Benjamin M Segal

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Experimental autoimmune encephalomyelitis
    Praveen Rao
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Methods Mol Med 102:363-75. 2004
  2. pmc GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Exp Med 207:953-61. 2010
  3. doi request reprint Neurosarcoidosis: diagnostic approaches and therapeutic strategies
    Benjamin M Segal
    Holtom Garrett Program in Neuroimmunology and Multiple Sclerosis Center, Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Curr Opin Neurol 26:307-13. 2013
  4. ncbi request reprint Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
    Benjamin M Segal
    Department of Neurology, Holtom Garrett Programme in Neuroimmunology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Lancet Neurol 7:796-804. 2008
  5. pmc The role of natural killer cells in curbing neuroinflammation
    Benjamin M Segal
    Department of Neurology, U M Multiple Sclerosis Program and Holtom Garrett Neuroimmunology Laboratory, University of Michigan, 4009 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Neuroimmunol 191:2-7. 2007
  6. pmc Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS
    Benjamin M Segal
    Department of Neurology, University of Michigan, Ann Arbor, 48109, USA
    Eur J Immunol 39:1713-5. 2009
  7. pmc Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, School of Medicine and Dentistry, University of Rochester, NY, USA
    Blood 113:3190-7. 2009
  8. pmc EAE mediated by a non-IFN-γ/non-IL-17 pathway
    Mark A Kroenke
    Holtom Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Eur J Immunol 40:2340-8. 2010
  9. ncbi request reprint Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis
    Mark A Kroenke
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci Res 85:1685-93. 2007
  10. pmc Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations
    Emily K Rainey-Barger
    Department of Neurology, University of Michigan Medical School, 4007 Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, United States
    J Neuroimmunol 259:47-54. 2013

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Experimental autoimmune encephalomyelitis
    Praveen Rao
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Methods Mol Med 102:363-75. 2004
    ..Subheading 3.3. describes methods for rating clinical disease in symptomatic animals. Subheading 3.4. includes instructions for the isolation of mononuclear cells from the inflamed spinal cords from mice with EAE...
  2. pmc GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Exp Med 207:953-61. 2010
    ..The current report reveals a previously unidentified role for GM-CSF in DC ontogeny and identifies langerin(+)CD103(+) DCs as an important subset in CD4(+) T cell-mediated autoimmune disease...
  3. doi request reprint Neurosarcoidosis: diagnostic approaches and therapeutic strategies
    Benjamin M Segal
    Holtom Garrett Program in Neuroimmunology and Multiple Sclerosis Center, Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Curr Opin Neurol 26:307-13. 2013
    ..This review focuses on central nervous system (CNS) complications of sarcoidosis...
  4. ncbi request reprint Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
    Benjamin M Segal
    Department of Neurology, Holtom Garrett Programme in Neuroimmunology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Lancet Neurol 7:796-804. 2008
    ....
  5. pmc The role of natural killer cells in curbing neuroinflammation
    Benjamin M Segal
    Department of Neurology, U M Multiple Sclerosis Program and Holtom Garrett Neuroimmunology Laboratory, University of Michigan, 4009 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Neuroimmunol 191:2-7. 2007
    ..Here we discuss the growing body of evidence that NK cells limit damage in autoimmune demyelinating disease by inhibiting autoreactive T cell responses without harming resident neurons or glia...
  6. pmc Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS
    Benjamin M Segal
    Department of Neurology, University of Michigan, Ann Arbor, 48109, USA
    Eur J Immunol 39:1713-5. 2009
    ..This paper contributes to a growing body of data that implicates IL-23 in the acquisition of CNS homing properties by autoreactive effector cells...
  7. pmc Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, School of Medicine and Dentistry, University of Rochester, NY, USA
    Blood 113:3190-7. 2009
    ....
  8. pmc EAE mediated by a non-IFN-γ/non-IL-17 pathway
    Mark A Kroenke
    Holtom Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Eur J Immunol 40:2340-8. 2010
    ..Our findings contribute to a growing body of data, indicating that individual cytokines vary in their importance across different models of CNS autoimmunity...
  9. ncbi request reprint Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis
    Mark A Kroenke
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci Res 85:1685-93. 2007
    ..Furthermore, induction of tolerance against a putative secondary epitope did not prevent clinical relapses...
  10. pmc Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations
    Emily K Rainey-Barger
    Department of Neurology, University of Michigan Medical School, 4007 Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, United States
    J Neuroimmunol 259:47-54. 2013
    ..Our system should be useful to further unravel how certain viral infections trigger MS exacerbations and to understand how CD8+ T cells can exert pathogenic effects within active demyelinating lesions...
  11. ncbi request reprint Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 175:641-5. 2005
    ..Our studies suggest that IL-12 could act in concert with other proinflammatory factors to stimulate CD4(+)CD25(-) T cell activation in the presence of Treg...
