H R Schumacher

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Hyaluronate effects on synovium and synovial fluid. A prospective blinded study in patients with osteoarthritis of the knee
    H R Schumacher
    VA Medical Center 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Osteoarthritis Cartilage 14:501-3. 2006
  2. doi Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee
    H R Schumacher
    University of Pennsylvania School of Medicine, and Philadelphia VA Medical Center, Philadelphia, PA, USA
    Osteoarthritis Cartilage 21:1035-41. 2013
  3. doi Synovial xanthomatosis: are there clues to mechanisms for this rare disease?
    H Ralph Schumacher
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Mod Rheumatol 22:907-11. 2012
  4. doi Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study
    H Ralph Schumacher
    VA Medical Center and University of Pennsylvania, PA 19104, USA
    Arthritis Care Res (Hoboken) 64:1462-70. 2012
  5. doi Efficacy and tolerability of celecoxib in the treatment of acute gouty arthritis: a randomized controlled trial
    H Ralph Schumacher
    University of Pennsylvania, VA Medical Center, 151K, University and Woodland Aves, Philadelphia, PA 19104, USA
    J Rheumatol 39:1859-66. 2012
  6. doi Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial
    H Ralph Schumacher
    University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 64:876-84. 2012
  7. pmc Elimination of rheumatoid synovium in situ using a Fas ligand 'gene scalpel'
    Haidi Zhang
    Division of Pharmaceutics and Industry Pharmacy, School of Pharmacy, Long Island University, Brooklyn, NY, USA
    Arthritis Res Ther 7:R1235-43. 2005
  8. pmc Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels
    Sung Mun Jung
    Division of Rheumatology, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arthritis Res Ther 9:R64. 2007
  9. pmc The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
    Michael A Becker
    The University of Chicago Pritzker School of Medicine, MC0930, University of Chicago Medical Center, 5841 S, Maryland Avenue, Chicago, IL 60637, USA
    Arthritis Res Ther 12:R63. 2010
  10. pmc Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes
    Frank Pessler
    Klinik und Poliklinik für Kinder und Jugendmedizin, Technische Universitat Dresden, Fetscherstrasse, 01307 Dresden, Germany
    Arthritis Res Ther 10:R64. 2008

Collaborators

Detail Information

Publications93

  1. ncbi Hyaluronate effects on synovium and synovial fluid. A prospective blinded study in patients with osteoarthritis of the knee
    H R Schumacher
    VA Medical Center 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Osteoarthritis Cartilage 14:501-3. 2006
  2. doi Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee
    H R Schumacher
    University of Pennsylvania School of Medicine, and Philadelphia VA Medical Center, Philadelphia, PA, USA
    Osteoarthritis Cartilage 21:1035-41. 2013
    ..To assess the efficacy of tart cherry juice in treating pain and other features of knee osteoarthritis (OA)...
  3. doi Synovial xanthomatosis: are there clues to mechanisms for this rare disease?
    H Ralph Schumacher
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Mod Rheumatol 22:907-11. 2012
    ..This uncommon cause of arthritis and nodules had been confused with rheumatoid arthritis by others in this case...
  4. doi Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study
    H Ralph Schumacher
    VA Medical Center and University of Pennsylvania, PA 19104, USA
    Arthritis Care Res (Hoboken) 64:1462-70. 2012
    ..To evaluate the efficacy and safety of the interleukin-1 inhibitor rilonacept (interleukin-1 Trap) for gout flare prevention during initiation of uric acid-lowering therapy (ULT)...
  5. doi Efficacy and tolerability of celecoxib in the treatment of acute gouty arthritis: a randomized controlled trial
    H Ralph Schumacher
    University of Pennsylvania, VA Medical Center, 151K, University and Woodland Aves, Philadelphia, PA 19104, USA
    J Rheumatol 39:1859-66. 2012
    ..To evaluate the analgesic efficacy of high-dose celecoxib in the treatment of moderate to extreme pain and inflammation associated with acute gouty arthritis...
  6. doi Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial
    H Ralph Schumacher
    University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 64:876-84. 2012
    ..To evaluate the interleukin-1 inhibitor rilonacept (Interleukin-1 Trap) for prevention of gout flares occurring in the first few months following initiation of urate-lowering therapy...
  7. pmc Elimination of rheumatoid synovium in situ using a Fas ligand 'gene scalpel'
    Haidi Zhang
    Division of Pharmaceutics and Industry Pharmacy, School of Pharmacy, Long Island University, Brooklyn, NY, USA
    Arthritis Res Ther 7:R1235-43. 2005
    ....
  8. pmc Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels
    Sung Mun Jung
    Division of Rheumatology, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arthritis Res Ther 9:R64. 2007
    ..These results support a need for further studies of the efficacy of these extracts in the treatment of inflammatory arthropathies and suggest elevation of PGD2 levels as a novel mechanism for an anti-inflammatory agent...
  9. pmc The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
    Michael A Becker
    The University of Chicago Pritzker School of Medicine, MC0930, University of Chicago Medical Center, 5841 S, Maryland Avenue, Chicago, IL 60637, USA
    Arthritis Res Ther 12:R63. 2010
    ..The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) > or = 8.0 mg/dL in a six-month trial...
  10. pmc Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes
    Frank Pessler
    Klinik und Poliklinik für Kinder und Jugendmedizin, Technische Universitat Dresden, Fetscherstrasse, 01307 Dresden, Germany
    Arthritis Res Ther 10:R64. 2008
    ..Injection of monosodium urate (MSU) crystals into the pouch elicits an acute inflammatory response similar to human gout. We conducted the present study to identify mRNAs that were highly regulated by MSU crystals in the pouch membrane...
  11. ncbi The practical management of gout
    H Ralph Schumacher
    University of Pennsylvania, Philadelphia, PA, USA
    Cleve Clin J Med 75:S22-5. 2008
    ..Regular monitoring of serum urate can ensure therapeutic dosing of urate-lowering agents to achieve levels below 6 mg/dL, which are associated with a reduction in flares and tophi...
  12. ncbi The pathogenesis of gout
    H Ralph Schumacher
    University of Pennsylvania, Philadelphia, PA, USA
    Cleve Clin J Med 75:S2-4. 2008
    ..This will stop both the acute attacks and the progressive joint damage...
  13. ncbi Outcome evaluations in gout
    H Ralph Schumacher
    Division of Rheumatology, University of Pennsylvania School of Medicine, and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Rheumatol 34:1381-5. 2007
    ..Final validation of these outcomes has not yet been achieved. In summary, the unique problems of evaluating outcomes in gout are finally being addressed. While no measures are available for use yet, an agenda has been developed...
  14. ncbi Magnetic resonance imaging in the quantitative assessment of gouty tophi
    H R Schumacher
    University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Int J Clin Pract 60:408-14. 2006
    ..89 +/- 2.05 cm3; p < 0.05). MRI can quantify tophus size in gout and deserves further comparison with other techniques for tophus size monitoring in assessing effects of gout therapy...
  15. ncbi Febuxostat: a non-purine, selective inhibitor of xanthine oxidase for the management of hyperuricaemia in patients with gout
    H Ralph Schumacher
    University of Pennsylvania, VA Medical Center, Philadelphia, Pennsylvania, USA
    Expert Opin Investig Drugs 14:893-903. 2005
    ..Febuxostat is well tolerated, the majority of treatment-related adverse events are transient and mild-to-moderate in severity. Febuxostat can broaden the therapeutic options for urate-lowering therapy in those with gout...
  16. ncbi Newer therapeutic approaches: gout
    H Ralph Schumacher
    Division of Rheumatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Rheum Dis Clin North Am 32:235-44, xii. 2006
    ..New agents under investigation include pegylated formulations of uricase and a new potent xanthine oxidase inhibitor, febuxostat. Some cardiovascular drugs have been shown to be uricosuric...
  17. ncbi Tophaceous gout: quantitative evaluation by direct physical measurement
    H Ralph Schumacher
    Division of Rheumatology, University of Pennsylvania Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Rheumatol 32:2368-72. 2005
    ..This multicenter study assessed intra- and interrater reproducibility of a simple and direct physical measurement...
  18. ncbi Outcome measures for acute and chronic gout
    H Ralph Schumacher
    University of Florida, Gainesville, Florida, USA
    J Rheumatol 32:2452-5. 2005
    ..Five domains for acute gout outcomes and 9 for chronic gout were identified along with proposed instruments for testing and validation. The unique problems of gout evaluation can and will be addressed...
  19. ncbi Injectable corticosteroids in treatment of arthritis of the knee
    H Ralph Schumacher
    Section of Rheumatology, VA Medical Center, Philadelphia, Penn 19104, USA
    Am J Med 118:1208-14. 2005
    ..The evidence assessing safety and efficacy is reviewed and analyzed. Intra-articular knee injection technique is described and is a procedure that is easy to learn and can be performed quickly in an office or hospital setting...
  20. doi Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial
    H Ralph Schumacher
    University of Pennsylvania and VA Medical Center, Philadelphia, PA 19104, USA
    Arthritis Rheum 59:1540-8. 2008
    ..To compare the urate-lowering efficacy and safety of febuxostat, allopurinol, and placebo in a large group of subjects with hyperuricemia and gout, including persons with impaired renal function...
  21. doi Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study
    H R Schumacher
    VA Medical Center, 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Rheumatology (Oxford) 48:188-94. 2009
    ..This 5-yr study assessed urate-lowering and clinical efficacy and safety of long-term febuxostat therapy in subjects with gout. The primary efficacy end-point was reduction to and maintenance of serum urate (sUA) levels < 6.0 mg/dl...
  22. doi Outcome domains for studies of acute and chronic gout
    H Ralph Schumacher
    Rheumatology Section, Veterans Affairs Medical Center, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
    J Rheumatol 36:2342-5. 2009
    ..Implications of patient perspectives, discretionary domains for specific studies, measurement instruments and a possible responder index are under study...
  23. ncbi Aspiration and injection therapies for joints
    H Ralph Schumacher
    University of Pennsylvania and VA Medical Center, Philadelphia, USA
    Arthritis Rheum 49:413-20. 2003
  24. doi Identification of broadly discriminatory tissue biomarkers of synovitis with binary and multicategory receiver operating characteristic analysis
    A Ogdie
    Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Biomarkers 15:183-90. 2010
    ..44). Multicategory ROC analysis ranked Ki-67, subintimal CD68, and CD15 as discriminating best among all six sample groups, and thus identified them as the most broadly applicable markers...
  25. doi Increased angiogenesis and cellular proliferation as hallmarks of the synovium in chronic septic arthritis
    F Pessler
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 59:1137-46. 2008
    ..To characterize histologic alterations and inflammatory infiltrates in the synovium of patients with chronic septic arthritis (SeA)...
  26. doi A histomorphometric analysis of synovial biopsies from individuals with Gulf War Veterans' Illness and joint pain compared to normal and osteoarthritis synovium
    F Pessler
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Clin Rheumatol 27:1127-34. 2008
    ..In summary, the GWVI and normal synovia were indistinguishable from each other and contained similar low-grade inflammatory cell populations consisting almost entirely of macrophages and T cells...
  27. doi The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis
    F Pessler
    The Children s Hospital of Philadelphia, Division of Rheumatology, Philadelphia, USA
    Ann Rheum Dis 67:1184-7. 2008
    ..To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A)...
  28. ncbi Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?
    J Li-Yu
    Department of Medicine, Hospital of the University of Pennsylvania, USA
    J Rheumatol 28:577-80. 2001
    ..To determine if lowering of serum uric acid (SUA) concentrations below 6 mg/dl or longer duration of lowered SUA will result in depletion of urate crystals from the knee joints and prevent further attacks of gout...
  29. ncbi Intra-articular corticosteroid preparations: different characteristics and their effect during inflammation induced by monosodium urate crystals in the rat subcutaneous air pouch
    M Rull
    Veterans Affairs Medical Center and University of Pennsylvania, