H R Schumacher
Affiliation: University of Pennsylvania
- Hyaluronate effects on synovium and synovial fluid. A prospective blinded study in patients with osteoarthritis of the kneeH R Schumacher
VA Medical Center 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
Osteoarthritis Cartilage 14:501-3. 2006
- Synovial xanthomatosis: are there clues to mechanisms for this rare disease?H Ralph Schumacher
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Mod Rheumatol 22:907-11. 2012..This uncommon cause of arthritis and nodules had been confused with rheumatoid arthritis by others in this case...
- Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy studyH Ralph Schumacher
VA Medical Center and University of Pennsylvania, PA 19104, USA
Arthritis Care Res (Hoboken) 64:1462-70. 2012..To evaluate the efficacy and safety of the interleukin-1 inhibitor rilonacept (interleukin-1 Trap) for gout flare prevention during initiation of uric acid-lowering therapy (ULT)...
- Efficacy and tolerability of celecoxib in the treatment of acute gouty arthritis: a randomized controlled trialH Ralph Schumacher
University of Pennsylvania, VA Medical Center, 151K, University and Woodland Aves, Philadelphia, PA 19104, USA
J Rheumatol 39:1859-66. 2012..To evaluate the analgesic efficacy of high-dose celecoxib in the treatment of moderate to extreme pain and inflammation associated with acute gouty arthritis...
- Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trialH Ralph Schumacher
University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
Arthritis Rheum 64:876-84. 2012..To evaluate the interleukin-1 inhibitor rilonacept (Interleukin-1 Trap) for prevention of gout flares occurring in the first few months following initiation of urate-lowering therapy...
- Elimination of rheumatoid synovium in situ using a Fas ligand 'gene scalpel'Haidi Zhang
Division of Pharmaceutics and Industry Pharmacy, School of Pharmacy, Long Island University, Brooklyn, NY, USA
Arthritis Res Ther 7:R1235-43. 2005....
- Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levelsSung Mun Jung
Division of Rheumatology, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA 19104, USA
Arthritis Res Ther 9:R64. 2007..These results support a need for further studies of the efficacy of these extracts in the treatment of inflammatory arthropathies and suggest elevation of PGD2 levels as a novel mechanism for an anti-inflammatory agent...
- The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trialMichael A Becker
The University of Chicago Pritzker School of Medicine, MC0930, University of Chicago Medical Center, 5841 S, Maryland Avenue, Chicago, IL 60637, USA
Arthritis Res Ther 12:R63. 2010..The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) > or = 8.0 mg/dL in a six-month trial...
- Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranesFrank Pessler
Klinik und Poliklinik für Kinder und Jugendmedizin, Technische Universitat Dresden, Fetscherstrasse, 01307 Dresden, Germany
Arthritis Res Ther 10:R64. 2008..Injection of monosodium urate (MSU) crystals into the pouch elicits an acute inflammatory response similar to human gout. We conducted the present study to identify mRNAs that were highly regulated by MSU crystals in the pouch membrane...
- The practical management of goutH Ralph Schumacher
University of Pennsylvania, Philadelphia, PA, USA
Cleve Clin J Med 75:S22-5. 2008..Regular monitoring of serum urate can ensure therapeutic dosing of urate-lowering agents to achieve levels below 6 mg/dL, which are associated with a reduction in flares and tophi...
- Outcome evaluations in goutH Ralph Schumacher
Division of Rheumatology, University of Pennsylvania School of Medicine, and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
J Rheumatol 34:1381-5. 2007..Final validation of these outcomes has not yet been achieved. In summary, the unique problems of evaluating outcomes in gout are finally being addressed. While no measures are available for use yet, an agenda has been developed...
- Aspiration and injection therapies for jointsH Ralph Schumacher
University of Pennsylvania and VA Medical Center, Philadelphia, USA
Arthritis Rheum 49:413-20. 2003
- Newer therapeutic approaches: goutH Ralph Schumacher
Division of Rheumatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Rheum Dis Clin North Am 32:235-44, xii. 2006..New agents under investigation include pegylated formulations of uricase and a new potent xanthine oxidase inhibitor, febuxostat. Some cardiovascular drugs have been shown to be uricosuric...
- Febuxostat: a non-purine, selective inhibitor of xanthine oxidase for the management of hyperuricaemia in patients with goutH Ralph Schumacher
University of Pennsylvania, VA Medical Center, Philadelphia, Pennsylvania, USA
Expert Opin Investig Drugs 14:893-903. 2005..Febuxostat is well tolerated, the majority of treatment-related adverse events are transient and mild-to-moderate in severity. Febuxostat can broaden the therapeutic options for urate-lowering therapy in those with gout...
- Outcome measures for acute and chronic goutH Ralph Schumacher
University of Florida, Gainesville, Florida, USA
J Rheumatol 32:2452-5. 2005..Five domains for acute gout outcomes and 9 for chronic gout were identified along with proposed instruments for testing and validation. The unique problems of gout evaluation can and will be addressed...
- Tophaceous gout: quantitative evaluation by direct physical measurementH Ralph Schumacher
Division of Rheumatology, University of Pennsylvania Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
J Rheumatol 32:2368-72. 2005..This multicenter study assessed intra- and interrater reproducibility of a simple and direct physical measurement...
- Injectable corticosteroids in treatment of arthritis of the kneeH Ralph Schumacher
Section of Rheumatology, VA Medical Center, Philadelphia, Penn 19104, USA
Am J Med 118:1208-14. 2005..The evidence assessing safety and efficacy is reviewed and analyzed. Intra-articular knee injection technique is described and is a procedure that is easy to learn and can be performed quickly in an office or hospital setting...
- Magnetic resonance imaging in the quantitative assessment of gouty tophiH R Schumacher
University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Int J Clin Pract 60:408-14. 2006..89 +/- 2.05 cm3; p < 0.05). MRI can quantify tophus size in gout and deserves further comparison with other techniques for tophus size monitoring in assessing effects of gout therapy...
- The pathogenesis of goutH Ralph Schumacher
University of Pennsylvania, Philadelphia, PA, USA
Cleve Clin J Med 75:S2-4. 2008..This will stop both the acute attacks and the progressive joint damage...
- Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trialH Ralph Schumacher
University of Pennsylvania and VA Medical Center, Philadelphia, PA 19104, USA
Arthritis Rheum 59:1540-8. 2008..To compare the urate-lowering efficacy and safety of febuxostat, allopurinol, and placebo in a large group of subjects with hyperuricemia and gout, including persons with impaired renal function...
- Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety studyH R Schumacher
VA Medical Center, 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
Rheumatology (Oxford) 48:188-94. 2009..This 5-yr study assessed urate-lowering and clinical efficacy and safety of long-term febuxostat therapy in subjects with gout. The primary efficacy end-point was reduction to and maintenance of serum urate (sUA) levels < 6.0 mg/dl...
- Outcome domains for studies of acute and chronic goutH Ralph Schumacher
Rheumatology Section, Veterans Affairs Medical Center, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
J Rheumatol 36:2342-5. 2009..Implications of patient perspectives, discretionary domains for specific studies, measurement instruments and a possible responder index are under study...
- Identification of broadly discriminatory tissue biomarkers of synovitis with binary and multicategory receiver operating characteristic analysisA Ogdie
Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Biomarkers 15:183-90. 2010..44). Multicategory ROC analysis ranked Ki-67, subintimal CD68, and CD15 as discriminating best among all six sample groups, and thus identified them as the most broadly applicable markers...
- Increased angiogenesis and cellular proliferation as hallmarks of the synovium in chronic septic arthritisF Pessler
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Arthritis Rheum 59:1137-46. 2008..To characterize histologic alterations and inflammatory infiltrates in the synovium of patients with chronic septic arthritis (SeA)...
- A histomorphometric analysis of synovial biopsies from individuals with Gulf War Veterans' Illness and joint pain compared to normal and osteoarthritis synoviumF Pessler
Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
Clin Rheumatol 27:1127-34. 2008..In summary, the GWVI and normal synovia were indistinguishable from each other and contained similar low-grade inflammatory cell populations consisting almost entirely of macrophages and T cells...
- Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?J Li-Yu
Department of Medicine, Hospital of the University of Pennsylvania, USA
J Rheumatol 28:577-80. 2001..To determine if lowering of serum uric acid (SUA) concentrations below 6 mg/dl or longer duration of lowered SUA will result in depletion of urate crystals from the knee joints and prevent further attacks of gout...
- The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysisF Pessler
The Children s Hospital of Philadelphia, Division of Rheumatology, Philadelphia, USA
Ann Rheum Dis 67:1184-7. 2008..To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A)...
- Intra-articular corticosteroid preparations: different characteristics and their effect during inflammation induced by monosodium urate crystals in the rat subcutaneous air pouchM Rull
Veterans Affairs Medical Center and University of Pennsylvania, Philadelphia, PA 19104, USA
Rheumatology (Oxford) 42:1093-100. 2003..When used for MSU crystal-induced inflammation these corticosteroid preparations suppressed some aspects of inflammation but may actually promote the persistence of MSU crystals and the formation of tophi...
- Subintimal Ki-67 as a synovial tissue biomarker for inflammatory arthropathiesF Pessler
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Ann Rheum Dis 67:162-7. 2008..We evaluated subintimal Ki-67+ cell density as a tissue biomarker for inflammatory arthropathies and compared it to subintimal CD68, a synovial biomarker of RA...
- Detection and initial characterization of synovial lining fragments in synovial fluidL Dai
University of Pennsylvania, USA
Rheumatology (Oxford) 45:533-7. 2006..We wished to establish a method for the reliable detection of these fragments in joint and bursa effusions and begin to characterize them by histochemical and immunohistochemical methods...
- Does acute synovitis (pseudogout) occur in patients with chronic pyrophosphate arthropathy (pseudo-osteoarthritis)?N Schlesinger
Division of Rheumatology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
Clin Exp Rheumatol 27:940-4. 2009..The two most common are: acute synovitis (pseudogout) and chronic pyrophosphate arthropathy ("pseudo-osteoarthritis"). We have conducted a study to examine whether these are overlapping syndromes...
- Clinical diagnostic criteria for gout: comparison with the gold standard of synovial fluid crystal analysisAarti Malik
University of Pennsylvania, VA Medical Center, Philadelphia, Pennsylvania, USA
J Clin Rheumatol 15:22-4. 2009..Several classification or diagnostic criteria sets for gout have been proposed but none validated...
- Sodium magnetic resonance imaging of proteoglycan depletion in an in vivo model of osteoarthritisAndrew J Wheaton
Department of Radiology, University of Pennsylvania, B1 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104-6100, USA
Acad Radiol 11:21-8. 2004..Furthermore, these results indicate that early degenerative events could be detected noninvasively in vivo in humans with PG-depleting diseases such as OA...
- Gout epidemiology: results from the UK General Practice Research Database, 1990-1999T R Mikuls
Department of Medicine, University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, USA
Ann Rheum Dis 64:267-72. 2005..CONCLUSION: Although gout is common in the UK, particularly among older men, the incidence of the disease seems to have remained stable during the 1990s...
- Gout: can management be improved?N Schlesinger
Section of Rheumatology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103 2714, USA
Curr Opin Rheumatol 13:240-4. 2001..Treatment of gout in transplant recipients brings into focus some of the issues regarding management of gout, because gout is a common problem among transplant patients...
- Chlamydial nucleic acids in synovium in osteoarthritis: what are the implications?N Olmez
Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
J Rheumatol 28:1874-80. 2001..To study whether there is evidence of bacterial DNA in some osteoarthritic (OA) joint tissues, and the clinical implications of finding bacterial DNA in this relatively noninflammatory disease...
- Quality of life and disability in patients with treatment-failure goutMichael A Becker
Division of Biological Sciences, Rheumatology Section, University of Chicago, Chicago, IL, USA
J Rheumatol 36:1041-8. 2009..The relationship between self-reported quality of life and disability and disease severity was evaluated in subjects with treatment-failure gout (n = 110) in a prospective, 52-week, observational study...
- Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritisDaniel O Clegg
Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
N Engl J Med 354:795-808. 2006..The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis...
- Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritisH Ralph Schumacher
Division of Rheumatology, University of Pennsylvania School of Medicine and Department of Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
BMJ 324:1488-92. 2002..CONCLUSION: Etoricoxib 120 mg once daily provides rapid and effective treatment for acute gouty arthritis comparable to indometacin 50 mg three times daily. Etoricoxib was generally safe and well tolerated in this study...
- Are there distinctive inflammatory flares after hylan g-f 20 intraarticular injections?Sally Pullman-Mooar
MCP Hahneman University School of Medicine, Philadelphia, Pennsylvania, USA
J Rheumatol 29:2611-4. 2002..This survey was designed to examine features of a group of patients with acute painful joint effusions following hylan G-F 20 (Synvisc) knee injections...
- Is there a role for Chlamydia pneumoniae infection in systemic lupus erythematosus and in the associated atherosclerotic cardiovascular disease?T Kitumnuaypong
Rheumatology Department, University of Pennsylvania, USA
Clin Exp Rheumatol 22:339-42. 2004....
- NFAT transcription factors--new players in the pathogenesis of inflammatory arthropathies?F Pessler
Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, 3405 Civic Center Boulevard, Philadelphia, PA 19104, USA
Autoimmun Rev 5:106-10. 2006..Specific anti-NFAT drug therapy may add to the pharmacologic armamentarium against rheumatoid arthritis, other inflammatory arthropathies, and related autoimmune disorders...
- Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studiesS Nalbant
Department of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104-4283, USA
Osteoarthritis Cartilage 11:50-4. 2003..New findings are that our sequential cases showed that there were some patients with no crystals at onset but that crystals appeared with progression of the disease. Fibril presence in SF also correlated with progression of the disease...
- Update on gout and hyperuricemiaJ F Baker
Department of Medicine, Division of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Clin Pract 64:371-7. 2010..Physicians should consider cardiovascular risk factors in patients with gout and treat them appropriately and aggressively...
- West meets East in rheumatologyLan X Chen
Rheumatology Division, School of Medicine, University of Pennsylvania Medical Center-Presbyterian and VAMC, 3600 Spruce Street, Philadelphia, PA 19104, USA
Curr Rheumatol Rep 7:251-3. 2005
- Gout: can we create an evidence-based systematic approach to diagnosis and management?Lan X Chen
University of Pennsylvannia, Penn Presbyterian Medical Center, Philadelphia, PA 19104 4283, USA
Best Pract Res Clin Rheumatol 20:673-84. 2006..Lifestyle measures should be addressed. If chronic tophaceous gout is diagnosed, urate lowering should be started without delay. New agents are under development that may help with difficult cases...
- Predictive factors in early arthritis: long-term follow-upH Ralph Schumacher
Rheumatology Division, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, 19104, USA
Semin Arthritis Rheum 33:264-72. 2004....
- Detection of changes in articular cartilage proteoglycan by T(1rho) magnetic resonance imagingAndrew J Wheaton
B1 Stellar Chance Laboratories, Department of Radiology, University of Pennsylvania, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
J Orthop Res 23:102-8. 2005..The effects of IL-1beta, primarily loss of PG, were confirmed by histological and immunochemical findings. The results from this study demonstrate that R(1rho) is able to track proteoglycan content in vivo...
- Why I do researchH Ralph Schumacher
University of Pennsylvania School of Medicine, and Arthritis Research, Department of Veterans Affairs Medical Center 151-K, University and Woodland Avenues, Philadelphia, PA 19104, USA
J Clin Rheumatol 11:228-32. 2005
- Iyengar yoga for treating symptoms of osteoarthritis of the knees: a pilot studySharon L Kolasinski
Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Altern Complement Med 11:689-93. 2005..The aim of this pilot study was to assess the feasibility of using yoga in the tradition of B.K.S. Iyengar to treat the symptoms of osteoarthritis of the knee...
- Quantitative analysis of immunohistologic features of very early rheumatoid synovitis in disease modifying antirheumatic drug- and corticosteroid-naÃ¯ve patientsJasvinder A Singh
Division of Rheumatology, University of Minnesota, Minneapolis, MN, USA
J Rheumatol 31:1281-5. 2004..Thus, there appear to be some potentially important differences from findings reported in well established disease...
- Correlation of T1rho with fixed charge density in cartilageAndrew J Wheaton
Department of Radiology, University of Pennsylvania, Philadelphia, USA
J Magn Reson Imaging 20:519-25. 2004..To establish the specificity of T1rho with respect to fixed charge density (FCD) as a measure of proteoglycan (PG) content in cartilage during the onset of osteoarthritis (OA)...
- Diagnosing early rheumatoid arthritis (RA). What are the problems and opportunities?H R Schumacher
Department of Rheumatology, University of Pennsylvania Hospital, 3rd Ravdin Building, 34th and Spruce Street, Philadelphia, Pennsylvania, USA
Clin Exp Rheumatol 21:S15-9. 2003..We review this area, focusing on work from our own research and how this has guided our thinking...
- Assessing single joints in arthritis clinical trialsJon T Giles
Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21224, USA
J Rheumatol 34:641-7. 2007..At OMERACT 8, the group developed a research agenda to perform additional validation studies of clinical and functional indices, imaging, synovial histopathology, and soluble biomarkers...
- Current trends in crystal identificationLan X Chen
VA Medical Center, Rheumatology Research 151K, Philadelphia, Pennsylvania 19104, USA
Curr Opin Rheumatol 18:171-3. 2006..Imaging is noted to provide increasing help, but microscopic crystal identification remains the gold standard. SUMMARY: Quality control is still a concern as is the infrequency of attempted arthrocentesis for crystal identification...
- Synovial fluid findings in a patient after hylan GF 20 injectionJennifer Kwan-Morley
VA Hospital, Philadelphia, PA, USA
J Clin Rheumatol 14:120. 2008
- Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?Joshua F Baker
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Med 118:816-26. 2005..Trials of SUA-lowering therapy in hyperuricemic patients evaluating the effect on cardiovascular outcomes are justified in high-risk patients...
- Decreased pain and synovial inflammation after etanercept therapy in patients with reactive and undifferentiated arthritis: an open-label trialStephanie D Flagg
University of Pennsylvania, VA Medical Centers, Philadelphia, Pennsylvania, USA
Arthritis Rheum 53:613-7. 2005..CONCLUSION: Etanercept was well-tolerated without clinical exacerbation of any suspected underlying infections and appeared to provide therapeutic benefit in our cohort of patients with reactive and undifferentiated arthritis...
- Utility of digital photographs of the hand for assessing the presence of hand osteoarthritisA G Stern
Division of Rheumatology, University of Pennsylvania Medical Center and Philadelphia VAMC, Philadelphia, PA, USA
Osteoarthritis Cartilage 12:360-5. 2004..Our study evaluated the accuracy, relative to a radiograph, of a digital photograph of the hands for the presence of OA in a particular joint, as well as for the diagnosis of nodal hand OA...
- Yoga-based intervention for carpal tunnel syndrome: a randomized trialM S Garfinkel
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
JAMA 280:1601-3. 1998..Carpal tunnel syndrome is a common complication of repetitive activities and causes significant morbidity...
- Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouchSelim Nalbant
University of Pennsylvania School of Medicine and the Arthritis Center, VA Medical Center, Philadelphia, Pennsylvania 19104-4283, USA
J Rheumatol 32:1762-4. 2005..Effects on cytokines need further investigation. COX-2 inhibitors deserve consideration for prophylactic use in interim gout...
- The promise of coxibs: how far have we progressed?H Ralph Schumacher
VA Medical Center, Philadelphia, PA 19104, USA
J Pain Symptom Manage 23:S1-4. 2002
- Hyperuricemia and incidence of hypertension among men without metabolic syndromeEswar Krishnan
School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Hypertension 49:298-303. 2007..09; 95% CI: 1.02 to 1.17). We conclude that the hyperuricemia-hypertension risk relationship is present among normotensive middle-aged men without diabetes/glucose intolerance or metabolic syndrome...
- Update on identification of pathogenic crystals in joint fluidLan X Chen
VA Medical Center, 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
Curr Rheumatol Rep 6:217-20. 2004..Recent advances have included progress in crystal identification on stained slides, attention to aspiration techniques, and arthrocenteses of asymptomatic joints. Challenges remain to increase use and optimize techniques...
- Ultrasonography for assessment of subcutaneous nodulesSelim Nalbant
Rheumatology Division of the Hospital of the University of Pennsylvania, Philadelphia, USA
J Rheumatol 30:1191-5. 2003..Tophi and rheumatoid nodules can be easily measured and these measurements used to help follow disease progression or response to therapy...
- Serum uric acid level and risk for peripheral arterial disease: analysis of data from the multiple risk factor intervention trialJoshua F Baker
Department of Medicine, University of Pennsylvania, USA
Angiology 58:450-7. 2007..A history of gouty arthritis is an independent and statistically significant predictor of incidence of PAD even after adjustment for the effect of underlying hyperuricemia...
- Phase I design and evaluation of an isometric muscle reeducation device for knee osteoarthritis rehabilitationRobert J Goldman
SensorPad Systems, Inc, Norristown, PA, USA
J Rehabil Res Dev 40:95-107. 2003..All changes were trends. The Isopad helped subjects with knee OA adhere to a supervised isometric program and meet progressive strength targets. The next-generation Isopad will be employed in a home-based program...
- Benefits and harms of doxycycline treatment for Gulf War veterans' illnesses: a randomized, double-blind, placebo-controlled trialSam T Donta
Veterans Affairs Medical Center, Boston, MA 02130, USA
Ann Intern Med 141:85-94. 2004..LIMITATIONS: Adherence to treatment after 6 months was poor. CONCLUSION: Long-term treatment with doxycycline did not improve outcomes of GWVIs at 1 year...
- Poor validation of medical record ICD-9 diagnoses of gout in a veterans affairs databaseAarti Malik
University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA, USA
J Rheumatol 36:1283-6. 2009..We evaluated whether we can document the accuracy of such diagnoses by review of medical records and then on direct interviews with a subset of patients...
- Synovial sarcoma of the foot mimicking acute gouty arthritisYing Du
Division of Rheumatology, Department of Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Rheumatol 32:2006-8. 2005..We describe a case of synovial sarcoma with an unusually acute presentation near the first metatarsophalangeal joint that resembled acute gouty arthritis...
- Necessary and discretionary activities in knee osteoarthritis: do they mediate the pain-depression relationship?Patricia A Parmelee
Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA
Pain Med 8:449-61. 2007..A key focus was the distinction of functional disability in necessary tasks (basic and instrumental activities of daily living) from discretionary, leisure activities...
- Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with goutMichael A Becker
Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
Arthritis Rheum 52:916-23. 2005..0 mg/dl)...
- The management of gout at an academic healthcare center in Beijing: a physician surveyWeigang Fang
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
J Rheumatol 33:2041-9. 2006..CONCLUSION: The physicians' reported management of gout at this major academic healthcare center in Beijing was often inconsistent with current evidence. High quality CME is required to improve Chinese physician management of gout...
- A survey of current evaluation and treatment of goutNaomi Schlesinger
Department of Medicine, The School of Public Health, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903 0019, USA
J Rheumatol 33:2050-2. 2006..To record diagnostic and treatment approaches to gouty arthritis among US rheumatologists...
- Cytokine and chemokine mRNA produced in synovial tissue chronically infected with Chlamydia trachomatis and C. pneumoniaeHerve C Gerard
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Rheumatol 29:1827-35. 2002....
- Febuxostat compared with allopurinol in patients with hyperuricemia and goutMichael A Becker
University of Chicago Pritzker School of Medicine, Chicago, USA
N Engl J Med 353:2450-61. 2005..Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout...
- Injectable corticosteroids in modern practiceBrian J Cole
Rush Cartilage Restoration Center, Rush University Medical Center, Chicago, IL 60612, USA
J Am Acad Orthop Surg 13:37-46. 2005..The accuracy of injections affects outcomes. Postinjection flare, facial flushing, and skin and fat atrophy are the most common side effects. Systemic complications of injectable corticosteroids are rare...
- Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysisTerence Rooney
Department of Rheumatology, St Vincent s University Hospital, Dublin 4, Ireland
Ann Rheum Dis 66:1656-60. 2007..To evaluate inter-observer agreement for microscopic measurement of inflammation in synovial tissue using manual quantitative, semiquantitative and computerised digital image analysis...
- Local ice therapy during bouts of acute gouty arthritisNaomi Schlesinger
Department of Medicine and New Jersey Medical School-University of Medicine and Dentistry of New Jersey, Newark, USA
J Rheumatol 29:331-4. 2002..Cold applications may be a useful adjunct to treatment of acute gouty arthritis...
- Serum urate levels and gout flares: analysis from managed care dataChaitanya A Sarawate
Health Outcomes Research, HealthCore, Inc, 800 Delaware Avenue, Wilmington, DE 19801 1366, USA
J Clin Rheumatol 12:61-5. 2006..The desired serum urate level (SUA) for prevention of gout attacks is widely recommended to be in the subsaturating range, <6.0 mg/dL...
- Update on goutNaomi Schlesinger
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
Arthritis Rheum 47:563-5. 2002
- Early arthritis clinics. Much early arthritis is unclassifiedH Ralph Schumacher
J Rheumatol 29:2258-60. 2002
- Chlamydia trachomatis genes whose products are related to energy metabolism are expressed differentially in active vs. persistent infectionHerve C Gerard
Department of Immunology and Microbiology, Wayne State University School of Medicine, Gordon H Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA
Microbes Infect 4:13-22. 2002..Metabolic rate in persistent C. trachomatis is lower than in actively growing cells, as judged from assays for relative chlamydial primary rRNA transcript levels in persistent vs. actively growing cells...
- Multicentric reticulohistiocytosis responding to tumor necrosis factor-alpha inhibition in a renal transplant patientSean E Shannon
Department of Rheumatology-Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, CSB, PO Box 250637, Charleston, SC 29425, USA
J Rheumatol 32:565-7. 2005..Within 2 months the patient showed dramatic clinical and serologic improvement that was maintained until she stopped treatment secondary to an upper respiratory tract infection. Once treatment was restarted, the symptoms again improved...
- Gout medication treatment patterns and adherence to standards of care from a managed care perspectiveChaitanya A Sarawate
Health Outcomes Research, HealthCore, Inc, 800 Delaware Ave, Fifth Floor, Wilmington, DE 19801 1366, USA
Mayo Clin Proc 81:925-34. 2006..To determine allopurinol treatment patterns and adherence to published standards of care for patients with gout...
- Gout and the risk of acute myocardial infarctionEswar Krishnan
University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Arthritis Rheum 54:2688-96. 2006....
- Characteristics of chronic gout in Northern Sulawesi, IndonesiaCecilia Padang
Indonesian Rheumatic Centre, Jakarta, Indonesia
J Rheumatol 33:1813-7. 2006..Improved education about gout seems needed. Urate-lowering drugs are not available in community health centers but are needed, especially in rural areas, as studied here...
- [Decision-making about gout by physicians of China and influencing factors thereof]Wei-Gang Fang
Department of General Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Zhonghua Yi Xue Za Zhi 86:1901-5. 2006..1, 95% CI 2.1 approximately 23.7). CONCLUSION: The management of gout by the physicians in China is often not consistent with that generally accepted internationally. High quality CME may improve the decision-making ability of physicians...
- Clinical Images: rheumatoid nodules in synoviumCesar Diaz-Torne
Hospital de Bellvitge, Barcelona, Spain
Arthritis Rheum 56:2104. 2007
- A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory diseaseTammy M Martin
Casey Eye Institute, CE RES, Oregon Health and Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA
Arthritis Rheum 52:269-74. 2005..We sought to determine whether a unique genetic region could be implicated in a specific manifestation-AAU-of a multisystem, inflammatory, genetically complex disease, AS...
- Synovial biopsy in the evaluation of nonrheumatic systemic diseases causing arthritisH Ralph Schumacher
Curr Opin Rheumatol 20:61-5. 2008
- Misdiagnosis of a chylous cyst as chest wall gouty tophus: a case of true pseudogoutLeena G Adhikesavan
Geisinger Medical Center, Danville, Pennsylvania 17822, USA
Arthritis Rheum 56:3854-7. 2007..Chylous cysts of the neck or chest wall can be caused by thoracic duct injury. Chyle contains 4-40 gm/liter of lipids, mostly triglycerides, and these can form birefringent crystals upon drying, leading to a false diagnosis of gout...