N Segev

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1
    Nava Segev
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Cell 46:4-6. 2012
  2. pmc Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex
    Randal Cox
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, IL 60607, USA
    BMC Evol Biol 7:12. 2007
  3. ncbi Ypt and Rab GTPases: insight into functions through novel interactions
    N Segev
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, 60607, USA
    Curr Opin Cell Biol 13:500-11. 2001
  4. ncbi Ypt/rab gtpases: regulators of protein trafficking
    N Segev
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, MBRB 4120, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Sci STKE 2001:re11. 2001
  5. pmc Coordination of intracellular transport steps by GTPases
    Nava Segev
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Semin Cell Dev Biol 22:33-8. 2011
  6. pmc The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32
    S Jones
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Biol Cell 11:4403-11. 2000
  7. pmc Identification of regulators for Ypt1 GTPase nucleotide cycling
    S Jones
    Department of Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 9:2819-37. 1998
  8. pmc Genetic interactions in yeast between Ypt GTPases and Arf guanine nucleotide exchangers
    S Jones
    Department of Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Genetics 152:1543-56. 1999

Research Grants

  1. YPTL GTPASE AND VESICULAR TRANSPORT
    Nava Segev; Fiscal Year: 2000
  2. Role of Ypt GTPases in Vesicular transport
    Nava Segev; Fiscal Year: 2004
  3. Role of Ypt GTPases in Intracellular Trafficking
    Nava Segev; Fiscal Year: 2009
  4. Role of Ypt GTPases in Intracellular Trafficking
    Nava Segev; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. ncbi Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1
    Nava Segev
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Cell 46:4-6. 2012
    ..However, the mechanism through which TORC1 senses amino acids is still a mystery. In the current issues of Molecular Cell and Cell, Bonfils et al. (2012) and Han et al. (2012) implicate leucyl-tRNA synthetase in this evolving story...
  2. pmc Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex
    Randal Cox
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, IL 60607, USA
    BMC Evol Biol 7:12. 2007
    ..While TRAPPI, which acts in early Golgi, is conserved from fungi to animals, not much is known about TRAPPII, which acts in late Golgi and consists of TRAPPI plus three additional subunits...
  3. ncbi Ypt and Rab GTPases: insight into functions through novel interactions
    N Segev
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, 60607, USA
    Curr Opin Cell Biol 13:500-11. 2001
    ....
  4. ncbi Ypt/rab gtpases: regulators of protein trafficking
    N Segev
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, MBRB 4120, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Sci STKE 2001:re11. 2001
    ..Finally, cross talk demonstrated among the various Ypt/Rabs, and between Ypt/Rabs and other signaling factors, suggests possible coordination among secretory steps, as well as between protein transport and other cellular processes...
  5. pmc Coordination of intracellular transport steps by GTPases
    Nava Segev
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Semin Cell Dev Biol 22:33-8. 2011
    ..The mechanisms proposed for GTPase-mediated transport-step coordination depend on the ability of single GTPases to interact with multiple effectors and on interactions of multiple GTPases through common accessory factors...
  6. pmc The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32
    S Jones
    Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Biol Cell 11:4403-11. 2000
    ..These data suggest the exciting possibility that a GEF complex common to Ypt1 and Ypt31/32 might coordinate the function of these GTPases in entry into and exit from the Golgi...
  7. pmc Identification of regulators for Ypt1 GTPase nucleotide cycling
    S Jones
    Department of Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 9:2819-37. 1998
    ..On the basis of our current and previous results, we propose a new model for the role of Ypt/Rab nucleotide cycling and the factors that regulate this process...
  8. pmc Genetic interactions in yeast between Ypt GTPases and Arf guanine nucleotide exchangers
    S Jones
    Department of Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Genetics 152:1543-56. 1999
    ..The genetic interactions observed between Arf GEFs and Ypt GTPases suggest the existence of a Ypt-Arf GTPase cascade in the secretory pathway...

Research Grants8

  1. YPTL GTPASE AND VESICULAR TRANSPORT
    Nava Segev; Fiscal Year: 2000
    ..Finally, interaction among exocytic Ypt proteins themselves will be explored. ..
  2. Role of Ypt GTPases in Vesicular transport
    Nava Segev; Fiscal Year: 2004
    ..To determine the mechanism by which Ypt effectors function, we will study the effect of mutations in Ypt effector genes on vesicle budding, targeting, or fusion, and the nature of their interaction with Ypt GTPases. ..
  3. Role of Ypt GTPases in Intracellular Trafficking
    Nava Segev; Fiscal Year: 2009
    ....
  4. Role of Ypt GTPases in Intracellular Trafficking
    Nava Segev; Fiscal Year: 2010
    ....