Sharvan Sehrawat

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 182:3191-201. 2009
  2. pmc Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency
    Pradeep B J Reddy
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 187:5745-55. 2011
  3. pmc Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response
    Sharvan Sehrawat
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    PLoS Pathog 6:e1000882. 2010
  4. pmc Galectin-1 reduces the severity of herpes simplex virus-induced ocular immunopathological lesions
    Naveen K Rajasagi
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 188:4631-43. 2012
  5. pmc In vitro-generated antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of herpes simplex virus-induced ocular immunoinflammatory lesions
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    J Virol 82:6838-51. 2008
  6. pmc Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor
    Amol Suryawanshi
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 186:3653-65. 2011
  7. ncbi request reprint Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Immunol 180:7636-47. 2008
  8. pmc Role of regulatory T cells during virus infection
    Tamara Veiga-Parga
    Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Immunol Rev 255:182-96. 2013
  9. ncbi request reprint An approach to control relapse of inflammatory lesions after discontinuation of primary therapy
    Pradeep B J Reddy
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
    PLoS ONE 9:e98051. 2014
  10. pmc Tregs and infections: on the potential value of modifying their function
    Sharvan Sehrawat
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Leukoc Biol 90:1079-87. 2011

Collaborators

  • Amol Suryawanshi
  • Susmit Suvas
  • Barry T Rouse
  • Pradeep B J Reddy
  • Naveen K Rajasagi
  • Tamara Veiga-Parga
  • Sachin Mulik
  • Mitsuomi Hirashima
  • Pranita P Sarangi
  • Madhu Khatri

Detail Information

Publications13

  1. pmc Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 182:3191-201. 2009
    ..Our results indicate that galectin-9 therapy may represent a useful approach to control HSV-induced lesions, the most common cause of infectious blindness in the Western world...
  2. pmc Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency
    Pradeep B J Reddy
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 187:5745-55. 2011
    ....
  3. pmc Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response
    Sharvan Sehrawat
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    PLoS Pathog 6:e1000882. 2010
    ..Our results indicate that manipulating galectin signals, as can be achieved using appropriate sugars, may represent a convenient and inexpensive approach to enhance acute and memory responses to a virus infection...
  4. pmc Galectin-1 reduces the severity of herpes simplex virus-induced ocular immunopathological lesions
    Naveen K Rajasagi
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 188:4631-43. 2012
    ..To our knowledge, our findings are the first to show that gal-1 treatment represents a useful approach to control lesion severity in a virally induced immunopathological disease...
  5. pmc In vitro-generated antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of herpes simplex virus-induced ocular immunoinflammatory lesions
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    J Virol 82:6838-51. 2008
    ..The suppression effect in vivo appeared to be polyspecific. The protocol we have developed could provide a useful additional approach to control virus-induced inflammatory disease...
  6. pmc Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor
    Amol Suryawanshi
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 186:3653-65. 2011
    ..Future therapies aimed to increase the production and activity of sVR-1 protein could benefit the management of stromal keratitis, an important cause of human blindness...
  7. ncbi request reprint Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators
    Sharvan Sehrawat
    Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Immunol 180:7636-47. 2008
    ....
  8. pmc Role of regulatory T cells during virus infection
    Tamara Veiga-Parga
    Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Immunol Rev 255:182-96. 2013
    ....
  9. ncbi request reprint An approach to control relapse of inflammatory lesions after discontinuation of primary therapy
    Pradeep B J Reddy
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
    PLoS ONE 9:e98051. 2014
    ..These results indicate that approaches such as neutralization of proinflammatory cytokines might be considered along with FTY720 treatment if interruption of drug therapy becomes necessary. ..
  10. pmc Tregs and infections: on the potential value of modifying their function
    Sharvan Sehrawat
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Leukoc Biol 90:1079-87. 2011
    ..This review focuses on our current understanding of the mechanisms required for the generation and sustenance of Tregs in vivo and the potential value of modulating Tregs to control microbe-induced immunopathological responses...
  11. pmc Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology
    Amol Suryawanshi
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 187:1919-30. 2011
    ..In conclusion, our results show that IL-17 and Th17 cells contribute to the pathogenesis of SK, the most common cause of infectious blindness in the Western world...
  12. ncbi request reprint IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology
    Pranita P Sarangi
    Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
    J Immunol 180:6297-306. 2008
    ..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically...
  13. doi request reprint Immunity and immunopathology to viruses: what decides the outcome?
    Barry T Rouse
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 0845, USA
    Nat Rev Immunol 10:514-26. 2010
    ....