Research Topics
Genomes and Genes | Ekihiro SekiSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
CCR1 and CCR5 promote hepatic fibrosis in miceEkihiro Seki
Department of Medicine, Columbia University, New York, New York 10032, USA
J Clin Invest 119:1858-70. 2009..Our data therefore support a role for the CC chemokine system in hepatic fibrogenesis and suggest distinct roles for CCR1 and CCR5 in Kupffer cells and HSCs...- A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approachesEkihiro Seki
Department of Medicine, University of California, La Jolla, CA, USA
Gastroenterology 143:307-20. 2012..We review the functions and pathways of JNK in liver physiology and pathology and discuss findings from preclinical studies with JNK inhibitors... - Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gutEkihiro Seki
Division of Gastroenterology, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, MC no 0702, Leichtag Biomedical Research Building, Room no 118B, La Jolla, CA 92093 0702, USA
J Physiol 590:447-58. 2012..This review summarizes recent studies investigating the role of TLRs, intestinal microbiota and bacterial translocation in liver fibrosis, alcoholic liver disease and non-alcoholic steatohepatitis... 
Toll-like receptors and adaptor molecules in liver disease: updateEkihiro Seki
Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
Hepatology 48:322-35. 2008..We further discuss recent advances regarding cytosolic pattern recognition receptors, RNA helicases that represents a new concept in chronic hepatitis C virus infection...- CCR2 promotes hepatic fibrosis in miceEkihiro Seki
Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0702, USA
Hepatology 50:185-97. 2009..Conclusion: Our results indicate that CCR2 promotes HSC chemotaxis and the development of hepatic fibrosis... - Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosisSamuele De Minicis
Department of Medicine, University of California San Diego, School of Medicine, San Diego, CA 92093 0602, USA
Hepatology 52:1420-30. 2010..CONCLUSION: NOX in both BM-derived and non-BM-derived cells contributes to liver fibrosis. NOX does not play a role in experimental steatosis and the generation of ROS in hepatocytes, but exerts a key role in fibrosis... 
Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasisAli Mencin
Department of Pediatrics, Morgan Stanley Children s Hospital of New York, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Hepatology 46:1443-52. 2007..Cholestasis therefore may lead to increased fibrosis in alpha1-AT deficiency, and the alpha1-ATZ mutation may act as a modifier gene in patients with concurrent cholestatic liver diseases such as cystic fibrosis...- Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesisSayaka Inokuchi
Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0702, USA
Proc Natl Acad Sci U S A 107:844-9. 2010.... - The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in miceYong Han Paik
Department of Medicine, University of California San Diego, La Jolla, CA, USA
Hepatology 53:1730-41. 2011..CONCLUSION: Both NOX1 and NOX2 have an important role in hepatic fibrosis in endogenous liver cells, including HSCs, whereas NOX2 has a lesser role in BM-derived cells... - c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in miceYuzo Kodama
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Gastroenterology 137:1467-1477.e5. 2009..However, the mechanism underlying the contribution of JNK to the progression from simple steatosis to steatohepatitis and liver fibrosis is unresolved... - Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2Kouichi Miura
Department of Medicine, School of Medicine, University of California San Diego, La Jolla, USA
Am J Physiol Gastrointest Liver Physiol 302:G1310-21. 2012..We concluded that CCR2 and Kupffer cells contribute to the progression of NASH by recruiting bone marrow-derived monocytes... - Gene expression profiles during hepatic stellate cell activation in culture and in vivoSamuele De Minicis
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Gastroenterology 132:1937-46. 2007..In this study, we determine gene expression changes in 3 different models of HSC activation and investigate whether HSC culture activation reproduces gene expression changes of HSC in vivo activation... - TLR4 enhances TGF-beta signaling and hepatic fibrosisEkihiro Seki
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Nat Med 13:1324-32. 2007..Accordingly, Myd88-deficient mice have decreased hepatic fibrosis. Thus, modulation of TGF-beta signaling by a TLR4-MyD88-NF-kappaB axis provides a novel link between proinflammatory and profibrogenic signals... - Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in miceKouichi Miura
Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
Gastroenterology 139:323-34.e7. 2010..We investigated the role of TLR9 signaling and the inflammatory cytokine interleukin-1beta (IL-1beta) in steatohepatitis, fibrosis, and insulin resistance... - Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cellsSamuele De Minicis
University of California at San Diego School of Medicine, La Jolla, CA, USA
Hepatology 48:2016-26. 2008.... - Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligationYosuke Osawa
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Liver Int 26:1138-47. 2006..CONCLUSION: Systemic profibrogenic mediators from the injury site affect the residual non-injured liver... - Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosisKojiro Taura
Department of Medicine, School of Medicine, University of California, San Diego, California, USA
Gastroenterology 135:1729-38. 2008..It functions as an agonist for the receptor tyrosine kinase with immunoglobulin G-like and endothelial growth factor-like domains 2 (Tie2) and counteracts apoptosis, promotes vascular sprouting or branching, and stabilizes vessels... - Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in miceKouichi Miura
Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA Department of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan
Hepatology 57:577-89. 2013..Conclusion: TLR2 and palmitic acid cooperatively activate the inflammasome in Kupffer cells and/or macrophages in the development of NASH. (HEPATOLOGY 2013;)... - CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in miceTomonori Aoyama
Division of Gastroenterology, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093 0702, USA
Hepatology 52:1390-400. 2010..CONCLUSION: The CX3CL1-CX3CR1 interaction inhibits inflammatory properties in Kupffer cells/macrophages and results in decreased liver inflammation and fibrosis... - Angiotensin-converting-enzyme 2 inhibits liver fibrosis in miceChristoph H Osterreicher
University of California San Diego, School of Medicine, San Diego, CA 92093 0602, USA
Hepatology 50:929-38. 2009..Whereas loss of ACE2 activity worsens liver fibrosis in chronic liver injury models, administration of recombinant ACE2 shows therapeutic potential... - Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in miceSayaka Inokuchi
Division of Gastroenterology, Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0702, USA
Alcohol Clin Exp Res 35:1509-18. 2011.... - Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinaseDavid A Brenner
Department of Medicine, UC San Diego Health Sciences, La Jolla, California, USA
Hepatol Res 41:683-6. 2011..The three pathways are related and synergistic through intracellular cross-talk. Disruption of any of these pathways may inhibit NASH-induced fibrosis and are potential targets for therapeutic intervention... - Toll-like receptor signaling in the liverRobert F Schwabe
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Gastroenterology 130:1886-900. 2006 - Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironmentsDavid A Brafman
Department of Bioengineering, University of California, San Diego, USA
Integr Biol (Camb) 1:513-24. 2009..Our results indicate that array-based screens may provide an efficient means for identifying candidate signaling pathways to be targeted for anti-fibrotic therapies... - Fatty acid amide hydrolase determines anandamide-induced cell death in the liverSoren V Siegmund
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Biol Chem 281:10431-8. 2006..In conclusion, FAAH and GSH are determinants of AEA-mediated cell death in the liver... - Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasisHiroshi Uchinami
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Hepatology 44:420-9. 2006.... - Transforming Growth Factor-β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1Ling Yang
Division of Gastroenterology, Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, California Division of Gastroenterology, Department of Internal Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
Gastroenterology 144:1042-1054.e4. 2013..TGF-β activates TAK1 and Smad signaling, which regulate cell death, proliferation, and carcinogenesis. However, it is not clear whether TGF-β signaling in hepatocytes, via TGF-β receptor-2 (Tgfbr2), promotes HCC and liver fibrosis... - p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen speciesToshiharu Sakurai
Department of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, Ohnohigashi, Osaka Sayama, Osaka, Japan
Cancer Res 73:215-24. 2013..Augmented oxidative stress of liver parenchymal cells may explain the close relationship between liver fibrosis and hepatocarcinogenesis... - CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destructionJoan Font-Burgada
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cancer Cell 21:711-2. 2012..In this issue of Cancer Cell, Nikolaou et al. show that the deubiquitinating enzyme CYLD is critical for controlling the balance between hepatocyte loss, regeneration, and malignant progression... - Toll-like receptors in liver fibrosis: cellular crosstalk and mechanismsLing Yang
Division of Gastroenterology, Department of Medicine, University of California San Diego, School of Medicine La Jolla, CA, USA
Front Physiol 3:138. 2012.... - Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected miceKeishi Adachi
Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
Int Immunol 16:787-98. 2004..berghei-induced liver injury. Our studies may have general implications for tissue injuries that are caused by 'bystander killing' or other poorly defined cell-mediated killing mechanisms... - ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor moleculesMasatatsu Yamamoto
Department of Molecular Oncology Division of Molecular and Cellular Biology Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Genes Cells 9:1055-67. 2004..These results demonstrate critical roles for ASC in the release of IL-1beta/IL-18 via activation of caspase-1 and provide new insights into the inflammatory responses for host defence and diseases... - Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regenerationEkihiro Seki
First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
Hepatology 41:443-50. 2005..In conclusion, the TLR/MyD88 pathway is essential for incidental liver restoration, particularly its early phase... - Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic miceTakanobu Kato
Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Fucyu, Tokyo 183-8526, Japan
Cancer Sci 94:679-85. 2003..Furthermore, this experimental mouse model provides a valuable method with which to investigate hepatocarcinogenesis... - Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine modelIchiro Ogushi
First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
Hepatology 38:335-44. 2003..In conclusion, NF-kappa B/decoy/ODN transfer in vivo effectively suppressed endotoxin-induced fatal liver injury in mice... - Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalingsEkihiro Seki
Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
J Hepatol 48:237-45. 2008..Here, we investigated this hypothesis by introducing suppressor of cytokine signaling (SOCS)-1 and SOCS3, potent negative regulators of STAT3 signaling, selectively in hepatocytes... - Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in miceEkihiro Seki
First Department of Surgery and Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
J Immunol 169:3863-8. 2002..These results indicated a critical role for TLRs/MyD88-dependent IL-12/TNF-alpha production and for IL-12- and IL-18-mediated IFN-gamma production in early phase clearance of LM...
Research Grants
- Synergistic actions by multiple Toll-like receptors in alcoholic liver diseaseEkihiro Seki; Fiscal Year: 2010..The results from this study will provide the potential targeting for the therapy of alcohol-induced organ pathogenesis including steatohepatitis and brain injury. ..