Research Topics
| A SchurrSummaryAffiliation: University of Louisville Country: USA Publications
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Publications
Lactate: a major and crucial player in normal function of both muscle and brainAvital Schurr
of Anaesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
J Physiol 586:2665-6. 2008
Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channelsA Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Curr Drug Targets 5:603-18. 2004..Some of the drugs were also tested for possible interaction with each other searching for possible synergy. These and other published studies in the field are reviewed here...- Lactate: the ultimate cerebral oxidative energy substrate?Avital Schurr
Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Cereb Blood Flow Metab 26:142-52. 2006..Concomitantly, it could satisfy both 'glucoseniks' and 'lactatians' in the ongoing debate... - Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological studyA Schurr
Department of Anesthesiology and Perioperative Medicine, University of Louisville, School of Medicine, Louisville, KY 40202, USA
Neuroscience 147:613-9. 2007.... - Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimentalA Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
J Neurosci Res 66:782-9. 2001..More importantly, lactate appears to play a crucial role in improving postischemic outcome... - Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemiaA Schurr
Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Brain Res 895:268-72. 2001..Blockade of lactate transport into neurons prevents its utilization and, consequently, exacerbates delayed ischemic neuronal damage... - Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slicesA Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Neurosci Lett 307:151-4. 2001..These results indicate that excitotoxic PC and hypoxic PC share similar mechanisms that possibly involve lactate production and its neuronal utilization... - Study of cerebral energy metabolism using the rat hippocampal slice preparationA Schurr
Department of Anesthesiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Methods 18:117-26. 1999..The outcome of this attempt, as described herewith, demonstrates the unmatched usefulness of the brain slice preparation as an in vitro tool in the field of neuroscience... - The glucose paradox in cerebral ischemia. New insightsA Schurr
Department of Anesthesiology, University of Louisville, School of Medicine, Kentucky 40292, USA
Ann N Y Acad Sci 893:386-90. 1999.... - Glia are the main source of lactate utilized by neurons for recovery of function posthypoxiaA Schurr
Department of Anesthesiology, University of Louisville School of Medicine, KY 40292, USA
Brain Res 774:221-4. 1997.... - Neurotoxicity of quinolinic acid and its derivatives in hypoxic rat hippocampal slicesA Schurr
Department of Anesthesiology, University of Louisville School of Medicine, KY 40292
Brain Res 568:199-204. 1991.... - The mRNA level of the potassium-chloride cotransporter KCC2 covaries with seizure susceptibility in inferior colliculus of the post-ischemic audiogenic seizure-prone ratK H Reid
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY, USA
Neurosci Lett 308:29-32. 2001..Using quantitative PCR, we found that a fivefold increase in collicular KCC2 mRNA levels was associated with a doubling of seizure incidence. A hypothesis linking KCC2 activity to seizure susceptibility is presented... - Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the ratE Gozal
Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Neurosci Lett 305:197-201. 2001.... - The neurotoxicity of sulfur-containing amino acids in energy-deprived rat hippocampal slicesA Schurr
Department of Anesthesiology, University of Louisville School of Medicine, KY 40292
Brain Res 601:317-20. 1993..Moreover, the results indicate a possible difference between the mechanism that lead to hypoxic neuronal damage and the one that lead to hypoglycemic neuronal damage... - Corticosterone-aggravated ischemic neuronal damage in vitro is relieved by vanadateR S Payne
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Neuroreport 12:1261-3. 2001..These results indicate that acute, short exposure to CT can significantly exacerbate postischemic outcome and that vanadate can antagonize CT action... - Glucose and the ischemic brain: a sour grape or a sweet treat?A Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Curr Opin Clin Nutr Metab Care 4:287-92. 2001..This understanding offers a unique opportunity to re-examine old dogmas and propose new ideas, in the form of an alternative hypothesis to explain 'the glucose paradox of cerebral ischemia'... - Corticosterone disrupts glucose-, but not lactate-supported hippocampal PS-LTPRalphiel S Payne
Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
Neurosci Lett 424:111-5. 2007.... - Energy metabolism, stress hormones and neural recovery from cerebral ischemia/hypoxiaAvital Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Neurochem Int 41:1-8. 2002.... - Ischemia-induced changes in monocarboxylate transporter 1 reactive cells in rat hippocampusMichael T Tseng
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
Neurol Res 25:83-6. 2003..The latter exhibited intense labeling both in the acute and long-term surviving rats. These data suggest that MCT1 plays a role in the initial and long-term neuronal survival in the hippocampus... - Lactate, glucose and energy metabolism in the ischemic brain (Review)Avital Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Int J Mol Med 10:131-6. 2002..This review revisits briefly the annals that brought about the lingering negative attitude toward lactate and expands on the more recent findings and debates that have illuminated this monocarboxylate in a different, more positive light... - Ouabain induction of cycling of multiple spike responses in hippocampal slices is delayed by lithiumR S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40292 0001, USA
J Psychiatr Res 34:115-20. 2000..The implications of these results and others regarding the pathophysiology of bipolar illness are discussed... - Bench-to-bedside review: a possible resolution of the glucose paradox of cerebral ischemiaAvital Schurr
Brain Attack Research Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Crit Care 6:330-4. 2002..Both the blockade of CT elevation by chemical adrenalectomy with metyrapone or the blockade of CT receptors in the brain with mifepristone (RU486) negated the aggravating effect of preischemic hyperglycemia on the postischemic outcome... - The glucose paradox of cerebral ischemia: evidence for corticosterone involvementRalphiel S Payne
Department of Anesthesiology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Brain Res 971:9-17. 2003.... - Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in ratsRalphiel S Payne
Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, 530 S. Jackson Street, Louisville, KY 40292, USA
Brain Res 1034:147-52. 2005..Sevoflurane-induced preconditioning confers neuroprotection during an early as well as late time window... - Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlatesA Goldbart
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
Neuroscience 122:585-90. 2003..We suggest that CREB changes play an important role in the neurocognitive morbidity of SDB patients... - Effect of intermittent hypoxia on long-term potentiation in rat hippocampal slicesRalphiel S Payne
Brain Attack Research Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
Brain Res 1029:195-9. 2004..These results suggest that the diminishment in the ability of neuronal tissue to express and sustain PS-LTP is correlated with previously reported biphasic changes in CREB phosphorylation and programmed cell death... - Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channelsFranz Kehl
Department of Anesthesiology, Klinik und Poliklinik für Anästhesiologie, Zenrum Operative Medizin, Julius Maximilans Universität, Oberdürrbacher Str 6, Wurzburg 97080, Germany
Brain Res 1021:76-81. 2004..It is concluded that sevoflurane is capable of inducing preconditioning in vitro in a dose-dependent fashion and involves activation of mitochondrial KATP channels...