Patrick Seale

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation
    Patrick Seale
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    Diabetes 64:2369-75. 2015
  2. pmc Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:96-105. 2011
  3. ncbi request reprint Orexin turns up the heat on obesity
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, PA 19104, USA
    Cell Metab 14:441-2. 2011
  4. pmc PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program
    Matthew J Harms
    Institute for Diabetes, Obesity, and Metabolism, Department of Cell and Developmental Biology
    Genes Dev 29:298-307. 2015
  5. pmc EBF2 determines and maintains brown adipocyte identity
    Sona Rajakumari
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 17:562-74. 2013
  6. pmc Ebf2 is a selective marker of brown and beige adipogenic precursor cells
    Wenshan Wang
    Institute for Diabetes, Obesity, Metabolism, Department of Cell and Developmental Biology, and
    Proc Natl Acad Sci U S A 111:14466-71. 2014
  7. doi request reprint Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation
    Hannah Dueck
    Department of Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Genome Biol 16:122. 2015
  8. pmc Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
    Matthew J Harms
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Cell Metab 19:593-604. 2014
  9. pmc Medicine. Beige can be slimming
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism and the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 328:1113-4. 2010
  10. doi request reprint Brown and beige fat: development, function and therapeutic potential
    Matthew Harms
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 19:1252-63. 2013

Collaborators

  • Kyoung Jae Won
  • Faiyaz Ahmad
  • Yugong Ho
  • Mineo Kurokawa
  • Shingo Kajimura
  • Jun Wu
  • Jeff Ishibashi
  • Sona Rajakumari
  • Matthew J Harms
  • Wenshan Wang
  • Hee Woong Lim
  • Jennifer M Spaethling
  • Hannah Dueck
  • Matthew Harms
  • James Eberwine
  • Stephen A Fisher
  • Tamas Bartfai
  • Junhyong Kim
  • Lisa M DiPilato
  • Maria A Lim
  • Mitchell A Lazar
  • David J Steger
  • Zachary Gerhart-Hines
  • Feng C Xia
  • Jai Yoon Sul
  • Jaehee Lee
  • Manuel Sanchez-Alavez
  • Sheryl G Beck
  • Morris J Birnbaum
  • Vincent Manganiello
  • Bernhard Kuhn
  • Tae Kyung Kim
  • Sangita Suresh
  • Mugdha Khaladkar
  • Chantal Francis
  • Suzanne N Shapira
  • Li Huang
  • Susumu Goyama
  • Pénélope Andreux
  • Johan Auwerx
  • Ishani Sandesara
  • Kendra K Bence
  • Tomohiko Sato
  • Robert G Kalb
  • Megan Kissig
  • An Hoa Giang
  • Matthew J Emmett
  • Tejvir S Khurana
  • Logan J Everett
  • Catherine Hou
  • Emanuele Loro
  • Dan Feng
  • Daniel A Pryma
  • Christine Ferrara
  • Randall R Reed
  • Anne Bugge
  • Erika R Briggs
  • Heather M Conroe
  • Kathleen H Wood
  • Zeynep Firtina

Detail Information

Publications15

  1. pmc Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation
    Patrick Seale
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    Diabetes 64:2369-75. 2015
    ..This review summarizes recent advances in our understanding of the transcriptional mechanisms that control brown and beige fat cell development. ..
  2. pmc Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:96-105. 2011
    ..These results demonstrate that Prdm16 is a cell-autonomous determinant of a brown fat-like gene program and thermogenesis in subcutaneous adipose tissues...
  3. ncbi request reprint Orexin turns up the heat on obesity
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, PA 19104, USA
    Cell Metab 14:441-2. 2011
    ..Sellayah et al. now reveal that a secreted neuropeptide, Orexin, functions a key driver of brown adipocyte differentiation through direct actions on brown adipose precursors...
  4. pmc PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program
    Matthew J Harms
    Institute for Diabetes, Obesity, and Metabolism, Department of Cell and Developmental Biology
    Genes Dev 29:298-307. 2015
    ..Together, these data indicate that PRDM16 controls chromatin architecture and superenhancer activity in BAT. ..
  5. pmc EBF2 determines and maintains brown adipocyte identity
    Sona Rajakumari
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 17:562-74. 2013
    ..Together, these results identify Ebf2 as a key transcriptional regulator of brown fat cell fate and function...
  6. pmc Ebf2 is a selective marker of brown and beige adipogenic precursor cells
    Wenshan Wang
    Institute for Diabetes, Obesity, Metabolism, Department of Cell and Developmental Biology, and
    Proc Natl Acad Sci U S A 111:14466-71. 2014
    ..Altogether, these results indicate that Ebf2 specifically marks and regulates the molecular profile of brown preadipose cells. ..
  7. doi request reprint Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation
    Hannah Dueck
    Department of Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Genome Biol 16:122. 2015
    ..This brings into question the relationship between transcriptome states and cell phenotypes. Additionally, single-cell transcriptomics presents unique analysis challenges that need to be addressed to answer this question...
  8. pmc Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
    Matthew J Harms
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Cell Metab 19:593-604. 2014
    ..Together, these results show that Prdm16 and Prdm3 control postnatal BAT identity and function...
  9. pmc Medicine. Beige can be slimming
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism and the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 328:1113-4. 2010
  10. doi request reprint Brown and beige fat: development, function and therapeutic potential
    Matthew Harms
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 19:1252-63. 2013
    ..Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease. ..
  11. pmc An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:2289-99. 2012
    ..These results indicate that Evi1 is a key regulator of adipogenic competency...
  12. pmc Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis
    Maria A Lim
    Division of Neurology, Department of Pediatrics, Research Institute, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA, Neuroscience Graduate Group
    Hum Mol Genet 23:4995-5008. 2014
    ..We propose that manipulations that increase fat mass and reduce energy expenditure will be beneficial in the setting of motor neuron disease. ..
  13. pmc The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
    Lisa M DiPilato
    Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 35:2752-60. 2015
    ..Taken together, these data suggest that phosphorylation of PDE3B by Akt is not required for insulin to suppress adipocyte lipolysis. ..
  14. doi request reprint Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis
    Jennifer M Spaethling
    Department of Pharmacology, Department of Genomics and Computational Biology, and Department of Cell and Developmental Biology, Perelman School of Medicine, and Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, USA
    FASEB J 30:81-92. 2016
    ..C., Dueck, H., Wang, W., Fisher, S. A., Sul, J.-Y., Seale, P., Kim, J., Bartfai, T., Eberwine, J. Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis. ..
  15. pmc The nuclear receptor Rev-erbα controls circadian thermogenic plasticity
    Zachary Gerhart-Hines
    1 Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA 2 The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 503:410-3. 2013
    ..Thus, Rev-erbα acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands. ..