  12. pmc IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    Mark A Kroenke
    Department of Neurology, Holtom Garrett Program in Neuroimmunology, University of Michigan, Ann Arbor, MI 48109, USA
    J Exp Med 205:1535-41. 2008
    ..These findings indicate that autoimmunity can be mediated by distinct effector populations that use disparate immunological pathways to achieve a similar clinical outcome...
  13. ncbi request reprint IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination
    Pratima Deshpande
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 605, Rochester, NY, 14642, USA
    J Neuroimmunol 173:35-44. 2006
    ..We conclude that IL-12-driven PSGL-1 expression can facilitate the development of autoimmune demyelination...
  14. ncbi request reprint Cutting edge: CNS CD11c+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25+CD4+ T cell-mediated immunosuppression, suggesting dual roles in the disease process
    Pratima Deshpande
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 178:6695-9. 2007
    ..Such paradoxical functions might reflect dual roles of CNS DCs in promoting local inflammation while setting the stage for remission...
  15. ncbi request reprint CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis
    Ludmila V Bagaeva
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Immunol 176:7676-85. 2006
    ..Our findings raise the possibility that reagents that antagonize or inhibit CXCL13 might be useful for the treatment of neuroinflammatory diseases such as multiple sclerosis...
  16. pmc Highly polarized Th17 cells induce EAE via a T-bet independent mechanism
    Heather M Grifka-Walk
    Holtom Garrett Program in Neuroimmunology and Multiple Sclerosis Center, Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Eur J Immunol 43:2824-31. 2013
    ....
  17. doi request reprint Th1-mediated experimental autoimmune encephalomyelitis is CXCR3 independent
    Stephen J Lalor
    Department of Neurology, Holtom Garrett Program in Neuroimmunology, University of Michigan, Ann Arbor, MI, USA
    Eur J Immunol 43:2866-74. 2013
    ....
  18. pmc Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis
    Ashley R Sandy
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 191:1606-13. 2013
    ....
  19. ncbi request reprint Experimental autoimmune encephalomyelitis
    Praveen Rao
    Department of Neurology, University of Michigan Multiple Sclerosis Center and Holtom Garrett Program in Neuroimmunology, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 900:363-80. 2012
    ..Subheading 3.4 includes instructions for the isolation of mononuclear cells from the inflamed spinal cords of mice with EAE. Subheading 3.5 describes a method for performing the enzyme-linked immunospot assay...
  20. ncbi request reprint IL-12 dependent/IFN gamma independent expression of CCR5 by myelin-reactive T cells correlates with encephalitogenicity
    Ludmila V Bagaeva
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 605, Rochester, NY 14642, USA
    J Neuroimmunol 137:109-16. 2003
    ..Our results suggest that reagents that block CCR5/beta-chemokine interactions and/or antagonize IL-12 might be useful for treatment of autoimmune demyelination...
  21. doi request reprint Differences in diffusion tensor imaging-derived metrics in the corpus callosum of patients with multiple sclerosis without and with gadolinium-enhancing cerebral lesions
    Tiffany J Braley
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    J Comput Assist Tomogr 36:410-5. 2012
    ..To analyze differences in corpus callosum diffusion tensor imaging metrics among patients with relapsing-remitting multiple sclerosis (MS) (RRMS) and secondary progressive MS (SPMS) with enhancing and nonenhancing cerebral lesions...
  22. ncbi request reprint Experimental autoimmune encephalomyelitis: cytokines, effector T cells, and antigen-presenting cells in a prototypical Th1-mediated autoimmune disease
    Benjamin M Segal
    Department of Neurology, Microbiology and Immunology and the Cancer Center, University of Rochester, 601 Elmwood Avenue, Box 605, Rochester, NY 14642, USA
    Curr Allergy Asthma Rep 3:86-93. 2003
    ..Although Th1 polarizing monokines, such as interleukin-12 (IL-12) and possibly IL-23, are critical for the manifestation of EAE, individual Th1 effector cytokines were found to be dispensible...
  23. pmc Treatment of CNS sarcoidosis with infliximab and mycophenolate mofetil
    Michael Moravan
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, NY, USA
    Neurology 72:337-40. 2009
    ..To describe the effects of the anti-tumor necrosis factor neutralizing antibody, infliximab, and the antiproliferative immunosuppressant, mycophenolate mofetil, in refractory neurosarcoidosis...
  24. pmc Lymphoid chemokines in the CNS
    Stephen J Lalor
    Holtom Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan, 4013 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Neuroimmunol 224:56-61. 2010
    ..In contrast, aberrant induction of CCL19, CCL21 and CXCL13 may support the establishment of chronic autoimmunity and hematopoietic tumors within the CNS...
