Randy Seeley

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight
    Dong Hoon Kim
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:907-15. 2010
  2. pmc Increased adipose tissue hypoxia and capacity for angiogenesis and inflammation in young diet-sensitive C57 mice compared with diet-resistant FVB mice
    D H Kim
    Department of Pharmacology, Korea University College of Medicine, Seoul, Republic of Korea
    Int J Obes (Lond) 37:853-60. 2013
  3. pmc The effect of vertical sleeve gastrectomy on food choice in rats
    H E Wilson-Pérez
    Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH, USA
    Int J Obes (Lond) 37:288-95. 2013
  4. doi request reprint Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats
    Kerstin Stemmer
    Institute for Diabetes and Obesity, Helmholtz Centre Munich, 85764 Neuherberg, Germany
    Endocrinology 154:2015-24. 2013
  5. pmc Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium
    Dong Hoon Kim
    Department of Pharmacology, Korea University College of Medicine, Seoul, Republic of Korea
    Diabetes 61:2299-310. 2012
  6. pmc All bariatric surgeries are not created equal: insights from mechanistic comparisons
    Margaret A Stefater
    Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Endocr Rev 33:595-622. 2012
  7. pmc Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats
    Joram D Mul
    Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 303:E103-10. 2012
  8. pmc The anorectic effect of CNTF does not require action in leptin-responsive neurons
    M A Stefater
    Metabolic Diseases Institute, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Endocrinology 153:2647-54. 2012
  9. ncbi request reprint Treating obesity like a tumor
    Randy J Seeley
    University of Cincinnati, Cincinnati, OH 45237, USA
    Cell Metab 15:1-2. 2012
  10. pmc Uroguanylin: how the gut got another satiety hormone
    Randy J Seeley
    Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 121:3384-6. 2011

Detail Information

Publications89

  1. pmc Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight
    Dong Hoon Kim
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:907-15. 2010
    ..We sought to determine how inhibiting adipose tissue vasculature changes key aspects of energy balance regulation and the neuroendocrine system that maintains energy balance...
  2. pmc Increased adipose tissue hypoxia and capacity for angiogenesis and inflammation in young diet-sensitive C57 mice compared with diet-resistant FVB mice
    D H Kim
    Department of Pharmacology, Korea University College of Medicine, Seoul, Republic of Korea
    Int J Obes (Lond) 37:853-60. 2013
    ..We hypothesized that diet-induced obese (DIO) mice have a greater capacity for WAT angiogenesis and remodeling than diet-resistant (DR) mice at a young age, before age or DIO...
  3. pmc The effect of vertical sleeve gastrectomy on food choice in rats
    H E Wilson-Pérez
    Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH, USA
    Int J Obes (Lond) 37:288-95. 2013
    ..We asked whether a bariatric surgical procedure limited to the stomach, vertical sleeve gastrectomy (VSG), causes a similar reduction of fat intake/preference...
  4. doi request reprint Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats
    Kerstin Stemmer
    Institute for Diabetes and Obesity, Helmholtz Centre Munich, 85764 Neuherberg, Germany
    Endocrinology 154:2015-24. 2013
    ..These data point toward important similarities and differences between bariatric procedures that should be considered in clinical settings as guidance for which procedure will be best for specific patient populations...
  5. pmc Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium
    Dong Hoon Kim
    Department of Pharmacology, Korea University College of Medicine, Seoul, Republic of Korea
    Diabetes 61:2299-310. 2012
    ..These studies suggest a novel role of the AT vasculature in glucose homeostasis and lipid metabolism...
  6. pmc All bariatric surgeries are not created equal: insights from mechanistic comparisons
    Margaret A Stefater
    Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Endocr Rev 33:595-622. 2012
    ....
  7. pmc Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats
    Joram D Mul
    Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 303:E103-10. 2012
    ..However, none of those variations appeared to affect the outcome of VSG. Taken together, these data suggest that the beneficial effect of VSG on body weight and glucose metabolism is not mediated by alterations in MC4R activity...
