Mark Schumacher

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons
    Catherine Chu
    University of California, San Francisco Department of Anesthesia and Perioperative Care 513 Parnassus Ave, RM, S436, University of California, San Francisco 94143 0427, USA
    Mol Pain 7:44. 2011
  2. pmc Transient receptor potential channels in pain and inflammation: therapeutic opportunities
    Mark A Schumacher
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0427, USA
    Pain Pract 10:185-200. 2010
  3. ncbi Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure?
    Helge Eilers
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Mol Interv 4:197-9. 2004
  4. pmc TRPV1 splice variants: structure and function
    Mark A Schumacher
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0427, USA
    Front Biosci (Landmark Ed) 15:872-82. 2010
  5. ncbi Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction
    Helge Eilers
    Department of Anesthesia, University of California, San Francisco, California 94143 0427, USA
    Anesthesiology 112:1452-63. 2010
  6. ncbi Isolation of an mRNA binding protein homologue that is expressed in nociceptors
    Helge Eilers
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, Box 0427, San Francisco, CA 94143 0427, USA
    Eur J Neurosci 20:2283-93. 2004
  7. ncbi Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor
    Qing Xue
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0427, USA
    J Neurochem 101:212-22. 2007
  8. ncbi The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation
    Helge Eilers
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0427, USA
    Neuroreport 18:969-73. 2007

Research Grants

  1. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark A Schumacher; Fiscal Year: 2010
  2. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 1999
  3. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2009
  4. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2005
  5. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2004
  6. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2003
  7. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2002
  8. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2001
  9. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2000
  10. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark A Schumacher; Fiscal Year: 2010

Collaborators

Detail Information

Publications8

  1. pmc Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons
    Catherine Chu
    University of California, San Francisco Department of Anesthesia and Perioperative Care 513 Parnassus Ave, RM, S436, University of California, San Francisco 94143 0427, USA
    Mol Pain 7:44. 2011
    ..mRNA encoding Sp1, Sp4 and TRPV1 were quantified by qRT-PCR under conditions of Sp1/Sp4 over-expression or siRNA mediated knockdown in cultured DRG neurons...
  2. pmc Transient receptor potential channels in pain and inflammation: therapeutic opportunities
    Mark A Schumacher
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0427, USA
    Pain Pract 10:185-200. 2010
    ..With the isolation of other members of the TRP channel family such as TRP cation channel, subfamily A, member 1, additional opportunities are emerging in the development of safe and effective analgesics...
  3. ncbi Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure?
    Helge Eilers
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Mol Interv 4:197-9. 2004
  4. pmc TRPV1 splice variants: structure and function
    Mark A Schumacher
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0427, USA
    Front Biosci (Landmark Ed) 15:872-82. 2010
    ..Moreover, TRPV1 splice variant subunits may also contribute unique properties of activation such as the detection of hypertonic conditions...
  5. ncbi Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction
    Helge Eilers
    Department of Anesthesia, University of California, San Francisco, California 94143 0427, USA
    Anesthesiology 112:1452-63. 2010
    ..This mechanism may explain the hyperalgesic actions of inhaled anesthetics and their adverse effects in the airways...
  6. ncbi Isolation of an mRNA binding protein homologue that is expressed in nociceptors
    Helge Eilers
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, Box 0427, San Francisco, CA 94143 0427, USA
    Eur J Neurosci 20:2283-93. 2004
    ....
  7. ncbi Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor
    Qing Xue
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0427, USA
    J Neurochem 101:212-22. 2007
    ..These findings support the hypothesis that NGF produced under conditions of tissue injury and/or inflammation directs an increase of TRPV1 expression in nociceptors in part through a transcription-dependent mechanism...
  8. ncbi The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation
    Helge Eilers
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0427, USA
    Neuroreport 18:969-73. 2007
    ..5'-splice variant-like-protein expression was detected in dorsal root ganglion. These results support the idea that coexpression of VR.5'sv or a similar variant could result in inhibitory modulation of TRPV1 activation...

Research Grants10

  1. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark A Schumacher; Fiscal Year: 2010
    ..We are studying a way to reduce or turn off the production of this receptor in sensory nerves as a way to control the pain from chronic peripheral inflammation. ..
  2. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 1999
    ..Since capsaicin is used as topical analgesics to treat pain, characterization of vanilloid receptor subtypes should provide important insight into the advancement of therapies designed to selectively block pain. ..
  3. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2009
    ..We are studying a way to reduce or turn off the production of this receptor in sensory nerves as a way to control the pain from chronic peripheral inflammation. ..
  4. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2005
    ..5' sv and SIC. Determining bow these factors increase or decrease the transcription of VR subtypes will provide a potential means to modulate pain transduction and hyperalgesia. ..
  5. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2004
    ..5' sv and SIC. Determining bow these factors increase or decrease the transcription of VR subtypes will provide a potential means to modulate pain transduction and hyperalgesia. ..
  6. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2003
    ..5' sv and SIC. Determining bow these factors increase or decrease the transcription of VR subtypes will provide a potential means to modulate pain transduction and hyperalgesia. ..
  7. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2002
    ..5' sv and SIC. Determining bow these factors increase or decrease the transcription of VR subtypes will provide a potential means to modulate pain transduction and hyperalgesia. ..
  8. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2001
    ..Since capsaicin is used as topical analgesics to treat pain, characterization of vanilloid receptor subtypes should provide important insight into the advancement of therapies designed to selectively block pain. ..
  9. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark Schumacher; Fiscal Year: 2000
    ..Since capsaicin is used as topical analgesics to treat pain, characterization of vanilloid receptor subtypes should provide important insight into the advancement of therapies designed to selectively block pain. ..
  10. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark A Schumacher; Fiscal Year: 2010
    ..We are studying a way to reduce or turn off the production of this receptor in sensory nerves as a way to control the pain from chronic peripheral inflammation. ..