Research Topics
Genomes and GenesSpecies | P A SchwartzkroinSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Osmolarity, ionic flux, and changes in brain excitabilityP A Schwartzkroin
Department of Neurological Surgery, University of Washington, Seattle 98195 6470, USA
Epilepsy Res 32:275-85. 1998..These experiments indicate that manipulation of ionic balance may not only facilitate epileptiform activities, but may also provide insight into new therapeutic strategies to block seizures...- Mechanisms underlying the anti-epileptic efficacy of the ketogenic dietP A Schwartzkroin
Department of Neurological Surgery and Physiology Biophysics, University of Washington, Seattle 98195 6470, USA
Epilepsy Res 37:171-80. 1999..An understanding of the mechanism underlying KD antiepileptic efficacy will help us not only to optimize the clinical use of the ketogenic diet, but also to develop novel antiepileptic treatments... - Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout miceV Lopantsev
Department of Pharmacology, University of Washington, Box 357280, Seattle, WA 98195 7280, USA
Neuroscience 116:237-48. 2003.... - Development of a model of status epilepticus in pigtailed macaque infant monkeysV M Gunderson
Center on Human Development and Disability, Regional Primate Research Center, University of Washington, Seattle 98195 7920, USA
Dev Neurosci 21:352-64. 1999..Measures included MRI, electrophysiology, behavior and morphology. Our results suggest that monkey models of SE may provide useful tools for understanding the effects of prolonged seizures during infancy and the origins of TLE in humans... 
Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neuronsS C Baraban
Department of Neurological Surgery, University of Washington, Seattle 98195, USA
J Physiol 498:679-89. 1997..5. These results indicate that selective modulation of interneuron ion channel activity may be a critical mechanism by which osmolarity can regulate excitability in the central nervous system...- Abnormal morphological and functional organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizuresH J Wenzel
Departments of Neurological Surgery and Physiology Biophysics, University of Washington, Seattle, Washington 98195, USA
J Neurosci 21:983-98. 2001..The p35-deficient mouse may therefore offer an experimental system in which we can dissect out the key morphological features that are causally related to epileptogenesis... - GABA(A)-dependent chloride influx modulates reversal potential of GABA(B)-mediated IPSPs in hippocampal pyramidal cellsV Lopantsev
Department of Neurological Surgery, University of Washington, Seattle, Washington 98195-6470, USA
J Neurophysiol 85:2381-7. 2001.... - Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatmentS C Baraban
Department of Neurological Surgery Physiology, University of Washington, Seattle 98195, USA
Epilepsy Res 23:189-94. 1996..These results suggest seizure susceptibility is enhanced in an animal model (MAMac) characterized by abnormal neuronal migration... - Norepinephrine-deficient mice have increased susceptibility to seizure-inducing stimuliP Szot
Department of Psychiatry, University of Washington, Seattle, Washington 98195, USA
J Neurosci 19:10985-92. 1999.... - Deletion of the K(V)1.1 potassium channel causes epilepsy in miceS L Smart
The V M Bloedel Hearing Research Center, and the Department of Otolaryngology Head and Neck Surgery, School of Medicine, University of Washington, Seattle 98195, USA
Neuron 20:809-19. 1998..Axonal action potential conduction was altered as well in the sciatic nerve--a deficit potentially related to the pathophysiology of episodic ataxia/myokymia, a disease associated with missense mutations of the human K(V)1.1 gene... - Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathologyG M McKhann
Department of Neurological Surgery, Columbia University, 710 West 168th Street, NI 42, New York, NY 10032, USA
Neuroscience 122:551-61. 2003..Unlike rats, mice exhibiting prolonged high-grade KA-induced seizure activity did not develop subsequent spontaneous behavioral seizures... - Evidence for increased seizure susceptibility in rats exposed to cocaine in uteroS C Baraban
Department of Neurological Surgery, University of Washington, Seattle 98195, USA
Brain Res Dev Brain Res 102:189-96. 1997..These studies provide strong experimental evidence that adult animals exposed to cocaine during gestation are at high risk for the development of seizure activity... - Bax involvement in p53-mediated neuronal cell deathH Xiang
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
J Neurosci 18:1363-73. 1998..These results demonstrate that Bax is required for neuronal cell death in response to some forms of cytotoxic injury and further support the key role for p53 activation in response to excitotoxic and genotoxic injury... - Developmental seizure susceptibility of kv1.1 potassium channel knockout miceJ M Rho
Department of Neurology and Pediatrics, Geriatric Research, Education and Clinical Center, Puget Sound Health Care System, University of Washington, Seattle, WA, USA
Dev Neurosci 21:320-7. 1999..The Kv1. 1 knockout mouse possesses many features desirable in a developmental animal epilepsy model and represents a clinically relevant model of early-onset epilepsies... - BOLD-fMRI of PTZ-induced seizures in ratsB P Keogh
Department of Radiology, University of Washington, Mail 357115, RR 218, Seattle, WA 98195, USA
Epilepsy Res 66:75-90. 2005..To develop a non-invasive method for exploring seizure initiation and propagation in the brain of intact experimental animals... - Transient potentiation of spontaneous EPSPs in rat mossy cells induced by depolarization of a single neuroneB W Strowbridge
Department of Neurological Surgery, University of Washington, Seattle, USA
J Physiol 494:493-510. 1996..The ability of depolarizing current pulses to potentiate TTX-resistant miniature EPSPs suggests that at least one component of this plasticity occurs at the granule cell-mossy cell synapse... - Knock-out mice reveal a critical antiepileptic role for neuropeptide YS C Baraban
Department of Neurological Surgery, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
J Neurosci 17:8927-36. 1997..Intracerebroventricular NPY infusion, before KA administration, prevented death in NPY-deficient mice. These results suggest a critical role for endogenous NPY in seizure control... - Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female ratC S Woolley
Department of Neurological Surgery, University of Washington, Seattle 98195, USA
J Comp Neurol 373:108-17. 1996..Such findings suggest a relatively active role for dendrites in the process of adult synapse formation... - Initiation and spread of epileptiform discharges in the methylazoxymethanol acetate rat model of cortical dysplasia: functional and structural connectivity between CA1 heterotopia and hippocampus/neocortexN Tschuluun
Department of Neurological Surgery, University of California, Davis, Medical Neuroscience Building, Room 612G, 1515 Newton Court, Davis, CA 95616, USA
Neuroscience 133:327-42. 2005..These data do not support the hypothesis that NMDs (heterotopic cell populations) serve as a focus and/or trigger for epileptiform activity, and/or facilitate propagation of epileptiform events... - Norepinephrine is required for the anticonvulsant effect of the ketogenic dietP Szot
Geriatric Research, Education and Clinical Center GRECC 182B, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Brain Res Dev Brain Res 129:211-4. 2001..These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect... - Morphological plasticity in an infant monkey model of temporal lobe epilepsyH Jürgen Wenzel
Department of Neurological Surgery Pathology, University of Washington School of Medicine, Seattle 98195, USA
Epilepsia 41:S70-5. 2000..To examine the consequences of early seizures, we elicited status epilepticus in immature, 5.5- to 7.0-month-old pigtailed macaques by unilateral microinfusion of bicuculline methiodide into the entorhinal cortex... - Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic dietJ M Rho
Department of Neurology, University of Washington School of Medicine, Seattle 98195, USA
Epilepsy Res 37:233-40. 1999..In our discussion of animal models of the KGD, we highlight the need to understand better the impact of important variables such as dietary composition, genetic background, and mode of seizure induction in the study of the KGD... - Behavioral and metabolic features of repetitive seizures in immature and mature ratsP Szot
Geriatric Research, Education and Clinical Center 182B, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
Epilepsy Res 46:191-203. 2001..The consequences of repetitive seizures in the immature animal results in distinctly different seizure behavior and neuronal activity pattern (c-fos expression) than that observed in the mature animal... - Evidence for p53-mediated modulation of neuronal viabilityH Xiang
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
J Neurosci 16:6753-65. 1996..These results demonstrate a direct relationship between p53 expression and loss of viability in CNS neurons... - Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell deathR S Morrison
Department of Neurological Surgery, University of Washington School of Medicine, Seattle 98195 6470, USA
J Neurosci 16:1337-45. 1996..These results demonstrate that p53 influences viability in multiple neuronal subtypes and brain regions after excitotoxic insult... - Mechanisms of brain plasticity: from normal brain function to pathologyP A Schwartzkroin
Department of Neurological Surgery, University of Washington, Seattle, Washington, USA
Int Rev Neurobiol 45:1-15. 2001..It is this general concept of plasticity-pathology relationship that will survive as the most influential legacy of Frank Morrell... - Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 geneT B Cole
Department of Biochemistry, The University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 96:1716-21. 1999..These results demonstrate that ZnT3 is required for transport of zinc into synaptic vesicles and suggest that vesicular zinc concentration is determined by the abundance of ZnT3... - Seizures and neuronal damage in mice lacking vesicular zincT B Cole
Department of Biochemistry, The University of Washington, Seattle 98195, USA
Epilepsy Res 39:153-69. 2000..Double knockout (ZnT3 and MT3) mice show the same response to kainic acid as ZnT3-/- mice, suggesting that ZnT3 and MT-III function in the same pathway... - Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brainH Wang
Geriatric Research Education and Clinical Center, VA Medical Center, Seattle, Washington 98108
J Neurosci 14:4588-99. 1994..This overlapping yet differential pattern of expression and specific subcellular localization may contribute to the unique profile of excitability displayed by a particular neuron... - Overexpression of a C-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cellsK I Fukuchi
Department of Pathology, University of Washington, Seattle 98195
Exp Neurol 127:253-64. 1994..The results are consistent with the hypothesis that the C-terminal region or its derivatives are neurotoxic and amyloidogenic...