  8. pmc The anorectic effect of CNTF does not require action in leptin-responsive neurons
    M A Stefater
    Metabolic Diseases Institute, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Endocrinology 153:2647-54. 2012
    ..These results indicate that despite anatomical overlap for CNTF and leptin action, CNTF appears to act within a distinct neuronal population to elicit its potent anorectic effect...
  9. ncbi request reprint Treating obesity like a tumor
    Randy J Seeley
    University of Cincinnati, Cincinnati, OH 45237, USA
    Cell Metab 15:1-2. 2012
    ..A growing body of evidence indicates that inhibiting these blood vessels can result in substantial weight loss, and now this has been demonstrated in nonhuman primates...
  10. pmc Uroguanylin: how the gut got another satiety hormone
    Randy J Seeley
    Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 121:3384-6. 2011
    ..This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity...
  11. ncbi request reprint The critical role of the melanocortin system in the control of energy balance
    Randy J Seeley
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
    Annu Rev Nutr 24:133-49. 2004
    ..Reviewed here is the wide range of evidence that points to the melanocortin system as a critical node in the diverse neurocircuitry that regulates food intake and body weight...
  12. ncbi request reprint The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity
    Randy J Seeley
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45226
    Endocrinology 146:3732-8. 2005
    ..These experiments support the hypothesis that melanocortin signaling primarily regulates total body adiposity and that food intake is adjusted as necessary to achieve a specific level of body adiposity...
  13. ncbi request reprint Fuel sensing and the central nervous system (CNS): implications for the regulation of energy balance and the treatment for obesity
    R J Seeley
    Department of Psychiatry and Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Obes Rev 6:259-65. 2005
    ..This information is used to adjust both caloric intake and the disposition of fuels in the periphery. Increased understanding of these CNS fuel-sensing mechanisms may lead to novel therapeutic targets for obesity...
  14. ncbi request reprint Principles for interpreting interactions among the multiple systems that influence food intake
    Randy J Seeley
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Am J Physiol Regul Integr Comp Physiol 283:R46-53. 2002
    ..Furthermore, the possibilities of using intake measures other than cumulative intake and complementary nonbehavioral endpoints are encouraged...
  15. ncbi request reprint Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
  16. ncbi request reprint Diet-induced obese mice are leptin insufficient after weight reduction
    Haifei Shi
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 17:1702-9. 2009
    ..In summary, HF-chow mice were resistant to further fat loss due to leptin insufficiency. Diet alteration from HF to low fat improved metabolic state of DIO mice, although their adiposity was defended at a higher level...
  17. doi request reprint Mice with chronically increased circulating ghrelin develop age-related glucose intolerance
    Jacquelyn A Reed
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 294:E752-60. 2008
    ..Despite the impaired glucose tolerance in L43 mice, insulin levels did not differ from those of wild-type mice. These findings suggest a role for ghrelin in age-associated impairments of glucose homeostasis...
  18. ncbi request reprint High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene
    John Andrews McQuade
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Behav Brain Res 151:313-9. 2004
    ..These findings suggest the D3-R signaling is involved in the regulation of body weight and body fat when mice are given access to diets differing in palatability and fat content...
  19. ncbi request reprint The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness
    Kimberly P Kinzig
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:10470-6. 2002
    ....
  20. ncbi request reprint The regulation of energy balance by the central nervous system
    Karine Proulx
    Department of Neuroscience, University of Cincinnati College of Medicine, 2170 East Galbraith Road, ML 0506, Building 43, Room 312, Cincinnati, OH 45237, USA
    Psychiatr Clin North Am 28:25-38, vii. 2005
  21. ncbi request reprint Neuropeptide Y prepares rats for scheduled feeding
    Deborah L Drazen
    Department of Psychiatry, University of Cincinnati, 2170 E Galbraith Rd, Bldg E, Rm 313, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1606-11. 2005
    ..These data suggest that NPY plays a role in mediating conditionable food-anticipatory responses that help to cope with the effects of large caloric loads...
