Magdalene Seiler

Summary

Affiliation: University of California, Irvine
Location: Irvine, USA
Publications:
PEER REVIEW
1. Seiler M and Schwab ME. Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat. Brain Res. 300:33-39 (1984).
2. Seiler M and Weiss DG. Nocodazole irreversibly reduces the capacity of rapid axoplasmic transport in vitro. J. Pharmacol. Exp. Ther. 242:277-283 (1987).
3. Aramant R, Seiler M, Turner JE. Donor age influences on the success of retinal grafts to adult rat retina. Invest. Ophthalmol. Vis. Sci. 29:498-503 (1988).
4. Seiler M and Turner JE. The activities of host and graft glial cells following retinal transplantation into the lesioned adult rat eye: developmental expression of glial markers. Dev. Brain Res. 43:111-122 (1988).
5. Aramant R, Seiler M, Ehinger B, Bergström A, Adolph AR, Turner JE. Neuronal markers in rat retinal grafts. Dev. Brain Res., 53:47-61 (1990).
6. Seiler M, Aramant R, Ehinger B, Adolph AR. Transplantation of embryonic retina to adult retina in rabbits. Exp. Eye Res., 51:225-228 (1990).
7. Aramant R, Seiler M, Ehinger B, Bergström A, Gustavii B, Brundin P, Adolph AR. Transplantation of human embryonic retina to adult rat retina. Restor. Neurol. Neurosci., 2:9-22 (1990).
8. Ehinger B, Bergström A, Seiler M, Aramant RB, Zucker CL, Gustavii B, Adolph AR. Ultrastructure of human retinal cell transplants with long survival times in rats. Exp. Eye Res., 53:447-460 (1991).
9. Aramant R, Seiler M. Cryopreservation and transplantation of immature rat retina into adult rat retina. Dev. Brain Res., 61:151-159 (1991).
10. Bergström A, Ehinger B, Wilke K, Zucker CL, Adolph AR, Aramant R, Seiler M. Transplantation of embryonic retina to the subretinal space in rabbits. Exp. Eye Res., 55(1):29-37 (1992).
11. Seiler M, Aramant R. Photoreceptor and glial markers in human embryonic retina and in human embryonic retinal transplants to rat retina. Dev. Brain Res., 80:81-95 (1994).
12. Zucker CL, Ehinger B, Seiler M, Aramant RB, Adolph AR. Ultrastructural circuitry of retinal cell transplants to rat retina. J. Neur. Transplant. Plast., 5(1):1-12 (1994)
13. Aramant R, Seiler M. Human embryonic retinal transplants in athymic immunodeficient rat hosts. J. Cell Transplant., 3(6): 461-474 (1994).
14. Seiler M, Aramant R, Bergström A. Co-Transplantation of embryonic retina and retinal pigment epithelial cells to rabbit retina. Curr. Eye Res., 14:199-207 (1995).
15. Seiler M, Aramant R. Transplantation of embryonic retinal donor cells, labelled with BrdU or carrying a genetic marker, to adult retina. Exp. Brain Res., 105(1):59?66
(1995).
16. Aramant R, Seiler M. Fiber and synaptic connections between embryonic retinal transplants and host retina. Exp. Neurol., 133:1-12 (1995).
17. Seiler MJ*, Aramant RB. Intact sheets of fetal retina transplanted to restore damaged rat retinas. Invest. Ophthalmol. Vis. Sci., 39:2121-2131 (1998).
18. Seiler MJ*, Aramant RB, Ball SL. Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin. Vision Res., 39:2589-2596 (1999).
19. Zrenner E*, Stett A, Weiss S, Aramant RB, Guenther E, Kohler K, Miliczek K-D, Seiler MJ, Haemmerle H. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res., 39:2555-2567 (1999).
20. Aramant RB*, Seiler MJ, Ball SL. Successful cotransplantation of intact sheets of fetal retina with retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci., 40:1557-1564 (1999).
21. Radtke ND*, Aramant RB, Seiler MJ, Petry HM. Preliminary report: indications of improved visual function following retinal sheet transplantation to retinitis pigmentosa patients. Am J Ophthalmol, 128:384-387 (1999).
22. Seiler MJ*, Liu OL, Cooper NGF, Callahan TL, Petry HM, Aramant RB. Selective photoreceptor damage in albino rats using continuous blue light – a protocol useful for retinal degeneration and transplantation research. Graefe’s Arch Clin Exp Ophthalmol, 238:599-607 (2000).
