M W Schwartz
Affiliation: University of Washington
Schwartz M, Porte D. Diabetes, obesity, and the brain. Science. 2005;307:375-9 pubmed
..Defects in this control system are implicated in the link between obesity and type 2 diabetes. ..
Brown J, Scarlett J, Matsen M, Nguyen H, Secher A, Jorgensen R, et al
. The Hypothalamic Arcuate Nucleus-Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes. 2019;68:1054-1061 pubmed publisher
Scarlett J, Muta K, Brown J, Rojas J, Matsen M, Acharya N, et al
. Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain. Diabetes. 2019;68:654-664 pubmed publisher
..We conclude that sustained remission of hyperglycemia induced by the central action of FGF1 involves both preservation of β-cell function and stimulation of HGU through increased hepatic glucokinase activity. ..
Bentsen M, Mirzadeh Z, Schwartz M. Revisiting How the Brain Senses Glucose-And Why. Cell Metab. 2019;29:11-17 pubmed publisher
..Precedent for such an organizational scheme is found in the thermoregulatory system, which we draw upon in this framework for understanding the role played by brain glucose sensing in glucose homeostasis. ..
Deem J, Muta K, Scarlett J, Morton G, Schwartz M. How Should We Think About the Role of the Brain in Glucose Homeostasis and Diabetes?. Diabetes. 2017;66:1758-1765 pubmed publisher
Schwartz M, Baskin D. Leptin and the brain: then and now. J Clin Invest. 2013;123:2344-5 pubmed publisher
..While substantial progress has been made in understanding brain mechanisms of leptin action, translating this knowledge into more effective treatment of obesity remains an elusive goal. ..
Morton G, Muta K, Kaiyala K, Rojas J, Scarlett J, Matsen M, et al
. Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure. Diabetes. 2017;66:823-834 pubmed publisher
Schwartz M, Seeley R, Woods S, Weigle D, Campfield L, Burn P, et al
. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 1997;46:2119-23 pubmed
..These findings support the hypothesis that leptin signaling in the brain involves activation of the hypothalamic melanocortin system. ..
Schwartz M, Erickson J, Baskin D, Palmiter R. Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology. 1998;139:2629-35 pubmed