  22. ncbi request reprint Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake
    Koro Gotoh
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 290:R202-7. 2006
    ..In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate...
  23. ncbi request reprint The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice
    Jennifer L Lachey
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237 0559, USA
    Endocrinology 146:458-62. 2005
    ..Such species differences are an important consideration when comparing results from rat and mouse studies...
  24. pmc GM-CSF action in the CNS decreases food intake and body weight
    Jacquelyn A Reed
    University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 115:3035-44. 2005
    ..Energy expenditure in GM-/- mice was decreased compared with that in GM+/+ mice. Taken together, these findings demonstrate that GM-CSF signaling in the CNS can regulate energy homeostasis...
  25. ncbi request reprint Cloned mice have an obese phenotype not transmitted to their offspring
    Kellie L K Tamashiro
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 8:262-7. 2002
    ..We also show that the obese phenotype is not transmitted to offspring generated by mating male and female cloned mice...
  26. ncbi request reprint Chronic food restriction and reduced dietary fat: risk factors for bouts of overeating
    Ryuichi Ogawa
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237 1625, USA
    Physiol Behav 86:578-85. 2005
    ..Chronic food restriction accompanied by reduced dietary fat may increase risk for bouts of overeating...
  27. doi request reprint Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
    Haifei Shi
    Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Am J Physiol Endocrinol Metab 294:E630-9. 2008
    ..Collectively, these data indicate that the action of leptin in POMC neurons is sexually different to influence the regulation of energy balance, fat distribution, and glucose homeostasis...
  28. pmc Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system
    Karine Proulx
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, OH, USA
    Diabetes 57:3231-8. 2008
    ..The purpose of these experiments was to determine whether hypothalamic mTOR complex 1 (mTORC1) signaling is involved in mediating the effects of FAS inhibitors...
  29. ncbi request reprint Insulin and leptin combine additively to reduce food intake and body weight in rats
    Ellen L Air
    Department of Biomedical Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0555, USA
    Endocrinology 143:2449-52. 2002
    ....
  30. ncbi request reprint Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 17:1641-5. 2009
    ..These effects are independent of the anorectic action of the drug...
  31. ncbi request reprint Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences
    Paul A Rushing
    Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Peptides 23:985-8. 2002
    ..In summary, these data are consistent with the conclusion that acute i3vt amylin infusion does not reduce food intake by producing aversive consequences...
  32. pmc New ways in which GLP-1 can regulate glucose homeostasis
    DAVID A D'ALESSIO
    Department of Medicine, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Invest 115:3406-8. 2005
    ..The authors' work points to an important need to integrate diverse GLP-1 signaling actions and peripheral GLP-1 function in order to better understand both normal and abnormal glucose homeostasis...
  33. ncbi request reprint The effect of fat removal on glucose tolerance is depot specific in male and female mice
    Haifei Shi
    University of Cincinnati, Cincinnati, Ohio 45237, USA
    Am J Physiol Endocrinol Metab 293:E1012-20. 2007
    ..These data illustrate both critical differences among various WAT depots and how they influence glucose homeostasis and highlight important differences between males and females in glucose regulation...
  34. pmc High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hepatology 52:934-44. 2010
    ..001) levels were significantly increased in HFHC mice. Hepatic oxidative stress, as indicated by liver superoxide expression (P = 0.002), 4-hydroxynonenal, and plasma (ox)CoQ9 (P < 0.001) levels, was highest in HFHC mice...
  35. ncbi request reprint Alcohol drinking in MCH receptor-1-deficient mice
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Alcohol Clin Exp Res 31:1325-37. 2007
    ..However, because the physiological relevance of this finding is unclear, we tested the hypothesis that endogenous MCH signaling enhances alcohol consumption...
