Research Topics
| G J SchwartzSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Publications
Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin CGeorge J Schwartz
University of Rochester School of Medicine, Rochester, NY, USA
Kidney Int 82:445-53. 2012..This equation works well in children with CKD in a range of GFR from 15 to 75 ml/min per 1.73 m2. Further studies are needed to establish the applicability to children of normal stature and muscle mass, and higher GFR...
Carbonic anhydrase IV is expressed in H(+)-secreting cells of rabbit kidneyG J Schwartz
Departments of Pediatrics and Medicine, University of Rochester School of Medicine, NY 14642, USA
Am J Physiol Renal Physiol 278:F894-904. 2000..Thus CA IV was expressed by H(+)-secreting cells of the rabbit kidney, suggesting an important role for CA IV in urinary acidification...- Glomerular filtration rate via plasma iohexol disappearance: pilot study for chronic kidney disease in childrenG J Schwartz
Department of Pediatrics, University of Rochester School of Medicine, Golisano Children s Hospital at Strong, Rochester, New York 14642, USA
Kidney Int 69:2070-7. 2006..GFR can be measured accurately using four-point iohexol plasma disappearance (in most cases, two points suffice); estimated GFR and urinary clearances are less useful... - Glomerular filtration rate measurement and estimation in chronic kidney diseaseGeorge J Schwartz
Pediatric Nephrology, University of Rochester Medical Center, Box 777, 601 Elmwood Avenue, Rochester, NY 14642, USA
Pediatr Nephrol 22:1839-48. 2007.... - The kallikrein-kinin system in sickle cell nephropathy: does it play a role?George J Schwartz
Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
J Pediatr Hematol Oncol 28:111-4. 2006 - Validation of creatinine assays utilizing HPLC and IDMS traceable standards in sera of childrenGeorge J Schwartz
University of Rochester Medical Center, Rochester, NY, USA
Pediatr Nephrol 24:113-9. 2009..We suggest that NIST develop a pediatric SCr standard reference material for use by assay manufacturers to improve accuracy and precision of assays at the low SCr levels observed in most pediatric patients... - New equations to estimate GFR in children with CKDGeorge J Schwartz
Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
J Am Soc Nephrol 20:629-37. 2009..413*(height/serum creatinine), provides a good approximation to the estimated GFR formula. Additional studies of children with higher GFR are needed to validate these formulas for use in screening all children for CKD... - Physiology and molecular biology of renal carbonic anhydraseGeorge J Schwartz
Pediatric Nephrology, University of Rochester School of Medicine, NY 14642, USA
J Nephrol 15:S61-74. 2002..To establish other roles for CA in the kidney will require further kinetic, functional, immunolocalization and cloning studies... - Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensinGeorge J Schwartz
Department of Pediatrics and Strong Children s Research Center, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Clin Invest 109:89-99. 2002..Hence, the adaptive conversion of beta-intercalated cells to alpha-intercalated cells during acid incubation depends upon ECM-associated hensin... 
Measurement and estimation of GFR in children and adolescentsGeorge J Schwartz
Department of Pediatrics, Pediatric Nephrology, Box 777, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Clin J Am Soc Nephrol 4:1832-43. 2009..However, at this time, there is no dependable substitute for an accurately determined GFR, and iohexol plasma disappearance offers the best combination of safety, accuracy, and reproducible precision...- Role of hensin in mediating the adaptation of the cortical collecting duct to metabolic acidosisGeorge J Schwartz
Departments of Pediatrics and Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Curr Opin Nephrol Hypertens 14:383-8. 2005..Hensin is secreted as a monomer which is then polymerized in the extracellular environment by a complex process requiring at least three other proteins... - Plasticity of intercalated cell polarity: effect of metabolic acidosisG J Schwartz
Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
Nephron 87:304-13. 2001..A key problem in renal physiology is to investigate the role of hensin in mediating the adaptation of the CCD to acidosis in vitro and in vivo... - Optimizing iohexol plasma disappearance curves to measure the glomerular filtration rate in children with chronic kidney diseaseGeorge J Schwartz
Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA
Kidney Int 77:65-71. 2010..Hence, the GFR can be accurately measured in children with chronic kidney disease using the slow component of the iohexol plasma disappearance curve, provided the duration of study is at least 5 h... - Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissuesG J Schwartz
Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
Exp Nephrol 8:152-60. 2000..These data characterize the rabbit Cct6 subunit and compare it to its homologues. The Western analyses support the concept that Cct complex is widely distributed among tissues and highly conserved among eukaryotes... - Expression of carbonic anhydrase IV mRNA in rabbit kidney: stimulation by metabolic acidosisC A Winkler
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
Am J Physiol 272:F551-60. 1997..It is likely that the regulation of CA IV mRNA and activity is relevant to the kidney's adaptation to CMA... - Maturation of carbonic anhydrase IV expression in rabbit kidneyC A Winkler
Department of Pediatrics, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Renal Physiol 280:F895-903. 2001..In the medullary collecting duct, there is a more robust maturation of CA IV mRNA and protein, commensurate with the high rate of HCO absorption in the neonatal segment... - Association of proteinuria with race, cause of chronic kidney disease, and glomerular filtration rate in the chronic kidney disease in children studyCraig S Wong
Department of Pediatrics, Division of Nephrology, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
Clin J Am Soc Nephrol 4:812-9. 2009..Urinary protein-to-creatinine ratios (Up/c) were used to measure level of proteinuria... - HCO3- absorption in rabbit outer medullary collecting duct: role of luminal carbonic anhydraseS Tsuruoka
Department of Pediatrics, University of Rochester School of Medicine, New York 14642, USA
Am J Physiol 274:F139-47. 1998..Acidosis substantially decreased the sensitivity of HCO3- transport to CA inhibition... - Carbonic anhydrase II mRNA is induced in rabbit kidney cortex during chronic metabolic acidosisG J Schwartz
Department of Pediatrics, University of Rochester Medical Center, New York 14642
Am J Physiol 265:F764-72. 1993..The stimulation of CA II mRNA was greater after 3 days than after 5-6 days of acid treatment. (ABSTRACT TRUNCATED AT 250 WORDS).. - Basolateral carbonic anhydrase IV in the proximal tubule is a glycosylphosphatidylinositol-anchored proteinJ M Purkerson
Department of Pediatrics, Strong Children s Research Center, University of Rochester School of Medicine, Rochester, New York, USA
Kidney Int 71:407-16. 2007..Thus, GPI-anchored CAIV resides in the basolateral membrane of proximal tubule epithelia where it may facilitate HCO(3) reabsorption via association with kNBC1... - Cyclosporin A produces distal renal tubular acidosis by blocking peptidyl prolyl cis-trans isomerase activity of cyclophilinSeiji Watanabe
Department of Pediatrics, Strong Children's Research Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
Am J Physiol Renal Physiol 288:F40-7. 2005..Thus CsA is able to prevent this adaptation by inhibition of a peptidyl prolyl cis-trans isomerase activity. Such inhibition may cause dRTA during acid loading... - The role of carbonic anhydrases in renal physiologyJ M Purkerson
Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York, USA
Kidney Int 71:103-15. 2007..For example, CAII on the cytoplasmic face and CAIV on the extracellular surface provide the 'push' and 'pull' for bicarbonate transport by supplying and dissipating substrate respectively... - Estimating and measuring glomerular filtration rate in childrenDana F Work
Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14618, USA
