D R Seals

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Blood pressure reductions with exercise and sodium restriction in postmenopausal women with elevated systolic pressure: role of arterial stiffness
    D R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    J Am Coll Cardiol 38:506-13. 2001
  2. pmc Human ageing and the sympathoadrenal system
    D R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 528:407-17. 2000
  3. ncbi request reprint Habitual exercise and the age-associated decline in large artery compliance
    Douglas R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Exerc Sport Sci Rev 31:68-72. 2003
  4. ncbi request reprint Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly
    D R Seals
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
    Am J Physiol 277:H947-55. 1999
  5. pmc Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men
    K D Monahan
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 529:263-71. 2000
  6. ncbi request reprint Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women
    H Tanaka
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado, Boulder 80309, Colorado 80262, USA
    J Appl Physiol 83:1947-53. 1997
  7. ncbi request reprint High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men
    Kristen L Jablonski
    Dept of Integrative Physiology, Univ of Colorado, Boulder, CO 80309, USA
    J Appl Physiol 103:1715-21. 2007
  8. ncbi request reprint Aging, habitual exercise, and dynamic arterial compliance
    H Tanaka
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    Circulation 102:1270-5. 2000
  9. ncbi request reprint Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults
    C Bell
    Department of Kinesiology and Applied Physiology University of Colorado, Boulder, Colorado 80309, USA
    J Clin Endocrinol Metab 86:4440-4. 2001
  10. ncbi request reprint Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance
    K D Monahan
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309, USA
    Am J Physiol Heart Circ Physiol 281:H284-9. 2001

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Blood pressure reductions with exercise and sodium restriction in postmenopausal women with elevated systolic pressure: role of arterial stiffness
    D R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    J Am Coll Cardiol 38:506-13. 2001
    ....
  2. pmc Human ageing and the sympathoadrenal system
    D R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 528:407-17. 2000
    ..These changes in sympathoadrenal function with advancing age may have a number of important physiological and pathophysiological consequences for human health and disease...
  3. ncbi request reprint Habitual exercise and the age-associated decline in large artery compliance
    Douglas R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Exerc Sport Sci Rev 31:68-72. 2003
    ..Recent findings indicate that regular aerobic exercise may favorably modulate age-associated decreases in central arterial compliance and the related adverse physiological and pathophysiological consequences...
  4. ncbi request reprint Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly
    D R Seals
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
    Am J Physiol 277:H947-55. 1999
    ..This appears to be related to the absence of age-associated increases in abdominal adiposity and arterial stiffness in the exercising women...
  5. pmc Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men
    K D Monahan
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 529:263-71. 2000
    ....
  6. ncbi request reprint Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women
    H Tanaka
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado, Boulder 80309, Colorado 80262, USA
    J Appl Physiol 83:1947-53. 1997
    ..This difference does not appear to be related to age-associated changes in maximal heart rate, body composition, or training factors...
  7. ncbi request reprint High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men
    Kristen L Jablonski
    Dept of Integrative Physiology, Univ of Colorado, Boulder, CO 80309, USA
    J Appl Physiol 103:1715-21. 2007
    ..These results support the hypothesis that oxidative stress plays a major role in the reduced resting whole leg blood flow and increased leg vasoconstriction observed with aging in men...
  8. ncbi request reprint Aging, habitual exercise, and dynamic arterial compliance
    H Tanaka
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    Circulation 102:1270-5. 2000
    ..A reduction in compliance of the large-sized cardiothoracic (central) arteries is an independent risk factor for the development of cardiovascular disease with advancing age...
  9. ncbi request reprint Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults
    C Bell
    Department of Kinesiology and Applied Physiology University of Colorado, Boulder, Colorado 80309, USA
    J Clin Endocrinol Metab 86:4440-4. 2001
    ..These results provide experimental support for the hypothesis that aging, sedentary living, and female sex are associated with attenuated sympathetic nervous system support of resting metabolic rate in healthy adult humans...
  10. ncbi request reprint Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance
    K D Monahan
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309, USA
    Am J Physiol Heart Circ Physiol 281:H284-9. 2001
    ..72; P < 0.01). We conclude that reduced carotid artery compliance may play an important mechanistic role in age-associated decrease in cardiovagal BRS in healthy sedentary humans...
  11. ncbi request reprint Cardiovascular, plasma norepinephrine, and thermal adjustments to prolonged exercise in young and older healthy humans
    K P Davy
    Department of Kinesiology, University of Colorado, Boulder 80309, USA
    Clin Physiol 15:169-81. 1995
    ....
  12. ncbi request reprint Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
    C A DeSouza
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Circulation 102:1351-7. 2000
    ..We determined the influence of regular aerobic exercise on the age-related decline in endothelium-dependent vasodilation...
  13. pmc Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects
    F A Dinenno
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 531:573-9. 2001
    ....
  14. ncbi request reprint Elevated heart rate variability in physically active postmenopausal women: a cardioprotective effect?
    K P Davy
    Department of Kinesiology, University of Colorado, Boulder 80309, USA
    Am J Physiol 271:H455-60. 1996
    ..Our findings may provide insight into a possible cardioprotective mechanism in physically active postmenopausal women...
  15. pmc Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults
    Ashley E Walker
    Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309, USA
    Hypertension 55:363-9. 2010
    ....
  16. pmc Cardiopulmonary baroreflex inhibition of sympathetic nerve activity is preserved with age in healthy humans
    H Tanaka
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309
    J Physiol 515:249-54. 1999
    ..As such, these findings are not consistent with the concept that this mechanism plays a role in the age-associated elevation in basal MSNA...
  17. pmc Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men
    F A Dinenno
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 534:287-95. 2001
    ..This adaptive process is produced by even a moderate training stimulus, is not obviously dependent on corresponding improvements in risk factors for atherosclerosis, and is robust, occurring in healthy men of different ages...
  18. ncbi request reprint Absence of age-related increase in central arterial stiffness in physically active women
    H Tanaka
    Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado at Boulder, 80309 0354, USA
    Arterioscler Thromb Vasc Biol 18:127-32. 1998
    ....
  19. ncbi request reprint The aging cardiovascular system: changes in autonomic function at rest and in response to exercise
    D R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Int J Sport Nutr Exerc Metab 11:S189-95. 2001
    ..Thus, regular aerobic (endurance) exercise modulates selective age-associated impairments in autonomic nervous system-physiological function...
  20. ncbi request reprint Adiposity and regional body fat distribution in physically active young and middle-aged women
    K P Davy
    Department of Kinesiology, University of Colorado, Boulder 80309, USA
    Int J Obes Relat Metab Disord 20:777-83. 1996
    ..To test the hypothesis that age does not directly influence body composition or regional body fat distribution throughout middle age in women...
  21. pmc Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase
    Jessica R Durrant
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    J Physiol 587:3271-85. 2009
    ..Increased eNOS protein and activation also may contribute to exercise-mediated preservation of NO bioavailability and EDD with ageing...
  22. doi request reprint Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, U S A
    Clin Sci (Lond) 120:13-23. 2011
    ..Some post-menopausal women without CVD may be less responsive to habitual aerobic exercise than MA/O men...
  23. ncbi request reprint Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity
    K D Monahan
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Denver, USA
    Circulation 104:1627-32. 2001
    ..70). Conclusions- These results demonstrate that age- and habitual exercise-related differences in cardiovagal BRS are associated with corresponding differences in carotid artery compliance among healthy men...
  24. ncbi request reprint Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men
    H Tanaka
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Colorado, USA
    Arterioscler Thromb Vasc Biol 21:82-7. 2001
    ..These results support the hypothesis that chronic increases in local distending pressure may be an important mechanism in the wall thickening that occurs with human aging in central elastic arteries...
  25. ncbi request reprint Hemodynamic sequelae of age-related increases in arterial stiffness in healthy women
    H Tanaka
    Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    Am J Cardiol 82:1152-5, A10. 1998
    ....
  26. ncbi request reprint Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men
    Iratxe Eskurza
    Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
    Am J Physiol Heart Circ Physiol 286:H1528-34. 2004
    ..mediated by ascorbic acid-sensitive oxidative stress (infusion experiments) and 2). affected by short-term, moderate daily ascorbic acid (vitamin C) supplementation...
  27. ncbi request reprint Plasma fibrinogen levels in healthy postmenopausal women: physical activity and hormone replacement status
    C A DeSouza
    Department of Kinesiology, University of Colorado, Boulder, USA
    J Gerontol A Biol Sci Med Sci 52:M294-8. 1997
    ....
  28. ncbi request reprint Age-related decline in RMR in physically active men: relation to exercise volume and energy intake
    R E Van Pelt
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
    Am J Physiol Endocrinol Metab 281:E633-9. 2001
    ....
  29. ncbi request reprint Regular walking increases peak limb vasodilatory capacity of older hypertensive humans: implications for arterial structure
    H Tanaka
    Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado at Boulder, 80309 0354, USA
    J Hypertens 16:423-8. 1998
    ..Although regular aerobic exercise has been shown to lower arterial blood pressure in older adult humans with essential hypertension, the mechanisms responsible for this hypotensive effect remain largely unknown...
  30. ncbi request reprint Smaller age-associated reductions in leg venous compliance in endurance exercise-trained men
    K D Monahan
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Am J Physiol Heart Circ Physiol 281:H1267-73. 2001
    ..01). These data indicate that calf venous compliance is reduced with age in sedentary and endurance-trained men, but compliance is better preserved in endurance-trained men...
  31. ncbi request reprint Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age
    K P Davy
    Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado at Boulder, USA
    Hypertension 32:298-304. 1998
    ..However, the reflex-mediated increases in limb vascular resistance during hypovolemia are smaller in older adults because of attenuated vasoconstrictor responsiveness to sympathetic stimulation...
  32. ncbi request reprint Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
    Phillip E Gates
    Department of Integrative Physiology, 354 UCB, Univ of Colorado, Boulder, CO 80309, USA
    J Appl Physiol 102:63-71. 2007
    ....
  33. pmc Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate
    Demetra D Christou
    Department of Intergrative Physiology, University of Colorado, Boulder, Colorado, USA
    J Appl Physiol 105:24-9. 2008
    ..Our findings indicate that, together, reductions in HR(int) and chronotropic responsiveness to beta-adrenergic stimulation largely explain decreases in HR(max) with aging, with the reduction in HR(int) playing by far the greatest role...
  34. pmc Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins
    Annemarie E Silver
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    J Vasc Res 47:1-8. 2010
    ..Thus, EC collected from peripheral veins may provide a useful surrogate for EC obtained from arteries for measurements of EC protein expression in humans...
  35. pmc Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing
    Iratxe Eskurza
    Department of Integrative Physiology, University of Colorado at Boulder, UCB 354, Boulder, CO 80309, USA
    J Physiol 556:315-24. 2004
    ....
  36. ncbi request reprint Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women
    C A DeSouza
    Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado, Boulder 80309, USA
    Arterioscler Thromb Vasc Biol 18:362-8. 1998
    ..Future studies need to determine whether women who are moderately active would demonstrate the same favorable hemostatic profile...
  37. ncbi request reprint Arterial stiffness and hormone replacement use in healthy postmenopausal women
    H Tanaka
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, University of Colorado at Boulder, Denver, USA
    J Gerontol A Biol Sci Med Sci 53:M344-6. 1998
    ..Arterial stiffness has been shown to be positively related to cardiovascular disease risk. Little, however, is known about the influence of hormone replacement use on arterial stiffness in females...
  38. ncbi request reprint Direct evidence for tonic sympathetic support of resting metabolic rate in healthy adult humans
    M B Monroe
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Am J Physiol Endocrinol Metab 280:E740-4. 2001
    ..38, P = 0.05; r = 0.44, P = 0.02, respectively). These findings provide direct evidence for the concept of tonic sympathetic beta-adrenergic support of RMR in healthy nonobese adults...
  39. ncbi request reprint Altered autonomic support of arterial blood pressure with age in healthy men
    P P Jones
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, USA
    Circulation 104:2424-9. 2001
    ..We tested the hypothesis that ANS support of BP is altered in healthy older humans...
  40. ncbi request reprint Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men
    Hirofumi Tanaka
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Appl Physiol 92:1458-64. 2002
    ..This lack of effect on carotid IMT may be due to the apparent inability of habitual exercise to prevent or reduce the age-associated elevation in carotid distending pressure...
  41. ncbi request reprint Oxidative stress explains differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women
    Kerrie L Moreau
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80262, USA
    Menopause 13:951-8. 2006
    ..To determine whether oxidative stress contributes to differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women...
  42. pmc Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise
    Ashley E Walker
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA
    Am J Hypertens 22:250-6. 2009
    ..The purpose of this study was to determine whether circulating LDL-C within the "normal" range modulates EDD in healthy older adults and whether young age or habitual aerobic exercise protects against this adverse effect...
  43. ncbi request reprint Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women
    Kerrie L Moreau
    Dept of Integrative Physiology, University of Colorado, Boulder, CO, USA
    J Appl Physiol 102:890-5. 2007
    ..This oxidative stress-related suppression of leg vascular conductance and blood flow may be linked in part to increased total and abdominal adiposity...
  44. pmc Thermogenic responsiveness to beta-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress
    Christopher Bell
    Department of Integrative Physiology, University of Colorado, Boulder, CO, USA
    J Physiol 570:629-35. 2006
    ..Our findings advance a novel mechanism by which habitual physical activity may modulate EE in humans, with potential implications for energy balance and body weight control...
  45. ncbi request reprint Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food
    Pamela Parker Jones
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    J Clin Endocrinol Metab 89:5138-44. 2004
    ..Differences in beta-adrenergic responsiveness to postprandial sympathoadrenal stimulation and/or nonsympathetic adrenergic influences likely explain the age- and habitual exercise-related differences in TEF...
  46. ncbi request reprint Age-predicted maximal heart rate revisited
    H Tanaka
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    J Am Coll Cardiol 37:153-6. 2001
    ..We sought to determine a generalized equation for predicting maximal heart rate (HRmax) in healthy adults...
  47. ncbi request reprint Maximal aerobic capacity across age in healthy Hispanic and Caucasian women
    B C Schiller
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309, USA
    J Appl Physiol 91:1048-54. 2001
    ..Thus it does not appear that Hispanic ethnicity per se modulates maximal aerobic capacity in this population...
  48. pmc Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing
    Iratxe Eskurza
    Department of Integrative Physiology, University of Colorado at Boulder, UCB 354, Boulder, CO 80309, USA
    J Physiol 571:661-8. 2006
    ..49). We conclude that XO does not contribute to oxidative stress-associated reductions in peripheral conduit artery EDD with ageing in humans, possibly due to an absence of age-associated up-regulation of endothelial XO...
  49. pmc Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction
    F A Dinenno
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
    J Physiol 536:977-83. 2001
    ..This may have important physiological and pathophysiological implications for the ageing human...
  50. ncbi request reprint Thermogenic responsiveness to nonspecific beta-adrenergic stimulation is not related to genetic variation in codon 16 of the beta2-adrenergic receptor
    Christopher Bell
    Department of Integrative Physiology, University of Colorado, Boulder, USA
    Am J Physiol Endocrinol Metab 290:E703-7. 2006
    ..This may be explained in part by a lack of association between this gene variant and tonic SNS activity...
  51. pmc Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults
    Iratxe Eskurza
    Department of Integrative Physiology, University of Colorado at Boulder, UCB 354, Boulder, CO 80309, USA
    J Physiol 568:1057-65. 2005
    ..These results suggest that BH4 bioactivity may be a key mechanism involved in the impairment of conduit artery EDD with sedentary ageing, and the EDD-preserving effect of habitual exercise...
  52. ncbi request reprint Modulatory influences on ageing of the vasculature in healthy humans
    Douglas R Seals
    Department of Integrative Physiology, University of Colorado, 354 UCB, Boulder, CO 80309, USA
    Exp Gerontol 41:501-7. 2006
    ..Of these, the existing evidence indicates that habitual aerobic exercise may be the single most important modulatory influence...
  53. ncbi request reprint Aortic input impedance increases with age in healthy men and women
    Luciano Mazzaro
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Hypertension 45:1101-6. 2005
    ..We conclude that aortic input impedance increases with advancing age in healthy men and women. This increase in aortic input impedance may be an important mechanism by which age increases the risk of cardiovascular disease in humans...
  54. ncbi request reprint Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women
    Kerrie L Moreau
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, Colorado, USA
    Eur J Cardiovasc Prev Rehabil 13:805-11. 2006
    ..Femoral artery intima-media thickness (IMT), an independent predictor of atherosclerotic disease risk, increases with age in sedentary adults. It is not known whether regular aerobic exercise modulates femoral IMT with ageing...
  55. pmc A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise
    Angela Bryan
    University of Colorado at Boulder, Department of Psychology, Boulder, CO 80309 0345, USA
    Health Psychol 26:30-9. 2007
    ..1995). The authors' objective was to test a transdisciplinary model of the ways in which genetic variants, physiological factors, and psychological factors are thought to influence exercise with 64 healthy, regular exercisers...
  56. pmc Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise
    Bradley S Fleenor
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    J Physiol 588:3971-82. 2010
    ..Adventitial TGF-β1-related oxidative stress may play a key role in collagen deposition and large elastic artery stiffening with ageing and the efficacious effects of voluntary aerobic exercise...
  57. pmc Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure
    Kristen L Jablonski
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA
    Ther Adv Cardiovasc Dis 3:347-56. 2009
    ..We tested the hypothesis that vascular endothelial function is related to dietary sodium intake among middle-aged and older adults (MA and O) with elevated systolic BP...
  58. pmc Habitual exercise and vascular ageing
    Douglas R Seals
    University of Colorado, 354 UCB, Boulder, CO 80309, USA
    J Physiol 587:5541-9. 2009
    ..Aerobic exercise also may protect arteries with ageing by increasing resistance to the effects of other CVD risk factors like LDL-cholesterol. Habitual aerobic exercise is an effective strategy to combat arterial ageing...
  59. pmc Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase
    Anthony J Donato
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Am J Physiol Heart Circ Physiol 297:H425-32. 2009
    ..Neither eNOS nor PeNOS is reduced with aging. Changes in ET-1 expression and bioactivity, but not eNOS, contribute to vascular endothelial dysfunction with aging...
  60. pmc Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    Circulation 119:1284-92. 2009
    ..We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans...
  61. pmc B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging
    Lisa A Lesniewski
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    J Gerontol A Biol Sci Med Sci 64:9-20. 2009
    ..04). Our results provide the first comprehensive evidence that B6D2F1 mice are a useful model for investigating mechanisms of reduced nitric oxide-dependent, oxidative stress-associated EDD and increased arterial stiffness with aging...
  62. pmc Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans
    Anthony J Donato
    Department of Integrative Physiology, Universty of Colorado at Boulder, 354 UCB, Boulder, CO 80309, USA
    J Appl Physiol 105:1359-63. 2008
    ..These results provide the first support for the concept that increased CYP 2C9 signaling does not contribute to impairments in EDD with aging in healthy adults...
  63. pmc Habitual exercise and arterial aging
    Douglas R Seals
    Department of Integrative Physiology, University of Colorado, 354 UCB, Boulder, CO 80309, USA
    J Appl Physiol 105:1323-32. 2008
    ..Habitual exercise favorably modulates several expressions of arterial aging, thus preserving vascular function and possibly reducing the risk of CVD...
  64. pmc Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults
    Gary L Pierce
    Department of Integrative Physiology, UCB 354, University of Colorado, Boulder, CO 80309, USA
    Hypertension 52:72-9. 2008
    ..The improvements in resistance artery function are mediated by an increase in NO bioavailability and are related to reductions in abdominal visceral fat...
  65. pmc Aging and vascular endothelial function in humans
    Douglas R Seals
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Clin Sci (Lond) 120:357-75. 2011
    ..Given the number of older adults now and in the future, more information is needed on effective strategies for the prevention and treatment of vascular endothelial aging...
  66. ncbi request reprint Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB
    Anthony J Donato
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Circ Res 100:1659-66. 2007
    ..Increased expression of NAD(P)H oxidase and nuclear factor-kappaB may contribute to endothelial oxidative stress with aging in humans...
  67. ncbi request reprint Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women
    Kerrie L Moreau
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309 0354, USA
    Hypertension 45:1107-12. 2005
    ..Increased abdominal fat storage, sympathetic nervous system activity, and LDL cholesterol may be mechanistically involved in oxidative stress-associated suppression of arterial compliance in postmenopausal women...
  68. ncbi request reprint Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men
    Demetra D Christou
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Circulation 111:1904-14. 2005
    ..We sought to determine whether fatness or fitness better predicted traditional CVD risk factors in men with broad fatness, aerobic fitness, and age ranges using 3 expressions of adiposity...
  69. ncbi request reprint Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men
    Demetra D Christou
    Department of Integrative Physiology, University of Colorado at Boulder, 354 UCB, Boulder, CO 80309, USA
    Circulation 111:494-8. 2005
    ..Short-term and tonic regulation of arterial blood pressure (BP) differ in premenopausal women and men of similar age. The autonomic nervous system (ANS) plays a critical role in BP regulation...
  70. pmc Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
    Anthony J Donato
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309, USA
    Aging Cell 7:805-12. 2008
    ....
  71. ncbi request reprint Decline in insulin action with age in endurance-trained humans
    Christopher M Clevenger
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    J Appl Physiol 93:2105-11. 2002
    ..Moreover, the age-related reduction in ISI in endurance-trained adults appears to be independent of adiposity...
  72. ncbi request reprint Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men
    Annemarie E Pimentel
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309, USA
    J Appl Physiol 94:2406-13. 2003
    ..84, P < 0.0001). We conclude that the rate of decline in maximal aerobic capacity during middle and older age is greater in endurance-trained men than in their sedentary peers and is associated with a marked decline in O(2) pulse...
  73. ncbi request reprint Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men
    Phillip E Gates
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309, USA
    J Clin Endocrinol Metab 88:4884-90. 2003
    ..We conclude that increasing adiposity contributes to the LV remodeling/reduced diastolic function that occurs with aging in healthy men...
  74. ncbi request reprint Use of acetylene breathing to determine cardiac output in young and older adults
    Christopher Bell
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309 0354, USA
    Med Sci Sports Exerc 35:58-64. 2003
    ..to compare estimates of Q(c) from open-circuit acetylene breathing with estimates of Q(c) from previously established closed-circuit acetylene rebreathing...
  75. pmc Basal leg blood flow in healthy women is related to age and hormone replacement therapy status
    Kerrie L Moreau
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 547:309-16. 2003
    ..In contrast to men, differences in leg sympathetic vasoconstrictor nerve activity do not explain group differences in leg blood flow and vascular conductance with ageing in women...
  76. ncbi request reprint Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women
    Kerrie L Moreau
    Department of Kinesiology and Applied Physiology, 354 UCB, University of Colorado at Boulder, 80309 0354, USA
    Cardiovasc Res 57:861-8. 2003
    ..We determined the effects of regular aerobic exercise, hormone replacement therapy (HRT), and their interaction on carotid arterial compliance using a combination of cross-sectional and intervention study designs...
  77. ncbi request reprint Baroreflex buffering in sedentary and endurance exercise-trained healthy men
    Demetra D Christou
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, UCB 354, Boulder, Colo 80309, USA
    Hypertension 41:1219-22. 2003
    ..These results support the concept that habitual vigorous endurance exercise does not modulate in vivo baroreflex buffering in healthy humans...
  78. ncbi request reprint Arterial intima-media thickness: site-specific associations with HRT and habitual exercise
    Kerrie L Moreau
    Department of Kinesiology and Applied Physiology University of Colorado at Boulder, Colorado 80309, USA
    Am J Physiol Heart Circ Physiol 283:H1409-17. 2002
    ....
  79. ncbi request reprint Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness
    Phillip E Gates
    Human Cardiovascular Research Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Eur Heart J 24:2213-20. 2003
    ..We sought to determine if attenuation of the age-associated increase in arterial stiffness by habitual aerobic-endurance exercise would have corresponding effects on left ventricular (LV) structure and diastolic function...
  80. ncbi request reprint Chronic sympathetic activation: consequence and cause of age-associated obesity?
    Douglas R Seals
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA
    Diabetes 53:276-84. 2004
    ....
  81. ncbi request reprint Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults
    Christopher Bell
    Department of Integrative Physiology, 354UCB, Univ of Colorado, Boulder, CO 80309 0354, USA
    J Appl Physiol 98:845-9. 2005
    ..9; young chronic = 19.1 +/- 0.8; older acute = 16.2 +/- 1.1; older chronic = 16.6 +/- 1.4 l/min) was changed. These data suggest that ascorbic acid administration does not affect the age-associated reduction in Q(max) and Vo(2max)...
  82. ncbi request reprint Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging
    Douglas R Seals
    Dept of Integrative Physiology, Univ of Colorado, 354 UCB, Boulder, CO 80309, USA
    Am J Physiol Heart Circ Physiol 287:H1895-905. 2004
    ....
  83. ncbi request reprint High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults
    Christopher Bell
    Department of Integrative Physiology, 354UCB, University of Colorado, Boulder, CO 80309 0354, USA
    J Clin Endocrinol Metab 89:3573-8. 2004
    ..Maintenance of high energy flux via regular exercise may be an effective strategy for maintaining energy expenditure and preventing age-associated obesity...
  84. pmc Is autonomic support of arterial blood pressure related to habitual exercise status in healthy men?
    Pamela Parker Jones
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 540:701-6. 2002
    ..Basal sympathetic nervous system (SNS) activity and alpha-adrenergic vascular sensitivity are significant physiological correlates of ANS support of BP in this population...
  85. ncbi request reprint Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging
    Demetra D Christou
    Dept of Integrative Physiology, University of Colorado at Boulder, UCB 354, Boulder, CO 80309, USA
    Am J Physiol Heart Circ Physiol 287:H1530-7. 2004
    ..These results may help explain how changes in body fat distribution with advancing age are linked to impairments in circulatory control...
  86. ncbi request reprint Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension
    Phillip E Gates
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Hypertension 44:35-41. 2004
    ..These improvements in central arterial compliance appear to be a key mechanism in the rapid normalization of SBP by sodium restriction in these patients...
  87. ncbi request reprint Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans
    Christopher Bell
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    J Clin Endocrinol Metab 88:4950-4. 2003
    ..These results indicate that increased oxidative stress: 1) is not a mechanism contributing to decreases in RMR with primary aging; and 2) does not modulate MSNA in healthy adult humans...
  88. ncbi request reprint Baroreflex buffering is reduced with age in healthy men
    Pamela Parker Jones
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, UCB 354, Boulder, CO 80309, USA
    Circulation 107:1770-4. 2003
    ..Baroreflex buffering is an important mechanism in arterial blood pressure control. The effect of healthy (physiological) aging on tonic baroreflex buffering in humans is unknown...