  36. ncbi request reprint Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy
    Haifei Shi
    University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 293:E316-26. 2007
    ..In summary, we have found sexual dimorphisms in the response to fat loss that point to important underlying differences in the strategies by which male and female mice regulate body weight...
  37. ncbi request reprint Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    Torsten P Vahl
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45267, USA
    Endocrinology 148:4965-73. 2007
    ..These data are consistent with an important component of neural mediation of GLP-1 action...
  38. pmc The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, Ohio 45237, USA
    J Neurosci 28:7202-8. 2008
    ..Overall, these findings point strongly to the possibility that reduced hypothalamic mTORC1 signaling contributes to the development of hyperphagia, weight gain, and leptin resistance during diet-induced obesity...
  39. pmc The role of GM-CSF in adipose tissue inflammation
    Dong Hoon Kim
    Department of Psychiartry, University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 295:E1038-46. 2008
    ..Collectively, the data suggest that the GM-CSF knockout mutation ameliorates peripheral insulin resistance in spite of increased adiposity by reducing inflammation in adipose tissue in response to a HFD...
  40. pmc Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity
    Margaret A Stefater
    Metabolic Disease Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 138:2426-36, 2436.e1-3. 2010
    ..Vertical sleeve gastrectomy (VSG) produces dramatic, sustained weight loss; we investigated whether these changes result from improved sensitivity to leptin...
  41. pmc Meal-anticipatory glucagon-like peptide-1 secretion in rats
    Torsten P Vahl
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    Endocrinology 151:569-75. 2010
    ..These findings document for the first time a cephalic increase of plasma GLP-1 and suggest that it functions to facilitate consumption of a large meal...
  42. ncbi request reprint Insulin and leptin as adiposity signals
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Recent Prog Horm Res 59:267-85. 2004
    ..Hence, insulin and leptin provide important negative feedback signals to the central nervous system, proportional to peripheral energy stores and coupled with catabolic circuits...
  43. pmc Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress
    Miyuki Tauchi
    Neuroscience Graduate Program, Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237 0506, USA
    Exp Neurol 210:458-66. 2008
    ..Overall, our data suggest that brain GLP-1 modulates HPA axis activity within the context of chronic stress, perhaps at the level of the adrenal gland...
  44. ncbi request reprint The role of CNS fuel sensing in energy and glucose regulation
    Daniela Cota
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Gastroenterology 132:2158-68. 2007
    ..The corollary to this hypothesis is that dysregulation of these fuel-sensing mechanisms in the brain may contribute to metabolic dysregulation underlying diseases, such as obesity and type 2 diabetes...
  45. pmc The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transposition
    Shrawan Gaitonde
    Department of Surgery, University Hospital University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Surg Res 178:33-9. 2012
    ..Ileal transposition involves a short segment of distal ileum being transposed to the proximal jejunum in an isoperistaltic direction, thereby avoiding any gastric resection or intestinal bypass...
  46. ncbi request reprint Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system
    David D'Alessio
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2163-9. 2007
    ..In addition, these data raise the possibility that intestinal lymph may serve as a specialized signaling conduit for regulatory peptides secreted by gastrointestinal endocrine cells...
  47. ncbi request reprint The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation
    Darleen Sandoval
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Annu Rev Physiol 70:513-35. 2008
    ..Consequently, dysfunction of the ability of the CNS to integrate fuel-sensing signals may underlie the etiology of metabolic diseases such as obesity and diabetes...
  48. pmc Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents
    Tammy L Kindel
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 19:380-7. 2011
    ..These data suggest that duodenal bypass alone is an insufficient mechanism to alter insulin sensitivity independent of weight loss in obese, nondiabetic rodents...
  49. ncbi request reprint Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor gene
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Ohio 45267 0559, USA
    Behav Neurosci 117:46-54. 2003
    ..These results support the hypothesis that D3Rs chronically inhibit the effects of adiposity hormones, thereby contributing to a net anabolic state...
