E M Schwarz
Affiliation: University of Rochester
- Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysisE M Schwarz
Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Res 2:165-8. 2000..Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale for clinical studies of anti-TNF therapy and other interventions for periprosthetic loosening...
- Efficacy of etanercept for wear debris-induced osteolysisL M Childs
Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
J Bone Miner Res 16:338-47. 2001....
- The role of autocrine growth factors in radiation damage to the epiphyseal growth plateD B Pateder
Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Radiat Res 155:847-57. 2001....
- BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehogC D Grimsrud
Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester Medical Center, NY 14642, USA
J Orthop Res 19:18-25. 2001....
- PTHrP modulates chondrocyte differentiation through AP-1 and CREB signalingA M Ionescu
Departments of Biochemistry, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 276:11639-47. 2001..Moreover, in combination, the effects of dominant negative c-Fos and CREB are synergistic, suggesting interaction between these signaling pathways during chondrocyte differentiation...
- RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysisC T Ritchlin
The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester 14642, USA
J Musculoskelet Neuronal Interact 4:276-84. 2004..Herein, we provide a review of the role of RANK, RANKL and OPG in erosive arthritis and periprosthetic osteolysis and discuss the potential of anti-RANKL therapy for these conditions...
- Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cellsH Ito
The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
Gene Ther 11:34-41. 2004..These results demonstrate that LAGT combined with rAAV is a promising procedure to facilitate gene induction in HuMSCs for human gene therapy...
- Bone implant interface, osteolysis and potential therapiesE M Schwarz
The Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY 14642, USA
J Musculoskelet Neuronal Interact 4:390-2. 2004
- Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2Q Zhang
University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 52:2708-18. 2005..To investigate why bisphosphonates are less effective at preventing focal bone loss in rheumatoid arthritis (RA) patients than in those with generalized osteoporosis, and the mechanisms involved...
- Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint componentsP F Pollice
Department of Orthopaedics, University of Rochester Medical Center, New York 14642, USA
J Bone Joint Surg Am 83:1057-61. 2001..This effect could increase implant longevity and decrease the need for revision arthroplasty...
- PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signalingD B Pateder
Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Cell Physiol 188:343-51. 2001..These findings demonstrate that PTHrP is expressed in chondrocytes undergoing endochondral ossification, and show regulation, at least in part, by TGF-beta through Smad mediated signaling events...
- Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysisL M Childs
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Bone Joint Surg Am 83:1789-97. 2001..It acts by binding to tumor necrosis factor-alpha and preventing signaling through the membrane-bound tumor necrosis factor receptors...
- Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosisR A Eliseev
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
Oncogene 27:3605-14. 2008..Our study provides the first evidence for Bax as a direct target of Runx2, suggesting that Runx2 may act as a proapoptotic factor in osteosarcoma cells...
- Investigation of the peak action wavelength of light-activated gene transductionM Myakishev-Rempel
LAGeT LLC, Rochester, NY, USA
Gene Ther 18:1043-51. 2011..In conclusion, 311 nm was found to be the optimal wavelength for LAGT on the basis of its superior efficacy at the peak dose and its broad safety range that is remarkably wider than the other UV wavelengths tested...
- A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesisW Huang
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Calcif Tissue Int 73:584-93. 2003..These studies demonstrate a rapid screening approach for identifying the potential collective effects of multiple factors on osteoclastic bone resorption...
- The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritisA P Anandarajah
Department of Allergy, Immunology and Rheumatology, University of Rochester, New York, USA
Ann Rheum Dis 67:296-301. 2008..To better understand this association, the effect of etanercept on OCPF and BMO was analysed in PsA patients with erosive arthritis...
- Functional integration of tissue-engineered bone constructsR E Guldberg
Institute for Bioengineering and Bioscience, School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
J Musculoskelet Neuronal Interact 4:399-400. 2004
- Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysisX Zhang
Department of Orthopedics, University of Rochester School of Medicine and Dentistry, New York, USA
J Bone Miner Res 16:660-70. 2001..These results provide direct evidence that COX-2 is an important mediator of wear debris-induced osteolysis and suggests that COX-2 inhibitors are potential therapeutic agents for the prevention of wear debris-induced osteolysis...
- Dynamic exercises in patients with rheumatoid arthritisA P Anandarajah
Allergy, Immunology and Rheumatology Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Ann Rheum Dis 63:1359-61. 2004
- Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activityJ E Puzas
Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Cells Tissues Organs 169:248-56. 2001..Additionally, we show that this enzyme is under the control of pro-inflammatory cytokines whereby TGFbeta and IL-1 stimulate and PGE(2) inhibits its activity...
- NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout miceE M Schwarz
Laboratory of Genetics, The Salk Institute, San Diego, California 92186 5800, USA
J Virol 72:5654-60. 1998..The attenuation in p50 -/- mice can be explained by rapid apoptosis of infected cells which allows host phagocytes to clear infected cells before the viral burst leading to a reduction of the viral burden and survival of the mice...
- Aseptic looseningP H Wooley
Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
Gene Ther 11:402-7. 2004..Gene transfer, however, offers novel possibilities. Here, we review the current state of the field and the experimental gene therapy approaches that have been investigated toward a solution to aseptic loosening of prosthetic implants...
- Calx, a Na-Ca exchanger gene of Drosophila melanogasterE M Schwarz
Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 94:10249-54. 1997..In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart. Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed...
- Immunological defects in mice with a targeted disruption in Bcl-3E M Schwarz
Laboratory of Genetics, The Salk Institute, San Diego, California 92186 5800, USA
Genes Dev 11:187-97. 1997..Additionally, spleens from Bcl-3(-/-) mice are abnormal and void of germinal centers. In contrast, the p50(-/-) mice have normal germinal centers. We propose that in in vivo, Bcl-3 can function independently of p50...