Eric R Secor

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc LC-MS/MS Identification of a Bromelain Peptide Biomarker from Ananas comosus Merr
    Eric R Secor
    Department of Immunology, UCONN Health Center, Farmington, CT 06030 1319, USA
    Evid Based Complement Alternat Med 2012:548486. 2012
  2. pmc Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma
    Eric R Secor
    Department of Immunology and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA
    Evid Based Complement Alternat Med 5:61-9. 2008
  3. ncbi request reprint Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma
    Eric R Secor
    Department of Immunology, University of Connecticut School of Medicine, CT, USA
    Altern Ther Health Med 18:9-17. 2012
  4. pmc Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro
    Eric R Secor
    Department of Immunology, University of Connecticut Health Center 263 Farmington Ave, MC1319Farmington, CT 06030, USA
    Int Immunopharmacol 9:340-6. 2009
  5. pmc Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma model
    Anurag Singh
    1Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA
    Immunol Cell Biol 86:535-8. 2008
  6. pmc Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease
    Jeffrey T McNamara
    Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Am J Pathol 180:1991-2000. 2012
  7. pmc Regulatory role of B cells in a murine model of allergic airway disease
    Anurag Singh
    Department of Immunology, University of Connecticut Health Center, Framington, CT 06030, USA
    J Immunol 180:7318-26. 2008
  8. pmc Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease
    Eric R Secor
    Department of Immunology, University of Connecticut, School of Medicine, Farmington, CT, USA
    Cell Immunol 237:68-75. 2005
  9. doi request reprint Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination
    Steven M Szczepanek
    Adult Sickle Cell Center, Division of Hematology Oncology, Lea Center for Hematologic Disorders, University of Connecticut Health Center, Farmington, Connecticut, USA
    Pediatr Res 74:141-7. 2013
  10. ncbi request reprint Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease
    Prakash M Kabbur
    Department of Pediatrics, University of Connecticut School of Medicine, Farmington, USA
    Cell Immunol 239:67-74. 2006

Collaborators

Detail Information

Publications14

  1. pmc LC-MS/MS Identification of a Bromelain Peptide Biomarker from Ananas comosus Merr
    Eric R Secor
    Department of Immunology, UCONN Health Center, Farmington, CT 06030 1319, USA
    Evid Based Complement Alternat Med 2012:548486. 2012
    ..In this study, a novel Br peptide was identified in the plasma of treated mice for the first time. This Br peptide could serve as a biomarker to standardize the therapeutic dose and maximize clinical utility...
  2. pmc Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma
    Eric R Secor
    Department of Immunology and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA
    Evid Based Complement Alternat Med 5:61-9. 2008
    ..0001) in AAD mice when compared with controls. These results suggest that oral treatment with bromelain had a beneficial therapeutic effect in this murine model of asthma and bromelain may also be effective in human conditions...
  3. ncbi request reprint Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma
    Eric R Secor
    Department of Immunology, University of Connecticut School of Medicine, CT, USA
    Altern Ther Health Med 18:9-17. 2012
    ..Researchers are investigating the benefits of lifestyle changes and alternative asthma treatments, including the ability of bromelain to inhibit inflammation. Bromelain is a commonly used, proteolytically active pineapple extract...
  4. pmc Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro
    Eric R Secor
    Department of Immunology, University of Connecticut Health Center 263 Farmington Ave, MC1319Farmington, CT 06030, USA
    Int Immunopharmacol 9:340-6. 2009
    ..This novel mechanism of action identifies how Br may exert its therapeutic benefits in inflammatory conditions...
  5. pmc Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma model
    Anurag Singh
    1Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA
    Immunol Cell Biol 86:535-8. 2008
    ..Thus, the resolution of airway inflammatory responses with chronic antigen inhalation is a localized response, not associated with loss of systemic responses to antigen...
  6. pmc Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease
    Jeffrey T McNamara
    Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Am J Pathol 180:1991-2000. 2012
    ..These B cell aggregates resembled tertiary ectopic lymphoid tissue and may thus provide a local environment for the salient cellular interactions that contribute to the development of LIT...
  7. pmc Regulatory role of B cells in a murine model of allergic airway disease
    Anurag Singh
    Department of Immunology, University of Connecticut Health Center, Framington, CT 06030, USA
    J Immunol 180:7318-26. 2008
    ..These findings illustrated a novel regulatory role for regional B cells in AAD and suggested a possible contributory role of B cells, along with other cell types, in the establishment of LIT...
  8. pmc Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease
    Eric R Secor
    Department of Immunology, University of Connecticut, School of Medicine, Farmington, CT, USA
    Cell Immunol 237:68-75. 2005
    ..The purpose of this study was to determine the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD)...
  9. doi request reprint Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination
    Steven M Szczepanek
    Adult Sickle Cell Center, Division of Hematology Oncology, Lea Center for Hematologic Disorders, University of Connecticut Health Center, Farmington, Connecticut, USA
    Pediatr Res 74:141-7. 2013
    ..Given the altered baseline immunity and proinflammatory state associated with SCD, we sought to determine the relative safety and efficacy of vaccination in transgenic SCD mice...
  10. ncbi request reprint Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease
    Prakash M Kabbur
    Department of Pediatrics, University of Connecticut School of Medicine, Farmington, USA
    Cell Immunol 239:67-74. 2006
    ..This study determined whether IL-10-dependent mechanisms mediated the local inhalational tolerance seen with chronic inhalational exposure to antigen...
  11. pmc Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell disease
    Steven M Szczepanek
    Adult Sickle Cell Clinical and Research Center, Farmington, Connecticut, USA
    Am J Pathol 181:1725-34. 2012
    ..Our findings suggest that altered SCD splenic morphological characteristics result in an impaired systemic immune response...
  12. doi request reprint Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells
    Eric R Secor
    Helen and Harry Gray Cancer Center and Department of Medicine, Hartford Hospital, 80 Seymour Street, P O Box 5037, Hartford, CT 06102 5037, USA Department of Medicine, University of CT Health Center UCHC, Farmington, CT 06030, USA
    Evid Based Complement Alternat Med 2013:702196. 2013
    ..These results provide additional insight into sBr's anti-inflammatory and antiallergic properties and rationale for translation into the clinical arena...
  13. ncbi request reprint Implementation of outcome measures in a complementary and alternative medicine clinic: evidence of decreased pain and improved quality of life
    Eric R Secor
    Wellness Center, New Britain, CT, USA
    J Altern Complement Med 10:506-13. 2004
    ....
  14. pmc Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium
    Bela Juhasz
    Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    Am J Physiol Heart Circ Physiol 294:H1365-70. 2008
    ..These results demonstrated for the first time that Br triggers an Akt-dependent survival pathway in the heart, revealing a novel mechanism of cardioprotective action and a potential therapeutic target against I/R injury...