EDWARD M contact SCHWARZ

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis
    E M Schwarz
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res 2:165-8. 2000
  2. doi request reprint In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice
    Echoe M Bouta
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    J Physiol 592:1213-23. 2014
  3. pmc Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model
    Justin M Green
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Rheumatol Rep 15:325. 2013
  4. pmc TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Arthritis Res Ther 10:R37. 2008
  5. pmc Increased lymphangiogenesis in joints of mice with inflammatory arthritis
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 9:R118. 2007
  6. pmc CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis
    Yahui Grace Chiu
    Allergy Immunology and Rheumatology Unit, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 12:R14. 2010
  7. pmc Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation
    Willis Huang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
    Arthritis Res Ther 5:R49-59. 2003
  8. ncbi request reprint Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo
    Edward M Schwarz
    The Center for Musculoskeletal Research, Box 665, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Orthop Res 21:1049-55. 2003
  9. ncbi request reprint Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes
    Michael Ulrich-Vinther
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 46:2095-104. 2002
  10. pmc Altered bone remodeling in psoriatic arthritis
    Kofi A Mensah
    Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Curr Rheumatol Rep 10:311-7. 2008

Research Grants

  1. PTH Effects of Craniofacial Allografts
    EDWARD M contact SCHWARZ; Fiscal Year: 2010
  2. B cells and draining lymph node function in arthritic flair
    Edward Schwarz; Fiscal Year: 2009
  3. PTH Effects of Craniofacial Allografts
    Edward Schwarz; Fiscal Year: 2009
  4. Revitalizing Allografts for Craniofacial Reconstruction
    Edward Schwarz; Fiscal Year: 2007
  5. PACAP Overexpression and Voiding Function
    Edward Schwarz; Fiscal Year: 2004
  6. Mouse Models for Interstitial Cystitis
    Edward Schwarz; Fiscal Year: 2004
  7. GENE THERAPY FOR ARTHRITIS IN THE TNFA-TRANSGENIC MOUSE
    Edward Schwarz; Fiscal Year: 2002
  8. B cells and draining lymph node function in arthritic flair
    Edward M Schwarz; Fiscal Year: 2010

Detail Information

Publications81

  1. pmc Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis
    E M Schwarz
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res 2:165-8. 2000
    ..Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale for clinical studies of anti-TNF therapy and other interventions for periprosthetic loosening...
  2. doi request reprint In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice
    Echoe M Bouta
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    J Physiol 592:1213-23. 2014
    ....
  3. pmc Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model
    Justin M Green
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Rheumatol Rep 15:325. 2013
    ..The results demonstrate an approach by which the potential osteoprotective effects of antioxidants in UHMWPE can be evaluated...
  4. pmc TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Arthritis Res Ther 10:R37. 2008
    ..The objective of the present study was to investigate the role of the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis in TNF-induced mobilization of osteoclast precursors (OCPs) from bone marrow...
  5. pmc Increased lymphangiogenesis in joints of mice with inflammatory arthritis
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 9:R118. 2007
    ..The lymphatic system may play an important role in the pathogenesis of inflammatory arthritis...
  6. pmc CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis
    Yahui Grace Chiu
    Allergy Immunology and Rheumatology Unit, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 12:R14. 2010
    ..Our previous studies showed an elevated frequency of OC precursors (OCP) in PsA patients. Here, we examined if OC arise from CD16-positive monocytes in PsA...
  7. pmc Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation
    Willis Huang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
    Arthritis Res Ther 5:R49-59. 2003
    ....
  8. ncbi request reprint Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo
    Edward M Schwarz
    The Center for Musculoskeletal Research, Box 665, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Orthop Res 21:1049-55. 2003
    ..Using the data from this pilot we provide a model power calculation for such a trial...
  9. ncbi request reprint Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes
    Michael Ulrich-Vinther
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 46:2095-104. 2002
    ..To evaluate the effects of ultraviolet (UV) light as an adjuvant for recombinant adeno-associated virus (rAAV) transduction in human articular chondrocytes...
  10. pmc Altered bone remodeling in psoriatic arthritis
    Kofi A Mensah
    Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Curr Rheumatol Rep 10:311-7. 2008
    ..It also discusses the effects of tumor necrosis factor inhibition on bone resorption and new bone formation in PsA...
  11. ncbi request reprint Bone implant interface, osteolysis and potential therapies
    E M Schwarz
    The Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Musculoskelet Neuronal Interact 4:390-2. 2004
  12. doi request reprint The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis
    Edward M Schwarz
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Adv Exp Med Biol 658:1-10. 2010
    ....
  13. pmc Clinical development of anti-RANKL therapy
    Edward M Schwarz
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res Ther 9:S7. 2007
    ....
  14. pmc CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice
    Jie Li
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R138. 2011
    ....
  15. ncbi request reprint Autoimmunity and bone
    Edward M Schwarz
    Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1068:275-83. 2006
    ..Thus, systemic factors produced by autoimmunity have a dramatic impact on active myelopoiesis and bone homeostasis...
  16. ncbi request reprint RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis
    C T Ritchlin
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester 14642, USA
    J Musculoskelet Neuronal Interact 4:276-84. 2004
    ..Herein, we provide a review of the role of RANK, RANKL and OPG in erosive arthritis and periprosthetic osteolysis and discuss the potential of anti-RANKL therapy for these conditions...
  17. pmc Dynamic exercises in patients with rheumatoid arthritis
    A P Anandarajah
    Allergy, Immunology and Rheumatology Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Ann Rheum Dis 63:1359-61. 2004
  18. ncbi request reprint The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritis
    A P Anandarajah
    Department of Allergy, Immunology and Rheumatology, University of Rochester, New York, USA
    Ann Rheum Dis 67:296-301. 2008
    ..To better understand this association, the effect of etanercept on OCPF and BMO was analysed in PsA patients with erosive arthritis...
  19. ncbi request reprint Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis
    X Zhang
    Department of Orthopedics, University of Rochester School of Medicine and Dentistry, New York, USA
    J Bone Miner Res 16:660-70. 2001
    ..These results provide direct evidence that COX-2 is an important mediator of wear debris-induced osteolysis and suggests that COX-2 inhibitors are potential therapeutic agents for the prevention of wear debris-induced osteolysis...
  20. ncbi request reprint Efficacy of etanercept for wear debris-induced osteolysis
    L M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 16:338-47. 2001
    ....
  21. ncbi request reprint Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis
    L M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bone Joint Surg Am 83:1789-97. 2001
    ..It acts by binding to tumor necrosis factor-alpha and preventing signaling through the membrane-bound tumor necrosis factor receptors...
  22. ncbi request reprint Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2
    Q Zhang
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 52:2708-18. 2005
    ..To investigate why bisphosphonates are less effective at preventing focal bone loss in rheumatoid arthritis (RA) patients than in those with generalized osteoporosis, and the mechanisms involved...
  23. ncbi request reprint A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis
    W Huang
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Calcif Tissue Int 73:584-93. 2003
    ..These studies demonstrate a rapid screening approach for identifying the potential collective effects of multiple factors on osteoclastic bone resorption...
  24. ncbi request reprint Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity
    J E Puzas
    Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Cells Tissues Organs 169:248-56. 2001
    ..Additionally, we show that this enzyme is under the control of pro-inflammatory cytokines whereby TGFbeta and IL-1 stimulate and PGE(2) inhibits its activity...
  25. ncbi request reprint Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
    H Ito
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Gene Ther 11:34-41. 2004
    ..These results demonstrate that LAGT combined with rAAV is a promising procedure to facilitate gene induction in HuMSCs for human gene therapy...
  26. ncbi request reprint BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog
    C D Grimsrud
    Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester Medical Center, NY 14642, USA
    J Orthop Res 19:18-25. 2001
    ....
  27. ncbi request reprint Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components
    P F Pollice
    Department of Orthopaedics, University of Rochester Medical Center, New York 14642, USA
    J Bone Joint Surg Am 83:1057-61. 2001
    ..This effect could increase implant longevity and decrease the need for revision arthroplasty...
  28. pmc Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
    J Clin Invest 109:1405-15. 2002
    ..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair...
  29. ncbi request reprint Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner
    Yu Feng Dong
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 21:2805-20. 2007
    ..Together, our findings show that Twist1 may be an important regulator of chondrocyte progression toward terminal maturation in response to TGF-beta and canonical Wnt signaling...
  30. pmc Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity
    Dan Li
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 26:96-105. 2008
    ..05). Collectively, these studies demonstrate the first quantitative model of implant-associated OM that defines the kinetics of microbial growth, osteolysis, and humoral immunity following infection...
  31. ncbi request reprint MRI and quantification of draining lymph node function in inflammatory arthritis
    Steven T Proulx
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1117:106-23. 2007
    ..63, P = 0.01) between LNcap and synovial volume. TNF-Tg mice with a lower LNcap display an accelerated progression of arthritis. These results indicate a protective function of enhanced lymphatic drainage in inflammatory arthritis...
  32. ncbi request reprint Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles
    Emily E Carmody
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 46:1298-308. 2002
    ....
  33. ncbi request reprint Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification
    Lee A Kaback
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Physiol 214:173-82. 2008
    ....
  34. ncbi request reprint Recent advances in gene delivery for structural bone allografts
    Hani A Awad
    Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
    Tissue Eng 13:1973-85. 2007
    ..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications...
  35. ncbi request reprint Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Tissue Eng 13:435-45. 2007
    ..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering...
  36. ncbi request reprint Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation
    Do Y Soung
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 22:1260-70. 2007
    ..We found that Runx3 is essential for mediating the early stage of endochondral ossification through cooperation with other Runx family members...
  37. ncbi request reprint NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007
    ..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption...
  38. ncbi request reprint Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes
    Michael J Zuscik
    Center for Muscluskeletal Research, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
    J Orthop Res 20:811-8. 2002
    ....
  39. ncbi request reprint Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae
    Tzong Jen Sheu
    Department of Orthopedics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Bone Miner Res 17:915-22. 2002
    ..The clone 5 peptide shows a high homology to glypican 4 (GPC4), a proteoglycan attachment receptor found in a number of cell types...
  40. pmc Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography
    Steven T Proulx
    Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Rheum 56:4024-37. 2007
    ....
  41. pmc Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery
    Patrick Basile
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, New York 14642, USA
    Mol Ther 16:466-73. 2008
    ..Collectively, our data demonstrate the feasibility and efficacy of therapeutic tendon allograft processing as a novel paradigm in tissue engineering in order to address difficult clinical problems such as tendon adhesions...
  42. ncbi request reprint Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes
    Dhruv B Pateder
    Department of Orthopaedic Surgery, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Radiat Res 157:62-8. 2002
    ....
  43. ncbi request reprint In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis
    Lisa M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:192-9. 2002
    ..These studies indicate that osteoclast depletion via RANK blockade is an effective method to prevent and reverse wear debris-induced osteolysis without jeopardizing osteogenesis...
  44. ncbi request reprint Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors
    Christopher R Good
    Department of Orthopaedics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Surg Oncol 79:174-9. 2002
    ..This report examines osteolytic bone tumor expression of receptor activator of nuclear factor B-ligand (RANK-L), a cytokine that is arguably the most critical regulator of osteoclast differentiation and activation...
  45. ncbi request reprint Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis
    Guoyong Yin
    Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Mol Ther 5:547-54. 2002
    ..These data suggest a novel mechanism by which endostatin inhibits angiogenesis, and demonstrates the potential utility of anti-angiogenic gene therapy for treatment of inflammatory arthritis...
  46. pmc What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?
    Rocky S Tuan
    Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Acad Orthop Surg 16:S42-8. 2008
    ....
  47. pmc Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
    Ruolin Guo
    Department of Pathology and Laboratory Medicine, and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:23084-92. 2008
    ..Inhibition of ubiquitin-mediated Smad1 and Runx2 degradation in osteoblasts could help to treat inflammation-induced osteoporosis...
  48. pmc Quantification of massive allograft healing with dynamic contrast enhanced-MRI and cone beam-CT: a pilot study
    Nicole Ehrhart
    Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA
    Clin Orthop Relat Res 466:1897-904. 2008
    ....
  49. pmc Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT
    Ryosuke Tsutsumi
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Box 665, Rochester, New York 14642 0001, USA
    J Orthop Res 26:1340-6. 2008
    ..001)...
  50. ncbi request reprint Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis
    J Jeffrey Goater
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14642, USA
    J Orthop Res 20:169-73. 2002
    ..This increased osteoclastogenesis was completely inhibited by the FLS-OPG, as osteoclast numbers in the calvaria of these animals were similar to that seen in the SHAM controls...
  51. pmc Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation
    Chao Xie
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bone Joint Surg Am 90:9-13. 2008
    ..Our current approach overcomes this encumbrance and enables examination of gene function in a time-dependent and repair-tissue-specific manner...
  52. pmc Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism
    Zhenqiang Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 283:9917-24. 2008
    ..TNF could induce c-Fos expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss...
  53. ncbi request reprint Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor
    Yu Feng Dong
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Physiol 208:77-86. 2006
    ....
  54. ncbi request reprint Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression
    Zhenqiang Yao
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:11846-55. 2006
    ..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease...
  55. ncbi request reprint A phage display technique identifies a novel regulator of cell differentiation
    Tzong Jen Sheu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 278:438-43. 2003
    ..We hypothesize that binding to TRAP may be one mechanism by which the full osteoblast phenotype is expressed during the process of bone remodeling...
  56. ncbi request reprint PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling
    Tian Fang Li
    Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 300:159-69. 2004
    ..These observations demonstrate potent prostaglandin regulatory effects on chondrocyte maturation and show a role for both PKA and PKC signaling in PGE2 regulatory events...
  57. ncbi request reprint Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway
    Tian Fang Li
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 299:128-36. 2004
    ..Overall, our results demonstrate that PTHrP downregulates Runx2 expression primarily through the PKA signaling pathway...
  58. ncbi request reprint Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo
    Cristin M Ferguson
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 665, Rochester, NY 14642, USA
    J Orthop Res 22:687-96. 2004
    ..The findings confirm a critical role for TGF-beta during skeletal development. A more complete understanding of the role of TGF-beta and its down-stream signals will lead to improved understanding and treatment of cartilage diseases...
  59. ncbi request reprint RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis
    Ping Li
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bone Miner Res 19:207-13. 2004
    ..RANK signaling is not required for the TNFalpha-stimulated increase in CD11b(hi) osteoclast precursors but is essential for mature osteoclast formation...
  60. ncbi request reprint CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter
    Andreia M Ionescu
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
    J Cell Physiol 198:428-40. 2004
    ....
  61. ncbi request reprint Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice
    Ping Li
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 50:265-76. 2004
    ..To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo...
  62. ncbi request reprint Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5
    Xuefeng Li
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Endocrinology 144:2514-23. 2003
    ..These findings demonstrate that RA induces the expression of BMP-signaling molecules and enhances BMP effects in chondrocytes...
  63. ncbi request reprint Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes
    M Hicham Drissi
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Cell Biochem 90:1287-98. 2003
    ..Factors or signals that alter either of these transcription factors regulate the rate of chondrocyte differentiation...
  64. ncbi request reprint Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing
    Lisa M Flick
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Orthop Res 21:676-84. 2003
    ..Together, these data imply that osteoclast depletion via inhibition of RANK signaling is a viable option for the treatment of pathological bone loss since no adverse effects on fracture healing are observed when therapy is discontinued...
  65. ncbi request reprint ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation
    Andreia M Ionescu
    Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 288:198-207. 2003
    ..Thus, ATF-2 regulates chondrocyte maturation as a direct target of TGF-beta signaling while CREB regulates differentiation by targeting genes independent of the individual signaling effects of TGF-beta or BMP-2...
  66. ncbi request reprint ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development
    Donghui Zhang
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 18:1593-604. 2003
    ..The findings suggest that BMP signaling modulates the Ihh/PTHrP signaling pathway that regulates the rate of chondrocyte differentiation...
  67. ncbi request reprint Use of zoledronate to treat osteoblastic versus osteolytic lesions in a severe-combined-immunodeficient mouse model
    Yu Po Lee
    Department of Orthopaedic Surgery, David Geffen School of Medicine, Los Angeles, California 90095, USA
    Cancer Res 62:5564-70. 2002
    ..Hence, bisphosphonates may not be ideal agents to prevent the formation of osteoblastic lesions associated with prostate cancer metastases to bone...
  68. pmc Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
    Hiromu Ito
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    Nat Med 11:291-7. 2005
    ..In conclusion, we find that RANKL and VEGF are necessary and sufficient for efficient autograft remodeling and can be transferred using rAAV to revitalize structural allografts...
  69. pmc Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts
    Hiroyuki Kaneki
    Department of Pathology and Laboratory Medicine, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    J Biol Chem 281:4326-33. 2006
    ..We propose that one of the mechanisms by which TNF inhibits bone formation in inflammatory bone disorders is by promoting Runx2 proteasomal degradation through up-regulation of Smurf1 and Smurf2 expression...
  70. pmc Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation
    Tian Fang Li
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Bone Miner Res 21:4-16. 2006
    ..Smad2 or Smad3 overexpression and BMP blockade abrogate accelerated maturation in Smad3-/- chondrocytes. BMP signaling is increased in TGF-beta deficiency and is required for accelerated chondrocyte maturation...
  71. ncbi request reprint Gene therapy with human osteoprotegerin decreases callus remodeling with limited effects on biomechanical properties
    Michael Ulrich-Vinther
    Department of Orthopaedics, Aarhus University Hospital, Noerrebrogade, DK 8000 Aarhus C, Denmark
    Bone 37:751-8. 2005
    ..039). The experiment demonstrates that AAV-OPG gene therapy decreases the fracture remodeling, but this does not influence the structural strength of healing fractures...
  72. ncbi request reprint Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis
    Michael Ulrich-Vinther
    Department of Orthopedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Bone Joint Surg Am 84:1405-12. 2002
    ..This study investigated whether gene therapy using a recombinant adeno-associated viral vector that expresses OPG can inhibit wear debris-induced osteolysis...
  73. ncbi request reprint Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions
    Brian T Feeley
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Center for Health Sciences 76 134, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Bone 38:154-66. 2006
    ..The role of BMPs in the formation of prostate cancer metastases to bone remains unknown. We hypothesized that BMPs influence the development and progression of osteolytic prostate cancer lesions...
  74. ncbi request reprint Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis
    Yongjun Wang
    Center for Musculoskeletal Research, Department of Orthopeadics, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 20:1624-36. 2005
    ..Runx1 induces mesenchymal stem cell commitment to the early stages of chondrogenesis...
  75. ncbi request reprint Biological effects of rAAV-caAlk2 coating on structural allograft healing
    Mette Koefoed
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Ther 12:212-8. 2005
    ..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation...
  76. ncbi request reprint The effects of RANK blockade and osteoclast depletion in a model of pure osteoblastic prostate cancer metastasis in bone
    Peter G Whang
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Center for Health Sciences 76 134, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    J Orthop Res 23:1475-83. 2005
    ..These results indicate that in vivo RANK blockade may not be effective for the prevention of osteoblastic metastasis but may potentially represent a novel therapy that limits the growth of established metastatic CaP lesions in bone...
  77. pmc Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta
    Yufeng Dong
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cell Biochem 95:1057-68. 2005
    ..Moreover, this pathway is modulated by members of the TGF-beta family and demonstrates the highly integrated nature of signals controlling endochondral ossification...
  78. ncbi request reprint Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles
    Xiaochao Wei
    Center for Musculoskeletal Research University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
    J Bone Miner Res 20:1136-48. 2005
    ..Fibroblasts pretreated with titanium or PGE2 stimulated osteoclast formation, showing the functional importance of RANKL induction. Synovial fibroblasts and their activation pathways are potential targets to prevent osteolysis...
  79. ncbi request reprint Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone
    Andrew H Gordon
    Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
    Cancer Res 65:3209-17. 2005
    ..These findings imply that NF-kappaB and its associated genes may be relevant therapeutic targets in osteolytic tumor burden...
  80. ncbi request reprint Adeno-associated virus-mediated osteoprotegerin gene transfer protects against particulate polyethylene-induced osteolysis in a murine model
    Shang You Yang
    Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Arthritis Rheum 46:2514-23. 2002
    ..Using an in vivo adeno-associated virus (AAV)-mediated gene transfer technique, this study was designed to evaluate the protective effects of OPG transgene against orthopedic wear debris-induced bone loss in a murine model of osteolysis...
  81. ncbi request reprint The TNF-alpha transgenic mouse model of inflammatory arthritis
    Ping Li
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Springer Semin Immunopathol 25:19-33. 2003
    ....

Research Grants15

  1. PTH Effects of Craniofacial Allografts
    EDWARD M contact SCHWARZ; Fiscal Year: 2010
    ..Here we propose to formally demonstrate that PTH has these effects and could be used as an adjuvant therapy during craniomaxillofacial reconstructive surgery. ..
  2. B cells and draining lymph node function in arthritic flair
    Edward Schwarz; Fiscal Year: 2009
    ..Here we propose to test this theory in mouse models and RA patients. ..
  3. PTH Effects of Craniofacial Allografts
    Edward Schwarz; Fiscal Year: 2009
    ..Here we propose to formally demonstrate that PTH has these effects and could be used as an adjuvant therapy during craniomaxillofacial reconstructive surgery. ..
  4. Revitalizing Allografts for Craniofacial Reconstruction
    Edward Schwarz; Fiscal Year: 2007
    ....
  5. PACAP Overexpression and Voiding Function
    Edward Schwarz; Fiscal Year: 2004
    ..If successful, the mice will be distributed to interested labs to assist with the rigorous characterization of the models as they relate to the neurochemical organization of voiding function. ..
  6. Mouse Models for Interstitial Cystitis
    Edward Schwarz; Fiscal Year: 2004
    ..Finally, we will attempt to generate a transgenic mouse model of IC by targeting the expression of a secreted form of mouse protamine-1 (sMP1) to the transitional epithelium and evaluate these animals in our system. ..
  7. GENE THERAPY FOR ARTHRITIS IN THE TNFA-TRANSGENIC MOUSE
    Edward Schwarz; Fiscal Year: 2002
    ..abstract_text> ..
  8. B cells and draining lymph node function in arthritic flair
    Edward M Schwarz; Fiscal Year: 2010
    ..Here we propose to test this theory in mouse models and RA patients. ..