Research Topics
Genomes and Genes
Species | Laura J ScottSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genesCristen J Willer
Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor 48109 2029, USA
Diabetes 56:256-64. 2007..03), although we also replicated 4 of 58 SNPs from genes that had only one previous report of association...- Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sampleLaura J Scott
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
Diabetes 55:2649-53. 2006..26, P > or = 0.0054). Our results strengthen the evidence that one or more variants in TCF7L2 are associated with increased risk of type 2 diabetes... 
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variantsLaura J Scott
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
Science 316:1341-5. 2007..This brings the number of T2D loci now confidently identified to at least 10...- Common variants in the GDF5-UQCC region are associated with variation in human heightSerena Sanna
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Genet 40:198-203. 2008..44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development... - New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskJosee Dupuis
Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
Nat Genet 42:105-16. 2010.... 
Newly identified loci that influence lipid concentrations and risk of coronary artery diseaseCristen J Willer
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
Nat Genet 40:161-9. 2008..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...- Optimal designs for two-stage genome-wide association studiesAndrew D Skol
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
Genet Epidemiol 31:776-88. 2007..Alternatively, the same cost savings can be had by relaxing the false positive rate by 2.5-fold, for example from 1/300,000 to 2.5/300,000, while retaining the same power... - Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap databaseCristen J Willer
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109, USA
Genet Epidemiol 30:180-90. 2006.... - SNP Function Portal: a web database for exploring the function implication of SNP allelesPinglang Wang
Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
Bioinformatics 22:e523-9. 2006..AVAILABILITY: http://brainarray.mbni.med.umich.edu/Brainarray/Database/SearchSNP/snpfunc.aspx... - Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studiesAndrew D Skol
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109-2029, USA
Nat Genet 38:209-13. 2006..30), and a relatively large proportion of markers are selected for follow-up in stage 2 (pi(markers) >or= 0.01)... - Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traitsElizabeth K Speliotes
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 7:e1001324. 2011.... - Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestryLaura J Scott
Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 106:7501-6. 2009..37, P = 0.042). Although these results are promising, analysis of additional samples will be required to confirm that variant(s) in these regions influence BP risk... - Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health bipolar sampleErika H Saunders
University of Michigan Depression Center, Ann Arbor, Michigan 48109, USA
Am J Med Genet B Neuropsychiatr Genet 147:18-26. 2008..We have found evidence of familiality for subphenotypes of BP. In multicenter samples, familiality may be overestimated if variability in diagnosis of subphenotypes between site/wave of ascertainment is not considered... - Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesEleftheria Zeggini
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Genet 40:638-45. 2008..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D... - Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levelsWei Min Chen
Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
J Clin Invest 118:2620-8. 2008.... - Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6qCorina Shtir
Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089, USA
Hum Hered 63:17-25. 2007..The purpose of this study was to examine carefully heterogeneity underlying evidence for linkage to type 2 diabetes (T2DM) on chromosome 6q from two sets of FUSION families... - Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in FinnsLori L Bonnycastle
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 2152, USA
Diabetes 55:2534-40. 2006..Our data suggest that common variants in several MODY genes play a modest role in type 2 diabetes susceptibility... - Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in FinnsKaren L Mohlke
Department of Genetics, University of North Carolina, 4109 F Neurosciences Research Building, 103 Mason Farm Road, CB 7264, 27599 7264, Chapel Hill, NC, USA
Hum Genet 118:245-54. 2005..Furthermore, our data do not support a reported maternal inheritance pattern of T2DM but instead show a strong effect of recall bias... - Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in FinnsKaren L Mohlke
Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD, USA
Mol Genet Metab 85:323-7. 2005..We tested haplotypes for association with diabetes-related traits and observed no excess of significant results... - Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetesKaisa Silander
Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
Diabetes 53:1141-9. 2004.... - A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14Kaisa Silander
Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
Diabetes 53:821-9. 2004.... - High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA poolsKaren L Mohlke
Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:16928-33. 2002..Based on these data and assuming pools of 500 individuals, we conclude that at significance level 0.05 we would have 95% (82%) power to detect population allele frequency differences of 0.07 for control allele frequencies of 0.10 (0.50)... - Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST)Chun Li
Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232 0700, USA
Am J Hum Genet 74:418-31. 2004..This makes our method a new tool for detecting linkage as well as association, especially in regions harboring a candidate gene. We have implemented these methods in the software package GIST (Genotype-IBD Sharing Test)...