David A Scott

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Neutrophils in periodontal inflammation
    David A Scott
    Center for Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA
    Front Oral Biol 15:56-83. 2012
  2. pmc Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity
    Juhi Bagaitkar
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 5:e9323. 2010
  3. pmc Tobacco smoke augments Porphyromonas gingivalis-Streptococcus gordonii biofilm formation
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 6:e27386. 2011
  4. pmc Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages
    K Guzik
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Cell Death Dis 2:e131. 2011
  5. pmc Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells
    Juhi Bagaitkar
    Microbiology and Immunology, University of Louisville, Louisville, KY, 40292, USA
    Tob Induc Dis 10:18. 2012
  6. pmc The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release
    Minqi Xu
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    BMC Cell Biol 9:19. 2008
  7. pmc Tobacco use increases susceptibility to bacterial infection
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA
    Tob Induc Dis 4:12. 2008
  8. pmc Diabetes-related molecular signatures in infrared spectra of human saliva
    David A Scott
    Oral Health and Systemic Disease, University of Louisville, Louisville, S Preston St, Louisville, KY, 40292, USA
    Diabetol Metab Syndr 2:48. 2010
  9. ncbi request reprint Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases
    David A Scott
    Oral Health and Systemic Disease Research Group, Department of Pharmacology and Toxicology, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, United States
    World J Gastroenterol 12:7451-9. 2006
  10. ncbi request reprint The influence of vitamin C on systemic markers of endothelial and inflammatory cell activation in smokers and non-smokers
    D A Scott
    Periodontics, Endodontics and Dental Hygiene, School of Dentistry, University of Louisville, 501 South Preston, Louisville, KY 40202, USA
    Inflamm Res 54:138-44. 2005

Collaborators

  • Huizhi Wang
  • Richard J Lamont
  • Nurcan Buduneli
  • Jill Suttles
  • Jan Potempa
  • R M Palmer
  • Denis F Kinane
  • Juhi Bagaitkar
  • Donald R Demuth
  • Diane E Renaud
  • Iris Zeller
  • Karina Adamowicz
  • K Guzik
  • Lisa R Williams
  • Minqi Xu
  • Brendan Silbert
  • Sean Fisher
  • Kunal Rehani
  • Michael J Barrington
  • Chris Lavelle
  • Pinar Gumus
  • Nejat Nizam
  • Justin A Hutcherson
  • Ravi Jotwani
  • Carlo A Daep
  • Carol K Patel
  • M Bzowska
  • J Smagur
  • J Skret
  • B Gajkowska
  • Carlo Amorin Daep
  • Deanne L Pierce
  • Mike Martin
  • Manjunatha R Bemakanakere
  • Craig McCutcheon
  • Leah Kells
  • Hashir Hamza
  • James E Scott
  • Hannah R Bishop
  • Konrad Jamrozik
  • David L Singer
  • Diane Renaud
  • Jean Pierre Picard
  • Lisbeth Evered
  • Abdel Soussi-Gounni
  • Michael Martin
  • Shirley C Gelskey
  • Kan Zhi Liu
  • Lisa Lix
  • Roman Kluger
  • Karen J Harris
  • Robert Watson
  • Catalena Birek

