J B Schwimmer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, and Rady Children s Hospital and Health Center, San Diego, California, USA
    Semin Liver Dis 27:312-8. 2007
  2. ncbi request reprint Health-related quality of life of severely obese children and adolescents
    Jeffrey B Schwimmer
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, School of Medicine, University of California, San Diego 92103, USA
    JAMA 289:1813-9. 2003
  3. ncbi request reprint Prevalence of fatty liver in children and adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, 200 West Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 118:1388-93. 2006
  4. pmc Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
    Circulation 118:277-83. 2008
  5. pmc Heritability of nonalcoholic fatty liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California 92103, USA
    Gastroenterology 136:1585-92. 2009
  6. ncbi request reprint Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, University of California, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 115:e561-5. 2005
  7. ncbi request reprint A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis
    J B Schwimmer
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of California, San Diedo School of Medicine, CA 92103 8450, USA
    Aliment Pharmacol Ther 21:871-9. 2005
  8. pmc SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of California, San Diego School of Medicine, San Diego, California 92103 8450, USA
    Gastroenterology 138:1357-64, 1364.e1-2. 2010
  9. doi request reprint Enteric-coated cysteamine for the treatment of paediatric non-alcoholic fatty liver disease
    R Dohil
    Department of Pediatrics, University of California, Rady Children s Hospital, San Diego, USA
    Aliment Pharmacol Ther 33:1036-44. 2011
  10. pmc Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease
    K D Kistler
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    Aliment Pharmacol Ther 31:396-406. 2010

Research Grants

  1. Adipose and Fatty Liver in the Metabolic Syndrome
    Jeffrey Schwimmer; Fiscal Year: 2006

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, and Rady Children s Hospital and Health Center, San Diego, California, USA
    Semin Liver Dis 27:312-8. 2007
    ..Moreover, these data should guide efforts to delineate the pathophysiology in children and adolescents. Our future ability to prevent and treat pediatric NAFLD is dependent upon such work...
  2. ncbi request reprint Health-related quality of life of severely obese children and adolescents
    Jeffrey B Schwimmer
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, School of Medicine, University of California, San Diego 92103, USA
    JAMA 289:1813-9. 2003
    ..One in 7 US children and adolescents is obese, yet little is known about their health-related quality of life (QOL)...
  3. ncbi request reprint Prevalence of fatty liver in children and adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, 200 West Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 118:1388-93. 2006
    ..Fatty liver disease is diagnosed increasingly in children, but the prevalence remains unknown. We sought to determine the prevalence of pediatric fatty liver as diagnosed by histology in a population-based sample...
  4. pmc Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
    Circulation 118:277-83. 2008
    ..The objective of this study was to determine the association between NAFLD and the presence of metabolic syndrome in overweight and obese children...
  5. pmc Heritability of nonalcoholic fatty liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California 92103, USA
    Gastroenterology 136:1585-92. 2009
    ..Therefore, a familial aggregation study was performed to test the hypothesis that NAFLD is highly heritable...
  6. ncbi request reprint Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, University of California, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 115:e561-5. 2005
    ..Obesity and insulin resistance are major established risk factors for NAFLD. The role of gender, race, and ethnicity on the prevalence of fatty liver in obese children is unknown...
  7. ncbi request reprint A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis
    J B Schwimmer
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of California, San Diedo School of Medicine, CA 92103 8450, USA
    Aliment Pharmacol Ther 21:871-9. 2005
    ..Children with non-alcoholic steatohepatitis are insulin-resistant and metformin has been proposed as a potential therapy. However, paediatric safety and efficacy data are absent...
  8. pmc SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of California, San Diego School of Medicine, San Diego, California 92103 8450, USA
    Gastroenterology 138:1357-64, 1364.e1-2. 2010
    ..The appropriate alanine aminotransferase (ALT) threshold value to use for diagnosis of chronic liver disease in children is unknown. We sought to develop gender-specific, biology-based, pediatric ALT thresholds...
  9. doi request reprint Enteric-coated cysteamine for the treatment of paediatric non-alcoholic fatty liver disease
    R Dohil
    Department of Pediatrics, University of California, Rady Children s Hospital, San Diego, USA
    Aliment Pharmacol Ther 33:1036-44. 2011
    ..Hepatic fat accumulation and oxidative stress contribute to its pathogenesis. Cysteamine bitartrate readily traverses cellular membranes and is a potent antioxidant...
  10. pmc Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease
    K D Kistler
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    Aliment Pharmacol Ther 31:396-406. 2010
    ..Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD...
  11. doi request reprint Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease
    Winston Dunn
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA 92103 8450, USA
    Hepatology 47:1947-54. 2008
    ..15 (95% confidence interval, 0.05-0.49). Using the healthy subject cut point, suspected NAFLD was observed in 14.3% of nondrinkers and 8.6% of wine drinkers. The adjusted odds ratio was 0.51 (95% confidence interval, 0.33-0.79)...
  12. ncbi request reprint Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease
    Jeffrey B Schwimmer
    Joint Program in Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Family and Preventive Medicine, Department of Pathology, The School of Medicine, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA
    J Pediatr 143:500-5. 2003
    ..To describe the clinical characteristics of nonalcoholic fatty liver disease (NAFLD) in children, including insulin resistance, and to test for correlation with liver pathology...
  13. pmc Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis
    Heather M Patton
    Division of Gastroenterology, University of California, San Diego, San Diego, California 92103, USA
    Gastroenterology 135:1961-1971.e2. 2008
    ..Noninvasive means to discriminate between NAFLD and nonalcoholic steatohepatitis (NASH) might diminish the requirement for liver biopsy or predict those at increased risk for progression...
  14. doi request reprint Non-alcoholic fatty liver disease is associated with low bone mineral density in obese children
    P E Pardee
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, 92123, USA
    Aliment Pharmacol Ther 35:248-54. 2012
    ..Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. Liver disease can be a cause of low bone mineral density. Whether or not NAFLD influences bone health is not known...
  15. ncbi request reprint Abnormal aminotransferase activity in women with polycystic ovary syndrome
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, San Diego, CA, USA
    Fertil Steril 83:494-7. 2005
    ..Women with elevated ALT had significantly higher body mass index, waist circumference, serum triglycerides, total cholesterol-to-HDL-cholesterol ratio, and degree of insulin resistance...
  16. ncbi request reprint Nonalcoholic fatty liver disease in the pediatric population
    Joel E Lavine
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego Medical Center and Children s Hospital, 200 W Arbor Drive, San Diego, CA 92103 8450, USA
    Clin Liver Dis 8:549-58, viii-ix. 2004
    ..Important differences between pediatric and adult fatty liver disease are highlighted...
  17. ncbi request reprint Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research
    Heather M Patton
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, CA, USA
    J Pediatr Gastroenterol Nutr 43:413-27. 2006
    ..A large, multicenter trial of vitamin E and metformin is underway as part of the NASH clinical research network...
  18. ncbi request reprint Lumen and the liver--together again in NASHville
    Jeffrey B Schwimmer
    Department of Pediatrics, University of California, San Diego, USA
    J Pediatr Gastroenterol Nutr 37:523-4. 2003
  19. pmc Relaxation effects in the quantification of fat using gradient echo imaging
    Mark Bydder
    MR3 Research Building, University of California San Diego, San Diego, CA 92103 8226, USA
    Magn Reson Imaging 26:347-59. 2008
    ..At short echo times, the spectral broadening effects manifest as a short apparent T2 for the fat component...
  20. doi request reprint Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease
    N J Barshop
    Department of Pediatrics, University of California, San Diego, CA, USA
    Aliment Pharmacol Ther 28:13-24. 2008
    ..However, significant histological differences exist between adult and paediatric NAFLD to warrant caution in extrapolation of adult data...
  21. pmc Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease
    Heather M Patton
    Departments of Medicine and Pediatrics, University of California, San Diego, San Diego, California, USA
    Am J Gastroenterol 105:2093-102. 2010
    ..We sought to determine whether MetS or its component features are associated with specific histological features or severity of NAFLD...
  22. pmc Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery
    Perrie E Pardee
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego, and Rady Children s Hospital, San Diego, California CA 92103 8450, USA
    Semin Pediatr Surg 18:144-51. 2009
    ..Several clinical trials for NAFLD are in progress; however, clinical trials focusing on NASH are needed. Heightened physician awareness of NAFLD, NASH, and associated risk factors is important to identify and treat affected children...
  23. pmc Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification
    Gavin Hamilton
    Department of Radiology, University of California, San Diego, San Diego, California 92103 8226, USA
    J Magn Reson Imaging 30:145-52. 2009
    ..To compare PRESS and STEAM MR spectroscopy for assessment of liver fat in human subjects...
  24. pmc Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Hepatology 51:1961-71. 2010
    ..05 for each). In older adults (age > or = 48 years), daily fructose consumption was associated with increased hepatic inflammation (P < 0.05) and hepatocyte ballooning (P = 0.05)...
  25. ncbi request reprint Television viewing and hypertension in obese children
    Perrie E Pardee
    Department of Pediatrics, School of Medicine, University of California, Rady Children s Hospital and Health Center, San Diego 92103 845, USA
    Am J Prev Med 33:439-43. 2007
    ..However, the association between TV viewing and hypertension in children is unknown. This study aimed to identify whether TV watching is associated with hypertension in obese children...
  26. ncbi request reprint The obesity epidemic and nonalcoholic fatty liver disease in children
    Winston Dunn
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103, USA
    Curr Gastroenterol Rep 10:67-72. 2008
    ..Such studies are imperative to address fundamental questions regarding cause and cure...
  27. ncbi request reprint Histopathology of pediatric nonalcoholic fatty liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, San Diego, CA 92103 8450, USA
    Hepatology 42:641-9. 2005
    ..NASH subtypes should be considered when interpreting liver biopsies and planning studies of the pathophysiology, genetics, natural history, or response to treatment in pediatric NAFLD...
  28. pmc Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network
    Kristin David
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    Hepatology 49:1904-12. 2009
    ..Conclusion: Adults with NAFLD have a significant decrement in QOL. Treatment of NAFLD should incorporate strategies to improve QOL, especially physical health...
  29. pmc Advances in pediatric nonalcoholic fatty liver disease
    Rohit Loomba
    Division of Gastroenterology, Department of Medicine, University of California at San Diego and Rady Children s Hospital, San Diego, CA, USA
    Hepatology 50:1282-93. 2009
    ..CONCLUSION: Public health awareness and intervention are needed to promote healthy diet, exercise, and lifestyle modifications to prevent and reduce the burden of disease in the community...
  30. pmc Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease
    Amy G Shah
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:1104-12. 2009
    ..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD...
  31. doi request reprint Adenovirus 36 and obesity in children and adolescents
    Charles Gabbert
    University of California, San Diego, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, School of Medicine, and Department of Gastroenterology, Rady Children s Hospital San Diego, 200 West Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 126:721-6. 2010
    ..The primary aim of this study was to assess the relationship between adenovirus 36 (AD36)-specific antibodies and obesity in children...
  32. doi request reprint Hepatic, cardiovascular, and endocrine outcomes of the histological subphenotypes of nonalcoholic fatty liver disease
    Eitan Rubinstein
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, Rady Children s Hospital, San Diego, California 92103 8450, USA
    Semin Liver Dis 28:380-5. 2008
    ....
  33. pmc Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
    Winston Dunn
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Am J Gastroenterol 103:2263-71. 2008
    ..The current study compared the survival of subjects with and without suspected NAFLD in a population-based cohort, and placed the finding in the context of previously published case series...
  34. ncbi request reprint Managing overweight in older children and adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Diego, 200 West Arbor Drive, San Diego, California 92103 8450, USA
    Pediatr Ann 33:39-44. 2004
    ..Many overweight and obese children and adolescents can achieve weight loss of 0.5 kg per week even over long periods. For some severely obese children, pharmacotherapy or surgery may be necessary...
  35. pmc Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T
    Takeshi Yokoo
    Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3 Laboratory, 408 Dickinson St, San Diego, CA 92103 8226, USA
    Radiology 251:67-76. 2009
    ....
  36. ncbi request reprint Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: a prospective cohort study
    Stavra A Xanthakos
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Pediatr Gastroenterol Nutr 41:16-22. 2005
    ..We tested the hypothesis that allergic colitis is overdiagnosed in healthy infants with rectal bleeding. The authors also determined whether rectal bleeding in infants without allergic colitis would resolve without diet change...
  37. doi request reprint Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis
    Fiona Hughes Cassidy
    Department of Radiology, University of California at San Diego, 200 W Arbor Dr, San Diego, CA 92103, USA
    Radiographics 29:231-60. 2009
    ....
  38. ncbi request reprint Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in children
    Joel E Lavine
    J Pediatr Gastroenterol Nutr 42:129-30. 2006
  39. doi request reprint Musculoskeletal pain in obese children and adolescents
    Steven D Stovitz
    Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Acta Paediatr 97:489-93. 2008
    ..To determine whether bodyweight is associated with musculoskeletal pain within a population of obese children and adolescents...
  40. doi request reprint Fast break on the fat brake: mechanism of peroxisome proliferator-activated receptor-delta regulation of lipid accumulation in hepatocytes
    Danielle B Andrews
    Hepatology 48:355-7. 2008
  41. doi request reprint Pediatric obesity: the unique issues in Latino-American male youth
    Steven D Stovitz
    Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Prev Med 34:153-60. 2008
    ....
  42. ncbi request reprint Health-related quality of life in pediatric patients with irritable bowel syndrome: a comparative analysis
    James W Varni
    Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A and M University, College Station, Texas 77843 3137, USA
    J Dev Behav Pediatr 27:451-8. 2006
    ..These findings suggest the need for targeted interventions to address these dimensions of impaired HRQOL...

Research Grants1

  1. Adipose and Fatty Liver in the Metabolic Syndrome
    Jeffrey Schwimmer; Fiscal Year: 2006
    ..abstract_text> ..