Mary E Sehl

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Determining duration of HER2-targeted therapy using stem cell extinction models
    Lindsay Riley
    Department of Biomathematics, School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e46613. 2012
  2. pmc Stem cell niche dynamics: from homeostasis to carcinogenesis
    Kevin S Tieu
    Computational and Systems Biology Interdepartmental Program, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Stem Cells Int 2012:367567. 2012
  3. pmc Decline in physical functioning in first 2 years after breast cancer diagnosis predicts 10-year survival in older women
    Mary Sehl
    Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    J Cancer Surviv 7:20-31. 2013
  4. pmc Attribution of functional limitation to cancer decreases in the year following breast cancer diagnosis in older patients
    Mary E Sehl
    Divisions of Geriatrics and Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA
    Crit Rev Oncol Hematol 71:62-9. 2009
  5. pmc Differential destruction of stem cells: implications for targeted cancer stem cell therapy
    Mary E Sehl
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095 7059, USA
    Cancer Res 69:9481-9. 2009
  6. pmc Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer
    Mary E Sehl
    Divisions of Hematology and Oncology and Geriatrics, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, USA
    Clin Cancer Res 15:2192-203. 2009
  7. pmc Extinction models for cancer stem cell therapy
    Mary Sehl
    Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Math Biosci 234:132-46. 2011
  8. pmc Association screening of common and rare genetic variants by penalized regression
    Hua Zhou
    Department of Statistics, North Carolina State University, Raleigh, NC 27695 8203, USA
    Bioinformatics 26:2375-82. 2010
  9. pmc Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women
    Carolyn J Crandall
    Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, UCLA Medicine GIM, 911 Broxton Ave, 1st Floor, Los Angeles, CA 90024, USA
    Breast Cancer Res 11:R51. 2009
  10. pmc Epigenetic predictor of age
    Sven Bocklandt
    Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e14821. 2011

Detail Information

Publications10

  1. pmc Determining duration of HER2-targeted therapy using stem cell extinction models
    Lindsay Riley
    Department of Biomathematics, School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e46613. 2012
    ..In order to guide clinical trials examining HER2-targeted therapy in the adjuvant setting, we propose a mathematical model to examine BCSC population dynamics and predict optimal duration of therapy...
  2. pmc Stem cell niche dynamics: from homeostasis to carcinogenesis
    Kevin S Tieu
    Computational and Systems Biology Interdepartmental Program, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Stem Cells Int 2012:367567. 2012
    ..Finally, we discuss experimental systems, most notably Drosophila, that can best be used to validate mathematical predictions...
  3. pmc Decline in physical functioning in first 2 years after breast cancer diagnosis predicts 10-year survival in older women
    Mary Sehl
    Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    J Cancer Surviv 7:20-31. 2013
    ..Although most patients recover after treatment, some patients do not. These changes may be magnified in older women with comorbid conditions and could impact survival outcomes...
  4. pmc Attribution of functional limitation to cancer decreases in the year following breast cancer diagnosis in older patients
    Mary E Sehl
    Divisions of Geriatrics and Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA
    Crit Rev Oncol Hematol 71:62-9. 2009
    ....
  5. pmc Differential destruction of stem cells: implications for targeted cancer stem cell therapy
    Mary E Sehl
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095 7059, USA
    Cancer Res 69:9481-9. 2009
    ..We anticipate that in conjunction with experimental observation of cancer stem cell killing rates, our results will be useful in screening targeted therapies for both hematologic and solid tumor malignancies...
  6. pmc Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer
    Mary E Sehl
    Divisions of Hematology and Oncology and Geriatrics, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, USA
    Clin Cancer Res 15:2192-203. 2009
    ..DNA damage recognition and repair play a major role in risk for breast cancer. We investigated 104 single nucleotide polymorphisms (SNP) in 17 genes whose protein products are involved in double-stranded break repair (DSBR)...
  7. pmc Extinction models for cancer stem cell therapy
    Mary Sehl
    Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Math Biosci 234:132-46. 2011
    ..The current cancer models demonstrate the virtue of attacking the same quantitative questions from a variety of modeling, mathematical, and computational perspectives...
  8. pmc Association screening of common and rare genetic variants by penalized regression
    Hua Zhou
    Department of Statistics, North Carolina State University, Raleigh, NC 27695 8203, USA
    Bioinformatics 26:2375-82. 2010
    ..This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants...
  9. pmc Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women
    Carolyn J Crandall
    Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, UCLA Medicine GIM, 911 Broxton Ave, 1st Floor, Los Angeles, CA 90024, USA
    Breast Cancer Res 11:R51. 2009
    ....
  10. pmc Epigenetic predictor of age
    Sven Bocklandt
    Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e14821. 2011
    ....