Raja R Seethala

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, A614 X Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Head Neck Pathol 7:S77-84. 2013
  2. pmc Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature
    Bryan K Ward
    Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Head Neck Oncol 1:41. 2009
  3. doi request reprint New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrine
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Arch Pathol Lab Med 133:950-9. 2009
  4. doi request reprint Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experience
    Raja R Seethala
    Department of Pathology, University of Pittsburgh School of Medicine, UPMC Presbyterian University Hospital, PA 15213, USA
    Arch Otolaryngol Head Neck Surg 136:385-92. 2010
  5. doi request reprint A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas
    Raja R Seethala
    Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Surg Pathol 34:1106-21. 2010
  6. pmc Current state of neck dissection in the United States
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, A616 3 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Head Neck Pathol 3:238-45. 2009
  7. doi request reprint Parathyroid lipoadenomas and lipohyperplasias: clinicopathologic correlations
    Raja R Seethala
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 32:1854-67. 2008
  8. pmc An update on grading of salivary gland carcinomas
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, A616 3 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Head Neck Pathol 3:69-77. 2009
  9. doi request reprint Progressive genetic alterations of adenoid cystic carcinoma with high-grade transformation
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 135:123-30. 2011
  10. ncbi request reprint Primary angiosarcoma of the bladder
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15217, USA
    Arch Pathol Lab Med 130:1543-7. 2006

Collaborators

Detail Information

Publications67

  1. pmc Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, A614 X Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Head Neck Pathol 7:S77-84. 2013
    ..Both oncocytic and apocrine EMCa behave very indolently in the limited literature to date...
  2. pmc Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature
    Bryan K Ward
    Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Head Neck Oncol 1:41. 2009
    ..Basal cell adenocarcinoma of a minor salivary gland is extremely rare. The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment...
  3. doi request reprint New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrine
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Arch Pathol Lab Med 133:950-9. 2009
    ..Recently described variants of epithelial-myoepithelial carcinoma have not been well characterized but raise a distinct set of differential diagnostic considerations than the classic type...
  4. doi request reprint Polymorphous low-grade adenocarcinoma: the University of Pittsburgh experience
    Raja R Seethala
    Department of Pathology, University of Pittsburgh School of Medicine, UPMC Presbyterian University Hospital, PA 15213, USA
    Arch Otolaryngol Head Neck Surg 136:385-92. 2010
    ..To reappraise the clinical and histologic variables associated with a more aggressive outcome in polymorphous low-grade adenocarcinoma (PLGA)...
  5. doi request reprint A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas
    Raja R Seethala
    Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Surg Pathol 34:1106-21. 2010
    ..There are 2 distinct subgroups within high-grade MEC, and the translocation negative tumors may actually be more appropriately categorized as another tumor type (such as adenosquamous carcinoma)...
  6. pmc Current state of neck dissection in the United States
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, A616 3 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Head Neck Pathol 3:238-45. 2009
    ..Rapid highly automated real-time RT-PCR based platforms will allow for incorporation of molecular findings into the intraoperative evaluation of a sentinel lymph node...
  7. doi request reprint Parathyroid lipoadenomas and lipohyperplasias: clinicopathologic correlations
    Raja R Seethala
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 32:1854-67. 2008
    ..Lipoadenomas are more difficult to localize preoperatively by imaging. Despite the potential difficulty at frozen section, accurate weight documentation and recognition of key histologic features diminish this challenge...
  8. pmc An update on grading of salivary gland carcinomas
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, A616 3 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Head Neck Pathol 3:69-77. 2009
    ..In the AFIP system intermediate grade tumors cluster with high grade tumors, while in the Brandwein system, they cluster with low grade tumors...
  9. doi request reprint Progressive genetic alterations of adenoid cystic carcinoma with high-grade transformation
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 135:123-30. 2011
    ..Although genome-wide imbalances have been characterized in conventional adenoid cystic carcinoma, other than p53 mutational status, the molecular profile of adenoid cystic carcinoma with high-grade transformation has not been explored...
  10. ncbi request reprint Primary angiosarcoma of the bladder
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15217, USA
    Arch Pathol Lab Med 130:1543-7. 2006
    ..Primary bladder angiosarcomas are extremely rare, and their clinical and pathologic features are not well described...
  11. ncbi request reprint Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:1683-94. 2007
    ..ACC-high-grade transformation is a highly aggressive salivary gland tumor with a variety of histologic patterns. The high propensity for lymph node metastases suggests a role for neck dissection in patients with this rare tumor...
  12. ncbi request reprint Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract
    Raja R Seethala
    Head and Neck Endocrine Division, Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:44-57. 2007
    ..Immunohistochemistry can aid diagnosis by highlighting the biphasic nature of the tumor...
  13. doi request reprint Histologic grading and prognostic biomarkers in salivary gland carcinomas
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Adv Anat Pathol 18:29-45. 2011
    ..Although aggressive histologic parameters (anaplasia, necrosis, and mitoses) are predictive of poor outcome, a standard grading scheme does not yet exists. Acinic cell carcinomas can also undergo high-grade transformation...
  14. doi request reprint Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test
    Joaquin J Garcia
    Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Pathol 42:2001-9. 2011
    ..However, we demonstrate that the presence of MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions...
  15. pmc Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer
    Sarah E Wheeler
    Departments of Otolaryngology and Pathology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 18:2850-60. 2012
    ..The present study aimed to better define the role of Src family kinases (SFKs) in EGFRvIII-mediated cell motility and tumor growth of head and neck squamous cell carcinomas (HNSCC)...
  16. doi request reprint The prognostic value of Ki-67, p53, epidermal growth factor receptor, 1p36, 9p21, 10q23, and 17p13 in skull base chordomas
    Craig Horbinski
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arch Pathol Lab Med 134:1170-6. 2010
    ..Skull base chordomas are rare, locally aggressive, notochord-derived neoplasms for which prognostically relevant biomarkers are not well established...
  17. doi request reprint Clear cell odontogenic carcinomas show EWSR1 rearrangements: a novel finding and a biological link to salivary clear cell carcinomas
    Elizabeth A Bilodeau
    School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Surg Pathol 37:1001-5. 2013
    ..In this study, we demonstrate for the first time the EWSR1-ATF1 translocation in a CCOC and demonstrate a concrete link between CCCs and at least a subset of CCOCs...
  18. doi request reprint Intraoperative pathologic examination in the era of molecular testing for differentiated thyroid cancer
    Kelly L McCoy
    Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Am Coll Surg 215:546-54. 2012
    ..We hypothesized that preoperative MT obviates the need for routine IOPE during lobectomy...
  19. doi request reprint Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significance"
    N Paul Ohori
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Cancer Cytopathol 118:17-23. 2010
    ..The use of ancillary molecular studies has not been widely explored for this diagnosis...
  20. pmc A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma
    Leo A Niemeier
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer 118:2069-77. 2012
    ..The objective of the study was to evaluate whether the combination of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and specific histopathologic features allows risk stratification of TPMC...
  21. pmc XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck
    Alec Vaezi
    Departments of Otolaryngology and Head and Neck Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, PA 15213, USA
    Clin Cancer Res 17:5513-22. 2011
    ..The purpose of this study was to determine whether XPF expression levels predict clinical response to DNA damaging agents in head and neck squamous cell carcinoma (HNSCC)...
  22. pmc Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms
    Stephen Y Lai
    Departments of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Clin Oncol 27:1235-42. 2009
    ..A phase I clinical trial was conducted to evaluate the safety and biologic effects of EGFR AS...
  23. doi request reprint Positron emission tomography-computed tomography adds to the management of salivary gland malignancies
    Ali Razfar
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 120:734-8. 2010
    ..To evaluate the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying salivary gland malignancies and to examine the role of PET-CT in the management of these patients...
  24. pmc Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:3390-7. 2011
    ..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management...
  25. pmc Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma
    Rebecca J Leeman-Neill
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Prev Res (Phila) 4:230-7. 2011
    ..The results of the present study provide the basis for exploring the efficacy of erlotinib for prevention of HNSCC in a clinical setting...
  26. doi request reprint PIK3CA mutations and PTEN loss in salivary duct carcinomas
    Christopher C Griffith
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 37:1201-7. 2013
    ..Two cases showed both PIK3CA mutation and PTEN loss, suggesting that these events are not mutually exclusive. These findings offer a molecular rationale for therapeutic targeting of the PI3K pathway in patients with SDC. ..
  27. doi request reprint Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: clinical implications
    Simion I Chiosea
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Laryngoscope 122:1690-4. 2012
    ..Mucoepidermoid carcinoma (MEC) with MAML2 translocation is believed to be associated with lower clinical stage, lower histologic grade, and better outcome. We summarized our prospective experience testing MEC for the MAML2 translocation...
  28. doi request reprint DOG1: a novel marker of salivary acinar and intercalated duct differentiation
    Jacinthe Chenevert
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Mod Pathol 25:919-29. 2012
    ..Strong staining can be used to support the diagnosis of acinic cell carcinoma. DOG1 may also be a marker of a 'transformed' myoepithelial phenotype in a subset of biphasic salivary gland malignancies...
  29. pmc Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 122:1020-30. 2012
    ....
  30. doi request reprint The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma
    Simion I Chiosea
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 36:343-50. 2012
    ..It appears that more than half of zymogen granule poor AciCCs are likely to represent MASC. Even after excluding cases of MASC, the presence of HGT in AciCC predicts poorer overall survival...
  31. doi request reprint Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    J Natl Cancer Inst 100:502-12. 2008
    ..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling...
  32. ncbi request reprint Clinicopathologic features as stronger prognostic factors than histology or grade in risk stratification of primary parotid malignancies
    Rohan R Walvekar
    Department of Otolaryngology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania, USA
    Head Neck 33:225-31. 2011
    ....
  33. doi request reprint Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands
    Simion I Chiosea
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA Department of Pathology, Virginia Mason Medical Center, Seattle, WA, USA
    Histopathology 61:387-94. 2012
    ..Mammary analogue secretory carcinoma (MASC) is a recently described tumour with ETV6 translocation. We aimed to characterize the clinical significance of recognizing MASC...
  34. pmc First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy
    Malabika Sen
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Discov 2:694-705. 2012
    ..These results provide the first demonstration of a successful strategy to inhibit tumor STAT3 signaling via systemic administration of a selective STAT3 inhibitor, thereby paving the way for broad clinical development...
  35. doi request reprint Squamous cell carcinoma metastatic to neck from an unknown primary: the potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus-positive oropharyngeal carcinoma prior to 1970
    Jacinthe Chenevert
    University of Pittsburgh Medical Center, Department of Pathology, Pittsburgh, Pennsylvania 15261, USA
    Laryngoscope 122:793-6. 2012
    ..At present, pathologic evaluation of SCCUP for human papillomavirus (HPV) improves discovery of occult oropharyngeal SCC and may partially explain increased incidence of HPV-positive oropharyngeal SCC...
  36. pmc Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3
    Rebecca J Leeman-Neill
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Carcinogenesis 30:1848-56. 2009
    ..Our results suggest that guggulsterone-mediated inhibition of STAT3 and HIF-1alpha provide a biologic rationale for further clinical investigation of this compound in the treatment of HNSCC...
  37. doi request reprint Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases
    Jing Yu
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Endocr Pathol 20:235-42. 2009
    ..A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented...
  38. doi request reprint Intraoperative qRT-PCR for detection of lymph node metastasis in head and neck cancer
    Robert L Ferris
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:1858-66. 2011
    ..The purpose of this study was to develop a rapid, automated, and quantitative real-time PCR (qRT-PCR) assay that can match final pathology in an intraoperative time frame...
  39. doi request reprint Early squamous cell carcinoma of the oral tongue: comparing margins obtained from the glossectomy specimen to margins from the tumor bed
    Ann Margaret V Chang
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Institute of Pathology, St Luke s Medical Center, Quezon City, Philippines
    Oral Oncol 49:1077-82. 2013
    ..To evaluate the impact of margin sampling on local recurrence in patients with pT1-2 pN0 conventional squamous cell carcinoma of the oral tongue...
  40. pmc SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells
    Michael S Leibowitz
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Cancer Res 19:798-808. 2013
    ..We investigated whether an overexpressed phosphatase was responsible for basal suppression of pSTAT1 and subsequent APM component-mediated immune escape in HNC cells...
  41. pmc Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma
    Sarah Wheeler
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 18:2278-89. 2012
    ..Tumor (n = 50) EGFR and EGFRvIII mRNA levels were quantified using real-time PCR...
  42. pmc Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN)
    Yvonne K Mburu
    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 287:3581-90. 2012
    ..As such, CCR7, NF-κB, and AP1 could be potentially useful therapeutic targets in controlling the progression and metastasis of SCCHN tumors...
  43. pmc Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma
    Melonie A Nance
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer 113:2082-9. 2008
    ..The treatment protocol and survival outcomes of patients treated for MEC of the head and neck was investigated...
  44. pmc Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes
    Raja R Seethala
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 14:1303-9. 2008
    ..Semiquantitative scores derived from the product of staining intensity (scale 0-3) score and percentage of positive tumor cells were correlated with clinical outcome...
  45. pmc Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer
    Athanassios Argiris
    University of Pittsburgh Medical Center Cancer Pavilion, 5th Floor, Pittsburgh, PA 15232, USA
    J Clin Oncol 28:5294-300. 2010
    ..We incorporated cetuximab, a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR), into the induction therapy and subsequent chemoradiotherapy of head and neck cancer (HNC)...
  46. doi request reprint Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors
    Raja R Seethala
    Department of Pathology, Presbyterian University Hospital, Pittsburgh, PA, USA
    Mod Pathol 25:26-35. 2012
    ..Altered immune status may have a role in their etiopathogenesis. Multiple synchronous tumors, origin in buccal mucosa, and malignant transformation may rarely occur...
  47. pmc p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Head Neck Pathol 1:123-31. 2007
    ..While RCCm, CD10, and vimentin performed adequately, they were significantly less reliable than p63 with both false positives and false negatives...
  48. doi request reprint Loss of heterozygosity of selected tumor suppressor genes in parathyroid carcinoma
    Linwah Yip
    Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Surgery 144:949-55; discussion 954-5. 2008
    ..The histologic diagnosis of parathyroid carcinoma (PC) is challenging. We evaluated a large PC series for loss of heterozygosity (LOH) of selected tumor suppressor genes with histopathologic correlation...
  49. pmc HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
    Lynn M Knowles
    Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 15:3740-50. 2009
    ....
  50. pmc Clear cell carcinoma and clear cell odontogenic carcinoma: a comparative clinicopathologic and immunohistochemical study
    Elizabeth A Bilodeau
    Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, 3501 Terrace St, Pittsburgh, PA 15261, USA
    Head Neck Pathol 5:101-7. 2011
    ..The differential diagnosis of clear cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other clear cell tumors on the basis of their immunohistochemical staining patterns is postulated...
  51. ncbi request reprint Pathology quiz case 2. Parathyroid lipoadenoma
    Raja R Seethala
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 132:1391-3. 2006
  52. doi request reprint Recurrent hyperparathyroidism and forearm parathyromatosis after total parathyroidectomy
    Adrienne L Melck
    Section of Endocrine Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Surgery 148:867-73; discussion 873-5. 2010
    ..We compared subtotal parathyroidectomy with total parathyroidectomy and immediate forearm autotransplantation (TPFA) in a large series with long-term follow-up...
  53. doi request reprint The cytological features of mammary analogue secretory carcinoma: a series of 6 molecularly confirmed cases
    Christopher C Griffith
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Cancer Cytopathol 121:234-41. 2013
    ..Because this tumor was described only recently, it remains relatively unknown outside of head and neck specialty pathology centers...
  54. pmc An informatics supported web-based data annotation and query tool to expedite translational research for head and neck malignancies
    Waqas Amin
    Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Cancer 9:396. 2009
    ....
  55. doi request reprint Salivary type tumors seen in consultation
    Simion I Chiosea
    Department of Pathology, Presbyterian Hospital, University of Pittsburgh Medical Center, PUH A616 2, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Virchows Arch 454:457-66. 2009
    ..Pathologists' adherence to recommendations by Association of Directors of Anatomic and Surgical Pathology regarding consultation practice is described...
  56. doi request reprint The selective expression of CD43 in adenoid cystic carcinoma
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 19104, USA
    Appl Immunohistochem Mol Morphol 16:165-72. 2008
    ..Hence, CD43 seems to be selectively expressed in a subset of ACC and its significance in salivary tumors is discussed...
  57. ncbi request reprint Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid gland
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, 6 Founders Pavilion, 3400 Spruce Street, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Head Neck 27:217-23. 2005
    ..Herein, we determine the relative accuracies of both FNA and FS in the diagnosis of salivary gland lesions...
  58. pmc Ectopic sphenoid sinus pituitary adenoma (ESSPA) with normal anterior pituitary gland: a clinicopathologic and immunophenotypic study of 32 cases with a comprehensive review of the english literature
    Lester D R Thompson
    Woodland Hills Medical Center, Department of Pathology, Southern California Kaiser Permanente Group, 5601 De Soto Avenue, Woodland Hills, CA 91365, USA
    Head Neck Pathol 6:75-100. 2012
    ..This will result in accurate classification, helping to prevent the potentially untoward side effects or complications of incorrect therapy...
  59. ncbi request reprint Postirradiation osteosarcoma of the mandible with heterologous differentiation
    Raja R Seethala
    Department of Pathology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Arch Pathol Lab Med 130:385-8. 2006
    ..To our knowledge, this is the first report of osteosarcoma of the mandible with heterologous differentiation...
  60. ncbi request reprint Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers
    Regiane S Andrade
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 65:1315-22. 2006
    ....
  61. doi request reprint Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis
    Gerard J Oakley
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 21:1461-9. 2008
    ..Podoplanin still remains the only positive marker for chondrosarcoma, though its accuracy is less than previously reported...
  62. pmc MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck
    Scott M Langevin
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer 117:1454-62. 2011
    ..However, the aberrant miR-137 promoter methylation observed in squamous cell carcinoma of the head and neck (SCCHN) suggests a tumor-specific molecular defect that may contribute to disease progression...
  63. doi request reprint EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Genes Chromosomes Cancer 50:559-70. 2011
    ..The distinction from MEC is particularly important, as conventional MEC grading schemes overgrade these indolent HCCCs, potentially impacting on treatment...
  64. pmc Adrenocortical carcinosarcoma: a case report and review of the literature
    Kotaro Sasaki
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15232 USA
    Diagn Pathol 5:51. 2010
    ..Awareness of this as a possibility will help in distinguishing this tumor from other carcinomas, melanomas, and true sarcomas...
  65. doi request reprint Craniofacial melorheostosis
    Meredith McDermott
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Comput Assist Tomogr 32:825-7. 2008
    ..We discuss a case of melorheostosis in the nasal cavity and skull base with an atypical radiographic appearance and suggest findings that may differentiate craniofacial melorheostosis from more common entities in this region...
  66. doi request reprint A novel complex BRAF mutation detected in a solid variant of papillary thyroid carcinoma
    Simion Chiosea
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA
    Endocr Pathol 20:122-6. 2009
    ..This mutation was identified both in the preoperative fine needle aspirate sample and in the surgical specimen after total thyroidectomy. Other rare BRAF mutations in PTC are reviewed...
  67. ncbi request reprint Comparison of p63 and p73 expression in benign and malignant salivary gland lesions
    Raja R Seethala
    University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Head Neck 27:696-702. 2005
    ..In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors...