Paola Secchiero

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Role of the RANKL/RANK system in the induction of interleukin-8 (IL-8) in B chronic lymphocytic leukemia (B-CLL) cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, Ferrara, Italy
    J Cell Physiol 207:158-64. 2006
  2. ncbi request reprint Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies
    P Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy
    Blood 98:2220-8. 2001
  3. ncbi request reprint Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Blood 111:1287-94. 2008
  4. ncbi request reprint TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells
    P Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100, Ferrara, Italy
    Cell Mol Life Sci 61:1965-74. 2004
  5. ncbi request reprint Differential gene expression induction by TRAIL in B chronic lymphocytic leukemia (B-CLL) cells showing high versus low levels of Zap-70
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy
    J Cell Physiol 213:229-36. 2007
  6. ncbi request reprint TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Blood 105:3413-9. 2005
  7. ncbi request reprint Aberrant expression of TRAIL in B chronic lymphocytic leukemia (B-CLL) cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy
    J Cell Physiol 205:246-52. 2005
  8. pmc Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Italy
    Am J Pathol 167:1599-607. 2005
  9. ncbi request reprint Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL)
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Blood 107:4122-9. 2006
  10. ncbi request reprint Antiangiogenic activity of the MDM2 antagonist nutlin-3
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Circ Res 100:61-9. 2007

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Role of the RANKL/RANK system in the induction of interleukin-8 (IL-8) in B chronic lymphocytic leukemia (B-CLL) cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, Ferrara, Italy
    J Cell Physiol 207:158-64. 2006
    ..Since IL-8 has been implicated in progression of B-CLL disease, our findings suggest that, by upregulating IL-8, the RANKL/RANK system may contribute to the pathogenesis of B-CLL...
  2. ncbi request reprint Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies
    P Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy
    Blood 98:2220-8. 2001
    ..Both mechanisms seem to be essential for TRAIL-mediated cytotoxicity...
  3. ncbi request reprint Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Blood 111:1287-94. 2008
    ....
  4. ncbi request reprint TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells
    P Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100, Ferrara, Italy
    Cell Mol Life Sci 61:1965-74. 2004
    ..Taken together, these data strengthen the notion that the TRAIL/TRAIL-R system likely plays a role in the biology of the vascular system by affecting the survival, migration and proliferation of VSMCs...
  5. ncbi request reprint Differential gene expression induction by TRAIL in B chronic lymphocytic leukemia (B-CLL) cells showing high versus low levels of Zap-70
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy
    J Cell Physiol 213:229-36. 2007
    ..Taken together, our findings suggest that a significant expression of Zap-70 modulate the response of B-CLL to TRAIL, which might represents an initial step in the pathogenesis of B-CLL...
  6. ncbi request reprint TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Blood 105:3413-9. 2005
    ..Taken together, our data suggest that TRAIL might play an important role in modulating leukocyte/endothelial cell adhesion by selectively down-regulating CCL8 and CXCL10 chemokines...
  7. ncbi request reprint Aberrant expression of TRAIL in B chronic lymphocytic leukemia (B-CLL) cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy
    J Cell Physiol 205:246-52. 2005
    ..Taken together, these findings suggest that an aberrant expression of TRAIL might contribute to the pathogenesis of B-CLL by promoting the survival in a subset of B-CLL cells...
  8. pmc Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Italy
    Am J Pathol 167:1599-607. 2005
    ..Taken together, our data indicate that COX-2 overexpression likely represents an additional mechanism of resistance to apoptosis in B-CLL and that pharmacological suppression of COX-2 might enhance chemotherapy-mediated apoptosis...
  9. ncbi request reprint Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL)
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Blood 107:4122-9. 2006
    ..Moreover, nutlin-3 synergized with both fludarabine and chlorambucil in inducing B-CLL apoptosis. Our data strongly suggest that nutlin-3 should be further investigated for clinical applications in the treatment of B-CLL...
  10. ncbi request reprint Antiangiogenic activity of the MDM2 antagonist nutlin-3
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Circ Res 100:61-9. 2007
    ....
