Research Topics

Genomes and Genes


David A Schwartz


Affiliation: University of Colorado Denver
Country: USA


  1. Hancock L, Hennessy C, Solomon G, Dobrinskikh E, Estrella A, Hara N, et al. Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice. Nat Commun. 2018;9:5363 pubmed publisher
    ..Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF. ..
  2. Mathai S, Yang I, Schwarz M, Schwartz D. Incorporating genetics into the identification and treatment of Idiopathic Pulmonary Fibrosis. BMC Med. 2015;13:191 pubmed publisher
    ..Future studies will be needed to characterize patient phenotypes and to understand how these genetic factors will influence clinical decision-making for both diagnosis and treatment of idiopathic pulmonary fibrosis. ..
  3. Yang I, Schwartz D. Epigenetic mechanisms and the development of asthma. J Allergy Clin Immunol. 2012;130:1243-55 pubmed publisher
    ..Epigenetic mechanisms represent a promising line of inquiry that might, in part, explain the inheritance and immunobiology of asthma. ..
  4. Yang I, Pedersen B, Liu A, O Connor G, Teach S, Kattan M, et al. DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol. 2015;136:69-80 pubmed publisher
    ..Our results demonstrate that DNA methylation marks in specific gene loci are associated with asthma and suggest that epigenetic changes might play a role in establishing the immune phenotype associated with asthma. ..
  5. KLIMENT C, Araki T, Doyle T, Gao W, Dupuis J, Latourelle J, et al. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015;15:134 pubmed publisher
    ..Moreover, HAAs were not associated with MUC5B promoter genotype. ..
  6. Macneal K, Schwartz D. The genetic and environmental causes of pulmonary fibrosis. Proc Am Thorac Soc. 2012;9:120-5 pubmed publisher
  7. Fingerlin T, Zhang W, Yang I, Ainsworth H, Russell P, Blumhagen R, et al. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet. 2016;17:74 pubmed publisher
    ..These studies reveal the importance of the HLA region for risk of fIIP and a basis for the potential etiologic role of auto-immunity in fIIP. ..
  8. Yang I, Pedersen B, Liu A, O Connor G, Pillai D, Kattan M, et al. The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol. 2017;139:1478-1488 pubmed publisher
    ..Epigenetic marks in respiratory epithelia are associated with allergic asthma and gene expression changes in inner-city children. ..