  89. ncbi request reprint Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension
    C A DeSouza
    Department of Kinesiology, University of Colorado, Boulder 80309, USA
    Am J Hypertens 10:1335-41. 1997
    ..004) and systolic blood pressure (r = 0.43, P = .05). The results of this study support the hypothesis that circulating levels of soluble cell adhesion molecules are elevated in older men with uncomplicated essential hypertension...
  90. ncbi request reprint Age and gender interactions in physiological functional capacity: insight from swimming performance
    H Tanaka
    Department of Kinesiology, University of Colorado, Boulder 80309, USA
    J Appl Physiol 82:846-51. 1997
    ..Moreover, the rate of decline with advancing age appears to be associated with event duration and gender...
  91. ncbi request reprint Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress
    Annemarie E Silver
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Circulation 115:627-37. 2007
    ..Obesity may alter vascular endothelial cell protein expression (VECPE) of molecules that influence susceptibility to atherosclerosis...
  92. ncbi request reprint Thermic effect of food and beta-adrenergic thermogenic responsiveness in habitually exercising and sedentary healthy adult humans
    Nicole R Stob
    Department of Integrative Physiology, University of Colorado, Boulder, CO, USA
    J Appl Physiol 103:616-22. 2007
    ..Our results also suggest that peripheral thermogenic responsiveness to beta-AR stimulation is a physiological determinant of TEF and hence energy balance in healthy adult humans...
  93. ncbi request reprint Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density
    Nicole R Stob
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309 0354, USA
    Exp Physiol 92:823-30. 2007
    ..06, P = 0.76). These findings indicate that increased beta(2)-AR density is not a mechanism contributing to the greater thermogenic responsiveness to beta-AR stimulation in adult humans who regularly perform aerobic exercise...
  94. pmc Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity
    Thomas J Larocca
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Mech Ageing Dev 131:165-7. 2010
    ..This may represent a novel molecular mechanism underlying the "anti-aging" effects of maintaining high aerobic fitness...
  95. ncbi request reprint Manuscript peer review: a helpful checklist for students and novice referees
    D R Seals
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder 80309, USA
    Adv Physiol Educ 23:52-8. 2000
    ..In this article we present these guidelines in the hope that they will serve as a helpful resource for students and other novice reviewers when critiquing scientific manuscripts...
  96. ncbi request reprint Influence of adiposity on tonic sympathetic support of resting metabolism in healthy adults
    C Bell
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Int J Obes Relat Metab Disord 27:1315-8. 2003
    ..Total and abdominal adiposity and/or body fat pattern modulate some SNS-mediated physiological functions...
  97. ncbi request reprint Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up
    Iratxe Eskurza
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder 80309, USA
    J Appl Physiol 92:2303-8. 2002
    ..Endurance-trained women who maintain or increase training volume demonstrated age-associated declines in maximal aerobic capacity not different from healthy sedentary women...
  98. ncbi request reprint Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance
    Anthony J Donato
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309, USA
    J Appl Physiol 94:764-9. 2003
    ....
  99. ncbi request reprint The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover
    Murray Esler
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 282:R909-16. 2002
    ....
  100. ncbi request reprint Cardiac vagal modulation of heart rate during prolonged submaximal exercise in animals with healed myocardial infarctions: effects of training
    Monica Kukielka
    Dept of Physiology, The Ohio State University, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 290:H1680-5. 2006
    ..Furthermore, exercise training attenuated these exercise-induced reductions in heart rate variability, suggesting maintenance of a higher cardiac vagal activity during exercise in the trained state...
  101. ncbi request reprint Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress
    Murray Esler
    Baker Medical Research Institute, Melbourne, Australia
    Biogerontology 3:45-9. 2002
    ..Sympathetic nervous responses with stressors were augmented. Conversely, adrenal medullary release of epinephrine was subnormal in the elderly, at rest and during stress...