David L Schwartz

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Phase I and initial phase II results from a trial investigating weekly docetaxel and carboplatin given neoadjuvantly and then concurrently with concomitant boost radiotherapy for locally advanced squamous cell carcinoma of the head and neck
    David L Schwartz
    Radiation Oncology Service, Seattle VA Puget Sound Health Care System, Seattle, Washington, USA
    Cancer 103:2534-43. 2005
  2. ncbi Staging of head and neck squamous cell cancer with extended-field FDG-PET
    David L Schwartz
    Department of Radiation Oncology, Division of Nuclear Medicine, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    Arch Otolaryngol Head Neck Surg 129:1173-8. 2003
  3. ncbi Postradiotherapy surveillance practice for head and neck squamous cell carcinoma--too much for too little?
    David L Schwartz
    Department of Radiation Oncology, Seattle VA PSHCS, 1660 S Columbian Way 174, Seattle, Washington, 98108, USA
    Head Neck 25:990-9. 2003
  4. ncbi FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma
    David L Schwartz
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98108, USA
    Int J Radiat Oncol Biol Phys 61:129-36. 2005
  5. ncbi Prospective imaging assessment of mortality risk after head-and-neck radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:667-74. 2010
  6. ncbi Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy
    Gokcen Yildirim
    The University of Texas M D Anderson Cancer Center, Department of Radiation Oncology, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 32:473-80. 2010
  7. ncbi Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy
    David L Schwartz
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 78:1356-65. 2010
  8. ncbi FDG-PET/CT-guided intensity modulated head and neck radiotherapy: a pilot investigation
    David L Schwartz
    Department of Radiation Oncology, University of Washington, Seattle, Washington, 1660 S Columbian Way 174, Seattle, WA 98108 1597, USA
    Head Neck 27:478-87. 2005
  9. ncbi Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
    David L Schwartz
    Department of Radiation Oncology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 9:2057-67. 2010
  10. ncbi Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy
    Aarti Bhatia
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 32:829-36. 2010

Detail Information

Publications36

  1. ncbi Phase I and initial phase II results from a trial investigating weekly docetaxel and carboplatin given neoadjuvantly and then concurrently with concomitant boost radiotherapy for locally advanced squamous cell carcinoma of the head and neck
    David L Schwartz
    Radiation Oncology Service, Seattle VA Puget Sound Health Care System, Seattle, Washington, USA
    Cancer 103:2534-43. 2005
    ..The current Phase I/II study assessed induction docetaxel/carboplatin given weekly for 4 weeks, followed by weekly docetaxel/carboplatin and concomitant boost radiotherapy (CB-XRT) for locally advanced head and neck squamous cell carcinoma...
  2. ncbi Staging of head and neck squamous cell cancer with extended-field FDG-PET
    David L Schwartz
    Department of Radiation Oncology, Division of Nuclear Medicine, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    Arch Otolaryngol Head Neck Surg 129:1173-8. 2003
    ..The effectiveness of FDG-PET for the detection of distant metastatic or synchronous disease remains unproven...
  3. ncbi Postradiotherapy surveillance practice for head and neck squamous cell carcinoma--too much for too little?
    David L Schwartz
    Department of Radiation Oncology, Seattle VA PSHCS, 1660 S Columbian Way 174, Seattle, Washington, 98108, USA
    Head Neck 25:990-9. 2003
    ..We cataloged follow-up for a specified patient cohort treated at three neighboring university, community, and Veterans Administration institutions...
  4. ncbi FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma
    David L Schwartz
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98108, USA
    Int J Radiat Oncol Biol Phys 61:129-36. 2005
    ..This pilot study prospectively examined the use of registered 18-F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT for preradiotherapy staging of the neck...
  5. ncbi Prospective imaging assessment of mortality risk after head-and-neck radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:667-74. 2010
    ..Unresolved questions include whether functional or anatomic imaging might improve mortality risk assessment for this disease. We addressed these issues in a prospective institutional trial...
  6. ncbi Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy
    Gokcen Yildirim
    The University of Texas M D Anderson Cancer Center, Department of Radiation Oncology, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 32:473-80. 2010
    ..Our aim was to evaluate the therapeutic outcomes of patients with squamous cell carcinoma of the tonsil that underwent tonsillectomies followed by radiotherapy...
  7. ncbi Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy
    David L Schwartz
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 78:1356-65. 2010
    ..To investigate long-term swallowing function in oropharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT), and to identify novel dose-limiting criteria predictive for dysphagia...
  8. ncbi FDG-PET/CT-guided intensity modulated head and neck radiotherapy: a pilot investigation
    David L Schwartz
    Department of Radiation Oncology, University of Washington, Seattle, Washington, 1660 S Columbian Way 174, Seattle, WA 98108 1597, USA
    Head Neck 27:478-87. 2005
    ..The intent of this study was to examine the use of registered FDG-PET/CT imaging to guide head and neck intensity modulated radiotherapy (IMRT) planning...
  9. ncbi Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
    David L Schwartz
    Department of Radiation Oncology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 9:2057-67. 2010
    ....
  10. ncbi Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy
    Aarti Bhatia
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 32:829-36. 2010
    ..The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT)...
  11. ncbi Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M. D. Anderson Cancer Center outcomes and patterns of failure
    Steven J Frank
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:1005-10. 2010
    ....
  12. ncbi Unilateral radiotherapy for the treatment of tonsil cancer
    Gregory M Chronowski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 83:204-9. 2012
    ..D. Anderson Cancer Center with unilateral radiotherapy techniques that irradiate the involved tonsil region and ipsilateral neck only...
  13. ncbi HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer Res 9:259-70. 2011
    ..We applied a multimodality preclinical imaging platform to mechanistically characterize tumor response to radiation, with a focus on HIF-1-dependent resistance pathways...
  14. ncbi Hypothyroidism in older patients with head and neck cancer after treatment with radiation: a population-based study
    Grace L Smith
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 31:1031-8. 2009
    ..In patients with head and neck cancer, radiation treatment (RT) is a risk factor for hypothyroidism. However, the specific magnitude of risk after RT in older patients is not known...
  15. ncbi IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes
    Erik P Sulman
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 73:399-409. 2009
    ..Limited data are available regarding the use of intensity-modulated radiotherapy (IMRT) for this indication. We reviewed our initial experience using IMRT for previously irradiated head and neck cancer patients...
  16. ncbi FDG-PET prediction of head and neck squamous cell cancer outcomes
    David L Schwartz
    Radiation Oncology Service, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, USA
    Arch Otolaryngol Head Neck Surg 130:1361-7. 2004
    ....
  17. ncbi Postoperative external beam radiotherapy for differentiated thyroid cancer: outcomes and morbidity with conformal treatment
    David L Schwartz
    Department of Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 74:1083-91. 2009
    ..To review institutional outcomes for patients treated for differentiated thyroid cancer with postoperative conformal external beam radiotherapy (EBRT)...
  18. ncbi Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer
    Benjamin J Moeller
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
    J Clin Oncol 27:2509-15. 2009
    ..We conducted a prospective trial to identify patient populations likely to benefit from the addition of functional imaging to the assessment of radiotherapy response...
  19. ncbi Simple carotid-sparing intensity-modulated radiotherapy technique and preliminary experience for T1-2 glottic cancer
    David I Rosenthal
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 77:455-61. 2010
    ..To investigate the dosimetry and feasibility of carotid-sparing intensity-modulated radiotherapy (IMRT) for early glottic cancer and to report preliminary clinical experience...
  20. ncbi Postoperative radiotherapy for advanced medullary thyroid cancer--local disease control in the modern era
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:883-8. 2008
    ..The purpose of this study is to catalog modern-era postoperative radiotherapy (external beam radiotherapy [EBRT]) outcomes for advanced medullary thyroid cancer...
  21. ncbi Tumor delineation using PET in head and neck cancers: threshold contouring and lesion volumes
    Eric C Ford
    University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195, USA
    Med Phys 33:4280-8. 2006
    ..The appropriate threshold level depends on lesion size and image reconstruction parameters. These effects should be carefully considered when using PET contour and/or volume information for radiotherapy applications...
  22. ncbi The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Unit 97, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 8:947-58. 2009
    ..Successful translation of targeted HIF-1 radiosensitization to the clinical setting will require specific consideration of tumor microenvironmental effects and mechanisms...
