S K Segall

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity
    Douglas Tsao
    Department of Chemistry University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Pain 8:25. 2012
  2. pmc Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities
    S K Segall
    Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, USA
    CNS Neurol Disord Drug Targets 11:222-35. 2012
  3. pmc Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice
    S K Segall
    Curriculum of Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Genes Brain Behav 9:933-46. 2010

Collaborators

  • Douglas Tsao
  • William Maixner
  • Nikolay V Dokholyan
  • Jeffrey S Mogil
  • Naim Rashid
  • Rachel L Redler
  • Robert E Sorge
  • Jeffrey S Wieskopf
  • Luda Diatchenko

Detail Information

Publications3

  1. pmc Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity
    Douglas Tsao
    Department of Chemistry University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Pain 8:25. 2012
    ..Our results suggest that inhibition of COMT via serotonin binding contributes to pain hypersensitivity, providing additional strategies for the treatment of clinical pain conditions...
  2. pmc Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities
    S K Segall
    Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, USA
    CNS Neurol Disord Drug Targets 11:222-35. 2012
    ..This will enable the translation of current findings into meaningful clinical applications such as diagnostic markers and novel therapeutic targets for complex human pain conditions...
  3. pmc Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice
    S K Segall
    Curriculum of Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Genes Brain Behav 9:933-46. 2010
    ..SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity. These results suggest that a haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors...