K E Sears

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Development of bat flight: morphologic and molecular evolution of bat wing digits
    Karen E Sears
    Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:6581-6. 2006
  2. ncbi Constraints on the morphological evolution of marsupial shoulder girdles
    Karen E Sears
    Committee on Evolutionary Biology, University of Chicago, Chicago, Illinois 60637, USA
    Evolution 58:2353-70. 2004
  3. ncbi Role of development in the evolution of the scapula of the giant sthenurine kangaroos (Macropodidae: Sthenurinae)
    Karen E Sears
    Division of Developmental Biology, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Morphol 265:226-36. 2005
  4. ncbi Molecular determinants of bat wing development
    K E Sears
    Howard Hughes Medical Institute, Pediatrics Department, University of Colorado at Denver, Denver, USA
    Cells Tissues Organs 187:6-12. 2008
  5. ncbi The evolutionary and developmental basis of parallel reduction in mammalian zeugopod elements
    Karen E Sears
    Howard Hughes Medical Institute, Section of Developmental Biology, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Am Nat 169:105-17. 2007
  6. ncbi The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora
    K E Sears
    Pediatrics Department, Howard Hughes Medical Institute, University of Colorado at Denver and Health Sciences Center, 12800 East, 19th Avenue, Aurora, CO 80045, USA
    Evol Dev 9:555-65. 2007

Research Grants

  1. Genetic and Morphologic Basis of Bat Wing Development
    KAREN SEARS; Fiscal Year: 2007

Detail Information

Publications6

  1. ncbi Development of bat flight: morphologic and molecular evolution of bat wing digits
    Karen E Sears
    Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:6581-6. 2006
    ..Together, our results suggest that an up-regulation of the Bmp pathway is one of the major factors in the developmental elongation of bat forelimb digits, and it is potentially a key mechanism in their evolutionary elongation as well...
  2. ncbi Constraints on the morphological evolution of marsupial shoulder girdles
    Karen E Sears
    Committee on Evolutionary Biology, University of Chicago, Chicago, Illinois 60637, USA
    Evolution 58:2353-70. 2004
    ....
  3. ncbi Role of development in the evolution of the scapula of the giant sthenurine kangaroos (Macropodidae: Sthenurinae)
    Karen E Sears
    Division of Developmental Biology, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Morphol 265:226-36. 2005
    ..e., sthenurine evolutionary history) suggests that pedomorphic shifts in morphology, most likely due to neotenic processes, occurred within the development of the scapula of giant sthenurines...
  4. ncbi Molecular determinants of bat wing development
    K E Sears
    Howard Hughes Medical Institute, Pediatrics Department, University of Colorado at Denver, Denver, USA
    Cells Tissues Organs 187:6-12. 2008
    ..Thus, bats can be added to the growing list of groups in which expression changes in key developmental genes have been linked to the evolution of morphological innovations (e.g. early bilaterians, cetaceans, insects)...
  5. ncbi The evolutionary and developmental basis of parallel reduction in mammalian zeugopod elements
    Karen E Sears
    Howard Hughes Medical Institute, Section of Developmental Biology, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Am Nat 169:105-17. 2007
    ..However, our findings also suggest that the developmental mechanisms behind the parallel evolution of other, more taxon-specific characteristics of limb reduction (i.e., element fusion) are not conserved...
  6. ncbi The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora
    K E Sears
    Pediatrics Department, Howard Hughes Medical Institute, University of Colorado at Denver and Health Sciences Center, 12800 East, 19th Avenue, Aurora, CO 80045, USA
    Evol Dev 9:555-65. 2007
    ....

Research Grants1

  1. Genetic and Morphologic Basis of Bat Wing Development
    KAREN SEARS; Fiscal Year: 2007
    ..In addition, understanding the normal roles of genes that also play a role in abnormal developmental events such as cancer (i.e., Ihh and BMP) will provide a knowledge base for additional healthcare-related biomedical research. ..