Research Topics
| ANN V contact SCHWARTZSummaryAffiliation: University of California Country: USA Publications
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Publications
Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trialAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
Diabetes Care 35:1525-31. 2012..To determine the effect of intensive versus standard glycemic control, we assessed fractures and falls as outcomes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) randomized trial...
Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trialAnn V Schwartz
Department of Biostatistics and Epidemiology, University of California San Francisco, San Francisco, CA 94107, USA
J Bone Miner Res 27:619-27. 2012..One year of an intensive lifestyle intervention in adults with type 2 diabetes, resulting in weight loss, was associated with a modest increase in hip bone loss despite improved fitness and glycemic control...
Effect of thiazolidinediones on skeletal health in women with Type 2 diabetesAnn V Schwartz
University of California San Francisco, Department of Epidemiology and Biostatistics, 185 Berry Street, Suite 5700, San Francisco, CA 94107, USA
Expert Opin Drug Saf 7:69-78. 2008..Clinicians should be aware of the potential for increased fracture risk when prescribing TZDs, particularly in postmenopausal women...- Diabetes and bone loss at the hip in older black and white adultsAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
J Bone Miner Res 20:596-603. 2005.... - Thiazolidinedione use and bone loss in older diabetic adultsAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, California 94107 1762, USA
J Clin Endocrinol Metab 91:3349-54. 2006..Activation of peroxisome proliferator-activated receptor-gamma by thiazolidinediones (TZDs) results in lower bone mass in mice... - Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trialAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
J Bone Miner Res 25:976-82. 2010..5 or less but does not reduce risk of NVF in women whose T-scores are greater than -2... - Diabetes, fracture, and bone fragilityAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Suite 5700, San Francisco, CA 94107, USA
Curr Osteoporos Rep 5:105-11. 2007..Clinicians need to be aware of the increased fracture risk associated with diabetes. Additional research is needed to clarify the mechanisms underlying this increased risk and the best approaches to fracture prevention... - Diabetes-related complications, glycemic control, and falls in older adultsAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107 1762, USA
Diabetes Care 31:391-6. 2008..We determined whether diabetes-related complications or treatments are associated with risk of falls in older diabetic adults... - Pentosidine and increased fracture risk in older adults with type 2 diabetesAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94107 1762, USA
J Clin Endocrinol Metab 94:2380-6. 2009..Type 2 diabetes is associated with higher fracture risk at a given bone mineral density. Advanced glycation endproducts (AGEs) accumulate in bone collagen with age and diabetes and may weaken bone... - Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetesAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
JAMA 305:2184-92. 2011..It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM... - Increased falling as a risk factor for fracture among older women: the study of osteoporotic fracturesAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, 74 New Montgomery Street, Suite 600, San Francisco, CA 94105, USA
Am J Epidemiol 161:180-5. 2005..An increase in the rate of falls, independent of the average rate, may be associated with a higher risk of frailty (hip and proximal humerus) fractures but not fractures at other sites... - Women, type 2 diabetes, and fracture riskAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, 94105, USA
Curr Diab Rep 4:364-9. 2004..Health care professionals should be aware of the increased fracture risk among older women with diabetes and should ensure screening, treatment, and fall prevention strategies are appropriately implemented... - Older women with diabetes have an increased risk of fracture: a prospective studyA V Schwartz
Department of Epidemiology, Division of Endocrinology, University of California San Francisco, San Francisco, California 94105, USA
J Clin Endocrinol Metab 86:32-8. 2001..This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes... - Diabetes Mellitus: Does it Affect Bone?A V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, CA, USA
Calcif Tissue Int 73:515-9. 2003..A better understanding of how diabetes metabolism and treatments affect bone would improve fracture prevention efforts in older diabetic adults... - Older women with diabetes have a higher risk of falls: a prospective studyAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
Diabetes Care 25:1749-54. 2002..To determine whether older women with diabetes have an increased risk of falls and whether known risk factors for falls account for any increased risk... - Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition studyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
Arch Intern Med 165:1612-7. 2005..Fracture prevention needs to target specific risk factors found in older adults with DM... - The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults: the Health, Aging, and Body Composition (Health ABC) studyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Diabetes Care 31:1767-72. 2008..Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance... - Reduced peripheral nerve function is related to lower hip BMD and calcaneal QUS in older white and black adults: the Health, Aging, and Body Composition StudyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Bone Miner Res 21:1803-10. 2006..Poor peripheral nerve function may directly affect bone... - Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trialDennis M Black
San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
JAMA 296:2927-38. 2006..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain... - Fat infiltration of muscle, diabetes, and clinical fracture risk in older adultsAnne L Schafer
Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Clin Endocrinol Metab 95:E368-72. 2010..Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture... - High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitusAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, San Francisco, California 94158, USA
J Clin Endocrinol Metab 95:5045-55. 2010..Cross-sectional epidemiological studies have found that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of certain fragility fractures despite normal or elevated bone mineral density (BMD)... - Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosisXiaojuan Li
Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA
J Magn Reson Imaging 33:974-9. 2011.... - Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition StudyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Bone Miner Res 19:1084-91. 2004..01) and higher hip BMD for each race-gender group (p < or = 0.01). Type 2 diabetes was associated with a 4-5% higher total hip BMD in all race-gender groups of elderly adults, independent of body composition and fasting insulin levels... - Predicting the development of diabetes in older adults: the derivation and validation of a prediction ruleAlka M Kanaya
Department of Medicine and Epidemiology and Biostatics, University of California, San Francisco, California 94115, USA
Diabetes Care 28:404-8. 2005..We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort... - Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF)Jane A Cauley
University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:134-43. 2009..These women experienced a lower risk of fractures, disability, and mortality, suggesting that this phenotype may be a marker of successful aging... - Sensory and motor peripheral nerve function and lower-extremity quadriceps strength: the health, aging and body composition studyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Am Geriatr Soc 57:2004-10. 2009..To determine whether sensory and motor nerve function is associated cross-sectionally with quadriceps or ankle dorsiflexion strength in an older community-based population... - Insulin resistance is associated with decreased quadriceps muscle strength in nondiabetic adults aged >or=70 yearsJoshua I Barzilay
Division of Endocrinology, Kaiser Permanente of Georgia, Emory University School of Medicine, Atlanta, Georgia, USA
Diabetes Care 32:736-8. 2009..Lower-limb muscle strength is reduced in many people with diabetes. In this study, we examined whether quadriceps muscle strength is reduced in relation to insulin resistance in well-functioning ambulatory nondiabetic individuals... - Central nervous system-active medications and risk for falls in older womenKristine E Ensrud
Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
J Am Geriatr Soc 50:1629-37. 2002..To determine whether current use of central nervous system (CNS)-active medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases the risk for subsequent falls... - Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and womenBret H Goodpaster
Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Diabetes Care 26:372-9. 2003.... - Racial differences in glycemic control in a well-functioning older diabetic population: findings from the Health, Aging and Body Composition StudyNathalie de Rekeneire
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 9205, USA
Diabetes Care 26:1986-92. 2003..We further hypothesized that the association of race with poorer glycemic control would be limited to those with lower education or lower income... - Diabetes and incidence of functional disability in older womenEdward W Gregg
Division of Diabetes Translation, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Diabetes Care 25:61-7. 2002..To examine the relationship between diabetes and the incidence of functional disability and to determine the predictors of functional disability among older women with diabetes... - Thiazolidinedione therapy gets complicated: is bone loss the price of improved insulin resistance?Ann V Schwartz
Diabetes Care 30:1670-1. 2007 - Effect of alendronate on bone mineral density and biochemical markers of bone turnover in type 2 diabetic women: the fracture intervention trialTheresa H M Keegan
Division of Epidemiology, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
Diabetes Care 27:1547-53. 2004..The objective of this project was to compare changes in BMD during 3 years of ALN treatment versus placebo in diabetic women... - Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adultsNadine R Sahyoun
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
Am J Clin Nutr 82:547-52. 2005..Recent evidence suggests that the rate of carbohydrate digestion and absorption may influence the development of type 2 diabetes... - Research profile. Too many fractures in type 2sPatty Walsh
Diabetes Forecast 55:93-5. 2002 - Thiazolidinediones and the risk of nontraumatic fractures in patients with diabetes: in replyElsa S Strotmeyer
Arch Intern Med 166:1043. 2006 - Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition studySeok Won Park
Department of Internal Medicine, Pochon CHA University, Pochon, Korea
Diabetes 55:1813-8. 2006..In conclusion, diabetes is associated with lower skeletal muscle strength and quality. These characteristics may contribute to the development of physical disability in older adults with diabetes... - Risk of fracture in women with type 2 diabetes: the Women's Health Initiative Observational StudyDenise E Bonds
M P H, Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
J Clin Endocrinol Metab 91:3404-10. 2006..Some but not all studies have shown higher rates of fracture in individuals with type 2 diabetes... - Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition studyNathalie de Rekeneire
Laboratory of Epidemiology, National Institute on Aging, Bethesda, MD 20892 9205, USA
Diabetes Care 29:1902-8. 2006..The objective of this study was to assess the association of inflammation with hyperglycemia (impaired fasting glucose [IFG]/impaired glucose tolerance [IGT]) and diabetes in older individuals... - Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) studyM Kathleen Figaro
Department of Medicine, Vanderbilt University Medical Center GRECC, 1310 24th Ave South, Room 4B111, Nashville, TN 37212, USA
Diabetes Care 29:2039-45. 2006..We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes... - Diabetes is associated with subclinical functional limitation in nondisabled older individuals: the Health, Aging, and Body Composition studyNathalie de Rekeneire
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
Diabetes Care 26:3257-63. 2003.... - Incident fall risk and physical activity and physical performance among older men: the Osteoporotic Fractures in Men StudyBenjamin K S Chan
Department of Endocrinology, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Am J Epidemiol 165:696-703. 2007..69, 0.85). Partitioning components of activity showed no association between fall risk and leisure activities but a positive association with household activities (for highest quartile vs.lowest: relative risk = 1.17, 95% CI: 1.07, 1.28)... - Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition studySeok Won Park
Department of Internal Medicine, Pochon CHA University, Pochon, Korea
Diabetes Care 30:1507-12. 2007..The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes... - Thiazolidinediones: new evidence of bone lossAnn V Schwartz
J Clin Endocrinol Metab 92:1232-4. 2007 - The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition studyBret H Goodpaster
Department of Medicine, MUH N809, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Gerontol A Biol Sci Med Sci 61:1059-64. 2006..The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking... - Knee extension strength cutpoints for maintaining mobilityTodd M Manini
Institute on Aging, Department of Aging and Geriatric Research, Amsterdam, The Netherlands
J Am Geriatr Soc 55:451-7. 2007..To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults... - Increased mortality associated with the metabolic syndrome in older women with diabetesTeresa A Hillier
Center for Health Research, Kaiser Permanente Northwest/Hawaii, 3800 N. Interstate Ave, Portland, Oregon 97227, USA
Diabetes Care 28:2258-60. 2005 - Alendronate and atrial fibrillationSteven R Cummings
N Engl J Med 356:1895-6. 2007
Research Grants
- DIABETES, PRE-DIABETES, AND FALLS IN OLDER ADULTSAnn Schwartz; Fiscal Year: 2004..These analyses will inform future efforts to design trials to prevent falls and maintain strength and balance in older adults with diabetes or pre-diabetes. ..
- Intensive Glycemic Control and Skeletal HealthAnn Schwartz; Fiscal Year: 2007..Change in bone mineral density over two years at the hip and lumbar spine will be determined in a subsample (N=240) using dual energy absorptiometry(DEXA). ..
- Intensive Glycemic Control and Skeletal HealthAnn Schwartz; Fiscal Year: 2009..Change in bone mineral density over two years at the hip and lumbar spine will be determined in a subsample (N=240) using dual energy absorptiometry (DEXA). ..
- Bone Marrow Adiposity, Bone and Body CompositionANN V contact SCHWARTZ; Fiscal Year: 2010..A better understanding of the process underlying the accumulation of marrow fat with age and osteoporosis may provide new targets for treatments to prevent bone loss. ..