  11. ncbi request reprint Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Curr Drug Metab 8:395-403. 2007
    ..Our data suggest that the combined treatment of nutlin-3 plus TRAIL might offer a novel therapeutic strategy for AML...
  12. ncbi request reprint Tumor-necrosis-factor-related apoptosis-inducing ligand and the regulation of hematopoiesis
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Curr Opin Hematol 15:42-8. 2008
    ....
  13. ncbi request reprint TRAIL regulates normal erythroid maturation through an ERK-dependent pathway
    Paola Secchiero
    Dept of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Blood 103:517-22. 2004
    ....
  14. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Italy
    Blood 100:2421-9. 2002
    ..Moreover, the dichotomous effect of TRAIL on malignant cells (early induction of apoptosis and monocytic maturation of the surviving cells) might have important therapeutic implications for the treatment of acute myeloid leukemia...
  15. ncbi request reprint Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    J Leukoc Biol 83:434-7. 2008
    ..Thus, a therapeutic regimen including CpG-ODN plus Nutlin-3 might have the advantage to preserve the immune activation of B-CLL cells while restraining the prosurvival/proliferative potential of CpG-ODN treatment...
  16. ncbi request reprint TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Circulation 107:2250-6. 2003
    ..TRAIL protein is expressed in the medial smooth cell layer of aorta and pulmonary artery, whereas endothelial cells express all TRAIL receptors (TRAIL-Rs)...
  17. ncbi request reprint Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, St Anna Hospital, University of Ferrara, Italy
    J Leukoc Biol 74:223-32. 2003
    ..These findings demonstrate that NF-kappaB is essential for monocytic maturation and is activated via distinct pathways, involving or not involving caspases, by the related cytokines TRAIL and TNF-alpha...
  18. pmc The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Neoplasia 9:853-61. 2007
    ..Taken together, these data disclose a novel, potentially relevant therapeutic role for Nutlin-3 in the treatment of both p53 wild-type and p53(-/-) AML, possibly in association with recombinant TRAIL...
  19. pmc An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Italy
    Am J Pathol 169:2236-44. 2006
    ..Altogether, these findings suggest that increased OPG production represents an early event in the natural history of diabetes mellitus, possibly contributing to disease-associated endothelial cell dysfunction...
  20. doi request reprint The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Clin Cancer Res 16:1824-33. 2010
    ..To characterize the role of the oncogene DEK in modulating the response to either Nutlin-3, a small-molecule inhibitor of the MDM2/p53 interaction, or chlorambucil in primary B-chronic lymphocytic leukemia (B-CLL) cells...
  21. doi request reprint Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Blood 113:4300-8. 2009
    ..Therefore, therapeutic combinations of Nutlin-3 + gamma-secretase inhibitors might potentiate the cytotoxicity of Nutlin-3 in p53(wild-type) leukemic cells...
  22. pmc Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Mediators Inflamm 2013:423407. 2013
    ..Our data provide new insights into the molecular mechanisms of CVD pathogenesis, highlighting new potential therapeutic targets...
  23. ncbi request reprint Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells
    Daniela Milani
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Italy
    J Neurochem 86:126-35. 2003
    ..Remarkably, caspase-dependent cleavage of NF-kappaB family members as well as of Akt and CREB proteins, but not of ERK, became prominent at 24 h, a time point coincident with the peak of caspase-dependent apoptosis...
  24. doi request reprint Trail down-regulates the release of osteoprotegerin (OPG) by primary stromal cells
    Federica Corallini
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    J Cell Physiol 226:2279-86. 2011
    ..In this respect, the ability of TRAIL to decrease the release of OPG, in the absence of cell cytotoxicity, was mimicked by the p38/MAPK inhibitor SB203580...
  25. ncbi request reprint Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development
    Elisabetta Melloni
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Italy
    J Cell Physiol 204:975-82. 2005
    ..A similar pro-maturation effect was observed when TRAIL was added to bone marrow-derived CD61(+) megakaryocytic cells. Thus, our data suggest a role of TRAIL as a regulator of megakaryocytopoiesis...
  26. doi request reprint Dexamethasone counteracts the anti-osteoclastic, but not the anti-leukemic, activity of TNF-related apoptosis inducing ligand (TRAIL)
    Giorgio Zauli
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    J Cell Physiol 222:357-64. 2010
    ..The ability of dexamethasone to counteract the TRAIL pathway envisions a novel mechanism mediating the pro-osteoclastic activity of dexamethasone in vivo...
  27. doi request reprint TNF-alpha modulates the migratory response of mesenchymal stem cells to TRAIL
    Federica Corallini
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Cell Mol Life Sci 67:1307-14. 2010
    ....
  28. doi request reprint Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets
    Barbara Toffoli
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 64 b, 44100 Ferrara, Italy
    Mol Cell Endocrinol 331:136-42. 2011
    ..Our data suggest that OPG might play an important role in promoting beta cell dysfunction and that the upregulation of the local RAS represents one possible mechanism responsible for the OPG-induced beta cell dysfunction...
  29. pmc GM-CSF Exhibits Anti-Inflammatory Activity on Endothelial Cells Derived from Chronic Venous Disease Patients
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 70, 44100 Ferrara, Italy
    Mediators Inflamm 2013:561689. 2013
    ..Since in vitro recombinant GM-CSF induced VEC proliferation and counteracted the induction of ICAM-1, VCAM-1 and OPG upon exposure to TNF- α , our data suggest an anti-inflammatory activity of GM-CSF on venous endothelial cells. ..
  30. ncbi request reprint Activation of the p53 pathway induces α-smooth muscle actin expression in both myeloid leukemic cells and normal macrophages
    Paola Secchiero
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    J Cell Physiol 227:1829-37. 2012
    ..Taken together, these data indicate that Nutlin-3 is a potent inducer of α-SMA in both normal and leukemic myeloid cells as well as in endothelial cells...
  31. ncbi request reprint Receptor activator of nuclear factor kappa B ligand (RANKL) modulates the expression of genes involved in apoptosis and cell cycle in human osteoclasts
    Erika Rimondi
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Ferrara, Italy
    Anat Rec (Hoboken) 290:838-45. 2007
    ..Finally, a long-term exposure of RANKL up-regulated the adaptor protein TRAF3 but not TRAF6...
  32. pmc Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes
    Diana Campioni
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Am J Pathol 166:557-63. 2005
    ..Thus, increased expression and release of TRAIL at the bone marrow level is likely to impair erythropoiesis and to contribute to the degree of anemia, the major clinical feature of MDS...
  33. ncbi request reprint Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation
    Erika Rimondi
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara, Ferrara, Italy
    J Cell Physiol 206:647-54. 2006
    ..Taken together, these data suggest that TRAIL might act as a paracrine trophic cytokine on intestinal epithelium, promoting intestinal cell differentiation...
  34. pmc Evidence for a proangiogenic activity of TNF-related apoptosis-inducing ligand
    Paola Secchiero
    Human Anatomy Section, Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, Ferrara 44100, Italy
    Neoplasia 6:364-73. 2004
    ....
  35. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL) up-regulates cyclooxygenase (COX)-1 activity and PGE(2) production in cells of the myeloid lineage
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Italy
    J Leukoc Biol 72:986-94. 2002
    ..These data indicate that the ability of TRAIL to up-regulate eicosanoid production and release is not confined to malignant leukemic cells, but it may also play a role in normal hematopoiesis...
  36. doi request reprint C-Reactive protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway
    Paola Secchiero
    AuDepartment of Morphology and Embryology, Laboratorio per le Tecnologie delle Terapie Avanzate Centre, University of Ferrara, Ferrara, Trieste, Italy
    Clin Cancer Res 19:1949-59. 2013
    ..To investigate the potential link between C-reactive protein (CRP), a known biomarker of acute and chronic inflammation, and TRAIL, a cytokine which plays a key role in the immune-surveillance against tumors...
  37. doi request reprint Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells
    Paola Secchiero
    aDepartment of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Stem Cells 26:2955-63. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  38. doi request reprint Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy
    Cytokine 63:92-6. 2013
    ..6; p=0.01), while showing a negative correlation with RI (R=-0.5; p=0.03). The potential implications of our findings for the pathophysiology of CVD are discussed...
  39. doi request reprint Anti-leukemic activity of dasatinib in both p53(wild-type) and p53(mutated) B malignant cells
    Raffaella Bosco
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Invest New Drugs 30:417-22. 2012
    ..Therefore, dasatinib might offer a novel therapeutic strategy not only for p53(wild-type), but also for p53(mutated) B malignancies that have the worst prognosis and urgently need innovative therapeutic approaches...
  40. pmc In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome
    Diana Campioni
    Department of Medical Sciences, Section of Hematology, Azienda Ospedaliero Universitaria, Arcispedale Sant Anna, University of Ferrara, Ferrara, Italy
    PLoS ONE 8:e56377. 2013
    ....
  41. pmc Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory phenotype
    Veronica Tisato
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    PLoS ONE 7:e39543. 2012
    ..Therefore, new insights on the characteristics of large vein endothelium would increase our knowledge of large vessel physiopathology...
  42. doi request reprint Pegylated TRAIL retains anti-leukemic cytotoxicity and exhibits improved signal transduction activity with respect to TRAIL
    Arianna Gonelli
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Invest New Drugs 30:828-32. 2012
    ..Overall, these data suggest that TRAIL pegylation retains, or even enhances, the biological activities of TRAIL relevant for its therapeutic applications...
  43. doi request reprint Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Invest New Drugs 30:803-7. 2012
    ..Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality...
  44. doi request reprint Nutlin-3 downregulates the expression of the oncogene TCL1 in primary B chronic lymphocytic leukemic cells
    Rebecca Voltan
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    Clin Cancer Res 17:5649-55. 2011
    ..The oncogene TCL1 plays a key role in the development of B chronic lymphocytic leukemia (B-CLL), but it is not known whether TCL1 could be modulated by therapeutic approaches...
  45. pmc Treatment with recombinant tumor necrosis factor-related apoptosis-inducing ligand alleviates the severity of streptozotocin-induced diabetes
    Giorgio Zauli
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Diabetes 59:1261-5. 2010
    ..To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment in a model of type 1 diabetes...
  46. ncbi request reprint Recent advances in the therapeutic perspectives of Nutlin-3
    Paola Secchiero
    Department of Morphology and Embryology and LTTA, University of Ferrara, Ferrara, Italy
    Curr Pharm Des 17:569-77. 2011
    ..Although Nutlin-3 is currently in phase I clinical trial for the treatment of retinoblastoma, its effects on normal tissues and cell types remain largely to be determined and will require further investigation in the future years...
  47. ncbi request reprint Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Circulation 114:1522-30. 2006
    ....
  48. ncbi request reprint The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Curr Pharm Des 14:2100-10. 2008
    ....
  49. pmc Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3
    Chiara Agnoletto
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy These two authors equally contributed to this work
    Oncotarget 5:4347-60. 2014
    ..Taken together, our data emphasize that DCA is a molecule that merits to be further evaluated as a chemotherapeutic agent for B-CLL, likely in combination with other therapeutic compounds. ..
  50. doi request reprint Nanoparticles engineered with rituximab and loaded with Nutlin-3 show promising therapeutic activity in B-leukemic xenografts
    Rebecca Voltan
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy
    Clin Cancer Res 19:3871-80. 2013
    ....
  51. pmc Association of soluble Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) with central adiposity and low-density lipoprotein cholesterol
    Gloria Brombo
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Clinical Nutrition, University of Ferrara, Ferrara, Italy
    PLoS ONE 8:e58225. 2013
    ..The aim of this study was to further investigate how soluble TRAIL concentrations independently correlate with major cardiovascular risk factors, including lipid, glycemic and anthropometric features...
  52. doi request reprint Patients affected by metabolic syndrome show decreased levels of circulating platelet derived growth factor (PDGF)-BB
    Veronica Tisato
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    Clin Nutr 32:259-64. 2013
    ..The development and/or progression of metabolic syndrome (MetS) in overweight and obese individuals have been associated to low-grade inflammation, but few studies have simultaneously analyzed the circulating levels of several cytokines...
  53. doi request reprint Release of a specific set of proinflammatory adipokines by differentiating 3T3-L1 cells
    Elisabetta Melloni
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    Nutrition 29:332-7. 2013
    ....
  54. doi request reprint An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Atherosclerosis 210:274-7. 2010
    ....
  55. doi request reprint Baseline serum concentrations of TRAIL in early rheumatoid arthritis: relationship with response to disease-modifying antirheumatic drugs
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 70, Ferrara, Italy
    J Rheumatol 37:1461-6. 2010
    ....
  56. doi request reprint Metalloproteinase 2 cleaves in vitro recombinant TRAIL: potential implications for the decreased serum levels of TRAIL after acute myocardial infarction
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, and Cardiovascular Institute, Azienda Ospedaliera Universitaria S Anna, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Atherosclerosis 211:333-6. 2010
    ..This study was designed to evaluate the potential role of metalloproteinase 2 (MMP2) in promoting the cleavage of TNF-related apoptosis inducing ligand (TRAIL), whose circulating levels are decreased after acute myocardial infarction (AMI)...
  57. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL): a potential candidate for combined treatment of hematological malignancies
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Italy
    Curr Pharm Des 10:3673-81. 2004
    ....
  58. ncbi request reprint Selective induction of TP53I3/p53-inducible gene 3 (PIG3) in myeloid leukemic cells, but not in normal cells, by Nutlin-3
    Rebecca Voltan
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    Mol Carcinog 53:498-504. 2014
    ....
  59. pmc Modulation of circulating cytokine-chemokine profile in patients affected by chronic venous insufficiency undergoing surgical hemodynamic correction
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy
    J Immunol Res 2014:473765. 2014
    ....
  60. ncbi request reprint TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases
    Stella Bernardi
    Department of Morphology and Embriology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Curr Drug Targets 13:1215-21. 2012
    ..Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes...
  61. pmc Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    PLoS ONE 5:e11140. 2010
    ..The effect of human bone marrow (BM) mesenchymal stem cells (MSC) on tumor cell growth is controversial, and no specific information is available on the effect of BM-MSC on NHL...
  62. doi request reprint Conjunctival sac fluid contains elevated levels of soluble TRAIL: implications for the anti-tumoral surveillance of the anterior surface of the eye
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    J Cell Physiol 218:199-204. 2009
    ..Taken together, our findings strongly support a major role of soluble TRAIL in protecting cornea and conjunctiva from tumor formation and/or invasion...
  63. ncbi request reprint Inverse correlation between circulating levels of TNF-related apoptosis-inducing ligand and 17β-estradiol
    Giorgio Zauli
    Institute for Maternal and Child Health G Z, O R, Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo, 34137 Trieste, Italy and Department of Morphology, Surgery, and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate Centre V T, E M, G B, R M, P S and Department of Medical Sciences S V, Department of Biomedical and Specialist Surgical Sciences C C, and Menopause and Osteoporosis Centre G B, University of Ferrara, 44121 Ferrara, Italy
    J Clin Endocrinol Metab 99:E659-64. 2014
    ..The regulation of the circulating levels of TNF-related apoptosis-inducing ligand (TRAIL), a cytokine of the TNF family, playing a key role in the immune surveillance against cancer, is incompletely understood...
  64. doi request reprint The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40
    Paola Secchiero
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy
    Acta Diabetol 50:899-906. 2013
    ..Overall, these data demonstrate that systemic administration of Nutlin-3 ameliorates the severity of STZ-induced DM and increases the levels of circulating IL-12p40...
  65. ncbi request reprint State of art and recent developments of anti-cancer strategies based on TRAIL
    Stella Bernardi
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    Recent Pat Anticancer Drug Discov 7:207-17. 2012
    ..Here, we review the most recent acquisitions and patents on TRAIL or TRAIL mimetics, as well as the combination therapies that could be used with them...
