- Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activityDouglas Tsao
Department of Chemistry University of North Carolina, Chapel Hill, NC 27599, USA
Mol Pain 8:25. 2012..Our results suggest that inhibition of COMT via serotonin binding contributes to pain hypersensitivity, providing additional strategies for the treatment of clinical pain conditions...
- Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalitiesS K Segall
Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, USA
CNS Neurol Disord Drug Targets 11:222-35. 2012..This will enable the translation of current findings into meaningful clinical applications such as diagnostic markers and novel therapeutic targets for complex human pain conditions...
- Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of miceS K Segall
Curriculum of Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Genes Brain Behav 9:933-46. 2010..SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity. These results suggest that a haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors...