Research Topics
| J R SchwebkeSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Natural history of asymptomatic bacterial vaginosis in a high-risk group of womenJane R Schwebke
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Sex Transm Dis 34:876-7. 2007- High rates of Trichomonas vaginalis among men attending a sexually transmitted diseases clinic: implications for screening and urethritis managementJane R Schwebke
Department of Medicine, University of Alabama at Birmingham, USA
J Infect Dis 188:465-8. 2003..The prevalence of these pathogens was 17%, 19.6%, and 17.7% respectively. In men with NGU, 19.9% were infected with trichomonas. These data have implications for treatment of NGU and control of trichomoniasis... 
Update of trichomoniasisJ R Schwebke
University of Alabama at Birmingham, 35294 0007, USA
Sex Transm Infect 78:378-9. 2002..More recently, however, appreciation of high rates of disease and of associations of trichomoniasis in women with adverse outcomes of pregnancy and increased risk for HIV infection suggest a need for increased control efforts...- Improved detection by DNA amplification of Trichomonas vaginalis in malesJane R Schwebke
Division of Infectious Diseases, University of Alabama at Birmingham, Zeigler Research Building 239, 703 19th Street South, Birmingham, AL 35294 0007, USA
J Clin Microbiol 40:3681-3. 2002..The use of PCR techniques in urine specimen-based detection of T. vaginalis was highly sensitive and revealed a prevalence of infection more than three times that revealed by culture for men at high risk for STDs... 
A randomized controlled trial of partner notification methods for prevention of trichomoniasis in womenJane R Schwebke
Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue S, Birmingham, AL 35294, USA
Sex Transm Dis 37:392-6. 2010..The usual approach is partner referral but it is estimated that only a minority of men seek care. We conducted a randomized trial to compare the effectiveness of 3 methods of partner notification...- Tinidazole vs metronidazole for the treatment of bacterial vaginosisJane R Schwebke
Department of Medicine, University of Alabama at Birmingham, 703 19th Street, Birmingham, AL 35294, USA
Am J Obstet Gynecol 204:211.e1-6. 2011..The purpose of this study was to compare the efficacy of 2 different doses of tinidazole with metronidazole for the treatment of bacterial vaginosis and to compare the side effects of the drugs... - Interrelationships of bacterial vaginosis and cervical inflammationJane R Schwebke
Department of Medicine and Biostatistics Center, University of Alabama at Birmingham, USA
Sex Transm Dis 29:59-64. 2002..Women with cervicitis frequently have bacterial vaginosis (BV). Prior studies have suggested that BV is involved in the pathogenesis of cervicitis... - Predictors of bacterial vaginosis in adolescent women who doucheJane R Schwebke
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Sex Transm Dis 31:433-6. 2004..Risk factors for bacterial vaginosis (BV) include douching and sexual activity, although the exact cause of BV is unknown... - TrichomoniasisJane R Schwebke
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, AL 35294 0007, USA
Clin Microbiol Rev 17:794-803, table of contents. 2004..As more is appreciated concerning the important public health implications of this common infection, more work will need to be done in understanding the diagnosis, treatment, and immunology of this organism... - Risk factors for bacterial vaginosis in women at high risk for sexually transmitted diseasesJane R Schwebke
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
Sex Transm Dis 32:654-8. 2005..The etiology of the microbiologic changes is unknown. The objective of this study was to determine risk factors associated with incident BV... - Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens--a randomized clinical trialJ R Schwebke
University of Alabama at Birmingham, 703 19th St South, Birmingham, AL 35294 0007, USA
Clin Infect Dis 52:163-70. 2011..A secondary aim was to compare the efficacy of doxycycline therapy and with that of azithromycin therapy... - Prevalence of Trichomonas vaginalis isolates with resistance to metronidazole and tinidazoleJane R Schwebke
Department of Medicine, University of Alabama at Birmingham, ZRB 239, 1530 3rd Ave S, Birmingham, AL 35294 0007, USA
Antimicrob Agents Chemother 50:4209-10. 2006..Resistance to metronidazole and tinidazole was present in 17/178 (9.6%) and 1/178 (0.56%) strains, respectively. In vitro resistance was poorly correlated with clinical response to treatment... - A randomized trial of the duration of therapy with metronidazole plus or minus azithromycin for treatment of symptomatic bacterial vaginosisJ R Schwebke
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Clin Infect Dis 44:213-9. 2007..In addition, we examined factors other than drug therapy associated with cure... - Gynecologic consequences of bacterial vaginosisJane R Schwebke
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, 703 19th Street South, Zeigler Research Building 239, Birmingham, AL 35294 0007, USA
Obstet Gynecol Clin North Am 30:685-94. 2003..The implications of screening and treating BV to prevent long-term complications are less clear and may depend on the availability of more effective treatment regimens... - Risk and prevalence of treatable sexually transmitted diseases at a Birmingham substance abuse treatment facilityL H Bachmann
Department of Medicine, University of Alabama at Birmingham 35924 0007, USA
Am J Public Health 90:1615-8. 2000..We evaluated the prevalence of gonorrhea, chlamydia, trichomoniasis, and syphilis in patients entering residential drug treatment... - Incidence and risk factors for sexually transmitted infections among women in an Alabama HIV clinicCheryl-Ann Monteiro
Department of Medicine, The University of Alabama at Birmingham, Alabama 35294, USA
AIDS Res Hum Retroviruses 20:577-83. 2004..99 (1.28, 3.08), and a higher CD4+ T cell count, RR = 1.15 (1.0028, 1.3115) for 100 cells. Interventions to prevent curable STI in HIV-infected women are warranted in primary care settings... - Midtrimester vaginal Mycoplasma genitalium in women with subsequent spontaneous preterm birthG C Lu
Division of Maternal Fetal Medicine, University of Alabama at Birmingham, 619 S 19th St, Birmingham, AL 35249, USA
Am J Obstet Gynecol 185:163-5. 2001..We sought to determine the midtrimester prevalence of Mycoplasma genitalium in women who had subsequent spontaneous preterm birth... - Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and preventionArlene C Sena
Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Clin Infect Dis 44:13-22. 2007..Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture... - Prevalence of Mobiluncus spp among women with and without bacterial vaginosis as detected by polymerase chain reactionJ R Schwebke
Department of Medicine, University of Alabama at Birmingham, USA
Sex Transm Dis 28:195-9. 2001..The authors used polymerase chain reaction (PCR) to compare the prevalence of Mobiluncus in women with and without bacterial vaginosis... - Humoral antibody to Mobiluncus curtisii, a potential serological marker for bacterial vaginosisJ R Schwebke
Division of Infectious Diseases, University of Alabama at Birmingham 35294 0006, USA
Clin Diagn Lab Immunol 3:567-9. 1996..Serum antibody to M. curtisii could be a useful serological marker for BV. The lack of correlation of antibody positivity to historical information regarding BV suggests that unrecognized or undiagnosed episodes of BV may be common... - Correlation of behaviors with microbiological changes in vaginal floraJ R Schwebke
University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
J Infect Dis 180:1632-6. 1999..Only a minority of women (11/51, 22%) maintained a "normal" lactobacillus-predominant flora. Factors associated with instability of the flora are similar to those epidemiologically associated with BV... - A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseasesJane R Schwebke
Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
Am J Obstet Gynecol 196:517.e1-6. 2007..The purpose of this study was to determine whether treatment of bacterial vaginosis (BV) decreases the incidence of sexually transmitted diseases (STDs)... - Association of Mobiluncus curtisii with recurrence of bacterial vaginosisMichelle C Meltzer
Department of Medicine University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA
Sex Transm Dis 35:611-3. 2008 - Vaginal leucocyte counts in women with bacterial vaginosis: relation to vaginal and cervical infectionsW M Geisler
Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
Sex Transm Infect 80:401-5. 2004..To evaluate whether an elevated vaginal leucocyte count in women with bacterial vaginosis (BV) predicts the presence of vaginal or cervical infections, and to assess the relation of vaginal WBC counts to clinical manifestations... - Association between genital tract cytomegalovirus infection and bacterial vaginosisShannon A Ross
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
J Infect Dis 192:1727-30. 2005..In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV... - Methods for detection of Trichomonas vaginalis in the male partners of infected women: implications for control of trichomoniasisMarcia M Hobbs
Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
J Clin Microbiol 44:3994-9. 2006..vaginalis in male partners required multiple specimens. The majority of male sexual partners in this study were infected, emphasizing the importance of partner evaluation and treatment... - Validity of self-obtained vaginal specimens for diagnosis of trichomoniasisJ R Schwebke
Division of Infectious Diseases, University of Alabama at Birmingham, 35294 0006, USA
J Clin Microbiol 35:1618-9. 1997..6 and 88.5%, respectively. There was no significant difference between the sensitivities of culture methods using self- and clinician-collected vaginal specimens for the diagnosis of trichomoniasis... - Sexually transmitted diseases in Ulaanbaatar, MongoliaJ R Schwebke
University of Alabama at Birmingham, School of Medicine, 35294 0006, USA
Int J STD AIDS 9:354-8. 1998..No patients were infected with HIV. STDs are a significant problem in Mongolia. Improved control efforts are urgently needed to prevent the emergence of HIV... - Viability of Trichomonas vaginalis in Copan universal transport medium and eSwab transport mediumC A Rivers
Department of Medicine, University of Alabama at Birmingham, Alabama 35294 0007, USA
J Clin Microbiol 46:3134-5. 2008..There were no significant culturable differences in the sensitivity of either of the transport media to that of bedside inoculation... - Partnership concurrency status and condom use among women diagnosed with Trichomonas vaginalisBronwen Lichtenstein
Department of Criminal Justice, University of Alabama, Birmingham, Alabama, USA
Womens Health Issues 18:369-74. 2008..Women diagnosed with T. vaginalis have a 2- to 3-fold higher risk of acquiring the human immunodeficiency virus and developing the acquired immunodeficiency syndrome... - Delayed versus immediate bedside inoculation of culture media for diagnosis of vaginal trichomonosisJ R Schwebke
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
J Clin Microbiol 37:2369-70. 1999..The sensitivities of the two methods were 100 and 97.4%, respectively. Delayed inoculation of culture medium for women without evidence of trichomonosis on direct microscopic examination is a valid diagnostic procedure... - A randomized, double-blind clinical trial of vaginal acidification versus placebo for the treatment of symptomatic bacterial vaginosisRobert L Holley
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Sex Transm Dis 31:236-8. 2004..CONCLUSION: Vaginal acidification with an acetic acid gel formulated to pH 3.9 to 4.1 was ineffective therapy for bacterial vaginosis... - Local and systemic cytokine levels in relation to changes in vaginal floraSpencer R Hedges
Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, 35294, USA
J Infect Dis 193:556-62. 2006..CONCLUSIONS: Women with intermediate flora generate significant cytokine responses. It is possible that the risks associated with BV may also affect women with intermediate flora and that appropriate treatment may reduce such risk... - Lactational amenorrhea as a risk factor for group a streptococcal vaginitisMicelle C Meltzer
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
Clin Infect Dis 46:e112-5. 2008..The case described here appears to be unusual in that it was sexually transmitted, and the lack of estrogen associated with anovualtion may have been a predisposing factor for this unusual sexually transmitted disease... - The association between Trichomonas vaginalis infection and level of vaginal lactobacilli, in nonpregnant womenMichelle R Torok
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Infect Dis 196:1102-7. 2007..6 [95% CI, 2.2-9.5]) but not in women with a lower educational level (OR, 1.6 [95% CI, 0.7-3.4]). Vaginal lactobacilli may be associated with trichomoniasis in women with higher levels of education or a related behavioral factor... - A pilot study of vaginal flora changes with randomization to cessation of douchingMark A Klebanoff
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Sex Transm Dis 33:610-3. 2006.... - Screening women in jails for chlamydial and gonococcal infection using urine tests: feasibility, acceptability, prevalence, and treatment ratesKristen J Mertz
Division of STD Prevention, National Center for HIV, STD, and TB Prevention, Atlanta, Georgia 30333, USA
Sex Transm Dis 29:271-6. 2002..New urine tests have made it easier to screen for these infections in nonclinical settings... - Vulvovaginal symptoms in women with bacterial vaginosisMark A Klebanoff
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Obstet Gynecol 104:267-72. 2004..The purpose of this study was to estimate the prevalence of symptoms among women with bacterial vaginosis compared with women without bacterial vaginosis by direct, explicit, and detailed questioning of these women... - Abnormal vaginal flora as a biological risk factor for acquisition of HIV infection and sexually transmitted diseasesJane R Schwebke
J Infect Dis 192:1315-7. 2005 - A longitudinal study of vaginal douching and bacterial vaginosis--a marginal structural modeling analysisRebecca M Brotman
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Am J Epidemiol 168:188-96. 2008..In the absence of a large randomized trial, these findings provide the best evidence to date for a risk of bacterial vaginosis associated with douching... - Cost-effective screening for trichomoniasisJane R Schwebke
Emerg Infect Dis 8:749; author reply 749-50. 2002 - Performance of a new, rapid assay for detection of Trichomonas vaginalisAnn Kurth
University of Washington Center for AIDS and STDs, Box 359931, 325 9th Ave, Seattle, WA 98104, USA
J Clin Microbiol 42:2940-3. 2004..4% [P = 0.04]) but was less specific (98.6% versus 100% [P = 0.001]). The XenoStrip rapid assay is well suited for use in settings with a moderately high prevalence of T. vaginalis infection, particularly when microscopy is not practical... - Trichomoniasis in adolescents: a marker for the lack of a public health response to the epidemic of sexually transmitted diseases in the United StatesJane R Schwebke
J Infect Dis 192:2036-8. 2005 - Why do women douche? A longitudinal study with two analytic approachesRebecca M Brotman
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21224
Ann Epidemiol 18:65-73. 2008..Although vaginal douching is associated with several adverse outcomes, the reasons why women douche have not been studied prospectively... - Partner notification methods for African American men being treated for trichomoniasis: a consideration of main men, Second Hitters, and Third PlayersBronwen Lichtenstein
Department of Criminal Justice, University of Alabama, USA
Med Anthropol Q 19:383-401. 2005..The findings suggest that STI control efforts must take the sexual hierarchy and its privacy implications into account if partner notification methods are to be acceptable to African American men... - The association of psychosocial stress and bacterial vaginosis in a longitudinal cohortTonja R Nansel
Division of Epidemiology, Statistics and Prevention Research, Department of Health and Human Services, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
Am J Obstet Gynecol 194:381-6. 2006..The purpose of this study was to assess the association of psychosocial stress with bacterial vaginosis in a longitudinal sample of nonpregnant women... - Dietary intake of selected nutrients affects bacterial vaginosis in womenYasmin H Neggers
Department of Human Nutrition, University of Alabama, Tuscaloosa, AL 35487, USA
J Nutr 137:2128-33. 2007..4, 0.2-0.8), and calcium (0.4, 0.3-0.7). We conclude that increased dietary fat intake is associated with increased risk of BV and severe BV, whereas increased intake of folate, vitamin A, and calcium may decrease the risk of severe BV...
Research Grants
- UAB Infectious Diseases Training GrantJane Schwebke; Fiscal Year: 2007..Pursuit of an MPH will also be available. The overall performance and direction of the training program will be reviewed by the Program Director, Co-Directors and Research Advisory Committee on a semi-annual basis. ..
- Tinidazole for the Treatment of Bacterial VaginosisJane Schwebke; Fiscal Year: 2007..In addition, we will measure vaginal and serum concentrations of drug during treatment and correlate with cure rates, short-term recurrence of BV, and severity of infection. ..
- Control of Trichomoniasis -A Paradigm for STD ControlJane Schwebke; Fiscal Year: 2006..vaginalis, to examine strain differences using PFGE, and to examine the prevalence of resistance strains and their potential contribution to treatment failure. ..
- Therapy and Prevention for Bacterial VaginosisJane Schwebke; Fiscal Year: 2006..We will also utilize specimens from these prospective studies to further study the association of Mobiluncus, an organism strongly associated with BV using sensitive PCR technology. ..
- Concordance Rates of Mobiluncus Among Sexual PartnersJane Schwebke; Fiscal Year: 2004..Our hypothesis is that Mobiluncus curtisii is important in the pathogenesis of BV and high concordance rates among sexual partners will be found suggesting sexual transmission. ..