  25. pmc IL-23 modulated myelin-specific T cells induce EAE via an IFNγ driven, IL-17 independent pathway
    Mark A Kroenke
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Behav Immun 25:932-7. 2011
    ..Our findings illustrate a novel mechanism by which IL-23 promotes encephalitogenicity and they further expand the spectrum of autoreactive T cells capable of mediating inflammatory demyelinating disease of the CNS...
  26. pmc The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous system
    Emily K Rainey-Barger
    Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Brain Behav Immun 25:922-31. 2011
    ..Thus, CXCL13 could be a therapeutic target in certain neuroinflammatory diseases, but not by blocking B cell recruitment to the CNS...
  27. pmc Sleep-disordered breathing in multiple sclerosis
    Tiffany J Braley
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Neurology 79:929-36. 2012
    ....
  28. ncbi request reprint CNS chemokines, cytokines, and dendritic cells in autoimmune demyelination
    Benjamin M Segal
    Department of Neurology, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 605, Rochester, NY 14642 0001, USA
    J Neurol Sci 228:210-4. 2005
  29. ncbi request reprint Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease
    Hiroshi T Ichikawa
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Immunol 169:2781-7. 2002
    ..Microbial pathogens could 1) release molecules that bind Toll-like receptors, and/or 2) stimulate microbe-specific T cells to express CD40 ligand, thereby licensing APCs that bear both microbial and autoantigens to break tolerance...
  30. pmc Obstructive sleep apnea and fatigue in patients with multiple sclerosis
    Tiffany J Braley
    University of Michigan Department of Neurology and Multiple Sclerosis Center, Ann Arbor, MI University of Michigan Department of Neurology and Sleep Disorders Center, Ann Arbor, MI
    J Clin Sleep Med 10:155-62. 2014
    ..The objectives of this study were to investigate the prevalence of diagnosed OSA and OSA risk among MS patients, and to assess relationships between fatigue severity, OSA, OSA risk, and sleep quality among persons with MS...
  31. pmc Fatigue, tiredness, lack of energy, and sleepiness in multiple sclerosis patients referred for clinical polysomnography
    Tiffany J Braley
    Department of Neurology, Sleep Disorders Center, and Holtom Garrett Program in Neuroimmunology, University of Michigan, C728 Med Inn Building, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Mult Scler Int 2012:673936. 2012
    ..Conclusion. In comparison to controls, MS patients report more fatigue, tiredness, and lack energy, but not sleepiness. Fatigue and related symptoms may arise from MS itself or in relation to reduced sleep efficiency...
  32. ncbi request reprint Cutting Edge: IL-10-producing CD4+ T cells mediate tumor rejection
    Benjamin M Segal
    Department of Neurology, The Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 168:1-4. 2002
    ..Hence, our findings demonstrate that IL-10-producing CD4+ T cells can manifest antitumor functions and suggest that IL-10 may have proinflammatory effects in disease states...
  33. doi request reprint Progressive decline in fractional anisotropy on serial DTI examinations of the corpus callosum: a putative marker of disease activity and progression in SPMS
    Wei Tian
    Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA
    Neuroradiology 54:287-97. 2012
    ..Diffusion tensor imaging (DTI) is sensitive in detecting acute brain tissue damage. We monitored SPMS patients over 12 months for diffusion changes within the corpus callosum (CC)...
  34. pmc Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitis
    Joshua S Stoolman
    Department of Neurology, Holtom Garrett Program in Neuroimmunology and Multiple Sclerosis Center, University of Michigan School of Medicine, Ann Arbor, MI 48109 Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109 and
    J Immunol 193:564-70. 2014
    ..This study illustrates how regional differences in chemokine expression within a target organ shape the spatial pattern and composition of autoimmune infiltrates, leading to disparate clinical outcomes. ..
  35. pmc B-cell targeting agents in the treatment of multiple sclerosis
    Tiffany J Braley
    Department of Neurology, University of Michigan, 4013 Biomedical Science Research Building, 109 Zina Pitcher Place, SPC 2200, Ann Arbor, MI, 48109, USA
    Curr Treat Options Neurol 15:259-69. 2013
    ..Further research into B-cell subset trafficking patterns, functional activities and interactions with other immune cells in the context of neuroinflammation is likely to inform the development of future generations of DMT...
  36. ncbi request reprint Fatigue in multiple sclerosis: current understanding and future directions
    Steven R Schwid
    Department of Neurology, University of Rochester Medical Center, NY, USA
    J Rehabil Res Dev 39:211-24. 2002
    ..Dividing fatigue into these components can provide objective assessments that are less likely to be confounded by other symptoms of MS, such as weakness, spasticity, cognitive impairment, and depressed mood...