Eric R Secor
Affiliation: University of Connecticut Health Center
- LC-MS/MS Identification of a Bromelain Peptide Biomarker from Ananas comosus MerrEric R Secor
Department of Immunology, UCONN Health Center, Farmington, CT 06030 1319, USA
Evid Based Complement Alternat Med 2012:548486. 2012..In this study, a novel Br peptide was identified in the plasma of treated mice for the first time. This Br peptide could serve as a biomarker to standardize the therapeutic dose and maximize clinical utility...
- Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of AsthmaEric R Secor
Department of Immunology and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA
Evid Based Complement Alternat Med 5:61-9. 2008..0001) in AAD mice when compared with controls. These results suggest that oral treatment with bromelain had a beneficial therapeutic effect in this murine model of asthma and bromelain may also be effective in human conditions...
- Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthmaEric R Secor
Department of Immunology, University of Connecticut School of Medicine, CT, USA
Altern Ther Health Med 18:9-17. 2012..Researchers are investigating the benefits of lifestyle changes and alternative asthma treatments, including the ability of bromelain to inhibit inflammation. Bromelain is a commonly used, proteolytically active pineapple extract...
- Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitroEric R Secor
Department of Immunology, University of Connecticut Health Center 263 Farmington Ave, MC1319Farmington, CT 06030, USA
Int Immunopharmacol 9:340-6. 2009..This novel mechanism of action identifies how Br may exert its therapeutic benefits in inflammatory conditions...
- Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma modelAnurag Singh
1Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA
Immunol Cell Biol 86:535-8. 2008..Thus, the resolution of airway inflammatory responses with chronic antigen inhalation is a localized response, not associated with loss of systemic responses to antigen...
- Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway diseaseJeffrey T McNamara
Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Am J Pathol 180:1991-2000. 2012..These B cell aggregates resembled tertiary ectopic lymphoid tissue and may thus provide a local environment for the salient cellular interactions that contribute to the development of LIT...
- Regulatory role of B cells in a murine model of allergic airway diseaseAnurag Singh
Department of Immunology, University of Connecticut Health Center, Framington, CT 06030, USA
J Immunol 180:7318-26. 2008..These findings illustrated a novel regulatory role for regional B cells in AAD and suggested a possible contributory role of B cells, along with other cell types, in the establishment of LIT...
- Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway diseaseEric R Secor
Department of Immunology, University of Connecticut, School of Medicine, Farmington, CT, USA
Cell Immunol 237:68-75. 2005..The purpose of this study was to determine the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD)...
- Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccinationSteven M Szczepanek
Adult Sickle Cell Center, Division of Hematology Oncology, Lea Center for Hematologic Disorders, University of Connecticut Health Center, Farmington, Connecticut, USA
Pediatr Res 74:141-7. 2013..Given the altered baseline immunity and proinflammatory state associated with SCD, we sought to determine the relative safety and efficacy of vaccination in transgenic SCD mice...
- Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway diseasePrakash M Kabbur
Department of Pediatrics, University of Connecticut School of Medicine, Farmington, USA
Cell Immunol 239:67-74. 2006..This study determined whether IL-10-dependent mechanisms mediated the local inhalational tolerance seen with chronic inhalational exposure to antigen...
- Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell diseaseSteven M Szczepanek
Adult Sickle Cell Clinical and Research Center, Farmington, Connecticut, USA
Am J Pathol 181:1725-34. 2012..Our findings suggest that altered SCD splenic morphological characteristics result in an impaired systemic immune response...
- Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic CellsEric R Secor
Helen and Harry Gray Cancer Center and Department of Medicine, Hartford Hospital, 80 Seymour Street, P O Box 5037, Hartford, CT 06102 5037, USA Department of Medicine, University of CT Health Center UCHC, Farmington, CT 06030, USA
Evid Based Complement Alternat Med 2013:702196. 2013..These results provide additional insight into sBr's anti-inflammatory and antiallergic properties and rationale for translation into the clinical arena...
- Implementation of outcome measures in a complementary and alternative medicine clinic: evidence of decreased pain and improved quality of lifeEric R Secor
Wellness Center, New Britain, CT, USA
J Altern Complement Med 10:506-13. 2004....
- Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardiumBela Juhasz
Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
Am J Physiol Heart Circ Physiol 294:H1365-70. 2008..These results demonstrated for the first time that Br triggers an Akt-dependent survival pathway in the heart, revealing a novel mechanism of cardioprotective action and a potential therapeutic target against I/R injury...