2911, USA
    Am J Epidemiol 168:1035-46. 2008
    ..Genetic admixture proportions provide a quantitative measure of ancestry differences among Latinos that can be used in analyses of genetic risk factors...
  39. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  40. pmc TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
    Robert M Plenge
    Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA
    N Engl J Med 357:1199-209. 2007
    ..We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis...
  41. pmc A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping
    Chao Tian
    Rowe Program in Human Genetics, Department of Biochemistry, University of California Davis, Davis, CA 95616, USA
    Am J Hum Genet 80:1014-23. 2007
    ..The results will enable studies of type 2 diabetes, rheumatoid arthritis, and other diseases among which epidemiological studies suggest differences in the distribution of ancestry-associated susceptibility...
  42. ncbi request reprint A hidden Markov modeling approach for admixture mapping based on case-control data
    Chun Zhang
    Departments of Statistics and Medicine and Rowe Program in Human Genetics, University of California, Davis, California 95616, USA
    Genet Epidemiol 27:225-39. 2004
    ..Finally, we observed that the genotype-based HMM performs very similarly in power as the haplotype-based HMM when the haplotypes are known and the set of markers is highly informative...
  43. ncbi request reprint Mexican American ancestry-informative markers: examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Hum Genet 114:263-71. 2004
    ..Together, these data provide additional support for the practical application of admixture mapping in the Mexican American population...
  44. ncbi request reprint Markers informative for ancestry demonstrate consistent megabase-length linkage disequilibrium in the African American population
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Hum Genet 113:211-9. 2003
    ..This examination of several genomic segments provides strong evidence that appropriate selection of informative markers is a crucial prerequisite for the application of admixture mapping to the AA population...
  45. ncbi request reprint Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles
    Patricia Irigoyen
    North Shore Long Island Jewish Institute for Medical Research, Manhasset, New York 11030, USA
    Arthritis Rheum 52:3813-8. 2005
    ..To examine the association between HLA-DRB1 alleles and the production of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) autoantibodies in patients with rheumatoid arthritis (RA)...
  46. ncbi request reprint The functional -169T-->C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans
    Xiaolan Hu
    Celera Diagnostics, Alameda, CA
    Arthritis Rheum 54:1022-5. 2006
  47. pmc Analysis and application of European genetic substructure using 300 K SNP information
    Chao Tian
    Rowe Program in Human Genetics, University of California Davis, Davis, California, United States of America
    PLoS Genet 4:e4. 2008
    ..The results provide further insight into European population genetic substructure and show that this information can be used for improving error rates in association testing of candidate genes and in replication studies of WGA scans...
  48. pmc Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis
    Damini Jawaheer
    Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, Manhasset, NY, 11030, USA
    Am J Hum Genet 71:585-94. 2002
    ....
  49. pmc A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping
    Chao Tian
    Rowe Program in Human Genetics, Department of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Hum Genet 79:640-9. 2006
    ..This is particularly important in the application of admixture mapping in complex genetic diseases for which only modest ethnicity risk ratios of relevant susceptibility genes are expected...
  50. ncbi request reprint The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis
    Ludmila Prokunina
    Uppsala University Uppsala, Sweden
    Arthritis Rheum 50:327-8. 2004
  51. ncbi request reprint The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  52. ncbi request reprint Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families
    Jonathan A Runstadler
    Davis Rowe Program in Human Genetics, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Arthritis Rheum 52:247-56. 2005
    ....
  53. ncbi request reprint Markers that discriminate between European and African ancestry show limited variation within Africa
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Hum Genet 111:566-9. 2002
    ....
  54. doi request reprint Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    Geoffrey Hom
    Genentech, South San Francisco, CA 94080, USA
    N Engl J Med 358:900-9. 2008
    ..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
  55. ncbi request reprint Gender and racial differences in rates of total hip replacement
    Franklin T Hoaglund
    J Bone Joint Surg Am 85:569-70; author reply 570-1. 2003
  56. ncbi request reprint Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
    Hiroyuki Miyoshi
    Institute of Experimental Animal Sciences, Osaka University Medical School, Osaka 565 0871, Japan
    Cancer Res 62:2261-6. 2002
    ..Although additional genetic events may be critical in hamartoma and adenocarcinoma development, these data strongly suggest that the initiation of polyposis is not the result of loss of heterozygosity in Lkb1...
  57. ncbi request reprint Genome-wide meta-analysis for rheumatoid arthritis
    Carol J Etzel
    Department of Epidemiology, UT MD Anderson Cancer Center, 1155 Pressler Street Unit 1340, Houston, TX 77030, USA
    Hum Genet 119:634-41. 2006
    ..This procedure provided marginal evidence (P<0.05) of linkage on chromosome 1, 2, 5 and 18, strong evidence (P<0.01) on chromosomes 8 and 16, and overwhelming evidence in the HLA region of chromosome 6...
  58. ncbi request reprint Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix
    Satoshi Hirohata
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:12182-9. 2002
    ..Punctin is the first member of a novel family of ADAMTS-like proteins that may have important functions in the extracellular matrix...
  59. ncbi request reprint Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families
    Damini Jawaheer
    Center for Genomics and Human Genetics, Manhasset, New York 11030, USA
    Arthritis Rheum 48:906-16. 2003
    ..A number of non-HLA loci that have shown evidence (P < 0.05) for linkage with rheumatoid arthritis (RA) have been previously identified. The present study attempts to confirm these findings...

Research Grants9

  1. MA Admixture Mapping Development & Application to NIDDM
    Michael Seldin; Fiscal Year: 2007
    ..Finally, the three strongest signals will be further investigated utilizing a dense set of SNPs in the putative susceptibility regions. ..
  2. Admixture Mapping Development and Testing in AA SLE
    Michael Seldin; Fiscal Year: 2009
    ..abstract_text> ..