Fernando Segade

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Glucose transporter 10 and arterial tortuosity syndrome: the vitamin C connection
    Fernando Segade
    Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA 19104, USA
    FEBS Lett 584:2990-4. 2010
  2. doi request reprint Functional evolution of the microfibril-associated glycoproteins
    Fernando Segade
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, 240 S 40th St, Philadelphia, PA 19104, USA
    Gene 439:43-54. 2009
  3. pmc The intracellular form of human MAGP1 elicits a complex and specific transcriptional response
    Fernando Segade
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Biochem Cell Biol 39:2303-13. 2007
  4. pmc Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study
    Fernando Segade
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Arch Otolaryngol Head Neck Surg 132:729-33. 2006
  5. ncbi request reprint Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells
    Fernando Segade
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1731:215-24. 2005
  6. doi request reprint Molecular evolution of the fibulins: implications on the functionality of the elastic fibulins
    Fernando Segade
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Gene 464:17-31. 2010
  7. ncbi request reprint Differential expression of facilitative glucose transporters in normal and tumour kidney tissues
    Nobuyasu Suganuma
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    BJU Int 99:1143-9. 2007
  8. pmc Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    BMC Med Genet 6:42. 2005
  9. ncbi request reprint Functional characterization of the promoter of the human glucose transporter 10 gene
    Fernando Segade
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1730:147-58. 2005
  10. ncbi request reprint Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2
    Claudio C Werneck
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:23045-51. 2004

Collaborators

Detail Information

Publications12

  1. doi request reprint Glucose transporter 10 and arterial tortuosity syndrome: the vitamin C connection
    Fernando Segade
    Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA 19104, USA
    FEBS Lett 584:2990-4. 2010
    ..In ATS, loss of GLUT10 results in defective collagen and/or elastin. TGFbeta activation represents a secondary response to a defective extracellular matrix...
  2. doi request reprint Functional evolution of the microfibril-associated glycoproteins
    Fernando Segade
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, 240 S 40th St, Philadelphia, PA 19104, USA
    Gene 439:43-54. 2009
    ..Correlated evolution between MAGP1 and the developmental regulator, Notch1, may explain some of the selective forces acting on MAGP2...
  3. pmc The intracellular form of human MAGP1 elicits a complex and specific transcriptional response
    Fernando Segade
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Biochem Cell Biol 39:2303-13. 2007
    ..These studies suggest a dual role for MAGP1, with extracellular MAGP1A involved in ECM function, and intracellular MAGP1B modulating the expression of genes that function in cell adhesion, migration and control of ECM deposition...
  4. pmc Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study
    Fernando Segade
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Arch Otolaryngol Head Neck Surg 132:729-33. 2006
    ..We have evaluated single nucleotide polymorphisms (SNPs) in the FBXO11 gene for association with chronic otitis media with effusion/recurrent otitis media (COME/ROM)...
  5. ncbi request reprint Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells
    Fernando Segade
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1731:215-24. 2005
    ..A sequence element spanning position -150 may represent the binding motif of an uncharacterized transcription factor. The basal transcriptional regulation of Mfap2 in muscle cells is discussed...
  6. doi request reprint Molecular evolution of the fibulins: implications on the functionality of the elastic fibulins
    Fernando Segade
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Gene 464:17-31. 2010
    ..Differentiation in gene expression further split Fibulin-5 from the other elastic fibulins, likely contributing to its nonredundant role in elastic fiber assembly...
  7. ncbi request reprint Differential expression of facilitative glucose transporters in normal and tumour kidney tissues
    Nobuyasu Suganuma
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    BJU Int 99:1143-9. 2007
    ....
  8. pmc Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    BMC Med Genet 6:42. 2005
    ..GLUT10 (gene symbol SLC2A10) is a facilitative glucose transporter within the type 2 diabetes (T2DM)-linked region on chromosome 20q12-13.1. Therefore, we evaluated GLUT10 as a positional candidate gene for T2DM in Caucasian Americans...
  9. ncbi request reprint Functional characterization of the promoter of the human glucose transporter 10 gene
    Fernando Segade
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1730:147-58. 2005
    ..In addition, a silencer region is present upstream of -696 which down-regulates SLC2A10 promoter activity independently of its distance to the transcript start site...
  10. ncbi request reprint Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2
    Claudio C Werneck
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:23045-51. 2004
    ..It is possible that these mutations alter the ability of fibrillin to bind MAGP-1, which may contribute to the severity of the disease...
  11. ncbi request reprint Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms
    Fernando Segade
    Department of Cell Biology and Physiology and the Division of Pulmonary and Critical Care Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:11050-7. 2002
    ..This suggests a second action site for MAGP1...
  12. pmc Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems
    Justin S Weinbaum
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 283:25533-43. 2008
    ..Increased body size and fat deposition in MAGP-1-mutant animals are particularly intriguing given the localization of obesity traits in humans to the region on chromosome 1 containing the MAGP-1 gene...