William R Schwan

Summary

Affiliation: University of Wisconsin-La Crosse
Country: USA

Publications

  1. ncbi Synthesis and minimum inhibitory concentrations of SK-03-92 against Staphylococcus aureus and other gram-positive bacteria
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, WI 54601, USA
    J Infect Chemother 18:124-6. 2012
  2. ncbi Osmolarity and pH growth conditions regulate fim gene transcription and type 1 pilus expression in uropathogenic Escherichia coli
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, Wisconsin 5460, USA
    Infect Immun 70:1391-402. 2002
  3. ncbi Use of optical mapping to sort uropathogenic Escherichia coli strains into distinct subgroups
    William R Schwan
    University of Wisconsin La Crosse, La Crosse, WI, USA
    Microbiology 156:2124-35. 2010
  4. ncbi Screening a mushroom extract library for activity against Acinetobacter baumannii and Burkholderia cepacia and the identification of a compound with anti-Burkholderia activity
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, WI, USA
    Ann Clin Microbiol Antimicrob 9:4. 2010
  5. ncbi Survival of uropathogenic Escherichia coli in the murine urinary tract is dependent on OmpR
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State St, La Crosse, WI 54601, USA
    Microbiology 155:1832-9. 2009
  6. ncbi Flagella allow uropathogenic Escherichia coli ascension into murine kidneys
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State Street, La Crosse, WI 54601, USA
    Int J Med Microbiol 298:441-7. 2008
  7. ncbi Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State Street, La Crosse, WI 54601, USA
    Infect Immun 73:1226-31. 2005
  8. ncbi Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during infection of murine and human tissues
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State Street, La Crosse, WI 54601, USA
    Infect Immun 74:399-409. 2006
  9. ncbi Mutations in the cueA gene encoding a copper homeostasis P-type ATPase reduce the pathogenicity of Pseudomonas aeruginosa in mice
    William R Schwan
    PathoGenesis Corporation, Seattle, WA 98119, USA
    Int J Med Microbiol 295:237-42. 2005
  10. ncbi Loss of hemolysin expression in Staphylococcus aureus agr mutants correlates with selective survival during mixed infections in murine abscesses and wounds
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State St, La Crosse, WI 54601, USA
    FEMS Immunol Med Microbiol 38:23-8. 2003

