E M Schwarz

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis
    E M Schwarz
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res 2:165-8. 2000
  2. ncbi request reprint Efficacy of etanercept for wear debris-induced osteolysis
    L M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 16:338-47. 2001
  3. ncbi request reprint The role of autocrine growth factors in radiation damage to the epiphyseal growth plate
    D B Pateder
    Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Radiat Res 155:847-57. 2001
  4. ncbi request reprint BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog
    C D Grimsrud
    Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester Medical Center, NY 14642, USA
    J Orthop Res 19:18-25. 2001
  5. ncbi request reprint RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis
    C T Ritchlin
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester 14642, USA
    J Musculoskelet Neuronal Interact 4:276-84. 2004
  6. ncbi request reprint PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling
    A M Ionescu
    Departments of Biochemistry, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:11639-47. 2001
  7. ncbi request reprint Bone implant interface, osteolysis and potential therapies
    E M Schwarz
    The Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Musculoskelet Neuronal Interact 4:390-2. 2004
  8. ncbi request reprint Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
    H Ito
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Gene Ther 11:34-41. 2004
  9. ncbi request reprint Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2
    Q Zhang
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 52:2708-18. 2005
  10. ncbi request reprint PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling
    D B Pateder
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Physiol 188:343-51. 2001

Collaborators

Detail Information

Publications24

  1. pmc Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis
    E M Schwarz
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res 2:165-8. 2000
    ..Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale for clinical studies of anti-TNF therapy and other interventions for periprosthetic loosening...
  2. ncbi request reprint Efficacy of etanercept for wear debris-induced osteolysis
    L M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 16:338-47. 2001
    ....
  3. ncbi request reprint The role of autocrine growth factors in radiation damage to the epiphyseal growth plate
    D B Pateder
    Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Radiat Res 155:847-57. 2001
    ....
  4. ncbi request reprint BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog
    C D Grimsrud
    Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester Medical Center, NY 14642, USA
    J Orthop Res 19:18-25. 2001
    ....
  5. ncbi request reprint RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis
    C T Ritchlin
    The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester 14642, USA
    J Musculoskelet Neuronal Interact 4:276-84. 2004
    ..Herein, we provide a review of the role of RANK, RANKL and OPG in erosive arthritis and periprosthetic osteolysis and discuss the potential of anti-RANKL therapy for these conditions...
  6. ncbi request reprint PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling
    A M Ionescu
    Departments of Biochemistry, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:11639-47. 2001
    ..Moreover, in combination, the effects of dominant negative c-Fos and CREB are synergistic, suggesting interaction between these signaling pathways during chondrocyte differentiation...
  7. ncbi request reprint Bone implant interface, osteolysis and potential therapies
    E M Schwarz
    The Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Musculoskelet Neuronal Interact 4:390-2. 2004
  8. ncbi request reprint Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
    H Ito
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Gene Ther 11:34-41. 2004
    ..These results demonstrate that LAGT combined with rAAV is a promising procedure to facilitate gene induction in HuMSCs for human gene therapy...
  9. ncbi request reprint Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2
    Q Zhang
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 52:2708-18. 2005
    ..To investigate why bisphosphonates are less effective at preventing focal bone loss in rheumatoid arthritis (RA) patients than in those with generalized osteoporosis, and the mechanisms involved...
  10. ncbi request reprint PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling
    D B Pateder
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Physiol 188:343-51. 2001
    ..These findings demonstrate that PTHrP is expressed in chondrocytes undergoing endochondral ossification, and show regulation, at least in part, by TGF-beta through Smad mediated signaling events...
  11. ncbi request reprint Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components
    P F Pollice
    Department of Orthopaedics, University of Rochester Medical Center, New York 14642, USA
    J Bone Joint Surg Am 83:1057-61. 2001
    ..This effect could increase implant longevity and decrease the need for revision arthroplasty...
  12. ncbi request reprint Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis
    L M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bone Joint Surg Am 83:1789-97. 2001
    ..It acts by binding to tumor necrosis factor-alpha and preventing signaling through the membrane-bound tumor necrosis factor receptors...
  13. ncbi request reprint A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis
    W Huang
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Calcif Tissue Int 73:584-93. 2003
    ..These studies demonstrate a rapid screening approach for identifying the potential collective effects of multiple factors on osteoclastic bone resorption...
  14. doi request reprint Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
    R A Eliseev
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
    Oncogene 27:3605-14. 2008
    ..Our study provides the first evidence for Bax as a direct target of Runx2, suggesting that Runx2 may act as a proapoptotic factor in osteosarcoma cells...
  15. pmc Investigation of the peak action wavelength of light-activated gene transduction
    M Myakishev-Rempel
    LAGeT LLC, Rochester, NY, USA
    Gene Ther 18:1043-51. 2011
    ..In conclusion, 311 nm was found to be the optimal wavelength for LAGT on the basis of its superior efficacy at the peak dose and its broad safety range that is remarkably wider than the other UV wavelengths tested...
  16. ncbi request reprint The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritis
    A P Anandarajah
    Department of Allergy, Immunology and Rheumatology, University of Rochester, New York, USA
    Ann Rheum Dis 67:296-301. 2008
    ..To better understand this association, the effect of etanercept on OCPF and BMO was analysed in PsA patients with erosive arthritis...
  17. ncbi request reprint Functional integration of tissue-engineered bone constructs
    R E Guldberg
    Institute for Bioengineering and Bioscience, School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    J Musculoskelet Neuronal Interact 4:399-400. 2004
  18. ncbi request reprint Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis
    X Zhang
    Department of Orthopedics, University of Rochester School of Medicine and Dentistry, New York, USA
    J Bone Miner Res 16:660-70. 2001
    ..These results provide direct evidence that COX-2 is an important mediator of wear debris-induced osteolysis and suggests that COX-2 inhibitors are potential therapeutic agents for the prevention of wear debris-induced osteolysis...
  19. pmc Dynamic exercises in patients with rheumatoid arthritis
    A P Anandarajah
    Allergy, Immunology and Rheumatology Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Ann Rheum Dis 63:1359-61. 2004
  20. ncbi request reprint Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity
    J E Puzas
    Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Cells Tissues Organs 169:248-56. 2001
    ..Additionally, we show that this enzyme is under the control of pro-inflammatory cytokines whereby TGFbeta and IL-1 stimulate and PGE(2) inhibits its activity...
  21. pmc NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice
    E M Schwarz
    Laboratory of Genetics, The Salk Institute, San Diego, California 92186 5800, USA
    J Virol 72:5654-60. 1998
    ..The attenuation in p50 -/- mice can be explained by rapid apoptosis of infected cells which allows host phagocytes to clear infected cells before the viral burst leading to a reduction of the viral burden and survival of the mice...
  22. ncbi request reprint Aseptic loosening
    P H Wooley
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Gene Ther 11:402-7. 2004
    ..Gene transfer, however, offers novel possibilities. Here, we review the current state of the field and the experimental gene therapy approaches that have been investigated toward a solution to aseptic loosening of prosthetic implants...
  23. pmc Calx, a Na-Ca exchanger gene of Drosophila melanogaster
    E M Schwarz
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 94:10249-54. 1997
    ..In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart. Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed...
  24. ncbi request reprint Immunological defects in mice with a targeted disruption in Bcl-3
    E M Schwarz
    Laboratory of Genetics, The Salk Institute, San Diego, California 92186 5800, USA
    Genes Dev 11:187-97. 1997
    ..Additionally, spleens from Bcl-3(-/-) mice are abnormal and void of germinal centers. In contrast, the p50(-/-) mice have normal germinal centers. We propose that in in vivo, Bcl-3 can function independently of p50...