Research Topics
Genomes and Genes | Raja R SeethalaSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literatureBryan K Ward
Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Head Neck Oncol 1:41. 2009..Basal cell adenocarcinoma of a minor salivary gland is extremely rare. The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment...
New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrineRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Arch Pathol Lab Med 133:950-9. 2009..Recently described variants of epithelial-myoepithelial carcinoma have not been well characterized but raise a distinct set of differential diagnostic considerations than the classic type...- Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experienceRaja R Seethala
Department of Pathology, University of Pittsburgh School of Medicine, UPMC Presbyterian University Hospital, PA 15213, USA
Arch Otolaryngol Head Neck Surg 136:385-92. 2010..To reappraise the clinical and histologic variables associated with a more aggressive outcome in polymorphous low-grade adenocarcinoma (PLGA)... - A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomasRaja R Seethala
Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Am J Surg Pathol 34:1106-21. 2010..There are 2 distinct subgroups within high-grade MEC, and the translocation negative tumors may actually be more appropriately categorized as another tumor type (such as adenosquamous carcinoma)... - Current state of neck dissection in the United StatesRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, A616 3 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
Head Neck Pathol 3:238-45. 2009..Rapid highly automated real-time RT-PCR based platforms will allow for incorporation of molecular findings into the intraoperative evaluation of a sentinel lymph node... - An update on grading of salivary gland carcinomasRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, A616 3 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
Head Neck Pathol 3:69-77. 2009..In the AFIP system intermediate grade tumors cluster with high grade tumors, while in the Brandwein system, they cluster with low grade tumors... - Parathyroid lipoadenomas and lipohyperplasias: clinicopathologic correlationsRaja R Seethala
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 32:1854-67. 2008..Lipoadenomas are more difficult to localize preoperatively by imaging. Despite the potential difficulty at frozen section, accurate weight documentation and recognition of key histologic features diminish this challenge... 
Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literatureRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 31:1683-94. 2007..ACC-high-grade transformation is a highly aggressive salivary gland tumor with a variety of histologic patterns. The high propensity for lymph node metastases suggests a role for neck dissection in patients with this rare tumor...- Primary angiosarcoma of the bladderRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15217, USA
Arch Pathol Lab Med 130:1543-7. 2006..Primary bladder angiosarcomas are extremely rare, and their clinical and pathologic features are not well described... - Histologic grading and prognostic biomarkers in salivary gland carcinomasRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Adv Anat Pathol 18:29-45. 2011..Although aggressive histologic parameters (anaplasia, necrosis, and mitoses) are predictive of poor outcome, a standard grading scheme does not yet exists. Acinic cell carcinomas can also undergo high-grade transformation... - Progressive genetic alterations of adenoid cystic carcinoma with high-grade transformationRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 135:123-30. 2011..Although genome-wide imbalances have been characterized in conventional adenoid cystic carcinoma, other than p53 mutational status, the molecular profile of adenoid cystic carcinoma with high-grade transformation has not been explored... - Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tractRaja R Seethala
Head and Neck Endocrine Division, Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Surg Pathol 31:44-57. 2007..Immunohistochemistry can aid diagnosis by highlighting the biphasic nature of the tumor... - Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancerSarah E Wheeler
Departments of Otolaryngology and Pathology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 18:2850-60. 2012..The present study aimed to better define the role of Src family kinases (SFKs) in EGFRvIII-mediated cell motility and tumor growth of head and neck squamous cell carcinomas (HNSCC)... - The prognostic value of Ki-67, p53, epidermal growth factor receptor, 1p36, 9p21, 10q23, and 17p13 in skull base chordomasCraig Horbinski
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Arch Pathol Lab Med 134:1170-6. 2010..Skull base chordomas are rare, locally aggressive, notochord-derived neoplasms for which prognostically relevant biomarkers are not well established... - Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic testJoaquin J Garcia
Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Hum Pathol 42:2001-9. 2011..However, we demonstrate that the presence of MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions... - Intraoperative pathologic examination in the era of molecular testing for differentiated thyroid cancerKelly L McCoy
Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Am Coll Surg 215:546-54. 2012..We hypothesized that preoperative MT obviates the need for routine IOPE during lobectomy... - Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significance"N Paul Ohori
Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
Cancer Cytopathol 118:17-23. 2010..The use of ancillary molecular studies has not been widely explored for this diagnosis... - A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinomaLeo A Niemeier
Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Cancer 118:2069-77. 2012..The objective of the study was to evaluate whether the combination of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and specific histopathologic features allows risk stratification of TPMC... - XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neckAlec Vaezi
Departments of Otolaryngology and Head and Neck Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, PA 15213, USA
Clin Cancer Res 17:5513-22. 2011..The purpose of this study was to determine whether XPF expression levels predict clinical response to DNA damaging agents in head and neck squamous cell carcinoma (HNSCC)... - Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanismsStephen Y Lai
Departments of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Clin Oncol 27:1235-42. 2009..A phase I clinical trial was conducted to evaluate the safety and biologic effects of EGFR AS... - Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samplesYuri E Nikiforov
Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Clin Endocrinol Metab 96:3390-7. 2011..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management... - Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinomaRebecca J Leeman-Neill
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Prev Res (Phila) 4:230-7. 2011..The results of the present study provide the basis for exploring the efficacy of erlotinib for prevention of HNSCC in a clinical setting... - Positron emission tomography-computed tomography adds to the management of salivary gland malignanciesAli Razfar
Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Laryngoscope 120:734-8. 2010..To evaluate the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying salivary gland malignancies and to examine the role of PET-CT in the management of these patients... - Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: clinical implicationsSimion I Chiosea
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Laryngoscope 122:1690-4. 2012..Mucoepidermoid carcinoma (MEC) with MAML2 translocation is believed to be associated with lower clinical stage, lower histologic grade, and better outcome. We summarized our prospective experience testing MEC for the MAML2 translocation... - DOG1: a novel marker of salivary acinar and intercalated duct differentiationJacinthe Chenevert
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Mod Pathol 25:919-29. 2012..Strong staining can be used to support the diagnosis of acinic cell carcinoma. DOG1 may also be a marker of a 'transformed' myoepithelial phenotype in a subset of biphasic salivary gland malignancies... - Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsyRobert L Ferris
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Laryngoscope 122:1020-30. 2012.... - The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinomaSimion I Chiosea
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 36:343-50. 2012..It appears that more than half of zymogen granule poor AciCCs are likely to represent MASC. Even after excluding cases of MASC, the presence of HGT in AciCC predicts poorer overall survival... - Clinicopathologic features as stronger prognostic factors than histology or grade in risk stratification of primary parotid malignanciesRohan R Walvekar
Department of Otolaryngology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania, USA
Head Neck 33:225-31. 2011.... - Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapyJun Wang
Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
J Natl Cancer Inst 100:502-12. 2008..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling... - First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapyMalabika Sen
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Cancer Discov 2:694-705. 2012..These findings have therapeutic implications beyond STAT3 to other “undruggable” targets in human cancers... - Squamous cell carcinoma metastatic to neck from an unknown primary: the potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus-positive oropharyngeal carcinoma prior to 1970Jacinthe Chenevert
University of Pittsburgh Medical Center, Department of Pathology, Pittsburgh, Pennsylvania 15261, USA
Laryngoscope 122:793-6. 2012..At present, pathologic evaluation of SCCUP for human papillomavirus (HPV) improves discovery of occult oropharyngeal SCC and may partially explain increased incidence of HPV-positive oropharyngeal SCC... - Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3Rebecca J Leeman-Neill
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Carcinogenesis 30:1848-56. 2009..Our results suggest that guggulsterone-mediated inhibition of STAT3 and HIF-1alpha provide a biologic rationale for further clinical investigation of this compound in the treatment of HNSCC... - Intraoperative qRT-PCR for detection of lymph node metastasis in head and neck cancerRobert L Ferris
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 17:1858-66. 2011..The purpose of this study was to develop a rapid, automated, and quantitative real-time PCR (qRT-PCR) assay that can match final pathology in an intraoperative time frame... - Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual casesJing Yu
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Endocr Pathol 20:235-42. 2009..A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented... - Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinomaSarah Wheeler
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 18:2278-89. 2012..Tumor (n = 50) EGFR and EGFRvIII mRNA levels were quantified using real-time PCR... - Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN)Yvonne K Mburu
Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 287:3581-90. 2012..As such, CCR7, NF-κB, and AP1 could be potentially useful therapeutic targets in controlling the progression and metastasis of SCCHN tumors... - Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodesRaja R Seethala
Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 14:1303-9. 2008..Semiquantitative scores derived from the product of staining intensity (scale 0-3) score and percentage of positive tumor cells were correlated with clinical outcome... - Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancerAthanassios Argiris
University of Pittsburgh Medical Center Cancer Pavilion, 5th Floor, Pittsburgh, PA 15232, USA
J Clin Oncol 28:5294-300. 2010..We incorporated cetuximab, a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR), into the induction therapy and subsequent chemoradiotherapy of head and neck cancer (HNC)... - Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinomaMelonie A Nance
Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Cancer 113:2082-9. 2008..The treatment protocol and survival outcomes of patients treated for MEC of the head and neck was investigated... - Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumorsRaja R Seethala
Department of Pathology, Presbyterian University Hospital, Pittsburgh, PA, USA
Mod Pathol 25:26-35. 2012..Altered immune status may have a role in their etiopathogenesis. Multiple synchronous tumors, origin in buccal mucosa, and malignant transformation may rarely occur... - Loss of heterozygosity of selected tumor suppressor genes in parathyroid carcinomaLinwah Yip
Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Surgery 144:949-55; discussion 954-5. 2008..The histologic diagnosis of parathyroid carcinoma (PC) is challenging. We evaluated a large PC series for loss of heterozygosity (LOH) of selected tumor suppressor genes with histopathologic correlation... - p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinomaJonathan B McHugh
Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
Head Neck Pathol 1:123-31. 2007..While RCCm, CD10, and vimentin performed adequately, they were significantly less reliable than p63 with both false positives and false negatives... - SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cellsMichael S Leibowitz
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
Clin Cancer Res 19:798-808. 2013..We investigated whether an overexpressed phosphatase was responsible for basal suppression of pSTAT1 and subsequent APM component-mediated immune escape in HNC cells... - Clear cell carcinoma and clear cell odontogenic carcinoma: a comparative clinicopathologic and immunohistochemical studyElizabeth A Bilodeau
Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, 3501 Terrace St, Pittsburgh, PA 15261, USA
Head Neck Pathol 5:101-7. 2011..The differential diagnosis of clear cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other clear cell tumors on the basis of their immunohistochemical staining patterns is postulated... - Recurrent hyperparathyroidism and forearm parathyromatosis after total parathyroidectomyAdrienne L Melck
Section of Endocrine Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Surgery 148:867-73; discussion 873-5. 2010..We compared subtotal parathyroidectomy with total parathyroidectomy and immediate forearm autotransplantation (TPFA) in a large series with long-term follow-up... - HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancerLynn M Knowles
Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 15:3740-50. 2009.... - Pathology quiz case 2. Parathyroid lipoadenomaRaja R Seethala
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 132:1391-3. 2006 - Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glandsSimion I Chiosea
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA Department of Pathology, Virginia Mason Medical Center, Seattle, WA, USA
