Research Topics
Species | WILLIAM SEELEYSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structuresE D Gennatas
Memory and Aging Center, Department of Neurology, University of California San Francisco, CA, USA
Neurology 78:1663-9. 2012..We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions...
Distinctive neurons of the anterior cingulate and frontoinsular cortex: a historical perspectiveWilliam W Seeley
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
Cereb Cortex 22:245-50. 2012..We close with a brief discussion regarding the functional and clinical relevance of these neurons and their home regions...
Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolutionWilliam W Seeley
Department of Neurology, University of California at San Francisco, CA 94143 1207, USA
Alzheimer Dis Assoc Disord 21:S50-7. 2007..We suggest that the regional and neuronal vulnerability patterns seen in bvFTD and AD underlie the divergent impact of these disorders on recently evolved social-emotional functions...- Selective functional, regional, and neuronal vulnerability in frontotemporal dementiaWilliam W Seeley
UCSF Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA
Curr Opin Neurol 21:701-7. 2008..Blending these disciplines may prove critical to our understanding of neurodegenerative diseases, which target specific anatomical systems. Recent research on frontotemporal dementia highlights the potential value of these approaches... - Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortexWilliam W Seeley
Memory and Aging Center, Department of Neurology, UCSF, USA
Brain 131:39-49. 2008..The findings suggest that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury... - Frontotemporal dementia neuroimaging: a guide for cliniciansWilliam W Seeley
Department of Neurology, University of California, San Francisco, and UCSF Memory and Aging Center, San Francisco, CA 94143 1207, USA
Front Neurol Neurosci 24:160-7. 2009..Future imaging research will seek to more directly assay disease by assessing network level pathophysiology and accumulation of misfolded proteins in cerebral tissues... - Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6W W Seeley
Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
Neurology 69:156-65. 2007..Clinical and laboratory features of the syndrome, however, have not been well characterized... - Neurodegenerative diseases target large-scale human brain networksWilliam W Seeley
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 62:42-52. 2009..Future studies may clarify how these complex systems are assembled during development and undermined by disease... - Anterior insula degeneration in frontotemporal dementiaWilliam W Seeley
Department of Neurology, UCSF Memory and Aging Center, University of California, 350 Parnassus Suite 905, San Francisco, CA 94143 1207, USA
Brain Struct Funct 214:465-75. 2010..The search for frontotemporal dementia treatments will depend on a rich understanding of insular biology and could help clarify specialized human language, social, and emotional functions... - Early frontotemporal dementia targets neurons unique to apes and humansWilliam W Seeley
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
Ann Neurol 60:660-7. 2006..Despite progress toward understanding the genetic and molecular bases of FTD, no class of selectively vulnerable neurons has been identified... - The natural history of temporal variant frontotemporal dementiaW W Seeley
Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 1207, USA
Neurology 64:1384-90. 2005..Left temporal atrophy has been linked to loss of semantic knowledge, whereas behavioral symptoms dominate the right temporal variant... - Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementiaWilliam W Seeley
UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
Arch Neurol 65:249-55. 2008..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear... - TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementiaJ D Rohrer
Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, UK
Neurology 75:2204-11. 2010..We sought to describe the antemortem clinical and neuroimaging features among patients with frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP)... - Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degenerationG D Rabinovici
Memory and Aging Center, University of California, San Francisco, California 94143, USA
Am J Alzheimers Dis Other Demen 22:474-88. 2007..001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD... - Neuroanatomy of the self: evidence from patients with frontotemporal dementiaB L Miller
Department of Neurology, UCSF School of Medicine, San Francisco, CA 94117, USA
Neurology 57:817-21. 2001.... - Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementiaJ D Woolley
Memory and Aging Center, Department of Neurology, University of California San Francisco, 1779 Turk St, San Francisco, CA 94115, USA
Neurology 69:1424-33. 2007..However, the role of these areas in determining feeding disturbances in neurologic patients remains uncertain... - Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry studyS M Brambati
Memory Aging Center, UCSF Department of Neurology, San Francisco, CA 94143, USA
Neurobiol Aging 30:103-11. 2009..These results identified the anatomic substrates of the previously reported clinical evolution of LTLV and RTLV into a unique 'merged' clinical syndrome characterized by semantic and behavioral deficits and bilateral temporal atrophy... - Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degenerationE J Kim
Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California 94117, USA
J Neurol Neurosurg Psychiatry 78:1375-8. 2007..Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo... - Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging featuresSharon J Sha
Department of Neurology, University of California, San Francisco, USA
Neurology 79:1002-11. 2012..To describe the phenotype of patients with C9FTD/ALS (C9ORF72) hexanucleotide repeat expansion... - Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's diseaseJuan Zhou
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
Brain 133:1352-67. 2010..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring... - Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directionsKatya Rascovsky
Memory and Aging Center, University of California, San Francisco, CA 94117, USA
Alzheimer Dis Assoc Disord 21:S14-8. 2007..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia... - A tensor based morphometry study of longitudinal gray matter contraction in FTDSimona M Brambati
Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Ave, Suite 706, San Francisco, CA 94143, USA
Neuroimage 35:998-1003. 2007..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD... - Dissociable intrinsic connectivity networks for salience processing and executive controlWilliam W Seeley
Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 27:2349-56. 2007..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior... - Benzodiazepines in schizophrenia: prefrontal cortex atrophy predicts clinical response to alprazolam augmentationWilliam W Seeley
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
World J Biol Psychiatry 3:221-4. 2002..Mechanistic considerations and suggestions for future research are discussed...
Research Grants
- FMRI/Pathology/Anterior Cingulate/Frontoinsular CortexWILLIAM SEELEY; Fiscal Year: 2007..The proposed research seeks to benefit the public health by clarifying the biological basis of dementia, ultimately promoting earlier diagnosis and better treatments for dementia patients. ..
- Selective Vulnerability in Frontotemporal DementiaWilliam W Seeley; Fiscal Year: 2010..This information may provide clues regarding new potential treatments for the disorder. ..