23. Woch G, Aramant RB, Seiler MJ, Sagdullaev BT, McCall MA*. Retinal transplants restore visual responses in rats with photoreceptor degeneration. Invest Ophthalmol Vis Sci, 42 (7): 1669-76 (2001).
24. Radtke ND*, Seiler MJ, Aramant RB, Petry HM, Pidwell DJ. Transplantation of intact sheets of fetal neural retina with its RPE in retinitis pigmentosa patients. Am J Ophthalmol, 133(4):544-550 (2002).
25. Aramant RB, Seiler MJ*. Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats. Exp Eye Res, 75(2): 115-125 (2002).
26. Yang P, Seiler MJ*, Aramant RB, Whittemore SR. Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo. J Neurosci Res, 69:466-476 (2002)
27. Yang P, Seiler MJ*, Aramant RB, Whittemore SR. Identification and isolation of human retinal progenitor cells. Exp Neurology, 177:326-331 (2002)
28.Sagdullaev BT, Aramant RB, Seiler MJ, Woch G, McCall MA*. Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. Invest Ophthalmol Vis Sci, 44(4):1686-1695 (2003).
29.Thomas BB, Seiler MJ, Sadda SR, Aramant RB*. Superior colliculus responses to light preserved by transplantation in a slow degeneration rat model. Exp Eye Res, 79(1): 29-39 (2004).
30.Qiu G, Seiler MJ, Arai S, Aramant RB, Sadda SR*. Alternative culture conditions for isolation and expansion of retinal progenitor cells. Curr Eye Res, 28(5): 327-336 (2004).
31.Radtke ND*, Aramant RB, Seiler MJ, Petry HM, Pidwell D. Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with Retinitis Pigmentosa. Arch Ophthalmol, 122: 1159-1165 (2004).
32.Thomas BB, Seiler MJ*, Sadda SR, Coffey PJ, Aramant RB. Optokinetic test to evaluate visual acuity of each eye independently. J Neurosci Meth, 138:7-13 (2004).
33.Palanker D*, Huie P, Vankov A, Aramant R, Seiler M, Fishman H, Marmor M, Blumenkranz M. Migration of Retinal Cells through a Perforated Membrane: Implications for a High-Resolution Prosthesis. Invest Ophthalmol Vis Sci, 45(9):3266-3270 (2004).
34.Arai S, Thomas BB, Seiler MJ, Aramant RB, Qiu G, Mui C, de Juan E, Sadda SR*. Restoration of visual responses following transplantation of intact retinal sheets in rd mice. Exp. Eye Res., 79(3):331-341 (2004)
35.Seiler MJ*, Sagdullaev BT, Woch G, Thomas BB, Aramant RB. Transsynaptic virus tracing from host brain to subretinal transplants. Eur J Neurosci, 21:161-172 (2005).
36.Qiu G, Seiler MJ, Mui C, Arai S, Aramant RB, de Juan E, Sadda SR*. Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats. Exp Eye Res, 80(4):515-525 (2005)
37.Thomas BB, Aramant RB, Sadda SR, Seiler MJ*. Light response differences in the superior colliculus of albino and pigmented rats. Neuroscience Letters, 385: 143–147 (2005)
38.Thomas BB, Arai S, Ikai Y, Qiu G, Chen Z, Aramant RB, Sadda SR, Seiler MJ*. Retinal Transplants Evaluated By Optical Coherence Tomography in Photoreceptor Degenerate Rats. J Neurosci Methods, 151: 186-193 (2006)
39.Thomas BB*, Samant DM, Seiler MJ, Aramant RB, Sheikholeslami S, Zhang K, Chen Z, Sadda SR. Behavioral Evaluation of Visual Function of Rats Using a Visual Discrimination Apparatus. J Neurosci Meth, 162: 84-90 (2007)
40.Qiu G, Seiler MJ, Thomas BB, Wu K, Radosevich M, Sadda SR*. Re-visiting Nestin Expression of Retinal Progenitor Cells in vitro and after transplantation in vivo. Exp Eye Res., 4: 1047-1059 (2007)
41.Colodetti L, Weiland JD*, Colodetti S, Ray A, Seiler MJ, Hinton DR, Humayun MS. Pathology of high current density stimulation in the retina. Exp. Eye Res., 85: 23-33 (2007)
42.Thomas BB, Seiler MJ, Aramant RB, Samant D, Arai S, Chen Z, Sadda SR*. Visual functional effects of constant blue light in a retinal degenerate rat model. Photochemistry and Photobiology, 83(3):759-65 (2007)
43.Peng Q, Thomas BB*, Aramant RB, Chen Z, Sadda SR, Seiler MJ. Structure and Function of Embryonic Rat Retinal Sheet Transplants. Curr. Eye Res. 32(9):781-789 (2007)
44.Seiler MJ, Thomas BB*, Chen Z, Arai S, Chadalavada S, Mahoney M, Sadda SR, Aramant RB. BDNF-Treated Retinal Progenitor Sheets Transplanted to Degenerate Rats - Improved Restoration of Visual Function. Exp Eye Res. 86(1): 92-104 (2008)
45.Leung KW, Liu M, Xu X, Seiler MJ, Barnstable CJ, Tombran-Tink J*. Expression of ZnT and ZIP Zinc Transporters in the human RPE and Their Regulation by Neurotrophic Factors. Invest Ophthalmol Vis Sci;49:1221–1231 (2008)
46.Radtke ND*, Petry HM, Pidwell D, Aramant RB, Seiler MJ. Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium. Am J Ophthalmol, 146:172-182 (2008)
47.Seiler MJ, Thomas BB*, Chen Z, Wu R, Sadda SR, Aramant RB. Retinal transplants restore visual responses - Transsynaptic tracing from visually responsive site in the superior colliculus (SC) labels transplant neurons. Eur J. Neurosci, 28:208-220 (2008) (selected for journal cover)
48.Seiler MJ, Aramant RB, Seeliger M, Bragadottir R, Mahoney M, Narfstrom K*. Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration. Veterinary Ophthalmology, 12(3):158–169 (2009)
49.Seiler MJ, Aramant RB, Thomas BB, Peng Q, Sadda SR, Keirstead HS*. Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets. Eur J. Neurosci, 31(3):508-520 (2010)
50.Seiler MJ?, Rao B?, Aramant RB, Yu L, Wang Q, Kitayama E, Pham S, Yan F, Chen Z, Keirstead HS*. Three-dimensional Optical Coherence Tomography Imaging of Retinal Sheet Implants in Live Rats. J. Neurosci. Methods, 188: 250–257 (2010)
51.Nistor G?, Seiler MJ?, Yan F, Ferguson D, Keirstead HS*. Three-Dimensional Early Retinal Progenitor 3D Tissue Constructs Derived from Human Embryonic Stem Cells. J. Neurosci. Methods, 190:63–70 (2010)
52.Yang PB?, Seiler MJ?, Aramant RB, Yan F, Mahoney MJ, Kitzes LM, Keirstead HS*. Trophic Factors GDNF and BDNF Improve Function of Retinal Sheet Transplants. Experimental Eye Research, 91: 727-738 (2010)
53.Harness JV, Turovets NA., Seiler MJ, Nistor G, Altun G, Ferguson D, Agapova L, Laurent LC, Loring JF, Keirstead HS*. Equivalence of Conventionally-Derived and Parthenote-Derived Human Embryonic Stem Cells. PLOS One, 6(1): e14499 (2011)
54.Martinez-Navarrete G, Seiler MJ*, Aramant RB, Fernandez-Sanchez L, Pinilla I, Cuenca N. Retinal Degeneration in Two Lines of Transgenic S334ter Rats. Experimental Eye Research, 92: 227-237 (2011)

ARTICLES IN PRESS
none

ARTICLES SUBMITTED
1.Seiler MJ?, Jones BW?, Aramant RB, Yang PB, Keirstead HS*, Marc RE. Host-graft circuitry of retinal sheet transplants to rats with retinal degeneration

NON PEER REVIEW
1. Seiler M, Aramant R, Ehinger B, Bergström A, Adolph AR. Characteristics of embryonic retina transplanted to rat and rabbit retina. Neuro-ophthalmology, 11(5):263-279 (1991).
2. Ehinger B, Zucker C, Bergström A, Seiler M, Aramant R, Adolph A. Electron microscopy of human first trimester and rat mid-term retinal cell transplants with long development time. Neuro-ophthalmology, 12(2):103-114 (1992).
3. Seiler MJ, Aramant RB, Keirstead HS. Transplants of retinal layers– a hope to preserve and restore vision? Optonics and Photonics News, 19(4): 37-42 (2008)

CHAPTERS
1. Turner JE, Blair JR, Seiler M, Aramant R, Laedtke TW, Chappell TE, Clarkson LM. Retinal transplants and optic nerve bridges: Possible strategies for visual recovery as a result of trauma or disease. Int. Rev. Neurobiol. 29:281-308 (1988).
2. Turner JE, Seiler M, Aramant R, Blair JR. Embryonic retinal grafts transplanted into the lesioned adult rat retina. Prog. Brain Res. 78:131-139 (1989).
3. Seiler M and Turner JE. Host and graft glial cell activities following retinal transplantation to the adult rat eye. In: R. Weiler, N.N. Osborne (eds.): Neurobiology of the inner retina. NATO ASI Series, Vol. H 31, Springer Verlag, Berlin; pp 481-486 (1989).
4. Aramant R, Seiler M, Ehinger B, Bergström A, Adolph AR, Gustavii B, Brundin P. Transplanting embryonic retina to the retina of adult animals. In: Retinal Degenerations, R.E. Anderson, J.G. Hollyfield, M.M. LaVail, Eds., CRC Press, Boca Raton, FL; pp 275-288 (1991).
5. Ehinger B, Zucker CL, Bergström A, Seiler M, Aramant R, Gustavii B, Adolph AR. Ultrastructure of long term retinal cell transplants to rat retina. In: Retinal Degenerations, R.E. Anderson, J.G. Hollyfield, M.M. LaVail, Eds., CRC Press, Boca Raton, FL; pp 263-273 (1991).
6. Aramant R, Seiler M. Transplantation of embryonic retinal cells into adult host eyes in animal models. In: Retinitis Pigmentosa - Present knowledge and outlook, E Rinaldi, F. Simonelli, L. Sebastio, Eds., Liviana Medicina s.r.l., Napoli, Padova, Italy; pp 419- 424 (1993).
7. Seiler M, Aramant R. Transplantation von embryonalen Netzhaut-zellen in die Augen adulter Wirtstiere (in German). In: Retinitis-Pigmentosa-Forschung in Deutschland - Programme - Projekte - Perspektiven, Helma Gusseck, Ed., Deutsche Retinitis Pigmentosa-Vereinigung e.V., Bad Nauheim/Bonn; pp. 99-103 (1993).
8. Aramant R, Seiler M. Embryonic retinal cell transplantation to adult retina. In: Retina, Aging and Transplantation, Proceedings of 5th Ophthalmological Symposium of the Foundation IPSEN, Y. Christen, M. Doly, M.T. Droix-Lefaix, Eds., Elsevier Press, Amsterdam; pp. 31-42 (1993).
9. Aramant RB, Seiler MJ. Retinal cell transplantation. In: 1996/1997 Yearbook of cell and tissue transplantation, R.P. Lanza, W.L. Chick, Eds., Kluwer Academic Publishers, Dordrecht, NL, pp. 193-201 (1996).
10. Aramant RB, Seiler MJ. Retinal Transplantation. Science & Medicine, 7(1):20-29 (2000).
11. Seiler MJ*, Aramant RB. Intact-sheet fetal retinal transplants can repair degenerated retinas. In: New Insights into Retinal Degenerative Diseases, J.G. Hollyfield, R.E. Anderson, M.M. LaVail, Eds., Kluwer Academic Publishers, pp. 163-174 (2001).
