WILLIAM SEELEY

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures
    E D Gennatas
    Memory and Aging Center, Department of Neurology, University of California San Francisco, CA, USA
    Neurology 78:1663-9. 2012
  2. doi request reprint Distinctive neurons of the anterior cingulate and frontoinsular cortex: a historical perspective
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cereb Cortex 22:245-50. 2012
  3. ncbi request reprint Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution
    William W Seeley
    Department of Neurology, University of California at San Francisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 21:S50-7. 2007
  4. ncbi request reprint Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex
    William W Seeley
    Memory and Aging Center, Department of Neurology, UCSF, USA
    Brain 131:39-49. 2008
  5. pmc Selective functional, regional, and neuronal vulnerability in frontotemporal dementia
    William W Seeley
    UCSF Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA
    Curr Opin Neurol 21:701-7. 2008
  6. ncbi request reprint Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6
    W W Seeley
    Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Neurology 69:156-65. 2007
  7. doi request reprint Frontotemporal dementia neuroimaging: a guide for clinicians
    William W Seeley
    Department of Neurology, University of California, San Francisco, and UCSF Memory and Aging Center, San Francisco, CA 94143 1207, USA
    Front Neurol Neurosci 24:160-7. 2009
  8. pmc Neurodegenerative diseases target large-scale human brain networks
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:42-52. 2009
  9. pmc Anterior insula degeneration in frontotemporal dementia
    William W Seeley
    Department of Neurology, UCSF Memory and Aging Center, University of California, 350 Parnassus Suite 905, San Francisco, CA 94143 1207, USA
    Brain Struct Funct 214:465-75. 2010
  10. ncbi request reprint Early frontotemporal dementia targets neurons unique to apes and humans
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
    Ann Neurol 60:660-7. 2006