Detail Information

Publications22

  1. pmc Neutrophils in periodontal inflammation
    David A Scott
    Center for Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA
    Front Oral Biol 15:56-83. 2012
    ..This review will cover the innate and inflammatory functions of neutrophils, and describe the importance and utility of neutrophils to the host response and the integrity of the periodontium in health and disease...
  2. pmc Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity
    Juhi Bagaitkar
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 5:e9323. 2010
    ..gingivalis...
  3. pmc Tobacco smoke augments Porphyromonas gingivalis-Streptococcus gordonii biofilm formation
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 6:e27386. 2011
    ..gingivalis biofilms of limited pro-inflammatory potential may explain the increased persistence of this pathogen in smokers. These findings may also be relevant to other biofilm-induced infectious diseases and conditions...
  4. pmc Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages
    K Guzik
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Cell Death Dis 2:e131. 2011
    ..These data provide mechanistic insight into the lack of accumulation of apoptotic neutrophil populations in the lungs of smokers and their increased susceptibility to degradative pulmonary diseases and bacterial infections...
  5. pmc Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells
    Juhi Bagaitkar
    Microbiology and Immunology, University of Louisville, Louisville, KY, 40292, USA
    Tob Induc Dis 10:18. 2012
    ..abstract:..
  6. pmc The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release
    Minqi Xu
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    BMC Cell Biol 9:19. 2008
    ..Key neutrophil effector functions (oxidative burst, bacterial killing, matrix metalloproteinase release) were also examined...
  7. pmc Tobacco use increases susceptibility to bacterial infection
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA
    Tob Induc Dis 4:12. 2008
    ..Further epidemiological, clinical and mechanistic research into this important area is warranted...
  8. pmc Diabetes-related molecular signatures in infrared spectra of human saliva
    David A Scott
    Oral Health and Systemic Disease, University of Louisville, Louisville, S Preston St, Louisville, KY, 40292, USA
    Diabetol Metab Syndr 2:48. 2010
    ..There is an ongoing need for improvements in non-invasive, point-of-care tools for the diagnosis and prognosis of diabetes mellitus. Ideally, such technologies would allow for community screening...
  9. ncbi request reprint Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases
    David A Scott
    Oral Health and Systemic Disease Research Group, Department of Pharmacology and Toxicology, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, United States
    World J Gastroenterol 12:7451-9. 2006
    ....
  10. ncbi request reprint The influence of vitamin C on systemic markers of endothelial and inflammatory cell activation in smokers and non-smokers
    D A Scott
    Periodontics, Endodontics and Dental Hygiene, School of Dentistry, University of Louisville, 501 South Preston, Louisville, KY 40202, USA
    Inflamm Res 54:138-44. 2005
    ....
  11. pmc Tobacco-induced alterations to Porphyromonas gingivalis-host interactions
    Juhi Bagaitkar
    Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
    Environ Microbiol 11:1242-53. 2009
    ..gingivalis adapts by altering gene expression and outer membrane proteins. These changes may explain, in part, the altered virulence and host-pathogen interactions that have been documented in vivo in smokers with periodontal disease...
  12. pmc The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells
    Huizhi Wang
    Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, Louisville, KY 40202, USA
    J Immunol 191:1164-74. 2013
    ..These findings demonstrate the negative regulatory function of JAK3 and elucidate the signaling pathway by which JAK3 differentially regulates TLR-mediated inflammatory cytokine production in innate immune cells. ..
  13. pmc Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice
    Karina Adamowicz
    Center for Oral Health and Systemic Disease, University of Louisville, Louisville, Kentucky 40292, United States of America
    Mol Med 18:1190-6. 2012
    ..These findings also may have relevance to other chronic inflammatory diseases and the systemic sequelae associated with periodontal infections...
  14. ncbi request reprint Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitis
    Iris Zeller
    Oral Health and Systemic Disease, University of Louisville, Louisville, KY
    J Periodontol 85:837-44. 2014
    ..gingivalis is suppressed in smokers in vivo and whether previously established in vitro tobacco-induced phenotypic P. gingivalis changes would be reflected in vivo...
  15. pmc GSK3β and the control of infectious bacterial diseases
    Huizhi Wang
    Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40292, USA
    Trends Microbiol 22:208-17. 2014
    ..A better understanding of complex bacteria-GSK3β interactions is likely to lead to more effective anti-inflammatory interventions and novel targets to circumvent pathogen colonization and survival. ..
  16. doi request reprint Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells
    Kunal Rehani
    Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, 501 S Preston Street, Louisville, KY 40292, USA
    Biochim Biophys Acta 1783:375-82. 2008
    ....
  17. ncbi request reprint Effects of smoking and gingival inflammation on salivary antioxidant capacity
    Nurcan Buduneli
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 33:159-64. 2006
    ..This study evaluated possible effects of smoking and gingival inflammation on salivary antioxidants in gingivitis patients...
  18. ncbi request reprint Progression of periodontal disease in a maintenance population of smokers and non-smokers: a 3-year longitudinal study
    Sean Fisher
    Department of Dental Diagnostics and Surgical Sciences, University of Manitoba, Winnipeg, MB, Canada
    J Periodontol 79:461-8. 2008
    ..Therefore, we set out to assess disease progression longitudinally in smoking and non-smoking subjects with chronic periodontitis undergoing periodontal maintenance therapy every 3 to 4 months...
  19. doi request reprint Homocysteine and C-reactive protein are not markers of cognitive impairment in patients with major cardiovascular disease
    Brendan Silbert
    Centre for Anaesthesia and Cognitive Function, Department of Anaesthesia, St Vincent s Health, Melbourne, Victoria, Australia
    Dement Geriatr Cogn Disord 25:309-16. 2008
    ..Raised concentrations of plasma homocysteine and C-reactive protein (CRP) are associated with vascular disease and have also been implicated as independent risk factors for cognitive impairment in population studies...
  20. ncbi request reprint Mechanisms of action of environmental factors--tobacco smoking
    Richard M Palmer
    King s College London, Guy s Hospital Campus, London Bridge, London SE1 9RT, UK
    J Clin Periodontol 32:180-95. 2005
    ..To review the potential biological mechanisms underlying the effects of tobacco smoking on periodontitis...
  21. ncbi request reprint Epidural anesthesia for coronary artery bypass surgery compared with general anesthesia alone does not reduce biochemical markers of myocardial damage
    Michael J Barrington
    Department of Anaesthesia, St Vincent s Hospital, Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia
    Anesth Analg 100:921-8. 2005
    ..We conclude that HTEA for CABG surgery had no effect on troponin release but improved postoperative analgesia and was associated with a reduced time to extubation...
  22. ncbi request reprint Are nicotine replacement strategies to facilitate smoking cessation safe?
    Chris Lavelle
    Faculty of Dentistry, University of Manitoba, Winnipeg, Manitoba, Canada
    J Can Dent Assoc 69:592-7. 2003
    ..Furthermore, nicotine replacement is usually delivered over the short term (a matter of weeks). Therefore, nicotine replacement is recognized as a relatively safe and effective aid to smoking cessation...

Research Grants3

  1. Infrared spectroscopy as a novel diagnostic tool for periodontitis
    David Scott; Fiscal Year: 2007
    ....
  2. Tobacco-induced alterations to P. gingivalis-host interactions
    David A Scott; Fiscal Year: 2010
    ..This study will provide some of the first information illustrating how P. gingivalis responds at the molecular level to cigarette smoke and may provide unique insights into disease pathogenesis in smokers. ..