GERALD SCHWARTING

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons
    Gerald A Schwarting
    The Shriver Center, 200 Trapelo Road, Waltham, MA 02452, USA
    Eur J Neurosci 19:11-20. 2004
  2. ncbi request reprint Gonadotropin-releasing hormone neuronal migration
    Gerald A Schwarting
    Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Waltham, MA, USA
    Semin Reprod Med 25:305-12. 2007
  3. pmc Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance
    Thomas K Knott
    Cell Biology Department, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neural Dev 7:17. 2012
  4. ncbi request reprint Olfactory axon guidance: the modified rules
    Gerald A Schwarting
    Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Neurosci Res 86:11-7. 2008
  5. ncbi request reprint Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium
    Gerald A Schwarting
    Shriver Center UMMS, 200 Trapelo Road, Waltham, MA 02452, USA
    J Mol Histol 38:543-53. 2007
  6. ncbi request reprint Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain
    Gerald A Schwarting
    Shriver Center University of Massachusetts Medical Center, Waltham, Massachusetts 02452, USA
    J Neurosci 26:6834-40. 2006
  7. pmc Regulation and function of axon guidance and adhesion molecules during olfactory map formation
    Gerald A Schwarting
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 112:2663-71. 2011
  8. ncbi request reprint Semaphorin 3A-mediated axon guidance regulates convergence and targeting of P2 odorant receptor axons
    Gerald A Schwarting
    The Shriver Center, 200 Trapelo Road, Waltham, MA 02452, USA
    Eur J Neurosci 19:1800-10. 2004
  9. ncbi request reprint Lactosamine differentially affects olfactory sensory neuron projections to the olfactory bulb
    Gerald A Schwarting
    Shriver Center, Waltham, Massachusetts 02452, USA
    Dev Neurobiol 67:1627-40. 2007
  10. ncbi request reprint Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons
    Timothy R Henion
    Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurosci 25:1894-903. 2005

Research Grants

  1. MECHANISMS OF GNRH NEURON MIGRATION DURING DEVELOPMENT
    GERALD SCHWARTING; Fiscal Year: 2000
  2. GLYCOCONJUGATES IN OLFACTORY CELL-CELL INTERACTIONS
    GERALD SCHWARTING; Fiscal Year: 2009
  3. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
  4. GLYCOCONJUGATES IN OLFACTORY CELL-CELL INTERACTIONS
    GERALD SCHWARTING; Fiscal Year: 2007
  5. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2007
  6. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2005
  7. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2003
  8. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2004
  9. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2003
  10. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons
    Gerald A Schwarting
    The Shriver Center, 200 Trapelo Road, Waltham, MA 02452, USA
    Eur J Neurosci 19:11-20. 2004
    ..Loss of function through a genetic deletion in either Dcc or Ntn1 results in the migration of many LHRH neurons to inappropriate destinations...
  2. ncbi request reprint Gonadotropin-releasing hormone neuronal migration
    Gerald A Schwarting
    Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Waltham, MA, USA
    Semin Reprod Med 25:305-12. 2007
    ..This review focuses on the different mechanisms used by these factors to regulate migration of GnRH-1 neurons...
  3. pmc Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance
    Thomas K Knott
    Cell Biology Department, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neural Dev 7:17. 2012
    ..The phenotype of these mice is similar to adenylyl cyclase 3 (AC3) knockout mice largely due to the significant down-regulation of AC3 activity in β3GnT2(-/-) neurons...
  4. ncbi request reprint Olfactory axon guidance: the modified rules
    Gerald A Schwarting
    Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Neurosci Res 86:11-7. 2008
    ..This review focuses attention on these non-OR factors and their roles in olfactory axon guidance...
  5. ncbi request reprint Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium
    Gerald A Schwarting
    Shriver Center UMMS, 200 Trapelo Road, Waltham, MA 02452, USA
    J Mol Histol 38:543-53. 2007
    ..Taken together, these results further support a role for Notch signaling in the regulation of olfactory neurogenesis and cell diversity...
  6. ncbi request reprint Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain
    Gerald A Schwarting
    Shriver Center University of Massachusetts Medical Center, Waltham, Massachusetts 02452, USA
    J Neurosci 26:6834-40. 2006
    ..The MM is smaller in CXCR4-/- mice, suggesting that some MM cells also require SDF-1/CXCR4 function for migration and survival...
  7. pmc Regulation and function of axon guidance and adhesion molecules during olfactory map formation
    Gerald A Schwarting
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 112:2663-71. 2011
    ..This review summarizes the current state of this field and the important molecules that impact on cAMP-dependent mechanism in olfactory axon guidance...
  8. ncbi request reprint Semaphorin 3A-mediated axon guidance regulates convergence and targeting of P2 odorant receptor axons
    Gerald A Schwarting
    The Shriver Center, 200 Trapelo Road, Waltham, MA 02452, USA
    Eur J Neurosci 19:1800-10. 2004
    ..Furthermore, Sema3A plays a key role in the convergence of axons expressing the odorant receptor P2 onto their appropriate targets...
  9. ncbi request reprint Lactosamine differentially affects olfactory sensory neuron projections to the olfactory bulb
    Gerald A Schwarting
    Shriver Center, Waltham, Massachusetts 02452, USA
    Dev Neurobiol 67:1627-40. 2007
    ..Neurons that are normally lactosamine negative, survive early postnatal degeneration in beta3GnT1-/- mice but extend axons that converge on inappropriate targets in the mutant OB...
  10. ncbi request reprint Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons
    Timothy R Henion
    Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurosci 25:1894-903. 2005
    ..These results reveal an essential role for lactosamine in sensory axon pathfinding and in the formation of OB synaptic connections...
  11. ncbi request reprint Live view of gonadotropin-releasing hormone containing neuron migration
    Elizabeth P Bless
    The Shriver Center at the University of Massachusetts Medical School, Waltham, Massachusetts 02254, USA
    Endocrinology 146:463-8. 2005
    ..These studies establish a model to evaluate the influences of specific molecules that are important for their migration...
  12. ncbi request reprint Patterning the developing and regenerating olfactory system
    Timothy R Henion
    Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 02452, USA
    J Cell Physiol 210:290-7. 2007
    ..It is now apparent that these and likely other additional molecules are required along with ORs to orchestrate the complex pattern of convergence and divergence that is unique to the olfactory system...
  13. ncbi request reprint Lactosamine modulates the rate of migration of GnRH neurons during mouse development
    Elizabeth Bless
    Curis Inc, Cambridge, MA 02138, USA
    Eur J Neurosci 24:654-60. 2006
    ..These results suggest that the loss of lactosamine on a subset of GnRH neurons impeded the rate of migration from the nose to the brain...
  14. pmc The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice
    John C Gill
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 149:4596-604. 2008
    ..These data establish that autocrine-paracrine GnRH-signaling is not a prerequisite for the developmental migration of GnRH neurons into the brain or for the projection of GnRH neurosecretory axons...
  15. ncbi request reprint Minireview: recent progress in gonadotropin-releasing hormone neuronal migration
    Stuart A Tobet
    Colorado State University, Department of Biomedical Sciences, 1617 Campus Delivery, Fort Collins, Colorado 80523, USA
    Endocrinology 147:1159-65. 2006
    ..It is likely that the multiple external factors converge on selective signal transduction pathways to engage the mechanical mechanisms needed to modulate GnRH neuronal movement and ultimately migration...
  16. ncbi request reprint Overexpression of glutamic acid decarboxylase-67 (GAD-67) in gonadotropin-releasing hormone neurons disrupts migratory fate and female reproductive function in mice
    Sabine Heger
    Division of Neuroscience, Oregon National Regional Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Endocrinology 144:2566-79. 2003
    ..The possibility arises that similar abnormalities in GABA homeostasis may contribute to syndromes of hypothalamic amenorrhea/oligomenorrhea in humans...

