Research Topics
| R ScofieldSummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
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Publications
Juvenile spondyloarthropathiesR Hal Scofield
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation RHS, ALS, Oklahoma City, OK, USA
Curr Rheumatol Rep 14:395-401. 2012..These agents also have serious complications, including induction of other autoimmune diseases...- Mapping susceptibility gene in systemic lupus erythematosusR Hal Scofield
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Methods Mol Biol 900:11-24. 2012..This effort can also be used to identify causal alleles from association intervals not yet otherwise identified... 
IL-21 and Sjögren's syndromeR Hal Scofield
Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, 1000 North Lincoln Blvd, Oklahoma City, OK 73104, USA
Arthritis Res Ther 13:137. 2011..Demonstration of IL-21 as a fundamental aspect of the pathophysiology of Sjögren's syndrome could lead to the development of anti-IL-21 therapy for this disease...
Anti-calreticulin segregates anti-Ro sera in systemic lupus erythematosus: anti-calreticulin is present in sera with anti-Ro alone but not in anti-Ro sera with anti-La or anti-ribonucleoproteinR H Scofield
Department of Medicine, University of Oklahoma Health Sciences Center, The Veterans Affairs Medical Center, and the W K Warren Medical Research Institute, Oklahoma City, USA
J Rheumatol 27:128-34. 2000..To examine a well characterized group of patients with systemic lupus erythematosus (SLE) for anti-calreticulin...- Genetic knock out of 60kD Ro (or SSA), a common lupus autoantigen, induces lupusR Hal Scofield
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Trends Immunol 25:1-3. 2004..These data add to the expanding cooperation between mouse and human SLE genetic studies and are the first in which ablation of an autoantigen induces an autoimmune disease... - Autoantibodies as predictors of diseaseR Hal Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Lancet 363:1544-6. 2004..Long-term large studies of outcome are needed to assess the use of assaying autoantibodies for prediction of disease. Such data could lead to intervention trials to prevent autoimmune disease, as are already underway in type 1 diabetes... - Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosomeR Hal Scofield
Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and Oklahoma City VAMC, Oklahoma City, OK 73104, USA
Arthritis Rheum 58:2511-7. 2008..The present study was undertaken to investigate the prevalence of Klinefelter's syndrome in a large population of patients with SLE... - Autoimmune thyroid disease is associated with a diagnosis of secondary Sjögren's syndrome in familial systemic lupusR Hal Scofield
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Ann Rheum Dis 66:410-3. 2007..Autoimmune thyroid disease is common in systemic lupus erythematosus (SLE). About 20% of patients with SLE have secondary Sjögren's syndrome... - Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sjogren's syndromeR Hal Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Immunol 175:8409-14. 2005..BALB/c mice immunized with 60-kDa Ro peptides develop anti-Ro, salivary gland lymphocyte infiltrates, and salivary dysfunction that is highly reminiscent of human Sjögren's syndrome... - Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreadingR Hal Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 38:719-28. 2005..These data may suggest a hitherto unappreciated mechanism by which oxidative stress facilitates epitope spreading in SLE... - Genetics of systemic lupus erythematosus and Sjögren's syndromeR Hal Scofield
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Curr Opin Rheumatol 21:448-53. 2009..To determine the advances made in the genetics of systemic lupus erythematosus (SLE) or Sjögren's syndrome as the era of genome-wide association and high-throughput single nucleotide typing begins... - Vasculitis in Sjögren's SyndromeR Hal Scofield
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
Curr Rheumatol Rep 13:482-8. 2011..Devic disease patients have salivary lymphocytic infiltration similar to that found among Sjögren's syndrome patients... - Immunization with peptides from 60 kDa Ro in diverse mouse strainsR H Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center and the Department of Veterans Affairs Medical Center, Oklahoma City, OK 73105, USA
Scand J Immunol 56:477-83. 2002..Furthermore, these data suggest that genetic variation is important with regard to responding towards short peptide immunization by epitope spreading... - Protein-protein interaction of the Ro-ribonucleoprotein particle using multiple antigenic peptidesR H Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Mol Immunol 36:1093-106. 1999..The present data indicate that there are protein-protein interactions between Ro and La... - Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13R Hal Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
Blood 101:992-7. 2003.... - Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjögren's syndrome?A N Scofield
Oklahoma Medical Research Program, University of Oklahoma Health Sciences Center, USA
Lupus 10:547-53. 2001..Thus, the fine specificity of antibody binding to 60 kDa Ro varies according to the presence of anti-La, not to the diagnosis of either SLE or SS... - Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies: a possible therapy to alleviate autoimmune disordersBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Mol Nutr Food Res 54:1202-9. 2010..In addition, the non-toxic curcumin could serve as a new protein stain in SDS-PAGE even though it is less sensitive than the Coomassie system which involves toxic chemicals... - Interaction of calcium and Ro60: increase of antigenicityR Hal Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation (OMRF, 825 NE 13th Street, MS# 38, Oklahoma City, OK 73104, USA
Mol Immunol 41:809-16. 2004..Thus, the observed intramolecular and intermolecular interactions and antigen-antibody interactions could be Ca2+ ion mediated conformational interactions, and we propose that 60 kDa Ro is a calcium binding protein... - Affinity immunoblotting for analysis of antibody clonotype distribution in a lupus patient developing anti-Ro 60 over timeBiji T Kurien
Oklahoma Medical Research Foundation, 825 NE 13th Street, OK 73104, Oklahoma City, USA
Methods Mol Biol 536:45-53. 2009..The bound IgG clonotypes were detected using alkaline phosphatase conjugated anti-IgG. The patient's sera demonstrated an oligoclonal response to the Ro 60 autoantigen that increased in complexity and affinity over time... - Autoimmunity and oxidatively modified autoantigensBiji T Kurien
Arthritis and Immunology Program, USA
Autoimmun Rev 7:567-73. 2008..However, this should be viewed in the light of disappointing results obtained with the use of antioxidants in cardiovascular disease... - Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLEAnil D'Souza
Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
BMC Med Genet 9:62. 2008..Hence we investigated the effects of a genetic polymorphism of catalase on risk and severity of SLE in 48 pedigrees with African American ancestry... - High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groupsBahram Namjou
Oklahoma Medical Research Foundation, Oklahoma City, USA
Arthritis Rheum 60:1085-95. 2009..STAT-1 and STAT-4 are transcription factors that play key roles in the interferon and Th1 signaling pathways, making them attractive candidates for involvement in SLE susceptibility... - Ultrarapid electrophoretic transfer of high and low molecular weight proteins using heatBiji T Kurien
Oklahoma Medical Research Foundation, 825 NE 13th Street, OKC, OK, 73104, USA
Methods Mol Biol 536:181-90. 2009..In summary, this procedure is particularly useful for the transfer of high molecular weight proteins, very rapid, and avoids the use of methanol... - Development of autoantibodies before the clinical onset of systemic lupus erythematosusMelissa R Arbuckle
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
N Engl J Med 349:1526-33. 2003..Furthermore, the appearance of autoantibodies in patients with SLE tends to follow a predictable course, with a progressive accumulation of specific autoantibodies before the onset of SLE, while patients are still asymptomatic... - Can low dose diagnostic dental radiation trigger Sjögren's syndrome?Biji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Med Hypotheses 69:995-1000. 2007..We hypothesize that diagnostic dental radiation could be a factor for the development of SS as a result of either radiation induced apoptosis or through oxidative modification of proteins... - Improving the solubility and pharmacological efficacy of curcumin by heat treatmentBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Assay Drug Dev Technol 5:567-76. 2007..Heat-solubilized curcumin should be considered in clinical trials involving curcumin, especially in the face of frustrating results obtained regarding curcumin-mediated correction of cystic fibrosis defects... - Autoimmunity and Klinefelter's syndrome: when men have two X chromosomesAmr H Sawalha
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Autoimmun 33:31-4. 2009..On the other hand, a gene dose effect could also be mediated by a gene without an SLE-associated polymorphism in that a gene that avoids X inactivation will have a higher level of expression in persons with two X chromosomes... - Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patientsS Malik
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Lupus 16:863-6. 2007..3% versus 27.4%, OR = 0.31, P = 0.0075). In conclusion, anti-La autoantibody is associated with less severe lupus. Patients with anti-La have a lower risk of renal involvement and seizures compared with anti-La negative lupus patients... - Common variants within MECP2 confer risk of systemic lupus erythematosusAmr H Sawalha
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
PLoS ONE 3:e1727. 2008..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE... - A brief review of other notable protein detection methods on blotsBiji T Kurien
Oklahoma Medical Research Foundation, 825 NE 13th Street, OK 73104, Oklahoma City, USA
Methods Mol Biol 536:557-71. 2009..These methods are briefly reviewed in this chapter... - Detection of La/SS-B by western blot using nanogold-tagged antibodies and silver enhancementShannon Maier
Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, MS 24, 825 NE 13th Street, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:491-7. 2009.... - Protein blotting: a reviewBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
J Immunol Methods 274:1-15. 2003 - Nonelectrophoretic bidirectional transfer of a single SDS-PAGE gel with multiple antigens to obtain 12 immunoblotsBiji T Kurien
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:55-65. 2009.... - A candidate region on 11p13 for systemic lupus erythematosus: a linkage identified in African-American familiesSwapan K Nath
Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
J Investig Dermatol Symp Proc 9:64-7. 2004.... - A brief review of other notable protein blotting methodsBiji T Kurien
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:367-84. 2009..All these methods are briefly reviewed in this chapter... - Free radical mediated peroxidative damage in systemic lupus erythematosusBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Life Sci 73:1655-66. 2003..Heat inactivated anti-SOD autoantibodies were able to inhibit the activity of the enzyme. We propose that the inhibition of SOD by autoantibodies is, in part, responsible for the increased free radical damage seen in the disease... - Male-only systemic lupusRachna Aggarwal
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Rheumatol 37:1480-7. 2010..Systemic lupus erythematosus (SLE) is more common among women than men, a ratio of about 10 to 1. We undertook this study to describe familial male SLE within a large familial SLE cohort... - Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification--an in vitro studyBiji T Kurien
Arthritis and Immunology Program, Oklahoma City, OK 73104, USA
J Ethnopharmacol 110:368-73. 2007..The pH at which the inhibition of HNE modification of substrate was observed was close to the physiological pH, making this formulation of curcumin potentially useful practically... - Determination of prolidase activity using matrix-assisted laser desorption/ionization time-of-flight mass spectrometryBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Anal Biochem 331:224-9. 2004..Using this method we have unambiguously identified subjects with homozygous or heterozygous prolidase deficiency. In addition to the advantage of rapid sample preparation time, this method is highly specific, reproducible, and sensitive... - In vitro modification of solid phase multiple antigenic peptides/autoantigens with 4-hydroxy-2-nonenal (HNE) provide ideal substrates for detection of anti-HNE antibodies and peptide antioxidantsBiji T Kurien
Arthritis and Immunology Program, 825 NE 13th Street, Oklahoma City, OK 73104, USA
J Immunol Methods 303:66-75. 2005..Glycyl-proline dipeptide and a MAP from the Sm autoantigen (PPPGMRPP) showed 0% inhibition of HNE-modification... - Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid diseaseBahram Namjou
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Arthritis Rheum 52:3646-50. 2005..CONCLUSION: These results suggest that stratifying SLE pedigrees by the presence of other autoimmune disorders may facilitate the discovery of genes related to SLE and that 5q14.3-15 harbors a susceptibility gene shared by SLE and AITD... - Prolidase deficiency and the biochemical assays used in its diagnosisBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Anal Biochem 349:165-75. 2006 - Barbering in mice: a model for trichotillomaniaBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
BMJ 331:1503-5. 2005 - Mechanized syringe homogenization of human and animal tissuesBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, 825 NE 13th Street, OK 73104, USA
Assay Drug Dev Technol 2:308-12. 2004..Use of the Bio-Mixer 1200 to homogenize animal or human tissue precludes the need to stay in the cold room as is the case with the other hands-on homogenization methods available, in addition to freeing up time for other experiments... - Extraction of nucleic acid fragments from gelsBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, USA
Anal Biochem 302:1-9. 2002 - Western blottingBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