Curr Opin Nephrol Hypertens 17:320-5. 2008..The aim of this review is to discuss the current options for determining glomerular filtration rate in children and the latest advances in research on this topic... - Parental assessment of executive function and internalizing and externalizing behavior in primary hypertension after anti-hypertensive therapyMarc B Lande
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Pediatr 157:114-9. 2010..To determine the change in parental ratings of executive function and behavior in children with primary hypertension after anti-hypertensive therapy... - Galectin-3 expression is induced in renal beta-intercalated cells during metabolic acidosisAndrew L Schwaderer
Department of Pediatrics, University of Rochester School of Medicine, New York, USA
Am J Physiol Renal Physiol 290:F148-58. 2006..Thus galectin-3 may play several important roles in the CCD, including mediating the adaptation of beta-intercalated cells during metabolic acidosis... - Parental assessments of internalizing and externalizing behavior and executive function in children with primary hypertensionMarc B Lande
Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA
J Pediatr 154:207-12. 2009..To determine the relations between hypertension and parental ratings of behavior and executive functions in children with primary hypertension and to examine the potential moderating influence of obesity... - Carbonic anhydrase XII mRNA encodes a hydratase that is differentially expressed along the rabbit nephronGeorge J Schwartz
Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
Am J Physiol Renal Physiol 284:F399-410. 2003..Western blotting of expressed CA XII with two anti-rabbit CA IV peptide antibodies showed no cross-reactivity. Our findings indicate that CA XII may contribute to the membrane CA activity of proximal tubules and collecting ducts... - Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiationHu Peng
Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Biol Chem 284:6465-75. 2009..These results are significant because this is the first time a direct role of peptidylprolyl cis-trans isomerase activity has been implicated in the process of epithelial differentiation... - Role of urinary supersaturation in the evaluation of children with urolithiasisMarc B Lande
Division of Pediatric Nephrology, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
Pediatr Nephrol 20:491-4. 2005..These results show that the benefit of adding supersaturation to the traditional evaluation was largely negated by consideration of urine volume... - Apoptotic response to albumin overload: proximal vs. distal/collecting tubule cellsElif Erkan
Golisano Children s Hospital at Strong, University of Rochester, Rochester, NY 14642, USA
Am J Nephrol 25:121-31. 2005.... - Elevated blood pressure and decreased cognitive function among school-age children and adolescents in the United StatesMarc B Lande
Golisano Children s Hospital at Strong, Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
J Pediatr 143:720-4. 2003..Cognitive tests were compared for children with elevated and normal BP. Linear regression was used to evaluate the relation between elevated BP and decreased test scores... - Low pH enhances expression of carbonic anhydrase II by cultured rat inner medullary collecting duct cellsG J Schwartz
Department of Pediatrics, University of Rochester Medical Center, New York 14642
Am J Physiol 266:C508-14. 1994..Thus incubation of IMCD cells in acid medium stimulates the expression of CA II mRNA and protein.(ABSTRACT TRUNCATED AT 250 WORDS).. - Expression of membrane-associated carbonic anhydrase isoforms IV, IX, XII, and XIV in the rabbit: induction of CA IV and IX during maturationJeffrey M Purkerson
Chief, Pediatric Nephrology, Box 777, Univ. of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Regul Integr Comp Physiol 288:R1256-63. 2005..The unique pattern of membrane-bound CA isoforms suggests different functional associations with transporters, depending on the physiological demands on the tissue... - Age, gender, and race effects on cystatin C levels in US adolescentsDarcy Groesbeck
Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin J Am Soc Nephrol 3:1777-85. 2008.... - Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H(+)-K(+)-ATPase deficiencyA M Simpson
Department of Pediatrics, Division of Nephrology, Box 777, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arch Dis Child 84:504-7. 2001.... - Back to basics: acidosis and alkalosisAndrew L Schwaderer
Pediatric Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Pediatr Rev 25:350-7. 2004 - Differentiation of columnar epithelia: the hensin pathwaySoundarapandian Vijayakumar
Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 W 168th St, New York, NY 10032, USA
J Cell Sci 119:4797-801. 2006..Moreover many human cancers have deletions in the hensin gene, which indicates that it is a tumor suppressor... - Case report 668. Carbonic anhydrase II deficiency syndrome (osteopetrosis associated with renal tubular acidosis and cerebral calcification)G J Schwartz