Histopathology 61:387-94. 2012..Mammary analogue secretory carcinoma (MASC) is a recently described tumour with ETV6 translocation. We aimed to characterize the clinical significance of recognizing MASC... - An informatics supported web-based data annotation and query tool to expedite translational research for head and neck malignanciesWaqas Amin
Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA
BMC Cancer 9:396. 2009.... - The selective expression of CD43 in adenoid cystic carcinomaRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 19104, USA
Appl Immunohistochem Mol Morphol 16:165-72. 2008..Hence, CD43 seems to be selectively expressed in a subset of ACC and its significance in salivary tumors is discussed... - Salivary type tumors seen in consultationSimion I Chiosea
Department of Pathology, Presbyterian Hospital, University of Pittsburgh Medical Center, PUH A616 2, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Virchows Arch 454:457-66. 2009..Pathologists' adherence to recommendations by Association of Directors of Anatomic and Surgical Pathology regarding consultation practice is described... - Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid glandRaja R Seethala
Department of Pathology and Laboratory Medicine, 6 Founders Pavilion, 3400 Spruce Street, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Head Neck 27:217-23. 2005..FS may be useful if FNA is nondiagnostic and may also be useful in confirming or refuting malignancy in some cases. Hence, both techniques are complementary to each other in the diagnosis of salivary gland lesions... - Ectopic sphenoid sinus pituitary adenoma (ESSPA) with normal anterior pituitary gland: a clinicopathologic and immunophenotypic study of 32 cases with a comprehensive review of the english literatureLester D R Thompson
Woodland Hills Medical Center, Department of Pathology, Southern California Kaiser Permanente Group, 5601 De Soto Avenue, Woodland Hills, CA 91365, USA
Head Neck Pathol 6:75-100. 2012..This will result in accurate classification, helping to prevent the potentially untoward side effects or complications of incorrect therapy... - Postirradiation osteosarcoma of the mandible with heterologous differentiationRaja R Seethala
Department of Pathology, M. D. Anderson Cancer Center, Houston, TX 77030, USA
Arch Pathol Lab Med 130:385-8. 2006..To our knowledge, this is the first report of osteosarcoma of the mandible with heterologous differentiation... - Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancersRegiane S Andrade
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
Int J Radiat Oncol Biol Phys 65:1315-22. 2006..These results support a potential clinical role of FDG-PET/CT in the early assessment of therapy response after definitive radiation therapy... - Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysisGerard J Oakley
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Mod Pathol 21:1461-9. 2008..Podoplanin still remains the only positive marker for chondrosarcoma, though its accuracy is less than previously reported... - MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neckScott M Langevin
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213 1863, USA
Cancer 117:1454-62. 2011..However, the aberrant miR-137 promoter methylation observed in squamous cell carcinoma of the head and neck (SCCHN) suggests a tumor-specific molecular defect that may contribute to disease progression... - EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary glandCristina R Antonescu
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Genes Chromosomes Cancer 50:559-70. 2011..The distinction from MEC is particularly important, as conventional MEC grading schemes overgrade these indolent HCCCs, potentially impacting on treatment... - Adrenocortical carcinosarcoma: a case report and review of the literatureKotaro Sasaki
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15232 USA
Diagn Pathol 5:51. 2010..Awareness of this as a possibility will help in distinguishing this tumor from other carcinomas, melanomas, and true sarcomas... - A novel complex BRAF mutation detected in a solid variant of papillary thyroid carcinomaSimion Chiosea
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA
Endocr Pathol 20:122-6. 2009..This mutation was identified both in the preoperative fine needle aspirate sample and in the surgical specimen after total thyroidectomy. Other rare BRAF mutations in PTC are reviewed... - Craniofacial melorheostosisMeredith McDermott
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Comput Assist Tomogr 32:825-7. 2008..We discuss a case of melorheostosis in the nasal cavity and skull base with an atypical radiographic appearance and suggest findings that may differentiate craniofacial melorheostosis from more common entities in this region... - Comparison of p63 and p73 expression in benign and malignant salivary gland lesionsRaja R Seethala
University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Head Neck 27:696-702. 2005..In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors...