John D Scott

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint High rate of spontaneous negativity for hepatitis C virus RNA after establishment of chronic infection in Alaska Natives
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
    Clin Infect Dis 42:945-52. 2006
  2. ncbi request reprint Influenza A pneumonia presenting as progressive focal infiltrates in a stem cell transplant recipient
    John D Scott
    Department of Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 359938, Seattle, WA 98104 2499, USA
    J Clin Virol 31:96-9. 2004
  3. pmc Chronic liver disease in Aboriginal North Americans
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98144, USA
    World J Gastroenterol 14:4607-15. 2008
  4. ncbi request reprint Role of combination therapy in chronic hepatitis B
    John D Scott
    Harborview Medical Center, 325 Ninth Avenue, Box 359938, Seattle, WA 98104, USA
    Curr Gastroenterol Rep 11:28-36. 2009
  5. pmc IL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection
    John Scott
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 204:419-25. 2011
  6. pmc Hepatitis C virus is infrequently evaluated and treated in an urban HIV clinic population
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
    AIDS Patient Care STDS 23:925-9. 2009
  7. doi request reprint Diagnosis of depression in former injection drug users with chronic hepatitis C
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98104, USA
    J Clin Gastroenterol 45:462-7. 2011
  8. pmc Anchored phosphatases modulate glucose homeostasis
    Simon A Hinke
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    EMBO J 31:3991-4004. 2012
  9. pmc Cost-effectiveness and population outcomes of general population screening for hepatitis C
    Phillip O Coffin
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 54:1259-71. 2012
  10. pmc Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection
    Matthew G Gold
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 288:17111-21. 2013

Research Grants

  1. HCV Kinetics and Determinants of Relapse
    John Scott; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint High rate of spontaneous negativity for hepatitis C virus RNA after establishment of chronic infection in Alaska Natives
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
    Clin Infect Dis 42:945-52. 2006
    ..Hepatitis C virus (HCV) leads to chronic infection in 70%-85% of exposed patients. Spontaneous clearance of the virus after chronic infection is believed to occur rarely...
  2. ncbi request reprint Influenza A pneumonia presenting as progressive focal infiltrates in a stem cell transplant recipient
    John D Scott
    Department of Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 359938, Seattle, WA 98104 2499, USA
    J Clin Virol 31:96-9. 2004
    ..Stem cell transplant recipients are susceptible to pulmonary infections, including influenza A. Typically, isolated influenza pneumonia has a diffuse, interstitial infiltrate pattern...
  3. pmc Chronic liver disease in Aboriginal North Americans
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98144, USA
    World J Gastroenterol 14:4607-15. 2008
    ..In addition, more research is needed on the treatment of hepatitis C virus (HCV) infection and non-alcoholic fatty liver disease (NAFLD) in this population...
  4. ncbi request reprint Role of combination therapy in chronic hepatitis B
    John D Scott
    Harborview Medical Center, 325 Ninth Avenue, Box 359938, Seattle, WA 98104, USA
    Curr Gastroenterol Rep 11:28-36. 2009
    ....
  5. pmc IL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection
    John Scott
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 204:419-25. 2011
    ..Mathematical models of hepatitis C virus (HCV) during therapy may elucidate mechanisms of action for antiviral therapy. In genome-wide association studies, IL28B gene polymorphisms are highly predictive of therapeutic clearance of HCV...
  6. pmc Hepatitis C virus is infrequently evaluated and treated in an urban HIV clinic population
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
    AIDS Patient Care STDS 23:925-9. 2009
    ..Further efforts to identify and to overcome barriers to HCV treatment are warranted...
  7. doi request reprint Diagnosis of depression in former injection drug users with chronic hepatitis C
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98104, USA
    J Clin Gastroenterol 45:462-7. 2011
    ..This study seeks to define the performance characteristics of 2 common depression screening tests and how psychiatric diagnoses affect adherence to treatment...
  8. pmc Anchored phosphatases modulate glucose homeostasis
    Simon A Hinke
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    EMBO J 31:3991-4004. 2012
    ..Thus anchored signalling events that facilitate insulin secretion and glucose homeostasis may be set by AKAP150 associated phosphatase activity...
  9. pmc Cost-effectiveness and population outcomes of general population screening for hepatitis C
    Phillip O Coffin
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 54:1259-71. 2012
    ..Current US guidelines recommend limiting hepatitis C virus (HCV) screening to high-risk individuals, and 50%-75% of infected persons remain unaware of their status...
  10. pmc Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection
    Matthew G Gold
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 288:17111-21. 2013
    ..We propose that this structure-directed evolution strategy might be generally applicable for the investigation of other protein interaction surfaces...
  11. pmc Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation
    Brian W Jones
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:17099-104. 2012
    ..Immunoblot and RT-PCR revealed that only the long isoforms of AKAP7 were detectable in ventricular cardiomyocytes. The results indicate that AKAP7 is not required for regulation of Ca(2+) handling in mouse cardiomyocytes...
  12. pmc Allele-specific PCR for determination of IL28B genotype
    Linda Cook
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    J Clin Microbiol 50:4144-6. 2012
    ..We describe an allele-specific PCR assay for the IL28B genotype. The assay is simple and robust, uses commonly available real-time PCR instrumentation, and is well suited for clinical laboratories offering IL28B genotyping...
  13. pmc Gravin is a transitory effector of polo-like kinase 1 during cell division
    David A Canton
    Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Mol Cell 48:547-59. 2012
    ..In situ detection of phospho-T766 Gravin in biopsy sections of human glioblastomas suggests that this phosphorylation event might identify malignant neoplasms...
  14. doi request reprint The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection
    George N Ioannou
    Divisions of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Hepatology 57:249-57. 2013
    ..05; 95% CI, 1.03-1.08), and low CD4+ cell count (AOR, 2.36; 95% CI, 1.3-4.2). Among 5999 HIV/HCV-coinfected patients, 994 (18%) had ever received HCV antiviral treatment, of whom 165 (17%) achieved sustained virologic response...
  15. ncbi request reprint Molecular diagnostics of hepatitis C virus infection: a systematic review
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington and Harborview Medical Center, Seattle 98104 2499, USA
    JAMA 297:724-32. 2007
    ..Nucleic acid tests are invaluable for the diagnosis of HCV infection and provide critical prognostic information for guiding treatment and measuring the response to antiviral therapy...
  16. pmc Cell signaling in space and time: where proteins come together and when they're apart
    John D Scott
    Department of Pharmacology, Howard Hughes Medical Institute, Box 357750, University of Washington School of Medicine, Seattle, WA 98195, USA
    Science 326:1220-4. 2009
    ..This requires that the activators, effectors, enzymes, and substrates that respond to cellular signals come together when they need to...
  17. pmc A-kinase anchoring proteins: from protein complexes to physiology and disease
    Graeme K Carnegie
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, School of Medicine, Seattle, Washington 98195, USA
    IUBMB Life 61:394-406. 2009
    ..These anchoring proteins form multi-protein complexes that integrate cAMP signaling with other pathways and signaling events. In this review, we focus on recent advances in the elucidation of AKAP function...
  18. pmc E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis
    Jonathan N Pruneda
    Department of Biochemistry, University of Washington, Seattle, WA, USA
    EMBO J 33:437-49. 2014
    ..Recognizing conserved E2 features, OspG can interact with at least ten distinct human E2s~Ub. Mouse oral infection studies indicate that E2~Ub conjugates act as novel regulators of OspG effector kinase function in eukaryotic host cells. ..
  19. pmc Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle
    Jose Mercado
    Department of Physiology and Biophysics and 2 Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA 98195
    J Gen Physiol 143:559-75. 2014
    ..We propose that AKAP150, PKC, and TRPV4 channels form dynamic subcellular signaling domains that control Ca(2+) influx into arterial myocytes...
  20. pmc AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes Mellitus
    Matthew A Nystoriak
    From the Department of Pharmacology, University of California, Davis M A N, M N C, C B N, C Y C, J L P, L T I, D M B, M F N Department of Pharmacology, University of Colorado, Denver M L D Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, WA P J N, S A H, J D S and Department of Physiology and Biophysics, University of Washington, Seattle L F S
    Circ Res 114:607-15. 2014
    ..Whether AKAP150 mediates BKCa channel suppression during hyperglycemia and diabetes mellitus is unknown...
  21. pmc An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria
    Christopher K Means
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:E1227-35. 2011
    ..Imaging, proteomic analysis, and subcellular fractionation experiments reveal that SKIP is enriched at the inner mitochondrial membrane where it associates with a prominent PKA substrate, the coiled-coil helix protein ChChd3...
  22. pmc Patient acceptance of universal screening for hepatitis C virus infection
    Phillip O Coffin
    Division of Allergy and Infectious Diseases, University of Washington, Seattle WA, USA
    BMC Infect Dis 11:160. 2011
    ..Although universal screening might be a cost-effective way to identify infections, prevent morbidity, and reduce transmission, few efforts have been made to determine patient opinions about new approaches to screening...
  23. ncbi request reprint Direct-acting antiviral-associated dermatitis during chronic hepatitis C virus treatment
    Lauren K Biesbroeck
    Division of Dermatology, Department of Medicine, University of Washington, Box 356524, Seattle, WA, 98195, USA
    Am J Clin Dermatol 14:497-502. 2013
    ..Dermatologists must be aware of these cutaneous adverse effects, as early intervention with topical corticosteroids and antihistamines may minimize the severity of the eruption and allow patients to complete antiviral therapy. ..
  24. pmc Project ECHO: a model for complex, chronic care in the Pacific Northwest region of the United States
    John D Scott
    School of Medicine, University of Washington, Seattle, WA 98104, USA
    J Telemed Telecare 18:481-4. 2012
    ..The Project ECHO model improves access to health care. It may provide a way to bring specialist care to rural areas in developing countries...
  25. pmc Scaffolding proteins: not such innocent bystanders
    F Donelson Smith
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Curr Biol 23:R515-7. 2013
    ..Though frequently considered to be inert organizational elements, two recent reports implicate kinase-scaffolding proteins as active participants in signal relay. ..
  26. pmc Creating order from chaos: cellular regulation by kinase anchoring
    John D Scott
    Howard Hughes Medical Institute and Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Annu Rev Pharmacol Toxicol 53:187-210. 2013
    ....
  27. pmc AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency
    Matthew G Gold
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA, USA
    EMBO Mol Med 4:15-26. 2012
    ..Thus, anchored PKA modulation of AQP0 is a homeostatic mechanism that must be physically intact to preserve lens transparency...
  28. pmc AKAP220 protein organizes signaling elements that impact cell migration
    Jeremy S Logue
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 286:39269-81. 2011
    ..This reveals an unappreciated role for this anchored kinase/microtubule effector protein network in the propagation of cell motility...
  29. pmc Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein
    Edward P Cheng
    Department of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA
    Circ Res 109:255-61. 2011
    ..2 channels causes long QT syndrome 8 (LQT8), a disease also known as Timothy syndrome. However, the mechanisms by which this mutation enhances Ca(V)1.2-LQT8 currents and generates lethal arrhythmias are unclear...
  30. pmc Organizing signal transduction through A-kinase anchoring proteins (AKAPs)
    Jeremy S Logue
    Howard Hughes Medical Institute and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA
    FEBS J 277:4370-5. 2010
    ..Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview...
  31. pmc Signal integration through blending, bolstering and bifurcating of intracellular information
    Catherine T Pawson
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, School of Medicine, Seattle, Washington, USA
    Nat Struct Mol Biol 17:653-8. 2010
    ..The ability to organize these enzymes into multiprotein complexes allows for a high degree of fidelity, efficiency and spatial precision in signaling responses...
  32. pmc Networking with AKAPs: context-dependent regulation of anchored enzymes
    Emily J Welch
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Interv 10:86-97. 2010
    ..This article charts the inception of the PKA-anchoring hypothesis, the characterization of AKAPs and their nomenclature, and the physiological roles of context-specific AKAP signaling complexes...

Research Grants2

  1. HCV Kinetics and Determinants of Relapse
    John Scott; Fiscal Year: 2007
    ....