Department of Pediatrics, Montefiore Medical Center, Bronx, New York
Skeletal Radiol 20:447-52. 1991..Thus, this is a patient with the CA II deficiency syndrome; he is the youngest reported case without any family history of osteopetrosis to be diagnosed initially on the basis of his radiographic features... - Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glandsVictor G Romanenko
Center for Oral Biology, Univ of Rochester Medical Center, Rochester, NY 14642, USA
Am J Physiol Gastrointest Liver Physiol 295:G1058-67. 2008..We conclude that ClC-2 is the inward-rectifying Cl(-) channel in duct cells, but its expression is not apparently required for the ion reabsorption or the barrier function of salivary ductal epithelium... - A fork in the road of cell differentiation in the kidney tubuleQais Al-Awqati
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 113:1528-30. 2004..These findings suggest that Foxi1 plays a critical role in determining cell identity during collecting duct development... - Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cellsElif Erkan
Department of Pediatrics, University of Rochester, School of Medicine, Rochester, New York, USA
J Am Soc Nephrol 18:1199-208. 2007..It is concluded that albumin induces apoptosis in human proximal tubule cells by stimulating mitochondrial apoptotic pathway independent of ROS production... - Apical H(+)/base transporters mediating bicarbonate absorption and pH(i) regulation in the OMCDKay-Pong Yip
Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
Am J Physiol Renal Physiol 283:F1098-104. 2002..10 pH/min using Schering 28080 (10 microM, lumen). These findings indicate that NBC3 contributes to pH(i) regulation in OMCD(is) type A intercalated cells and plays only a minor role in mediating [J(HCO(3)(-))] in the OMCD(is)... - Citrate reverses cyclosporin A-induced metabolic acidosis and bone resorption in ratsShuichi Tsuruoka
Department of Pharmacology, Division of Clinical Pharmacology, Jichi Medical School, 3311 Yakushiji, Mimamikawachi, Tochigi, Japan
Am J Nephrol 25:233-9. 2005..The interaction of CsA and NO in causing metabolic acidosis and bone demineralization has not been studied previously. Nor has the salubrious effect of citrate therapy... - National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratificationRonald J Hogg
North Texas Hospital for Children and the Department of Clinical Research at Medical City Dallas Hospital, Dallas, Texas 75230, USA
Pediatrics 111:1416-21. 2003.... - Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosisShuichi Tsuruoka
Department of Pharmacology, Jichi Medical School, Tochigi, Japan
Am J Physiol Renal Physiol 291:F866-73. 2006.... - Inhibition of Rho-kinase reduces renal Na-H exchanger activity and causes natriuresis in ratKenta Nishiki
Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
J Pharmacol Exp Ther 304:723-8. 2003..We conclude that apical NHE activity is increased in SHR PCT compared with controls and that inhibition of Rho-kinase reduces PCT NHE activities and causes natriuresis... - Functional analysis of ABCA8, a new drug transporterShuichi Tsuruoka
Department of Clinical Pharmacology, Jichi Medical School, 3311 Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
Biochem Biophys Res Commun 298:41-5. 2002..Northern blot analysis revealed expression in most organs, especially in heart, skeletal muscle, and liver. Thus, ABCA8 is a new member of the xenobiotic transporter ABC-subfamily... - Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporterBernardo V Alvarez
Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Biochemistry 42:12321-9. 2003..The tethering of CAII and CAIV close to the NBC1 HCO(3)(-) transport site maximizes the transmembrane HCO(3)(-) gradient local to NBC1 and thereby activates the transport rate... - Nitric oxide production modulates cyclosporin A-induced distal renal tubular acidosis in the ratShuichi Tsuruoka
Department of Clinical Pharmacology, Jichi Medical School, 3311 Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
J Pharmacol Exp Ther 305:840-5. 2003..These results suggest that CsA causes dRTA by inhibiting H+ pumps in the distal nephron. Inhibition of NO synthesis may be one of the mechanisms underlying the CsA effect...
Research Grants
- BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULEGeorge Schwartz; Fiscal Year: 2007..These studies should show how hensin and associated proteins mediate the kidney's adaptation to acid-base disturbances. ..
- BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULEGeorge Schwartz; Fiscal Year: 2003..The objective is to better understand the role of membrane carbonic anhydrases (CAs) in mediating renal acid-base transport. ..
- BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULEGeorge J Schwartz; Fiscal Year: 2010..These studies should show how hensin and associated proteins mediate the kidney's adaptation to acid-base disturbances. ..