David A Schwartz
Affiliation: University of Colorado Denver
Hancock L, Hennessy C, Solomon G, Dobrinskikh E, Estrella A, Hara N, et al
. Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice. Nat Commun. 2018;9:5363 pubmed publisher
..Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF. ..
Mathai S, Yang I, Schwarz M, Schwartz D. Incorporating genetics into the identification and treatment of Idiopathic Pulmonary Fibrosis. BMC Med. 2015;13:191 pubmed publisher
..Future studies will be needed to characterize patient phenotypes and to understand how these genetic factors will influence clinical decision-making for both diagnosis and treatment of idiopathic pulmonary fibrosis. ..
Yang I, Schwartz D. Epigenetic mechanisms and the development of asthma. J Allergy Clin Immunol. 2012;130:1243-55 pubmed publisher
..Epigenetic mechanisms represent a promising line of inquiry that might, in part, explain the inheritance and immunobiology of asthma. ..
Yang I, Pedersen B, Liu A, O Connor G, Teach S, Kattan M, et al
. DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol. 2015;136:69-80 pubmed publisher
..Our results demonstrate that DNA methylation marks in specific gene loci are associated with asthma and suggest that epigenetic changes might play a role in establishing the immune phenotype associated with asthma. ..
KLIMENT C, Araki T, Doyle T, Gao W, Dupuis J, Latourelle J, et al
. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015;15:134 pubmed publisher
..Moreover, HAAs were not associated with MUC5B promoter genotype. ..
Macneal K, Schwartz D. The genetic and environmental causes of pulmonary fibrosis. Proc Am Thorac Soc. 2012;9:120-5 pubmed publisher
Fingerlin T, Zhang W, Yang I, Ainsworth H, Russell P, Blumhagen R, et al
. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet. 2016;17:74 pubmed publisher
..These studies reveal the importance of the HLA region for risk of fIIP and a basis for the potential etiologic role of auto-immunity in fIIP. ..
Yang I, Pedersen B, Liu A, O Connor G, Pillai D, Kattan M, et al
. The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol. 2017;139:1478-1488 pubmed publisher
..Epigenetic marks in respiratory epithelia are associated with allergic asthma and gene expression changes in inner-city children. ..