Research Grants

  1. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
  2. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi Synthesis and minimum inhibitory concentrations of SK-03-92 against Staphylococcus aureus and other gram-positive bacteria
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, WI 54601, USA
    J Infect Chemother 18:124-6. 2012
    ..aureus. Besides the activity against gram-positive bacteria, this new drug also exhibits activity against Mycobacterium strains...
  2. ncbi Osmolarity and pH growth conditions regulate fim gene transcription and type 1 pilus expression in uropathogenic Escherichia coli
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, Wisconsin 5460, USA
    Infect Immun 70:1391-402. 2002
    ..Taken together, our data suggest that the environmental cues that we tested may regulate expression of type 1 pili in specific in vivo niches, such as murine kidneys and possibly human kidneys...
  3. ncbi Use of optical mapping to sort uropathogenic Escherichia coli strains into distinct subgroups
    William R Schwan
    University of Wisconsin La Crosse, La Crosse, WI, USA
    Microbiology 156:2124-35. 2010
    ..coli strains, including those involved in infections outside of the intestinal tract and epidemic strains with distinct patterns of antibiotic resistance...
  4. ncbi Screening a mushroom extract library for activity against Acinetobacter baumannii and Burkholderia cepacia and the identification of a compound with anti-Burkholderia activity
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, WI, USA
    Ann Clin Microbiol Antimicrob 9:4. 2010
    ..Thus, new drugs are needed to treat infections by these species. Mushrooms could be a potential source for new drugs to treat A. baumannii and BCC infections...
  5. ncbi Survival of uropathogenic Escherichia coli in the murine urinary tract is dependent on OmpR
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State St, La Crosse, WI 54601, USA
    Microbiology 155:1832-9. 2009
    ..This study has fulfilled molecular Koch's postulates by showing the pivotal role OmpR plays in UPEC survival within the murine urinary tract...
  6. ncbi Flagella allow uropathogenic Escherichia coli ascension into murine kidneys
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State Street, La Crosse, WI 54601, USA
    Int J Med Microbiol 298:441-7. 2008
    ..coli flagella may be of importance in allowing the bacteria to ascend from the bladder and initiate kidney infections in humans, and the use of an antibody against the flagella could prevent the spread of UPEC into the kidneys...
  7. ncbi Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State Street, La Crosse, WI 54601, USA
    Infect Immun 73:1226-31. 2005
    ..These data show that binding of type 1 fimbriae (pili) to d-mannose receptors triggers a cross talk that leads to down-regulation of the capsule assembly region 1 operon in uropathogenic E. coli...
  8. ncbi Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during infection of murine and human tissues
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State Street, La Crosse, WI 54601, USA
    Infect Immun 74:399-409. 2006
    ..Thus, putP is transcriptionally activated by a low-proline and high osmotic environment both in growth media and in murine or human clinical specimens...
  9. ncbi Mutations in the cueA gene encoding a copper homeostasis P-type ATPase reduce the pathogenicity of Pseudomonas aeruginosa in mice
    William R Schwan
    PathoGenesis Corporation, Seattle, WA 98119, USA
    Int J Med Microbiol 295:237-42. 2005
    ..aeruginosa strains demonstrated 20-fold attenuation by the cueA mutants within spleens of mice. This data suggests the P. aeruginosa CueA protein may be important in maintaining copper homeostasis both in vitro and in vivo...
  10. ncbi Loss of hemolysin expression in Staphylococcus aureus agr mutants correlates with selective survival during mixed infections in murine abscesses and wounds
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State St, La Crosse, WI 54601, USA
    FEMS Immunol Med Microbiol 38:23-8. 2003
    ..aureus cells residing in abscesses and wounds...
  11. ncbi Low-proline environments impair growth, proline transport and in vivo survival of Staphylococcus aureus strain-specific putP mutants
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, WI 54601, USA
    Microbiology 150:1055-61. 2004
    ..These results show that the mutation in putP led to attenuated growth in low-proline media and by corollary low-proline murine organ tissues due to less efficient transport of proline into the bacteria...
  12. ncbi The two-component response regulator RcsB regulates type 1 piliation in Escherichia coli
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, Wisconsin 54601, USA
    J Bacteriol 189:7159-63. 2007
    ..The orientation depends upon the ratios of the FimB and FimE recombinases. Here, we report that the two-component response regulator RcsB influences the piliation state by controlling fimB and fimE transcription...
  13. ncbi Antibacterial compounds from mushrooms II: lanostane triterpenoids and an ergostane steroid with activity against Bacillus cereus isolated from Fomitopsis pinicola
    Xue Ting Liu
    Department of Chemistry, University of Wisconsin La Crosse, La Crosse, Wisconsin 54601, USA
    Planta Med 76:464-6. 2010
    ..Each of the purified compounds (1-6) was tested for antibacterial activity against B. cereus using standard MIC assays. Compounds 1-6 had MIC values of 32, 16, 32, 32, 128, and 64 microg/mL, respectively...
  14. ncbi Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis
    Xue Ting Liu
    Department of Chemistry, University of Wisconsin La Crosse, La Crosse, WI 54601, USA
    Planta Med 76:182-5. 2010
    ..faecalis. Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens...
  15. ncbi Mutational and transcriptional analyses of the Staphylococcus aureus low-affinity proline transporter OpuD during in vitro growth and infection of murine tissues
    Keith J Wetzel
    Department of Microbiology, University of Wisconsin La Crosse, La Crosse, WI, USA
    FEMS Immunol Med Microbiol 61:346-55. 2011
    ..The differential regulation of proline transport genes in S. aureus may be an adaptation for life in a variety of environments, including survival within the human body...
  16. ncbi An assessment of emergency preparedness in western Wisconsin
    Gary D Gilmore
    University of Wisconsin La Crosse, 201 Mitchell Hall, 1725 State St, La Crosse, WI 54601, USA
    WMJ 106:71-7. 2007
    ..Preparedness has been prioritized in Wisconsin, but little has been done to gauge the knowledge, training, and resource gaps that remain-especially those that are necessary for a coordinated community response...
  17. ncbi Escherichia coli pyomyositis in an immunocompromised host
    Umesh Sharma
    Hospital Medicine, Mayo Clinic Health System, 700 West Ave S, La Crosse, WI 54601, USA
    WMJ 110:182-4. 2011
    ..Pyomyositis due to Escherichia coli (E. coil) is rarely reported in immunocompromised patients with hematological malignancy...
  18. ncbi OmpR regulation of the uropathogenic Escherichia coli fimB gene in an acidic/high osmolality environment
    Ann E Rentschler
    University of Wisconsin La Crosse, La Crosse, WI, USA
    Microbiology 159:316-27. 2013
    ..Together these results suggest that OmpR may be post-transcriptionally regulated in UPEC cells growing in a low pH/high osmolality environment, which regulates fimB in UPEC...

Research Grants2

  1. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  2. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..By understanding how the fim genes are regulated, we may be able to treat urinary tract infections in the future through dietary changes or drugs that affect the regulatory cascade that leads to type 1 pilus expression. ..