Methods 38:283-93. 2006..Finally, a brief description of methods generally used to detect antigens on blots is also described... - Lipid peroxidation in systemic lupus erythematosusBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, USA
Indian J Exp Biol 44:349-56. 2006..Immunization with an oxidatively modified autoantigen led to the rapid development of autoimmunity compared to immunization with the unmodified autoantigen. Thus, oxidative damage appears to play an important role in SLE pathogenesis... - Heat-mediated, ultra-rapid electrophoretic transfer of high and low molecular weight proteins to nitrocellulose membranesBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
J Immunol Methods 266:127-33. 2002..In summary, this procedure is very rapid, avoids the use of methanol and is particularly useful for the transfer of high molecular weight proteins... - Epstein-Barr virus and systemic lupus erythematosusJudith A James
Arthritis and Immunology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Curr Opin Rheumatol 18:462-7. 2006..Although many genetic and environmental factors are associated, this review will focus on the evolving evidence for key Epstein-Barr virus specific roles... - An overview of Western blotting for determining antibody specificities for immunohistochemistryBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Methods Mol Biol 717:55-67. 2011..Specificity of antibodies used for immunohistochemistry is of critical importance and therefore Western blot is a "must" to address antibodies' specificity... - Experimental animal urine collection: a reviewBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, OK 73104, USA
Lab Anim 38:333-61. 2004..A continuous refinement in the procedures for collecting urine from experimental animals will be the most efficient way of proceeding in obtaining pure urine specimens for obtaining reliable research data... - Neonatal lupus manifests as isolated neutropenia and mildly abnormal liver functionsSivalingam Kanagasegar
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
J Rheumatol 29:187-91. 2002..Furthermore, although other factors may contribute, these data suggest that anti-60 kDa Ro is directly involved in the pathogenesis of neutropenia... - Whole and strip nitrocellulose membrane as well as a new-line-immunoblotting of antigen using the chemiluminescence techniqueYaser Dorri
Oklahoma Medical Research Foundation, 825 NE 13th St, Arthritis and Immunology Department, MS 24, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:417-32. 2009.... - Tryptic peptide purification using polyvinylidene difluoride membrane for matrix-assisted laser desorption ionization time of flight mass spectrometryBiji T Kurien
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:39-44. 2009..Using this procedure, we were able to identify a cross-reactive D1 autoantigen on the surface of neutrophils that bound antibodies targeting Ro 60 autoantigen in systemic lupus erythematosus... - Problems with multiple use of transfer buffer in protein electrophoretic transferYaser Dorri
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, USA
J Biomol Tech 21:1-2. 2010..Here, we comment on this report, as we believe this method is not accurate and useful for protein analysis, and it can cause background binding as well as inaccurate protein analysis... - Oxidatively modified autoantigens in autoimmune diseasesBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, OK 73104, USA
Free Radic Biol Med 41:549-56. 2006.... - Epstein-Barr virus and molecular mimicry in systemic lupus erythematosusBrian D Poole
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma, OK 73104, USA
Autoimmunity 39:63-70. 2006..This paper reviews some of the current literature supporting roles for EBV exposure and epitope spreading in SLE... - Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegenerationSandra E Gomez-Mejiba
Free Radical Biology and Aging Research Program, MS 21, 825 NE 13th Street, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, United States
Mutat Res 674:62-72. 2009.... - Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemiaJennifer A Kelly
Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Proc Natl Acad Sci U S A 99:11766-71. 2002..Thus, we show strong evidence for an SLE susceptibility gene, SLEH1, near D11S2002 in African-American pedigrees multiplex for SLE that have at least one SLE-affected patient with hemolytic anemia... - Protein stains to detect antigen on membranesAnil D'Souza
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:433-40. 2009..Detection is often synonymous to staining, i.e., the reversible or irreversible binding by the proteins of a colored organic or inorganic chemical... - Introduction to protein blottingBiji T Kurien
Oklahoma Medical Research Foundation, 825 NE 13th Street, OK 73104, Oklahoma City, USA
Methods Mol Biol 536:9-22. 2009..The scientific community is now confronted with a variety of ways and means to carry out this transfer... - Horizons in Sjögren's syndrome geneticsPamela H Williams
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Clin Rev Allergy Immunol 32:201-9. 2007..Newly developed genomic capacity will provide, in the future, a much closer approximation of the true picture of the genetic architecture of Sjögren's syndrome... - Mapping the systematic lupus erythematosus susceptibility genesSwapan K Nath
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Methods Mol Med 102:11-29. 2004..SLE is a complex clinical illness, and investigation of the genetics of the illness based on clinical manifestations revealed linkages not found without consideration of the phenotype of the disease... - Grid-immunoblottingOlga Yeliosof
Oklahoma Medical Research Foundation, 825 NE 13th Street Mailstop 24, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:289-92. 2009..Grid-Immunoblotting is a fast, simple, and efficient method for simultaneously testing multiple allergens utilizing small amount of antibody... - Systemic lupus erythematosus and C1q: A quantitative ELISA for determining C1q levels in serumSkyler P Dillon
Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
Biotechnol J 4:1210-4. 2009..We report an average concentration of 113 +/- 40 microg/mL for C1q in non-SLE serum. The assay designed here will be useful in the high-throughput measurement of serum C1q in SLE cases... - Phosphoprotein detection on protein electroblot using a phosphate-specific fluorophoreLee Broderick Bockus
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:385-93. 2009..It can also be followed by standard chemiluminescent, colorimetric, and fluorogenic detection techniques used in immunoblotting... - The genetics of primary Sjögren's syndromeAmr H Sawalha
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Curr Rheumatol Rep 5:324-32. 2003..No doubt a much more comprehensive description of the genetics of this disorder will soon emerge... - Autoantibody prevalence and lupus characteristics in a unique African American populationDiane L Kamen
Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Arthritis Rheum 58:1237-47. 2008..Because of the unique homogeneous nature of the Gullah, we sought to define the genetic and environmental factors contributing to systemic lupus erythematosus (SLE) in this population... - A nonsense mutation of PEPD in four Amish children with prolidase deficiencyHeng Wang
Das Deutsch Center DDC Clinic for Special Needs Children, Middlefield, Ohio 44062, USA
Am J Med Genet A 140:580-5. 2006..793 T > C in exon 11, resulting in a premature stop-codon at amino acid residue 265 (p.R265X). It is speculated that the severe phenotype in these patients might be associated with the type of the PEPD gene mutation... - SOD1 interacts directly with hemoglobin in vitroBiji T Kurien
Thromb Haemost 92:218-20. 2004 - Anti-Ro and anti-nRNP response in unaffected family members of SLE patientsLatisha D Heinlen
Lupus 12:335-7. 2003 - Four men in a space station - To say nothing of the cow! The quest for finding respite and work in the ultimate frontierBiji T Kurien
Med Hypotheses 68:1195-9. 2007..The anaerobic environment is particularly suitable for biogas generation and if successful they plan to get NASA to launch space vehicles to Mars using this natural fuel with the ISS as the staging area... - Milk-alkali syndrome in pre-eclamptic pregnancy: report of a patient and evaluation of albumin-corrected calcium in pre-eclamptic pregnanciesStefanie Addington
J Okla State Med Assoc 99:480-4. 2006..Albumin-corrected calcium is frequently high in women with pre-eclampsia but ionized calcium is not...
Research Grants
- The X chromosome in systemic lupus erythematosusR Scofield; Fiscal Year: 2007..This proposal will determine whether the presence of two X chromosomes is a risk factor for women and men with Klinefelter's syndrome (47,XXY). ..
- The X chromosome in systemic lupus erythematosusR Hal Scofield; Fiscal Year: 2010..This proposal will determine whether the presence of two X chromosomes is a risk factor for women and men with Klinefelter's syndrome (47,XXY). ..
- Sjogren's model with anti-Ro/La and Salivary Pathology and DysfunctionR Scofield; Fiscal Year: 2007..Improved understanding of the disease at a fundamental level is possible through study of animal models. Such understanding may lead to improved recognition and treatment. ..
- Genetics of Severe Systemic Lupus Erythematosus (SLE) defined by thrombocytopeniaR Scofield; Fiscal Year: 2007..Finally, Specific Aim 4 will assemble a new cohort of families multiplex for SLE so that linkages and associations as well as particular polvmorphisms can be prospectively confirmed. ..
- Sjogren's model with anti-Ro/La and Salivary Pathology and DysfunctionR Hal Scofield; Fiscal Year: 2010..Improved understanding of the disease at a fundamental level is possible through study of animal models. Such understanding may lead to improved recognition and treatment. ..