DOROTHY D SEARS

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice
    Justin Chapman
    Pfizer Inc, San Diego, California, United States of America
    PLoS ONE 5:e13959. 2010
  2. ncbi The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes
    Dorothy Sears Worrall
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    Mol Endocrinol 16:378-89. 2002
  3. pmc Selective modulation of promoter recruitment and transcriptional activity of PPARgamma
    DOROTHY D SEARS
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC0673, La Jolla, CA 92093, USA
    Biochem Biophys Res Commun 364:515-21. 2007
  4. pmc 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice
    DOROTHY D SEARS
    Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 4:e7250. 2009
  5. pmc Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
    D D Sears
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:18745-50. 2009
  6. pmc Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats
    Gene Hsiao
    Department of Bioengineering, University of California, San Diego, CA, USA
    Am J Physiol Endocrinol Metab 300:E164-74. 2011
  7. pmc Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity
    Pingping Li
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 147:815-26. 2011
  8. pmc FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes
    WuQiang Fan
    Division of Endocrinology Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:12188-97. 2009
  9. pmc PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization
    Shigeki Sugii
    Gene Expression Laboratory, Howard Hughes Medical Institute and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:22504-9. 2009
  10. pmc Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice
    Pingping Li
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0673, USA
    J Biol Chem 285:15333-45. 2010

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice
    Justin Chapman
    Pfizer Inc, San Diego, California, United States of America
    PLoS ONE 5:e13959. 2010
    ..The cellular components and mechanisms that regulate the onset of diet-induced insulin resistance are not clearly defined...
  2. ncbi The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes
    Dorothy Sears Worrall
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    Mol Endocrinol 16:378-89. 2002
    ....
  3. pmc Selective modulation of promoter recruitment and transcriptional activity of PPARgamma
    DOROTHY D SEARS
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC0673, La Jolla, CA 92093, USA
    Biochem Biophys Res Commun 364:515-21. 2007
    ..Selective modulation of PPARgamma by TZDs resulted in distinct expression profiles and transcription kinetics which may be due to differential promoter activation and chromatin remodeling of target genes...
  4. pmc 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice
    DOROTHY D SEARS
    Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 4:e7250. 2009
    ..Thus, we tested the hypothesis that 12/15LO is involved in the onset of high fat diet (HFD)-induced insulin resistance...
  5. pmc Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
    D D Sears
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:18745-50. 2009
    ..We have uniquely characterized coordinated cellular and tissue functional pathways that are characteristic of insulin resistance, TZD-induced insulin sensitization, and potential TZD responsiveness...
  6. pmc Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats
    Gene Hsiao
    Department of Bioengineering, University of California, San Diego, CA, USA
    Am J Physiol Endocrinol Metab 300:E164-74. 2011
    ..Other PPARγ ligand treatment-induced functional pathway changes were detected in adipose tissue, skeletal muscle, and liver profiles but were not related to degree of insulin sensitization...
  7. pmc Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity
    Pingping Li
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 147:815-26. 2011
    ....
  8. pmc FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes
    WuQiang Fan
    Division of Endocrinology Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:12188-97. 2009
    ....
  9. pmc PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization
    Shigeki Sugii
    Gene Expression Laboratory, Howard Hughes Medical Institute and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:22504-9. 2009
    ....
  10. pmc Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice
    Pingping Li
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0673, USA
    J Biol Chem 285:15333-45. 2010
    ....
  11. ncbi Fat-induced inflammation unchecked
    Olivia Osborn
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 12:553-4. 2010
    ..2010) show that by inhibiting lipoprotein lipase (LPL) activity in mesenteric lymph nodes, Angiopoietin-like protein 4 (Angptl4) protects resident macrophages from dietary saturated fatty acid (SFA)-induced inflammation...

Research Grants1

  1. IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    DOROTHY SEARS; Fiscal Year: 2004
    ..abstract_text> ..