Laura J Scott

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes
    Cristen J Willer
    Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor 48109 2029, USA
    Diabetes 56:256-64. 2007
  2. ncbi request reprint Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample
    Laura J Scott
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Diabetes 55:2649-53. 2006
  3. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
  4. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
  5. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
  6. ncbi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
  7. ncbi request reprint Optimal designs for two-stage genome-wide association studies
    Andrew D Skol
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
    Genet Epidemiol 31:776-88. 2007
  8. pmc Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
    Jeroen R Huyghe
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 45:197-201. 2013
  9. ncbi request reprint Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database
    Cristen J Willer
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109, USA
    Genet Epidemiol 30:180-90. 2006
  10. ncbi request reprint SNP Function Portal: a web database for exploring the function implication of SNP alleles
    Pinglang Wang
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 22:e523-9. 2006

Detail Information

Publications25

  1. ncbi request reprint Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes
    Cristen J Willer
    Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor 48109 2029, USA
    Diabetes 56:256-64. 2007
    ..03), although we also replicated 4 of 58 SNPs from genes that had only one previous report of association...
  2. ncbi request reprint Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample
    Laura J Scott
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Diabetes 55:2649-53. 2006
    ..26, P > or = 0.0054). Our results strengthen the evidence that one or more variants in TCF7L2 are associated with increased risk of type 2 diabetes...
  3. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..This brings the number of T2D loci now confidently identified to at least 10...
  4. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
    ..44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development...
  5. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  6. ncbi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  7. ncbi request reprint Optimal designs for two-stage genome-wide association studies
    Andrew D Skol
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
    Genet Epidemiol 31:776-88. 2007
    ..Alternatively, the same cost savings can be had by relaxing the false positive rate by 2.5-fold, for example from 1/300,000 to 2.5/300,000, while retaining the same power...
  8. pmc Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
    Jeroen R Huyghe
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 45:197-201. 2013
    ..This study demonstrates that exome array genotyping is a valuable approach to identify low-frequency variants that contribute to complex traits...
  9. ncbi request reprint Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database
    Cristen J Willer
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109, USA
    Genet Epidemiol 30:180-90. 2006
    ....
  10. ncbi request reprint SNP Function Portal: a web database for exploring the function implication of SNP alleles
    Pinglang Wang
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 22:e523-9. 2006
    ....
  11. pmc Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants
    Clement Ma
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Genet Epidemiol 37:539-50. 2013
    ..We also establish MAC as the key parameter determining test calibration for joint and meta-analysis. ..
  12. ncbi request reprint Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
    Andrew D Skol
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109 2029, USA
    Nat Genet 38:209-13. 2006
    ..30), and a relatively large proportion of markers are selected for follow-up in stage 2 (pi(markers) >or= 0.01)...
  13. pmc Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    Elizabeth K Speliotes
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 7:e1001324. 2011
    ....
  14. pmc Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:7501-6. 2009
    ..37, P = 0.042). Although these results are promising, analysis of additional samples will be required to confirm that variant(s) in these regions influence BP risk...
  15. ncbi request reprint Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health bipolar sample
    Erika H Saunders
    University of Michigan Depression Center, Ann Arbor, Michigan 48109, USA
    Am J Med Genet B Neuropsychiatr Genet 147:18-26. 2008
    ..We have found evidence of familiality for subphenotypes of BP. In multicenter samples, familiality may be overestimated if variability in diagnosis of subphenotypes between site/wave of ascertainment is not considered...
  16. pmc Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q
    Corina Shtir
    Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089, USA
    Hum Hered 63:17-25. 2007
    ..The purpose of this study was to examine carefully heterogeneity underlying evidence for linkage to type 2 diabetes (T2DM) on chromosome 6q from two sets of FUSION families...
  17. ncbi request reprint A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:821-9. 2004
    ....
  18. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  19. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  20. ncbi request reprint Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:1141-9. 2004
    ....
  21. ncbi request reprint Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns
    Karen L Mohlke
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD, USA
    Mol Genet Metab 85:323-7. 2005
    ..We tested haplotypes for association with diabetes-related traits and observed no excess of significant results...
  22. ncbi request reprint Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns
    Karen L Mohlke
    Department of Genetics, University of North Carolina, 4109 F Neurosciences Research Building, 103 Mason Farm Road, CB 7264, 27599 7264, Chapel Hill, NC, USA
    Hum Genet 118:245-54. 2005
    ..Furthermore, our data do not support a reported maternal inheritance pattern of T2DM but instead show a strong effect of recall bias...
  23. ncbi request reprint Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns
    Lori L Bonnycastle
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 2152, USA
    Diabetes 55:2534-40. 2006
    ..Our data suggest that common variants in several MODY genes play a modest role in type 2 diabetes susceptibility...
  24. pmc High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools
    Karen L Mohlke
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:16928-33. 2002
    ..Based on these data and assuming pools of 500 individuals, we conclude that at significance level 0.05 we would have 95% (82%) power to detect population allele frequency differences of 0.07 for control allele frequencies of 0.10 (0.50)...
  25. pmc Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST)
    Chun Li
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232 0700, USA
    Am J Hum Genet 74:418-31. 2004
    ..This makes our method a new tool for detecting linkage as well as association, especially in regions harboring a candidate gene. We have implemented these methods in the software package GIST (Genotype-IBD Sharing Test)...