David A Scott

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi Neutrophils in periodontal inflammation
    David A Scott
    Center for Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA
    Front Oral Biol 15:56-83. 2012
  2. ncbi The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release
    Minqi Xu
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    BMC Cell Biol 9:19. 2008
  3. ncbi The influence of vitamin C on systemic markers of endothelial and inflammatory cell activation in smokers and non-smokers
    D A Scott
    Periodontics, Endodontics and Dental Hygiene, School of Dentistry, University of Louisville, 501 South Preston, Louisville, KY 40202, USA
    Inflamm Res 54:138-44. 2005
  4. ncbi Tobacco use increases susceptibility to bacterial infection
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA
    Tob Induc Dis 4:12. 2008
  5. ncbi Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases
    David A Scott
    Oral Health and Systemic Disease Research Group, Department of Pharmacology and Toxicology, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, United States
    World J Gastroenterol 12:7451-9. 2006
  6. ncbi Diabetes-related molecular signatures in infrared spectra of human saliva
    David A Scott
    Oral Health and Systemic Disease, University of Louisville, Louisville, S Preston St, Louisville, KY, 40292, USA
    Diabetol Metab Syndr 2:48. 2010
  7. ncbi Tobacco smoke augments Porphyromonas gingivalis-Streptococcus gordonii biofilm formation
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 6:e27386. 2011
  8. ncbi Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity
    Juhi Bagaitkar
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 5:e9323. 2010
  9. ncbi Tobacco-induced alterations to Porphyromonas gingivalis-host interactions
    Juhi Bagaitkar
    Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
    Environ Microbiol 11:1242-53. 2009
  10. ncbi Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells
    Kunal Rehani
    Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, 501 S Preston Street, Louisville, KY 40292, USA
    Biochim Biophys Acta 1783:375-82. 2008

Research Grants

  1. Infrared spectroscopy as a novel diagnostic tool for periodontitis
    David Scott; Fiscal Year: 2007
  2. Tobacco-induced alterations to P. gingivalis-host interactions
    David A Scott; Fiscal Year: 2010

Collaborators

  • Huizhi Wang
  • Jan Potempa
  • Nurcan Buduneli
  • R M Palmer
  • Denis F Kinane
  • Juhi Bagaitkar
  • Diane E Renaud
  • Donald R Demuth
  • Karina Adamowicz
  • Lisa R Williams
  • Minqi Xu
  • Brendan Silbert
  • Sean Fisher
  • Kunal Rehani
  • Michael J Barrington
  • Chris Lavelle
  • Iris Zeller
  • Ravi Jotwani
  • Carol K Patel
  • Carlo A Daep
  • Deanne L Pierce
  • Carlo Amorin Daep
  • Mike Martin
  • Manjunatha R Bemakanakere
  • Hashir Hamza
  • Konrad Jamrozik
  • Diane Renaud
  • Shirley C Gelskey
  • Kan Zhi Liu
  • Jean-Pierre Picard
  • Lisbeth Evered
  • Leah Kells
  • James E Scott
  • David L Singer
  • Abdel Soussi-Gounni
  • Michael Martin
  • Lisa Lix
  • Craig McCutcheon
  • Hannah R Bishop
  • Jean Pierre Picard
  • Roman Kluger
  • Robert Watson
  • Karen J Harris
  • Catalena Birek

