Patrick Seale

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:96-105. 2011
  2. ncbi request reprint Orexin turns up the heat on obesity
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, PA 19104, USA
    Cell Metab 14:441-2. 2011
  3. pmc EBF2 determines and maintains brown adipocyte identity
    Sona Rajakumari
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 17:562-74. 2013
  4. ncbi request reprint Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
    Matthew J Harms
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Cell Metab 19:593-604. 2014
  5. pmc Medicine. Beige can be slimming
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism and the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 328:1113-4. 2010
  6. doi request reprint Brown and beige fat: development, function and therapeutic potential
    Matthew Harms
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 19:1252-63. 2013
  7. pmc An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:2289-99. 2012
  8. pmc The nuclear receptor Rev-erbα controls circadian thermogenic plasticity
    Zachary Gerhart-Hines
    1 Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA 2 The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 503:410-3. 2013

Collaborators

  • Kyoung Jae Won
  • Mineo Kurokawa
  • Shingo Kajimura
  • Jun Wu
  • Jeff Ishibashi
  • Sona Rajakumari
  • Matthew J Harms
  • Hee Woong Lim
  • Zachary Gerhart-Hines
  • Matthew Harms
  • Tomohiko Sato
  • Susumu Goyama
  • Wenshan Wang
  • Catherine Hou
  • Emanuele Loro
  • Logan J Everett
  • Mitchell A Lazar
  • Daniel A Pryma
  • Randall R Reed
  • Matthew J Emmett
  • Tejvir S Khurana
  • An Hoa Giang
  • Dan Feng
  • Erika R Briggs
  • Anne Bugge
  • Christine Ferrara
  • David J Steger
  • Zeynep Firtina
  • Heather M Conroe
  • Kathleen H Wood

Detail Information

Publications8

  1. pmc Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:96-105. 2011
    ..These results demonstrate that Prdm16 is a cell-autonomous determinant of a brown fat-like gene program and thermogenesis in subcutaneous adipose tissues...
  2. ncbi request reprint Orexin turns up the heat on obesity
    Patrick Seale
    Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, PA 19104, USA
    Cell Metab 14:441-2. 2011
    ..Sellayah et al. now reveal that a secreted neuropeptide, Orexin, functions a key driver of brown adipocyte differentiation through direct actions on brown adipose precursors...
  3. pmc EBF2 determines and maintains brown adipocyte identity
    Sona Rajakumari
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 17:562-74. 2013
    ..Together, these results identify Ebf2 as a key transcriptional regulator of brown fat cell fate and function...
  4. ncbi request reprint Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
    Matthew J Harms
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Cell Metab 19:593-604. 2014
    ..Together, these results show that Prdm16 and Prdm3 control postnatal BAT identity and function...
  5. pmc Medicine. Beige can be slimming
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism and the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 328:1113-4. 2010
  6. doi request reprint Brown and beige fat: development, function and therapeutic potential
    Matthew Harms
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 19:1252-63. 2013
    ..Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease. ..
  7. pmc An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation
    Jeff Ishibashi
    Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:2289-99. 2012
    ..These results indicate that Evi1 is a key regulator of adipogenic competency...
  8. pmc The nuclear receptor Rev-erbα controls circadian thermogenic plasticity
    Zachary Gerhart-Hines
    1 Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA 2 The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 503:410-3. 2013
    ..Thus, Rev-erbα acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands. ..