  66. ncbi request reprint TRAIL, caspases and maturation of normal and leukemic myeloid precursors
    Federica Corallini
    Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100, Ferrara, Italy
    Leuk Lymphoma 47:1459-68. 2006
    ..Moreover, the complex interplay among the signaling pathways triggered by TRAIL/TRAIL-receptors in myeloid cells is discussed in some detail...
  67. ncbi request reprint TRAIL and osteoprotegerin: a role in endothelial physiopathology?
    Federica Corallini
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Front Biosci 13:135-47. 2008
    ..Further studies are needed to address how the TRAIL/OPG interaction, their reciprocal balance and/or interplay affect vascular biology in order to design innovative therapeutic strategies in vascular diseases...
  68. ncbi request reprint The tumour necrosis factor-related apoptosis-inducing ligand-osteoprotegerin system in limited systemic sclerosis: a new disease marker?
    Gabriella Castellino
    Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Sant Anna, University of Ferrara, Corso della Giovecca, 203, 44100 Ferrara, Italy
    Rheumatology (Oxford) 49:1173-6. 2010
    ..To investigate the role of the TNF-related apoptosis-inducing ligand-osteoprotegerin (TRAIL-OPG) system in the pathogenesis of limited SSc (lSSc)...
  69. pmc Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults
    Stefano Volpato
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Via Savonarola, 9, I 44100 Ferrara, Italy
    Atherosclerosis 215:452-8. 2011
    ..We tested the hypothesis that TRAIL levels predict mortality in a population based sample of community dwelling men and women...
  70. doi request reprint MicroRNAs as new players in the genomic galaxy and disease puzzles
    Elisa Barbarotto
    Department of Morphology and Embryology, University of Ferrara, Ferrera, Italy
    Clin Transl Sci 1:50-6. 2008
    ..This review describes the role of miRNAs in human disease, methodology for evaluating miRNA gene expression, and the potential role of miRNAs as therapeutic agents and targets for the treatment of disease...
  71. pmc Potential prognostic significance of decreased serum levels of TRAIL after acute myocardial infarction
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    PLoS ONE 4:e4442. 2009
    ....
  72. pmc Cell-based therapies for diabetic complications
    Stella Bernardi
    Department of Morphology and Embriology and LTTA Centre, University of Ferrara, 44100 Ferrara, Italy
    Exp Diabetes Res 2012:872504. 2012
    ..We review the evidence supporting their use in this setting, the therapeutic benefits that these cells have shown so far as well as the challenges that cell-based therapies in diabetic complications put out...
  73. ncbi request reprint Human herpesvirus 7 infection impairs the survival/differentiation of megakaryocytic cells
    Arianna Gonelli
    Haematologica 87:1223-5. 2002
    ..These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis...
  74. pmc Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets
    Bianca Rocca
    Research Center on Physiopathology of Hemostasis, Catholic University of Rome, 00168 Rome, Italy
    Proc Natl Acad Sci U S A 99:7634-9. 2002
    ....
  75. ncbi request reprint IFN-alpha2b increases interleukin-10 expression in primary activated human CD8+ T cells
    Sabrina Curreli
    Institute of Human Virology, University of Maryland Biotechnology Institute and University of Maryland Medical Center, Baltimore, MD 21201, USA
    J Interferon Cytokine Res 22:1167-73. 2002
    ..Our data indicate that IFN-alpha promotes the development of a CD8(+) T cell population with enhanced anti-inflammatory activity, which may play a critical role in the regulation of a proper immune response...
  76. doi request reprint Soluble TRAIL does not impair the anti-osteoclastic activity of osteoprotegerin
    Giorgio Zauli
    J Cell Mol Med 12:1063-5. 2008
  77. ncbi request reprint TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors
    Giorgio Zauli
    Department of Biomedicine, University of Trieste, Trieste, Italy
    J Cell Physiol 214:117-25. 2008
    ..Taken together, our data strongly suggest that recombinant TRAIL inhibits osteoclastogenesis by inducing the ubiquitin-mediated degradation of p27(Kip1)...