  50. pmc Transplantation or removal of intra-abdominal adipose tissue prevents age-induced glucose insensitivity
    Michelle T Foster
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237, United States
    Physiol Behav 101:282-8. 2010
    ..Taken together, these data suggest that surgical removal or addition of intra-abdominal fat prevents age-induced insulin resistance by different mechanisms and is a suitable model to investigate naturally occurring obesity...
  51. ncbi request reprint Regulation of food intake through hypothalamic signaling networks involving mTOR
    Stephen C Woods
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Annu Rev Nutr 28:295-311. 2008
    ....
  52. ncbi request reprint Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism
    Tammy L Kindel
    Department of Pathology and Laboratory Medicine, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH, USA
    J Gastrointest Surg 13:1762-72. 2009
    ..We compared two procedures that increase distal small bowel stimulation, ileal interposition (IT), and duodenal-jejunal exclusion (DJE)...
  53. doi request reprint Targeting the CNS to treat type 2 diabetes
    Darleen A Sandoval
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    Nat Rev Drug Discov 8:386-98. 2009
    ..These findings present new targets for therapies that may be capable of both inducing weight loss and improving glucose regulation...
  54. ncbi request reprint Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559 Cincinnati, OH 45267 0559, USA
    Endocrinology 143:2995-3000. 2002
    ..These data indicate that despite several similarities between MCH and orexin-A, these two lateral hypothalamic area peptides stimulate food intake by recruiting different neural circuits and exert different effects on food choice...
  55. ncbi request reprint Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Building 43, Third Floor, Cincinnati, Ohio 45237, USA
    Endocrinology 145:3404-12. 2004
    ....
  56. ncbi request reprint 7-OH-DPAT selectively reduces intake of both chow and high fat diets in different food intake regimens
    John Andrews M McQuade
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Pharmacol Biochem Behav 76:517-23. 2003
    ..However, in animals that had access to HF diet, 7-OH-DPAT dose-dependently reduced intake. These results support a potential role for the D3-R in ingestive behavior particularly in situations that involve a significant learned component...
  57. ncbi request reprint Adrenalectomy alters the sensitivity of the central nervous system melanocortin system
    Deborah L Drazen
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Diabetes 52:2928-34. 2003
    ..We conclude that the potent weight-reducing effects of ADX likely involve heightened responsiveness to melanocortin receptor stimulation...
  58. ncbi request reprint Monitoring of stored and available fuel by the CNS: implications for obesity
    Randy J Seeley
    Department of Psychiatry and Obesity Research Center, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
    Nat Rev Neurosci 4:901-9. 2003
  59. ncbi request reprint Two novel paradigms for the simultaneous assessment of conditioned taste aversion and food intake effects of anorexic agents
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, P O Box 670559, Cincinnati, OH 45267, USA
    Physiol Behav 79:761-6. 2003
    ..These results suggest that both the appetitive and aversive consequences of anorexic agents can be assessed simultaneously during either acute or chronic drug administration...
  60. ncbi request reprint Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Endocrinology 144:2941-6. 2003
    ..These results indicate that consumption of a HF diet decreases signaling through the melanocortin system, an abnormality that could contribute to diet-induced obesity...
  61. ncbi request reprint Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus
    Min Liu
    Cincinnati Obesity Research Center, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Brain Res 971:232-8. 2003
    ..v.t. injection of NPY was combined with lipid infusion. These results suggest that NPY and lipid may regulate apo AIV gene expression in the rat hypothalamus...
  62. ncbi request reprint Insulin and the blood-brain barrier
    Stephen C Woods
    Department of Psychiatry, Box 670559, University of Cincinnati, Cincinnati, OH 45267, USA
    Curr Pharm Des 9:795-800. 2003
    ..Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition...
  63. ncbi request reprint A controlled high-fat diet induces an obese syndrome in rats
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati School of Medicine, OH 45267, USA
    J Nutr 133:1081-7. 2003
    ..This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat influences the regulation of energy balance...
  64. ncbi request reprint Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 284:R494-9. 2003
    ..Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake...
  65. ncbi request reprint Expression of biologically active rat apolipoprotein AIV in Escherichia coli
    Min Liu
    Department of Pathology, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0529, USA
    Physiol Behav 78:149-55. 2003
    ....
  66. ncbi request reprint The catabolic action of insulin in the brain is mediated by melanocortins
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:9048-52. 2002
    ..These data suggest that the hypothalamic melanocortin system mediates the anorexic effects of central insulin, as well as of leptin...
  67. ncbi request reprint Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus
    Min Liu
    The Obesity Research Center, Department of Pathology and Laboratory Medicine, University of Cincinnati Medical College, Ohio 45267, USA
    Am J Physiol Endocrinol Metab 287:E366-70. 2004
    ..This raises the possibility that dysregulation of hypothalamic apo A-IV could contribute to diet-induced obesity...
  68. ncbi request reprint Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Endocrinology 147:23-30. 2006
    ..Together, these data are consistent with a role for ghrelin in the regulation of anticipatory processes involved in food intake and nutrient disposition...
  69. ncbi request reprint Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats
    April D Strader
    Genome Research Institute, Department of Psychiatry, University of Cincinnati, 2071 E Galbraith Rd, Reading, OH 45237, USA
    Am J Physiol Endocrinol Metab 288:E447-53. 2005
    ..These findings support the importance of evaluating the contribution of gastrointestinal hormones to the weight loss seen with bariatric surgery...
  70. pmc Mice lacking the syndecan-3 gene are resistant to diet-induced obesity
    April D Strader
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 114:1354-60. 2004
    ..The data implicate syndecan-3 in the regulation of body weight and suggest that inhibition of syndecan-3 may provide a therapeutic approach for the treatment of obesity resulting from exposure to high-fat diets...
  71. ncbi request reprint Clinical endocrinology and metabolism. Regulation of energy homeostasis by peripheral signals
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Best Pract Res Clin Endocrinol Metab 18:497-515. 2004
    ..Considerable effort is being directed towards finding ways to intervene in specific circuits to help accomplish weight loss...
  72. ncbi request reprint Comparative analysis of ACTH and corticosterone sampling methods in rats
    Torsten P Vahl
    Dept of Internal Medicine, Division of Endocrinology and Metabolism, Univ of Cincinnati, 2170 E Galbraith Rd, Bldg 43, Rm 315, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 289:E823-8. 2005
    ..However, collection of blood under pentobarbital sodium or CO2 anesthesia is likely to confound the results of stress studies when ACTH is an important endpoint...
  73. ncbi request reprint Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity
    Karine Proulx
    Genome Research Institute, ML 0506, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 289:R729-37. 2005
    ..Despite that OEA-induced anorexia is unlikely to be due to impaired motor activity, our data raise a cautionary note in how specific behavioral and metabolic effects of OEA should be interpreted...
  74. ncbi request reprint The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry North, 2170 East Galbraith Rd, Cincinnati, OH 45243, USA
    Peptides 26:751-7. 2005
    ....
  75. pmc The effect of vertical sleeve gastrectomy on a rat model of polycystic ovarian syndrome
    Hilary E Wilson-Pérez
    Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 152:3700-5. 2011
    ..In addition, the dissociation of body weight loss without improved glucose tolerance suggests that glucose intolerance may be a body weight-independent phenomenon in women with PCOS...
  76. pmc Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice
    Karen K Ryan
    Department of Internal Medicine, Division of Endocrinology, The University of Cincinnati College of Medicine, 2170 East Galbraith Road, Mail Location 0503, Cincinnati, Ohio 45237, USA
    Endocrinology 151:2603-12. 2010
    ..We conclude that this larger size-for-age represents a faster rate of growth early in development rather than an obese, diabetic phenotype in adulthood...
