Affiliation: University of Chicago
- Modular nature of Blimp-1 in the regulation of gene expression during B cell maturationRoger Sciammas
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 172:5427-40. 2004..Furthermore, mutagenesis of Blimp-1 reveals multiple effector domains, which regulate distinct genes. This indicates that Blimp-1 subdivides the maturation program into select and tunable pathways...
- Blimp-1; immunoglobulin secretion and the switch to plasma cellsR Sciammas
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA
Curr Top Microbiol Immunol 290:201-24. 2005..These data hint at the complexity of Blimp-1 and the genetic program that it initiates to produce a pool of plasma cells necessary for specific immunity...
- The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouseStephane D Vincent
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 132:1315-25. 2005..Thus Blimp1 probably acts to turn off the default pathway that allows epiblast cells to adopt a somatic cell fate, and shifts the transcriptional program so that they become exclusively allocated into the germ cell lineage...
- Shedding B cell identityHarinder Singh
Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, 929 East 57th Street, CIS W522, Chicago, Illinois 60637, USA
Immunity 24:239-40. 2006..In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state...
- Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiationRoger Sciammas
Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
Immunity 25:225-36. 2006..We propose a gene-regulatory network in which graded expression of IRF-4 developmentally coordinates isotype switching with plasma cell differentiation...
- Multilineage transcriptional priming and determination of alternate hematopoietic cell fatesPeter Laslo
Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, 929 East 57th Street, GCIS W522, IL 60637, USA
Cell 126:755-66. 2006..These results are used to assemble and mathematically model a gene regulatory network that exhibits both graded and bistable behaviors and accounts for the onset and resolution of mixed lineage patterns during cell fate determination...