12. Aramant RB, Seiler MJ*. Retinal transplantation – advantages of intact sheets. Prog Retin Eye Res 21:57-73 (2002).
13. Aramant RB, Seiler MJ*. Progress in retinal sheet transplantation. Prog Retin Eye Res 23(5): 475-494 (2004).
14. Seiler MJ*, Aramant RB. Transplantation of neuroblastic progenitor cells as a sheet preserves and restores retinal function. Seminars in Ophthalmology, 20:31-42, 2005
15. Thomas BB, Aramant RB, Sadda SR, Seiler MJ*. Retinal transplantation – A treatment strategy for retinal degenerative diseases. In: Retinal Degenerative Diseases, edited by Joe G. Hollyfield, Robert E. Anderson, and Matthew M. LaVail. Series: Advances in Experimental Medicine and Biology, Vol. 572. Springer, New York, NY, 2006, pp.367-376, 2006
16. Aramant RB*, Radtke N.D., Seiler MJ. Recent results in retinal transplantation give hope for restoring vision. In Retinal Degenerations: Genetics, Progression, and Therapeutics, eds. J. Tombran-Tink and C. Barnstable, Humana Press, Totowa, NJ, 2006, pp.363-381

CHAPTER in preparation
Seiler MJ, Aramant RB, Keirstead HS. Retinal sheet transplantation – visual restoration and synaptic connectivity. Invitation for publication in Prog Retin Eye Res (deadline Sept. 2011)

Publications

  1. ncbi Can subretinal microphotodiodes successfully replace degenerated photoreceptors?
    E Zrenner
    University Eye Hospital, Department II, Tuebingen, Germany
    Vision Res 39:2555-67. 1999
  2. ncbi Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats
    Biju B Thomas
    Department of Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA
    J Neurosci Methods 151:186-93. 2006
  3. ncbi Visual functional effects of constant blue light in a retinal degenerate rat model
    Biju B Thomas
    Doheny Retina Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Photochem Photobiol 83:759-65. 2007
  4. ncbi Retinal transplantation. A treatment strategy for retinal degenerative diseases
    Biju B Thomas
    Dept. Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Adv Exp Med Biol 572:367-76. 2006
  5. ncbi Behavioral evaluation of visual function of rats using a visual discrimination apparatus
    Biju B Thomas
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Neurosci Methods 162:84-90. 2007
  6. ncbi Structure and function of embryonic rat retinal sheet transplants
    Qing Peng
    Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People s Republic of China
    Curr Eye Res 32:781-9. 2007
  7. ncbi BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function
    Magdalene J Seiler
    Ophthalmology USC, Doheny, Los Angeles, CA, USA
    Exp Eye Res 86:92-104. 2008
  8. ncbi Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors
    Kar Wah Leung
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:1221-31. 2008
  9. ncbi Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium
    Norman D Radtke
    Retina Vitreous Resource Center, University of Louisville, Louisville, Kentucky, USA
    Am J Ophthalmol 146:172-182. 2008
  10. ncbi Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration
    Magdalene J Seiler
    Department of Ophthalmology, Keck School of Medicine, University of South California, Los Angeles, CA, USA
    Vet Ophthalmol 12:158-69. 2009

Detail Information

Publications32

  1. ncbi Can subretinal microphotodiodes successfully replace degenerated photoreceptors?
    E Zrenner
    University Eye Hospital, Department II, Tuebingen, Germany
    Vision Res 39:2555-67. 1999
    ..Ganzfeld electroretinograms and histology showed no significant side effect of subretinal implants on retinal function or the architecture of the inner retina...
  2. ncbi Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats
    Biju B Thomas
    Department of Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA
    J Neurosci Methods 151:186-93. 2006
    ..OCT is a useful technique for in vivo screening and evaluation of retinal transplants. This technique determines surgical outcomes at a much earlier stage...
  3. ncbi Visual functional effects of constant blue light in a retinal degenerate rat model
    Biju B Thomas
    Doheny Retina Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Photochem Photobiol 83:759-65. 2007
    ..Histological evaluation showed reduction of the rod population in the central area of the light-damaged retina. Exposure to constant BL considerably reduces the residual visual responses in a rapid degenerating RD rat model...
  4. ncbi Retinal transplantation. A treatment strategy for retinal degenerative diseases
    Biju B Thomas
    Dept. Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Adv Exp Med Biol 572:367-76. 2006
    ..Modified functional evaluation techniques permit better understanding of the physiological mechanisms underlying visual improvement in animal models...
  5. ncbi Behavioral evaluation of visual function of rats using a visual discrimination apparatus
    Biju B Thomas
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Neurosci Methods 162:84-90. 2007
    ..03, paired t-test). This apparatus could be useful to train rats at a very early age to distinguish between two different visual stimuli and may be effective for visual functional evaluations following therapeutic interventions...
  6. ncbi Structure and function of embryonic rat retinal sheet transplants
    Qing Peng
    Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People s Republic of China
    Curr Eye Res 32:781-9. 2007
    ..To evaluate retinal sheet transplants in S334ter-line-3 retinal degenerate rats by comparing visual responses recorded electrophysiologically with morphology based on light and electron microscopy...
