Genomes and Genes
David A Scott
Affiliation: University of Louisville
- Neutrophils in periodontal inflammationDavid A Scott
Center for Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA
Front Oral Biol 15:56-83. 2012..This review will cover the innate and inflammatory functions of neutrophils, and describe the importance and utility of neutrophils to the host response and the integrity of the periodontium in health and disease...
- Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophagesK Guzik
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Cell Death Dis 2:e131. 2011..These data provide mechanistic insight into the lack of accumulation of apoptotic neutrophil populations in the lungs of smokers and their increased susceptibility to degradative pulmonary diseases and bacterial infections...
- Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cellsJuhi Bagaitkar
Microbiology and Immunology, University of Louisville, Louisville, KY, 40292, USA
Tob Induc Dis 10:18. 2012..abstract:..
- The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 releaseMinqi Xu
Department of Oral Biology, University of Manitoba, Winnipeg, Canada
BMC Cell Biol 9:19. 2008..Key neutrophil effector functions (oxidative burst, bacterial killing, matrix metalloproteinase release) were also examined...
- Diabetes-related molecular signatures in infrared spectra of human salivaDavid A Scott
Oral Health and Systemic Disease, University of Louisville, Louisville, S Preston St, Louisville, KY, 40292, USA
Diabetol Metab Syndr 2:48. 2010..There is an ongoing need for improvements in non-invasive, point-of-care tools for the diagnosis and prognosis of diabetes mellitus. Ideally, such technologies would allow for community screening...
- Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseasesDavid A Scott
Oral Health and Systemic Disease Research Group, Department of Pharmacology and Toxicology, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, United States
World J Gastroenterol 12:7451-9. 2006....
- The influence of vitamin C on systemic markers of endothelial and inflammatory cell activation in smokers and non-smokersD A Scott
Periodontics, Endodontics and Dental Hygiene, School of Dentistry, University of Louisville, 501 South Preston, Louisville, KY 40202, USA
Inflamm Res 54:138-44. 2005....
- Tobacco use increases susceptibility to bacterial infectionJuhi Bagaitkar
Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA
Tob Induc Dis 4:12. 2008..Further epidemiological, clinical and mechanistic research into this important area is warranted...
- Tobacco smoke augments Porphyromonas gingivalis-Streptococcus gordonii biofilm formationJuhi Bagaitkar
Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, United States of America
PLoS ONE 6:e27386. 2011..gingivalis biofilms of limited pro-inflammatory potential may explain the increased persistence of this pathogen in smokers. These findings may also be relevant to other biofilm-induced infectious diseases and conditions...
- Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivityJuhi Bagaitkar
Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
PLoS ONE 5:e9323. 2010..gingivalis...
- Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failureHuaxin Zhou
Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA Department of Oncology, Cancer Institute, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China and Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, USA
FASEB J 29:3737-49. 2015....
- The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cellsHuizhi Wang
Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, Louisville, KY 40202, USA
J Immunol 191:1164-74. 2013..These findings demonstrate the negative regulatory function of JAK3 and elucidate the signaling pathway by which JAK3 differentially regulates TLR-mediated inflammatory cytokine production in innate immune cells. ..
- Porphyromonas gingivalis-induced reactive oxygen species activate JAK2 and regulate production of inflammatory cytokines through c-JunHuizhi Wang
Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, Louisville, Kentucky, USA
Infect Immun 82:4118-26. 2014..gingivalis-induced inflammatory cytokine production and that the JNK/c-Jun signaling axis is involved in the ROS-dependent regulation of IL-1β and IL-6 production. ..
- Tobacco-induced alterations to Porphyromonas gingivalis-host interactionsJuhi Bagaitkar
Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
Environ Microbiol 11:1242-53. 2009..gingivalis adapts by altering gene expression and outer membrane proteins. These changes may explain, in part, the altered virulence and host-pathogen interactions that have been documented in vivo in smokers with periodontal disease...
- Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in miceKarina Adamowicz
Center for Oral Health and Systemic Disease, University of Louisville, Louisville, Kentucky 40292, United States of America
Mol Med 18:1190-6. 2012..These findings also may have relevance to other chronic inflammatory diseases and the systemic sequelae associated with periodontal infections...
- Increased infection with key periodontal pathogens during gestational diabetes mellitusHimabindu Gogeneni
Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY, USA
J Clin Periodontol 42:506-12. 2015..We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden...
- FOXO responses to Porphyromonas gingivalis in epithelial cellsQian Wang
Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA
Cell Microbiol 17:1605-17. 2015..These data position FOXO as an important signalling node in the epithelial cell-P. gingivalis interaction, with particular relevance to cell fate and dysbiotic host responses. ..
- Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitisIris Zeller
Oral Health and Systemic Disease, University of Louisville, Louisville, KY
J Periodontol 85:837-44. 2014..gingivalis is suppressed in smokers in vivo and whether previously established in vitro tobacco-induced phenotypic P. gingivalis changes would be reflected in vivo...
- 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytesHuizhi Wang
Department of Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY, 40292, USA
Inflamm Res 65:61-9. 2016..To elucidate the influence of 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP), a canonical Wnt/β-catenin pathway activator, on the inflammatory response of TLR-engaged innate cells in vitro...
- Noncanonical activation of β-catenin by Porphyromonas gingivalisYun Zhou
Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA
Infect Immun 83:3195-203. 2015..Catenin activation in epithelial cells by P. gingivalis may contribute to a proliferative phenotype. ..
- GSK3β and the control of infectious bacterial diseasesHuizhi Wang
Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40292, USA
Trends Microbiol 22:208-17. 2014..A better understanding of complex bacteria-GSK3β interactions is likely to lead to more effective anti-inflammatory interventions and novel targets to circumvent pathogen colonization and survival. ..
- Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cellsKunal Rehani
Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, 501 S Preston Street, Louisville, KY 40292, USA
Biochim Biophys Acta 1783:375-82. 2008....
- Tobacco cessation treatment education for dental students using standardized patientsJacqueline A Singleton
Dr Singleton is Associate Professor, Department of Oral Health and Rehabilitation, School of Dentistry, University of Louisville Dr Carrico is Associate Professor, Division of Infectious Diseases, Department of Medicine, University of Louisville Dr Myers is Associate Professor, Child Health Services Research Unit, Department of Pediatrics, University of Louisville Dr Scott is Associate Professor, Oral Health and Systemic Disease, Department of Oral Health and Rehabilitation, University of Louisville Dr Wilson is Chairperson and Professor, Department of Health Promotion and Behavioral Sciences, University of Louisville and Ms Worth is Professional Education and Training Manager, Kentucky Cancer Program, University of Louisville
J Dent Educ 78:895-905. 2014..These findings suggest that using SPs is a valuable educational method to promote the provision of TCT by dental students and graduates. ..
- Effects of smoking and gingival inflammation on salivary antioxidant capacityNurcan Buduneli
Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
J Clin Periodontol 33:159-64. 2006..This study evaluated possible effects of smoking and gingival inflammation on salivary antioxidants in gingivitis patients...
- Homocysteine and C-reactive protein are not markers of cognitive impairment in patients with major cardiovascular diseaseBrendan Silbert
Centre for Anaesthesia and Cognitive Function, Department of Anaesthesia, St Vincent s Health, Melbourne, Victoria, Australia
Dement Geriatr Cogn Disord 25:309-16. 2008..Raised concentrations of plasma homocysteine and C-reactive protein (CRP) are associated with vascular disease and have also been implicated as independent risk factors for cognitive impairment in population studies...
- Mechanisms of action of environmental factors--tobacco smokingRichard M Palmer
King s College London, Guy s Hospital Campus, London Bridge, London SE1 9RT, UK
J Clin Periodontol 32:180-95. 2005..To review the potential biological mechanisms underlying the effects of tobacco smoking on periodontitis...
- Epidural anesthesia for coronary artery bypass surgery compared with general anesthesia alone does not reduce biochemical markers of myocardial damageMichael J Barrington
Department of Anaesthesia, St Vincent s Hospital, Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia
Anesth Analg 100:921-8. 2005..We conclude that HTEA for CABG surgery had no effect on troponin release but improved postoperative analgesia and was associated with a reduced time to extubation...
- Progression of periodontal disease in a maintenance population of smokers and non-smokers: a 3-year longitudinal studySean Fisher
Department of Dental Diagnostics and Surgical Sciences, University of Manitoba, Winnipeg, MB, Canada
J Periodontol 79:461-8. 2008..Therefore, we set out to assess disease progression longitudinally in smoking and non-smoking subjects with chronic periodontitis undergoing periodontal maintenance therapy every 3 to 4 months...
- Are nicotine replacement strategies to facilitate smoking cessation safe?Chris Lavelle
Faculty of Dentistry, University of Manitoba, Winnipeg, Manitoba, Canada
J Can Dent Assoc 69:592-7. 2003..Furthermore, nicotine replacement is usually delivered over the short term (a matter of weeks). Therefore, nicotine replacement is recognized as a relatively safe and effective aid to smoking cessation...
- Infrared spectroscopy as a novel diagnostic tool for periodontitisDavid Scott; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..