  78. ncbi request reprint Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo
    Giorgio Zauli
    Department of Biomedicine, University of Trieste, Italy
    Blood 110:536-43. 2007
    ..Our data suggest that a pathological increase of OPG serum levels might play an important role in promoting leukocyte/endothelial cell adhesion...
  79. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sequentially upregulates nitric oxide and prostanoid production in primary human endothelial cells
    Giorgio Zauli
    Department of Normal Human Morphology, University of Trieste, Via Manzoni 16, 34138 Trieste
    Circ Res 92:732-40. 2003
    ..Because NO and prostanoids play a crucial role in the state of blood vessel vasodilatation and angiogenesis, our data suggest that TRAIL might play an important role in endothelial cell function...
  80. ncbi request reprint Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase
    Vittoria Cenni
    Laboratory of Cell Biology and Electron Microscopy, Rizzoli Orthopedic Institute, Via Di Barbiano 1 10, I 40136 Bologna, Italy
    Int J Oncol 25:1599-608. 2004
    ..Moreover, the discovery that multidrug resistant osteosarcomas are highly sensitive to TRAIL-induced apoptosis indicates TRAIL as a new candidate for the treatment of multidrug resistant bone malignancies...
  81. ncbi request reprint The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology
    Giorgio Zauli
    Department of Normal Human Morphology, University of Trieste, Via Manzoni 16, 34138 Trieste, Italy
    Cytokine Growth Factor Rev 17:245-57. 2006
    ....
  82. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF
    Giorgio Zauli
    Department of Normal Human Morphology, University of Trieste, Italy
    Blood 104:2044-50. 2004
    ..Thus, our data demonstrate that TRAIL blocks osteoclastic differentiation and suggest that inhibition of the p38/MAPK pathway by TRAIL likely plays an important role in this process...
  83. ncbi request reprint Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity
    Prisco Mirandola
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Parma, Ospedale Maggiore, Via Gramsci, 14, I 43100 Parma, Italy
    Blood 104:2418-24. 2004
    ..Thus, once activated the major cytotoxic effector cells are potentially sensitive to TRAIL but are physiologically protected from its apoptotic action by intracellular level of c-FLIP...
  84. ncbi request reprint MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway
    Giorgio Zauli
    Department of Biomedicine, University of Trieste, Trieste, Italy
    J Bone Miner Res 22:1621-30. 2007
    ..Moreover, repeated exposure to Nutlin-3 suppressed osteoclastic differentiation, without affecting cell survival at any culture time...
  85. ncbi request reprint Modulation of the expression and activity of cyclooxygenases in normal and accelerated erythropoiesis
    Bianca Rocca
    Departments of Internal Medicine, Catholic University School of Medicine, 00168 Rome, Italy
    Exp Hematol 32:925-34. 2004
    ..The present study was aimed at characterizing the expression and activity of cyclooxygenase (COX) isoenzymes in erythropoiesis...
  86. pmc TRAIL activates a caspase 9/7-dependent pathway in caspase 8/10-defective SK-N-SH neuroblastoma cells with two functional end points: induction of apoptosis and PGE2 release
    Giorgio Zauli
    Department of Human Normal Morphology, University of Trieste, Trieste 34138, Italy
    Neoplasia 5:457-66. 2003
    ..Finally, both induction of apoptosis and PGE2 release were completely abrogated by the broad caspase inhibitor z-VAD-fmk, suggesting that both biologic end points were regulated in SK-N-SH cells through a caspase 9/7-dependent pathway...
  87. doi request reprint The puzzling role of TRAIL in endothelial cell biology
    Paola Secchiero
    Arterioscler Thromb Vasc Biol 28:e4; author reply e5-6. 2008
  88. ncbi request reprint NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells
    Marco Vitale
    Institute of Human Anatomy, University of Parma, Ospedale Maggiore, Parma, Italy
    Anat Rec 266:87-92. 2002
    ....
  89. doi request reprint Potential involvement of TRAIL in Treg cell-mediated osteoclast suppression: comment on the article by Zaiss et al
    Giorgio Zauli
    Arthritis Rheum 58:1887; author reply 1887-8. 2008