  7. ncbi BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function
    Magdalene J Seiler
    Ophthalmology USC, Doheny, Los Angeles, CA, USA
    Exp Eye Res 86:92-104. 2008
    ..The mechanism of the BDNF effects--either promoting functional integration between the transplant and the host retina and/or synergistic action with other putative humoral factors released by the RPCs--still needs to be elucidated...
  8. ncbi Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors
    Kar Wah Leung
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:1221-31. 2008
    ..The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to these cells were examined...
  9. ncbi Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium
    Norman D Radtke
    Retina Vitreous Resource Center, University of Louisville, Louisville, Kentucky, USA
    Am J Ophthalmol 146:172-182. 2008
    ....
  10. ncbi Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration
    Magdalene J Seiler
    Department of Ophthalmology, Keck School of Medicine, University of South California, Los Angeles, CA, USA
    Vet Ophthalmol 12:158-69. 2009
    ..To investigate whether sheets of fetal retinal allografts can integrate into the dystrophic Abyssinian cat retina with progressive rod cone degeneration...
  11. ncbi Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets
    M J Seiler
    Reeve Irvine Research Center, Gillespie Neuroscience Research Facility, School of Medicine, University of California at Irvine, Irvine, CA 92697 4292, USA
    Eur J Neurosci 31:508-20. 2010
    ....
  12. ncbi Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats
    Magdalene J Seiler
    Department of Anatomy and Neurobiology, University of California, Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Irvine, CA, United States
    J Neurosci Methods 188:250-7. 2010
    ..To obtain three-dimensional images from retinal transplants in live animals and evaluate the placement and structural quality of the transplants...
  13. ncbi Three-dimensional early retinal progenitor 3D tissue constructs derived from human embryonic stem cells
    Gabriel Nistor
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, University of California at Irvine, Irvine, CA, USA
    J Neurosci Methods 190:63-70. 2010
    ..To develop three-dimensional (3D) constructs of retinal pigment epithelium (RPE) and early retina progenitor cells from human embryonic stem cells (hESCs)...
  14. ncbi Trophic factors GDNF and BDNF improve function of retinal sheet transplants
    Pamela B Yang
    Anatomy and Neurobiology, Univ of California, Irvine, CA, USA
    Exp Eye Res 91:727-38. 2010
    ..In conclusion, treatment of retinal transplants with GDNF and BDNF improved the restoration of visual responses in RD rats; and GDNF appears to exert greater overall restoration than BDNF...
  15. ncbi Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells
    Julie V Harness
    Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, California, United States of America
    PLoS ONE 6:e14499. 2011
    ..The objective of this work was to determine points of equivalence and differences between conventionally-derived hESC and parthenote-derived hESC lines (phESC) in the undifferentiated state and during neural differentiation...
  16. ncbi Light response differences in the superior colliculus of albino and pigmented rats
    Biju B Thomas
    Department of Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, DVRC 402, 1355 San Pablo St, Los Angeles, CA 90033, USA
    Neurosci Lett 385:143-7. 2005
    ..This can be attributed to the transmission of rod-driven responses. The differences observed in the light response characteristics of albino rats may be indicative of their visual abnormalities...
  17. ncbi Transplantation of neuroblastic progenitor cells as a sheet preserves and restores retinal function
    Magdalene J Seiler
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Semin Ophthalmol 20:31-42. 2005
    ..The beneficial effect of retinal transplantation likely involves two mechanisms: trophic effects, e.g., rescue of host cones; and synaptic connectivity between transplant and host retina...
  18. ncbi Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin
    M J Seiler
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA
    Vision Res 39:2589-96. 1999
    ..Rhodopsin distribution did not change. The shift of signal transduction proteins correlated to the light conditions indicates that normal phototransduction processes were established in photoreceptors of transplanted retinal sheets...
  19. ncbi Selective photoreceptor damage in albino rats using continuous blue light. A protocol useful for retinal degeneration and transplantation research
    M J Seiler
    Department of Ophthalmology and Visual Sciences, University of Louisville, KY 40202, USA
    Graefes Arch Clin Exp Ophthalmol 238:599-607. 2000
    ..To develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to be used as recipient for evaluating retinal transplants...
  20. ncbi Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats
    Robert B Aramant
    Departments of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202, USA
    Exp Eye Res 75:115-25. 2002
    ....
  21. ncbi Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo
    Peng Yang
    Department of Ophthalmology and Visual Sciences, University of Louisville, Kentucky 40202, USA
    J Neurosci Res 69:466-76. 2002
    ....