  77. ncbi request reprint The role of energy expenditure in the differential weight loss in obese women on low-fat and low-carbohydrate diets
    Bonnie J Brehm
    R D, University of Cincinnati, P O Box 210038, Cincinnati, Ohio 45221 0038, USA
    J Clin Endocrinol Metab 90:1475-82. 2005
    ..The differential weight loss is not explained by differences in REE, TEF, or physical activity and likely reflects underreporting of food consumption by the low-fat dieters...
  78. ncbi request reprint Is the energy homeostasis system inherently biased toward weight gain?
    Michael W Schwartz
    Department of Medicine, University of Washington, Seattle, USA
    Diabetes 52:232-8. 2003
    ..Teleological, molecular, physiological, and clinical aspects of this hypothesis are presented, along with a discussion of currently available supporting evidence...
  79. ncbi request reprint Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 51:3196-201. 2002
    ..Understanding the mechanisms by which FAS inhibition in the CNS reduces food intake could lead to specific targets for the manipulation of energy balance and the treatment of obesity...
  80. ncbi request reprint More neurons, less weight
    Randy J Seeley
    Nat Med 11:1276-8. 2005
  81. pmc Mice lacking ghrelin receptors resist the development of diet-induced obesity
    Jeffrey M Zigman
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:3564-72. 2005
    ..Moreover, our data suggest that ghrelin signaling is required for development of the full phenotype of diet-induced obesity...
  82. ncbi request reprint How diabetes went to our heads
    Randy J Seeley
    Nat Med 12:47-9; discussion 49. 2006
  83. ncbi request reprint C75 inhibits food intake by increasing CNS glucose metabolism
    Matthew D Wortman
    Nat Med 9:483-5. 2003
  84. ncbi request reprint Fat hormones pull their weight in the CNS
    Randy J Seeley
    Nat Med 10:454-5. 2004
  85. ncbi request reprint Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway
    Ofer Reizes
    Procter Gamble Pharmaceuticals, Inc, Health Care Research Center, Mason, Ohio 45040, USA
    Ann N Y Acad Sci 994:66-73. 2003
    ..Collectively, the data suggest that the modulation of melanocortin regulation of energy balance by syndecan-3 is modulated by the action of a TIMP-3-sensitive metalloprotease...
  86. ncbi request reprint CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors
    Kimberly P Kinzig
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 23:6163-70. 2003
    ..Although diverse neural circuits must necessarily process disparate stressors, the current data implicate a role for the GLP-1 system as a critical mediator of multiple stress responses...
  87. pmc Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity
    Ji Yeon Lee
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 3:e1639. 2008
    ..These results demonstrate that STAT5 mediates energy homeostasis in response to endogenous cytokines such as GM-CSF...
  88. ncbi request reprint Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects
    Kevin D O'Brien
    Department of Medicine, Division of Cardiology, Box 356422, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195 6422, USA
    J Clin Endocrinol Metab 90:2244-9. 2005
    ..03). Thus, in otherwise healthy, obese women, weight loss was associated with significant decreases in both SAA and CRP. These effects were proportional to the amount of weight lost but independent of dietary macronutrient composition...
  89. ncbi request reprint Effect of growth hormone on susceptibility to diet-induced obesity
    Darlene E Berryman
    School of Human and Consumer Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA
    Endocrinology 147:2801-8. 2006
    ..More importantly, because there were genotype-specific effects of diet, these data stress the importance of diet selection and sampling multiple adipose depots in studies with these mouse models...

Research Grants29

  1. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2004
    ..The information from this proposal will be critical to a complete picture of how energy balance is regulated and how disorders of energy balance such as obesity may be treated. ..
  2. CNS GLP-1: Multiple roles in ingestion and adiposity
    Randy Seeley; Fiscal Year: 2004
    ..This information could lend itself to the development of therapeutic strategies for both wasting conditions as well as obesity. ..