  23. ncbi Tumor hypoxia imaging with [F-18] fluoromisonidazole positron emission tomography in head and neck cancer
    Joseph G Rajendran
    Department of Radiology, University of Washington, Veterans Administration Puget Sound Health Care System, Seattle 98195, USA
    Clin Cancer Res 12:5435-41. 2006
    ..F-18] fluoromisonidazole (FMISO) positron emission tomography (PET) has the ability to noninvasively quantify regional hypoxia. We investigated the prognostic effect of pretherapy FMISO-PET on survival in head and neck cancer...
  24. ncbi The development of a telemedical cancer center within the Veterans Affairs Health Care System: a report of preliminary clinical results
    Kevin G Billingsley
    Department of Surgery, VA Puget Sound Health Care System and the University of Washington Seattle, Washington 98108, USA
    Telemed J E Health 8:123-30. 2002
    ..Preliminary clinical results demonstrate the program is feasible and it improves access to multidisciplinary cancer care. Potential benefits include improved referral coordination and minimization of patient travel and treatment delays...
  25. ncbi Long-term radiotherapy outcomes for nasal cavity and septal cancers
    Matthew W Allen
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:401-6. 2008
    ..Carcinoma of the nasal cavity and septum has historically been associated with a poor prognosis. This report updates the long-term outcomes for radiotherapy (RT) of this disease site at the University of Texas M.D. Anderson Cancer Center...
  26. ncbi DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 17:2035-43. 2011
    ..We examined whether differential expression of double-strand DNA break (DSB) repair proteins in HNSCC, the chief mediators of DNA repair following irradiation, predict for treatment outcomes...
  27. ncbi Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging
    Joseph G Rajendran
    Department of Radiology, University of Washington, Seattle, 98195, USA
    Clin Cancer Res 10:2245-52. 2004
    ..Although acute hypoxia results in accelerated glycolysis, cellular metabolism is slowed in chronic hypoxia, prompting us to look for discordance between FMISO and FDG uptake...
  28. ncbi Radiation therapy does not impact local complication rates after free flap reconstruction for head and neck cancer
    Seungtaek Choi
    Department of Radiation Oncology, University of Washington, Seattle, USA
    Arch Otolaryngol Head Neck Surg 130:1308-12. 2004
    ..Postoperative complication rates were not significantly affected by administration, timing, dose, or extent of XRT...
  29. ncbi Technology insight: PET and PET/CT in head and neck tumor staging and radiation therapy planning
    Steven J Frank
    University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Nat Clin Pract Oncol 2:526-33. 2005
    ..The use of PET/CT for staging and detecting both primary and recurrent head and neck cancer is valuable; however, its application in radiation treatment planning should be viewed as investigational...
  30. ncbi FDG-PET staging of head and neck cancer--can improved imaging lead to improved treatment?
    David L Schwartz
    J Natl Cancer Inst 100:688-9. 2008
  31. ncbi The effect of dental artifacts, contrast media, and experience on interobserver contouring variations in head and neck anatomy
    David I Rosenthal
    Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Oncol 30:191-8. 2007
    ..To investigate interobserver variability in the delineation of head-and-neck (H&N) anatomic structures on CT images, including the effects of image artifacts and observer experience...
  32. ncbi Intensity-modulated radiotherapy: is xerostomia still prevalent?
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Curr Oncol Rep 7:131-6. 2005
    ....
  33. ncbi Outcomes after radiotherapy for squamous cell carcinoma of the eyelid
    Janjira Petsuksiri
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:111-8. 2008
    ..Squamous cell carcinoma (SCC) of the eyelid is a rare malignancy with metastatic potential. In the current study, the outcomes of patients with SCC of the eyelid were evaluated after definitive and postoperative radiation therapy...
  34. ncbi Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get?
    Jennifer C O'Daniel
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 69:1290-6. 2007
    ..To quantify the differences between planned and delivered parotid gland and target doses, and to assess the benefits of daily bone alignment for head and neck cancer patients treated with intensity-modulated radiotherapy (IMRT)...
  35. ncbi Comparison of 2D radiographic images and 3D cone beam computed tomography for positioning head-and-neck radiotherapy patients
    Heng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:916-25. 2008
    ..To assess the benefit of patient-specific headrest...
  36. ncbi Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe
    Parmeswaran Diagaradjane
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:731-41. 2008
    ..To develop and validate an optical imaging nanoprobe for the discrimination of epidermal growth factor (EGF) receptor (EGFR)-overexpressing tumors from surrounding normal tissues that also expresses EGFR...