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures
    E D Gennatas
    Memory and Aging Center, Department of Neurology, University of California San Francisco, CA, USA
    Neurology 78:1663-9. 2012
    ..We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions...
  2. doi request reprint Distinctive neurons of the anterior cingulate and frontoinsular cortex: a historical perspective
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cereb Cortex 22:245-50. 2012
    ..We close with a brief discussion regarding the functional and clinical relevance of these neurons and their home regions...
  3. ncbi request reprint Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution
    William W Seeley
    Department of Neurology, University of California at San Francisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 21:S50-7. 2007
    ..We suggest that the regional and neuronal vulnerability patterns seen in bvFTD and AD underlie the divergent impact of these disorders on recently evolved social-emotional functions...
  4. ncbi request reprint Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex
    William W Seeley
    Memory and Aging Center, Department of Neurology, UCSF, USA
    Brain 131:39-49. 2008
    ..The findings suggest that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury...
  5. pmc Selective functional, regional, and neuronal vulnerability in frontotemporal dementia
    William W Seeley
    UCSF Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA
    Curr Opin Neurol 21:701-7. 2008
    ..Blending these disciplines may prove critical to our understanding of neurodegenerative diseases, which target specific anatomical systems. Recent research on frontotemporal dementia highlights the potential value of these approaches...
  6. ncbi request reprint Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6
    W W Seeley
    Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Neurology 69:156-65. 2007
    ..Clinical and laboratory features of the syndrome, however, have not been well characterized...
  7. doi request reprint Frontotemporal dementia neuroimaging: a guide for clinicians
    William W Seeley
    Department of Neurology, University of California, San Francisco, and UCSF Memory and Aging Center, San Francisco, CA 94143 1207, USA
    Front Neurol Neurosci 24:160-7. 2009
    ..Future imaging research will seek to more directly assay disease by assessing network level pathophysiology and accumulation of misfolded proteins in cerebral tissues...
  8. pmc Neurodegenerative diseases target large-scale human brain networks
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:42-52. 2009
    ..Future studies may clarify how these complex systems are assembled during development and undermined by disease...
  9. pmc Anterior insula degeneration in frontotemporal dementia
    William W Seeley
    Department of Neurology, UCSF Memory and Aging Center, University of California, 350 Parnassus Suite 905, San Francisco, CA 94143 1207, USA
    Brain Struct Funct 214:465-75. 2010
    ..The search for frontotemporal dementia treatments will depend on a rich understanding of insular biology and could help clarify specialized human language, social, and emotional functions...
  10. ncbi request reprint Early frontotemporal dementia targets neurons unique to apes and humans
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
    Ann Neurol 60:660-7. 2006
    ..Despite progress toward understanding the genetic and molecular bases of FTD, no class of selectively vulnerable neurons has been identified...
  11. pmc The natural history of temporal variant frontotemporal dementia
    W W Seeley
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 1207, USA
    Neurology 64:1384-90. 2005
    ..Left temporal atrophy has been linked to loss of semantic knowledge, whereas behavioral symptoms dominate the right temporal variant...
  12. pmc Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia
    William W Seeley
    UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
    Arch Neurol 65:249-55. 2008
    ..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear...
  13. ncbi request reprint Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration
    Carole S Scherling
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA
    Ann Neurol 75:116-26. 2014
    ..Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders, including frontotemporal degeneration (FTD). We investigated the clinical correlates of elevated CSF NfL levels in FTD...
  14. pmc Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration
    G D Rabinovici
    Memory and Aging Center, University of California, San Francisco, California 94143, USA
    Am J Alzheimers Dis Other Demen 22:474-88. 2007
    ..001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD...
  15. pmc TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia
    J D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Neurology 75:2204-11. 2010
    ..We sought to describe the antemortem clinical and neuroimaging features among patients with frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP)...
  16. ncbi request reprint Neuroanatomy of the self: evidence from patients with frontotemporal dementia
    B L Miller
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94117, USA
    Neurology 57:817-21. 2001
    ....
  17. ncbi request reprint Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia
    J D Woolley
    Memory and Aging Center, Department of Neurology, University of California San Francisco, 1779 Turk St, San Francisco, CA 94115, USA
    Neurology 69:1424-33. 2007
    ..However, the role of these areas in determining feeding disturbances in neurologic patients remains uncertain...
  18. pmc Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration
    E J Kim
    Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California 94117, USA
    J Neurol Neurosurg Psychiatry 78:1375-8. 2007
    ..Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo...
  19. pmc Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study
    S M Brambati
    Memory Aging Center, UCSF Department of Neurology, San Francisco, CA 94143, USA
    Neurobiol Aging 30:103-11. 2009
    ..These results identified the anatomic substrates of the previously reported clinical evolution of LTLV and RTLV into a unique 'merged' clinical syndrome characterized by semantic and behavioral deficits and bilateral temporal atrophy...
  20. pmc Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging features
    Sharon J Sha
    Department of Neurology, University of California, San Francisco, USA
    Neurology 79:1002-11. 2012
    ..To describe the phenotype of patients with C9FTD/ALS (C9ORF72) hexanucleotide repeat expansion...
  21. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010
    ..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
  22. ncbi request reprint Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007
    ..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
  23. pmc A tensor based morphometry study of longitudinal gray matter contraction in FTD
    Simona M Brambati
    Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Ave, Suite 706, San Francisco, CA 94143, USA
    Neuroimage 35:998-1003. 2007
    ..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD...
  24. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  25. ncbi request reprint Benzodiazepines in schizophrenia: prefrontal cortex atrophy predicts clinical response to alprazolam augmentation
    William W Seeley
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    World J Biol Psychiatry 3:221-4. 2002
    ..Mechanistic considerations and suggestions for future research are discussed...

Research Grants3

  1. FMRI/Pathology/Anterior Cingulate/Frontoinsular Cortex
    WILLIAM SEELEY; Fiscal Year: 2007
    ..The proposed research seeks to benefit the public health by clarifying the biological basis of dementia, ultimately promoting earlier diagnosis and better treatments for dementia patients. ..
  2. Selective Vulnerability in Frontotemporal Dementia
    WILLIAM SEELEY; Fiscal Year: 2009
    ..This information may provide clues regarding new potential treatments for the disorder. ..
  3. Selective Vulnerability in Frontotemporal Dementia
    William W Seeley; Fiscal Year: 2010
    ..This information may provide clues regarding new potential treatments for the disorder. ..