  3. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2005
    ..The information from this proposal will be critical to a complete picture of how energy balance is regulated and how disorders of energy balance such as obesity may be treated. ..
  4. CNS GLP-1: Multiple roles in ingestion and adiposity
    Randy Seeley; Fiscal Year: 2005
    ..This information could lend itself to the development of therapeutic strategies for both wasting conditions as well as obesity. ..
  5. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2006
    ..The information from this proposal will be critical to a complete picture of how energy balance is regulated and how disorders of energy balance such as obesity may be treated. ..
  6. Roles of GM-CSF in Energy and Glucose Regulation
    Randy Seeley; Fiscal Year: 2006
    ..The aims presented here are an important step in unveiling the specific roles that GM-CSF plays in the normal regulation of body weight and its potential connection to the pathology of diabetes. ..
  7. Roles of GM-CSF in Energy and Glucose Regulation
    Randy Seeley; Fiscal Year: 2007
    ..The aims presented here are an important step in unveiling the specific roles that GM-CSF plays in the normal regulation of body weight and its potential connection to the pathology of diabetes. ..
  8. CNS GLP-1 signaling in energy and glucose homeostasis
    Randy Seeley; Fiscal Year: 2007
    ..Furthermore, the advent of pharmaceuticals that utilize GLP-I R signaling to treat diabetes makes understanding the physiology of GLP-I directly applicable to clinical care. ..
  9. CNS GLP-1 signaling in energy and glucose homeostasis
    Randy Seeley; Fiscal Year: 2009
    ..Furthermore, the advent of pharmaceuticals that utilize GLP-I R signaling to treat diabetes makes understanding the physiology of GLP-I directly applicable to clinical care. ..
  10. Roles of GM-CSF in Energy and Glucose Regulation
    Randy Seeley; Fiscal Year: 2009
    ..The aims presented here are an important step in unveiling the specific roles that GM-CSF plays in the normal regulation of body weight and its potential connection to the pathology of diabetes. ..
  11. CNS GLP-1: Multiple roles in ingestion and adiposity
    Randy Seeley; Fiscal Year: 2003
    ..This information could lend itself to the development of therapeutic strategies for both wasting conditions as well as obesity. ..
  12. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2003
    ..The information from this proposal will be critical to a complete picture of how energy balance is regulated and how disorders of energy balance such as obesity may be treated. ..
  13. CNS GLP-1: Multiple roles in ingestion and adiposity
    Randy Seeley; Fiscal Year: 2002
    ..This information could lend itself to the development of therapeutic strategies for both wasting conditions as well as obesity. ..
  14. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 1999
    ....
  15. CNS MEDIATION OF VISCERAL ILLNESS
    Randy Seeley; Fiscal Year: 1999
    ..Understanding these systems is and important first step in devising therapeutic strategies for the many and varied clinical situations complicated by visceral illness. ..
  16. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 1999
    ....
  17. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2000
    ....
  18. CNS MEDIATION OF VISCERAL ILLNESS
    Randy Seeley; Fiscal Year: 2000
    ..Understanding these systems is and important first step in devising therapeutic strategies for the many and varied clinical situations complicated by visceral illness. ..
  19. CNS GLP-1: Multiple roles in ingestion and adiposity
    Randy Seeley; Fiscal Year: 2001
    ..This information could lend itself to the development of therapeutic strategies for both wasting conditions as well as obesity. ..
  20. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2001
    ....
  21. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2002
    ..The information from this proposal will be critical to a complete picture of how energy balance is regulated and how disorders of energy balance such as obesity may be treated. ..
  22. Roles of GM-CSF in Energy and Glucose Regulation
    Randy J Seeley; Fiscal Year: 2010
    ..The aims presented here are an important step in unveiling the specific roles that GM-CSF plays in the normal regulation of body weight and its potential connection to the pathology of diabetes. ..