J J Sekelsky

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing
    J J Sekelsky
    Section of MCB, University of California, Davis, CA 95616, USA
    Nucleic Acids Res 27:3762-9. 1999
  2. pmc Damage control: the pleiotropy of DNA repair genes in Drosophila melanogaster
    J J Sekelsky
    Department of Genetics, Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Genetics 148:1587-98. 1998
  3. ncbi request reprint Nucleotide excision repair endonuclease genes in Drosophila melanogaster
    J J Sekelsky
    Department of Genetics, Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Mutat Res 459:219-28. 2000
  4. pmc Identification of novel Drosophila meiotic genes recovered in a P-element screen
    J J Sekelsky
    Department of Genetics, Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    Genetics 152:529-42. 1999
  5. pmc The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1
    J J Sekelsky
    Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Genetics 141:619-27. 1995
  6. ncbi request reprint Meiotic synapsis in the absence of recombination
    K S McKim
    Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Science 279:876-8. 1998
  7. ncbi request reprint The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
    K L Hari
    Department of Genetics, University of California, Davis 95616, USA
    Cell 82:815-21. 1995
  8. pmc DNA repair in Drosophila: insights from the Drosophila genome sequence
    J J Sekelsky
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 150:F31-6. 2000
  9. pmc Biochemical characterization of the small isoform of Drosophila melanogaster RECQ5 helicase
    A Z Ozsoy
    Curriculum in Genetics and Molecular Biology, Department of Biology and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 29:2986-93. 2001
  10. pmc Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
    J J Sekelsky
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 139:1347-58. 1995

Collaborators

Detail Information

Publications13

  1. pmc Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing
    J J Sekelsky
    Section of MCB, University of California, Davis, CA 95616, USA
    Nucleic Acids Res 27:3762-9. 1999
    ..A combination of RACE and cDNA analysis of human RECQ5 demonstrates extensive alternative splicing for this gene also, including some forms lacking helicase motifs and other conserved regions...
  2. pmc Damage control: the pleiotropy of DNA repair genes in Drosophila melanogaster
    J J Sekelsky
    Department of Genetics, Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Genetics 148:1587-98. 1998
  3. ncbi request reprint Nucleotide excision repair endonuclease genes in Drosophila melanogaster
    J J Sekelsky
    Department of Genetics, Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Mutat Res 459:219-28. 2000
    ..The Drosophila Ercc1 gene maps to polytene region 51D1-2. The nucleotide excision repair gene mus210 maps nearby (51E-F) but is distinct from Ercc1...
  4. pmc Identification of novel Drosophila meiotic genes recovered in a P-element screen
    J J Sekelsky
    Department of Genetics, Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    Genetics 152:529-42. 1999
    ..Although most of these are alleles of previously undescribed genes, five were in the known genes alphaTubulin67C, CycE, push, and Trl. The five mutations in known genes produce novel phenotypes for those genes...
  5. pmc The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1
    J J Sekelsky
    Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Genetics 141:619-27. 1995
    ..cerevisiae, in that it requires an NER protein. The biochemical properties of the Rad1 protein allow us to explain the observation that mei-9 mutants suppress reciprocal exchange without suppressing the frequency of gene conversion...
  6. ncbi request reprint Meiotic synapsis in the absence of recombination
    K S McKim
    Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Science 279:876-8. 1998
    ..Furthermore, the basic processes of early meiosis may have different functional or temporal relations, or both, in yeast and Drosophila...
  7. ncbi request reprint The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
    K L Hari
    Department of Genetics, University of California, Davis 95616, USA
    Cell 82:815-21. 1995
    ..Thus, the mei-41 gene of Drosophila may be considered to be a functional homolog of the human ATM gene...
  8. pmc DNA repair in Drosophila: insights from the Drosophila genome sequence
    J J Sekelsky
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 150:F31-6. 2000
  9. pmc Biochemical characterization of the small isoform of Drosophila melanogaster RECQ5 helicase
    A Z Ozsoy
    Curriculum in Genetics and Molecular Biology, Department of Biology and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 29:2986-93. 2001
    ..5-fold higher than that observed for the ATPase activity (900 min(-1)). The purified protein catalyzed unwinding of partial duplex substrates up to at least 93 bp, however, unwinding of an 89 bp blunt duplex substrate was not detected...
  10. pmc Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
    J J Sekelsky
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 139:1347-58. 1995
    ..Hence, MAD is a member of a novel, highly conserved protein family...
  11. pmc mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development
    M H Brodsky
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 USA
    Genes Dev 14:666-78. 2000
    ..Similar mechanisms may account for the puzzling array of symptoms observed in humans with mutations in the ATM tumor suppressor gene...
  12. ncbi request reprint mei-41 is required for precocious anaphase in Drosophila females
    K S McKim
    Section of Molecular and Cellular Biology, University of California at Davis, 95616, USA
    Chromosoma 109:44-9. 2000
    ..The effect of mei-41 is dependent on double-strand break formation. Thus, in mutants that fail to initiate meiotic recombination the absence of mei-41 has no effect...
  13. ncbi request reprint The bond between sisters
    J J Sekelsky
    Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Cell 83:157-60. 1995