  22. ncbi Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa
    Botir T Sagdullaev
    Department of Psychological and Brain Science, University of Louisville, Louisville, Kentucky 40292, USA
    Invest Ophthalmol Vis Sci 44:1686-95. 2003
    ..The mechanisms underlying this functional recovery remain to be resolved, but these results suggest that transplantation should be further explored as a therapy for RP...
  23. ncbi Superior colliculus responses to light - preserved by transplantation in a slow degeneration rat model
    Biju B Thomas
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California, 1450 San Pablo St, Los Angeles, CA 90033, USA
    Exp Eye Res 79:29-39. 2004
    ..30-50 msec). CONCLUSIONS: Fetal retinal sheet transplantation showed a long-term rescue effect on visual function in this animal model of slow photoreceptor degeneration...
  24. ncbi Alternative culture conditions for isolation and expansion of retinal progenitor cells
    G Qiu
    Department of Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles 90033-3699, USA
    Curr Eye Res 28:327-36. 2004
    ..This morphology change occurred at P9-P10 in the serum-free medium, and at P5-P6 in the other two culture systems. CONCLUSIONS: The serum-free medium may be superior for preventing RPC differentiation during expansion...
  25. ncbi Progress in retinal sheet transplantation
    Robert B Aramant
    Department of Anatomical Sciences and Neurobiology, University of Louisville, KY, USA
    Prog Retin Eye Res 23:475-94. 2004
    ....
  26. ncbi Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa
    Norman D Radtke
    Retina Vitreous Resource Center, Norton Audubon Hospital, KY, USA
    Arch Ophthalmol 122:1159-65. 2004
    ..To report the subjective and objective improvement in vision in a patient with autosomal dominant retinitis pigmentosa after transplantation of a sheet of fetal neural retina together with its retinal pigment epithelium...
  27. ncbi Optokinetic test to evaluate visual acuity of each eye independently
    Biju B Thomas
    Department of Ophthalmology, Doheny Retina Institute/DVRC 402, Keck School of Medicine at the University of Southern California, 1355 San Pablo St, Los Angeles, CA 90033, USA
    J Neurosci Methods 138:7-13. 2004
    ..In conclusion, contributions from the fellow eye to the optokinetic tracking response can be limited by this testing modification, which is useful for evaluation of treatment effects to one eye...
  28. ncbi Migration of retinal cells through a perforated membrane: implications for a high-resolution prosthesis
    Daniel Palanker
    Department of Ophthalmology, School of Medicine, Stanford University, CA 94305 4085, USA
    Invest Ophthalmol Vis Sci 45:3266-70. 2004
    ..This is a report of a phenomenon of retinal cellular migration into a perforated membrane that may help to address this problem...
  29. ncbi Restoration of visual responses following transplantation of intact retinal sheets in rd mice
    S Arai
    Doheny Retina Institute, Keck School of Medicine, University of Southern California, DEI 3610, 1450 San Pablo Street, Los Angeles 90033-3699, USA
    Exp Eye Res 79:331-41. 2004
    ..Increased recoverin-staining in the host retina in light-responsive animals suggested that host cone rescue was the likely mechanism of vision restoration in this transplant model...
  30. ncbi Transsynaptic virus tracing from host brain to subretinal transplants
    Magdalene J Seiler
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA
    Eur J Neurosci 21:161-72. 2005
    ..This study provides evidence that PRV spreads in the retina as in other parts of the CNS and is useful to outline transplant-host circuitry...
  31. ncbi Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats
    Guanting Qiu
    Department of Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, 1450 San Pablo St. DEI-3600, Los Angeles, CA 90033, USA
    Exp Eye Res 80:515-25. 2005
    ..The similarity of the in vitro and in vivo RPC differentiation profiles suggests that intrinsic signals may have a significant contribution to RPC cell fate determination...
  32. ncbi Cell replacement and visual restoration by retinal sheet transplants
    Magdalene J Seiler
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, University of California at Irvine, 1101 Gross Hall, 845 Health Science Rd, Irvine, CA 92697 4265, USA
    Prog Retin Eye Res 31:661-87. 2012
    ..Supply of fetal donor tissue will always be limited but the model can set a standard and provide an informative base for optimal cell replacement therapies such as embryonic stem cell (ESC)-derived therapy...