A Schurr

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Lactate: a major and crucial player in normal function of both muscle and brain
    Avital Schurr
    of Anaesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Physiol 586:2665-6. 2008
  2. ncbi Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Curr Drug Targets 5:603-18. 2004
  3. ncbi Lactate: the ultimate cerebral oxidative energy substrate?
    Avital Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cereb Blood Flow Metab 26:142-52. 2006
  4. ncbi Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological study
    A Schurr
    Department of Anesthesiology and Perioperative Medicine, University of Louisville, School of Medicine, Louisville, KY 40202, USA
    Neuroscience 147:613-9. 2007
  5. ncbi Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Neurosci Res 66:782-9. 2001
  6. ncbi Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Brain Res 895:268-72. 2001
  7. ncbi Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slices
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Neurosci Lett 307:151-4. 2001
  8. ncbi Study of cerebral energy metabolism using the rat hippocampal slice preparation
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Methods 18:117-26. 1999
  9. ncbi The glucose paradox in cerebral ischemia. New insights
    A Schurr
    Department of Anesthesiology, University of Louisville, School of Medicine, Kentucky 40292, USA
    Ann N Y Acad Sci 893:386-90. 1999
  10. ncbi Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, KY 40292, USA
    Brain Res 774:221-4. 1997

Collaborators

Detail Information

Publications27

  1. pmc Lactate: a major and crucial player in normal function of both muscle and brain
    Avital Schurr
    of Anaesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Physiol 586:2665-6. 2008
  2. ncbi Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Curr Drug Targets 5:603-18. 2004
    ..Some of the drugs were also tested for possible interaction with each other searching for possible synergy. These and other published studies in the field are reviewed here...
  3. ncbi Lactate: the ultimate cerebral oxidative energy substrate?
    Avital Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cereb Blood Flow Metab 26:142-52. 2006
    ..Concomitantly, it could satisfy both 'glucoseniks' and 'lactatians' in the ongoing debate...
  4. ncbi Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological study
    A Schurr
    Department of Anesthesiology and Perioperative Medicine, University of Louisville, School of Medicine, Louisville, KY 40202, USA
    Neuroscience 147:613-9. 2007
    ....
  5. ncbi Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Neurosci Res 66:782-9. 2001
    ..More importantly, lactate appears to play a crucial role in improving postischemic outcome...
  6. ncbi Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Brain Res 895:268-72. 2001
    ..Blockade of lactate transport into neurons prevents its utilization and, consequently, exacerbates delayed ischemic neuronal damage...
  7. ncbi Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slices
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Neurosci Lett 307:151-4. 2001
    ..These results indicate that excitotoxic PC and hypoxic PC share similar mechanisms that possibly involve lactate production and its neuronal utilization...
  8. ncbi Study of cerebral energy metabolism using the rat hippocampal slice preparation
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Methods 18:117-26. 1999
    ..The outcome of this attempt, as described herewith, demonstrates the unmatched usefulness of the brain slice preparation as an in vitro tool in the field of neuroscience...
  9. ncbi The glucose paradox in cerebral ischemia. New insights
    A Schurr
    Department of Anesthesiology, University of Louisville, School of Medicine, Kentucky 40292, USA
    Ann N Y Acad Sci 893:386-90. 1999
    ....
  10. ncbi Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, KY 40292, USA
    Brain Res 774:221-4. 1997
    ....
  11. ncbi Neurotoxicity of quinolinic acid and its derivatives in hypoxic rat hippocampal slices
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, KY 40292
    Brain Res 568:199-204. 1991
    ....
  12. ncbi The mRNA level of the potassium-chloride cotransporter KCC2 covaries with seizure susceptibility in inferior colliculus of the post-ischemic audiogenic seizure-prone rat
    K H Reid
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA
    Neurosci Lett 308:29-32. 2001
    ..Using quantitative PCR, we found that a fivefold increase in collicular KCC2 mRNA levels was associated with a doubling of seizure incidence. A hypothesis linking KCC2 activity to seizure susceptibility is presented...
  13. ncbi Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the rat
    E Gozal
    Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
    Neurosci Lett 305:197-201. 2001
    ....
  14. ncbi The neurotoxicity of sulfur-containing amino acids in energy-deprived rat hippocampal slices
    A Schurr
    Department of Anesthesiology, University of Louisville School of Medicine, KY 40292
    Brain Res 601:317-20. 1993
    ..Moreover, the results indicate a possible difference between the mechanism that lead to hypoxic neuronal damage and the one that lead to hypoglycemic neuronal damage...
  15. ncbi Corticosterone-aggravated ischemic neuronal damage in vitro is relieved by vanadate
    R S Payne
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Neuroreport 12:1261-3. 2001
    ..These results indicate that acute, short exposure to CT can significantly exacerbate postischemic outcome and that vanadate can antagonize CT action...
  16. ncbi Glucose and the ischemic brain: a sour grape or a sweet treat?
    A Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Curr Opin Clin Nutr Metab Care 4:287-92. 2001
    ..This understanding offers a unique opportunity to re-examine old dogmas and propose new ideas, in the form of an alternative hypothesis to explain 'the glucose paradox of cerebral ischemia'...
  17. ncbi Corticosterone disrupts glucose-, but not lactate-supported hippocampal PS-LTP
    Ralphiel S Payne
    Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Neurosci Lett 424:111-5. 2007
    ....
  18. ncbi Energy metabolism, stress hormones and neural recovery from cerebral ischemia/hypoxia
    Avital Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Neurochem Int 41:1-8. 2002
    ....
  19. ncbi Ischemia-induced changes in monocarboxylate transporter 1 reactive cells in rat hippocampus
    Michael T Tseng
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
    Neurol Res 25:83-6. 2003
    ..The latter exhibited intense labeling both in the acute and long-term surviving rats. These data suggest that MCT1 plays a role in the initial and long-term neuronal survival in the hippocampus...
  20. ncbi Lactate, glucose and energy metabolism in the ischemic brain (Review)
    Avital Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Int J Mol Med 10:131-6. 2002
    ..This review revisits briefly the annals that brought about the lingering negative attitude toward lactate and expands on the more recent findings and debates that have illuminated this monocarboxylate in a different, more positive light...
  21. ncbi Ouabain induction of cycling of multiple spike responses in hippocampal slices is delayed by lithium
    R S El-Mallakh
    Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40292 0001, USA
    J Psychiatr Res 34:115-20. 2000
    ..The implications of these results and others regarding the pathophysiology of bipolar illness are discussed...
  22. pmc Bench-to-bedside review: a possible resolution of the glucose paradox of cerebral ischemia
    Avital Schurr
    Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Crit Care 6:330-4. 2002
    ..Both the blockade of CT elevation by chemical adrenalectomy with metyrapone or the blockade of CT receptors in the brain with mifepristone (RU486) negated the aggravating effect of preischemic hyperglycemia on the postischemic outcome...
  23. ncbi The glucose paradox of cerebral ischemia: evidence for corticosterone involvement
    Ralphiel S Payne
    Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Brain Res 971:9-17. 2003
    ....
  24. ncbi Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats
    Ralphiel S Payne
    Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, 530 S Jackson Street, Louisville, KY 40292, USA
    Brain Res 1034:147-52. 2005
    ..Sevoflurane-induced preconditioning confers neuroprotection during an early as well as late time window...
  25. ncbi Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates
    A Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
    Neuroscience 122:585-90. 2003
    ..We suggest that CREB changes play an important role in the neurocognitive morbidity of SDB patients...
  26. ncbi Effect of intermittent hypoxia on long-term potentiation in rat hippocampal slices
    Ralphiel S Payne
    Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Brain Res 1029:195-9. 2004
    ..These results suggest that the diminishment in the ability of neuronal tissue to express and sustain PS-LTP is correlated with previously reported biphasic changes in CREB phosphorylation and programmed cell death...
  27. ncbi Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels
    Franz Kehl
    Department of Anesthesiology, Klinik und Poliklinik für Anästhesiologie, Zenrum Operative Medizin, Julius Maximilans Universität, Oberdürrbacher Str 6, Wurzburg 97080, Germany
    Brain Res 1021:76-81. 2004
    ..It is concluded that sevoflurane is capable of inducing preconditioning in vitro in a dose-dependent fashion and involves activation of mitochondrial KATP channels...