Detail Information

Publications17

  1. ncbi Neutrophils in periodontal inflammation
    David A Scott
    Center for Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA
    Front Oral Biol 15:56-83. 2012
    ..This review will cover the innate and inflammatory functions of neutrophils, and describe the importance and utility of neutrophils to the host response and the integrity of the periodontium in health and disease...
  2. ncbi The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release
    Minqi Xu
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    BMC Cell Biol 9:19. 2008
    ..Key neutrophil effector functions (oxidative burst, bacterial killing, matrix metalloproteinase release) were also examined...
  3. ncbi The influence of vitamin C on systemic markers of endothelial and inflammatory cell activation in smokers and non-smokers
    D A Scott
    Periodontics, Endodontics and Dental Hygiene, School of Dentistry, University of Louisville, 501 South Preston, Louisville, KY 40202, USA
    Inflamm Res 54:138-44. 2005
    ....
  4. ncbi Tobacco use increases susceptibility to bacterial infection
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA
    Tob Induc Dis 4:12. 2008
    ..Further epidemiological, clinical and mechanistic research into this important area is warranted...
  5. ncbi Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases
    David A Scott
    Oral Health and Systemic Disease Research Group, Department of Pharmacology and Toxicology, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, United States
    World J Gastroenterol 12:7451-9. 2006
    ....
  6. ncbi Diabetes-related molecular signatures in infrared spectra of human saliva
    David A Scott
    Oral Health and Systemic Disease, University of Louisville, Louisville, S Preston St, Louisville, KY, 40292, USA
    Diabetol Metab Syndr 2:48. 2010
    ..There is an ongoing need for improvements in non-invasive, point-of-care tools for the diagnosis and prognosis of diabetes mellitus. Ideally, such technologies would allow for community screening...
  7. ncbi Tobacco smoke augments Porphyromonas gingivalis-Streptococcus gordonii biofilm formation
    Juhi Bagaitkar
    Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 6:e27386. 2011
    ..gingivalis biofilms of limited pro-inflammatory potential may explain the increased persistence of this pathogen in smokers. These findings may also be relevant to other biofilm-induced infectious diseases and conditions...
  8. ncbi Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity
    Juhi Bagaitkar
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 5:e9323. 2010
    ..gingivalis...
  9. ncbi Tobacco-induced alterations to Porphyromonas gingivalis-host interactions
    Juhi Bagaitkar
    Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
    Environ Microbiol 11:1242-53. 2009
    ..gingivalis adapts by altering gene expression and outer membrane proteins. These changes may explain, in part, the altered virulence and host-pathogen interactions that have been documented in vivo in smokers with periodontal disease...
  10. ncbi Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells
    Kunal Rehani
    Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, 501 S Preston Street, Louisville, KY 40292, USA
    Biochim Biophys Acta 1783:375-82. 2008
    ....
  11. ncbi Inhibition of GSK3 Abolishes Bacterial-Induced Periodontal Bone Loss in Mice
    Karina Adamowicz
    Center for Oral Health and Systemic Disease, University of Louisville, Louisville, Kentucky, United States of America Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Mol Med 18:1190-6. 2012
    ..These findings also may have relevance to other chronic inflammatory diseases and the systemic sequelae associated with periodontal infections...
  12. ncbi Effects of smoking and gingival inflammation on salivary antioxidant capacity
    Nurcan Buduneli
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 33:159-64. 2006
    ..This study evaluated possible effects of smoking and gingival inflammation on salivary antioxidants in gingivitis patients...
  13. ncbi Progression of periodontal disease in a maintenance population of smokers and non-smokers: a 3-year longitudinal study
    Sean Fisher
    Department of Dental Diagnostics and Surgical Sciences, University of Manitoba, Winnipeg, MB, Canada
    J Periodontol 79:461-8. 2008
    ..Therefore, we set out to assess disease progression longitudinally in smoking and non-smoking subjects with chronic periodontitis undergoing periodontal maintenance therapy every 3 to 4 months...
  14. ncbi Homocysteine and C-reactive protein are not markers of cognitive impairment in patients with major cardiovascular disease
    Brendan Silbert
    Centre for Anaesthesia and Cognitive Function, Department of Anaesthesia, St Vincent s Health, Melbourne, Victoria, Australia
    Dement Geriatr Cogn Disord 25:309-16. 2008
    ..Raised concentrations of plasma homocysteine and C-reactive protein (CRP) are associated with vascular disease and have also been implicated as independent risk factors for cognitive impairment in population studies...
  15. ncbi Mechanisms of action of environmental factors--tobacco smoking
    Richard M Palmer
    King s College London, Guy s Hospital Campus, London Bridge, London SE1 9RT, UK
    J Clin Periodontol 32:180-95. 2005
    ..To review the potential biological mechanisms underlying the effects of tobacco smoking on periodontitis...
  16. ncbi Epidural anesthesia for coronary artery bypass surgery compared with general anesthesia alone does not reduce biochemical markers of myocardial damage
    Michael J Barrington
    Department of Anaesthesia, St Vincent s Hospital, Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia
    Anesth Analg 100:921-8. 2005
    ..We conclude that HTEA for CABG surgery had no effect on troponin release but improved postoperative analgesia and was associated with a reduced time to extubation...
  17. ncbi Are nicotine replacement strategies to facilitate smoking cessation safe?
    Chris Lavelle
    Faculty of Dentistry, University of Manitoba, Winnipeg, Manitoba, Canada
    J Can Dent Assoc 69:592-7. 2003
    ..Furthermore, nicotine replacement is usually delivered over the short term (a matter of weeks). Therefore, nicotine replacement is recognized as a relatively safe and effective aid to smoking cessation...

Research Grants3

  1. Infrared spectroscopy as a novel diagnostic tool for periodontitis
    David Scott; Fiscal Year: 2007
    ....
  2. Tobacco-induced alterations to P. gingivalis-host interactions
    David A Scott; Fiscal Year: 2010
    ..This study will provide some of the first information illustrating how P. gingivalis responds at the molecular level to cigarette smoke and may provide unique insights into disease pathogenesis in smokers. ..