Research Grants19

  1. MECHANISMS OF GNRH NEURON MIGRATION DURING DEVELOPMENT
    GERALD SCHWARTING; Fiscal Year: 2000
    ..it has also been associated with numerous other neurological problems, including mental retardation. Results from these studies will aid our understanding of the development of the nervous system. ..
  2. GLYCOCONJUGATES IN OLFACTORY CELL-CELL INTERACTIONS
    GERALD SCHWARTING; Fiscal Year: 2009
    ..In addition, as a model for spontaneous regeneration, these studies are likely to broaden our understanding of potential treatments for peripheral nerve injury and neurodegenerative disease. ..
  3. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
    ..These studies will lead to an understanding of the complex factors that guide GnRH neurons to their proper destinations in the hypothalamus to control the hypothalamic-pituitary-gonadal axis. ..
  4. GLYCOCONJUGATES IN OLFACTORY CELL-CELL INTERACTIONS
    GERALD SCHWARTING; Fiscal Year: 2007
    ..In addition, as a model for spontaneous regeneration, these studies are likely to broaden our understanding of potential treatments for peripheral nerve injury and neurodegenerative disease. ..
  5. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2007
    ..These studies will lead to an understanding of the complex factors that guide GnRH neurons to their proper destinations in the hypothalamus to control the hypothalamic-pituitary-gonadal axis. ..
  6. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2005
    ..These studies are intended to broaden our knowledge of mechanisms used to organize connections in the mammalian nervous system. ..
  7. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2003
    ..These studies are intended to broaden our knowledge of mechanisms used to organize connections in the mammalian nervous system. ..
  8. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2004
    ..These studies are intended to broaden our knowledge of mechanisms used to organize connections in the mammalian nervous system. ..
  9. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2003
    ..These studies are intended to broaden our knowledge of mechanisms used to organize connections in the mammalian nervous system. ..
  10. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2002
    ..These studies are intended to broaden our knowledge of mechanisms used to organize connections in the mammalian nervous system. ..
  11. MECHANISMS OF GNRH NEURON MIGRATION DURING DEVELOPMENT
    GERALD SCHWARTING; Fiscal Year: 2000
    ..Results from these studies will aid in our understanding of fundamental mechanisms in nervous system development. ..
  12. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2001
    ..These studies are intended to broaden our knowledge of mechanisms used to organize connections in the mammalian nervous system. ..
  13. GLYCOCONJUGATES IN OLFACTORY CELL-CELL INTERACTIONS
    Gerald A Schwarting; Fiscal Year: 2010
    ..In addition, as a model for spontaneous regeneration, these studies are likely to broaden our understanding of potential treatments for peripheral nerve injury and neurodegenerative disease. ..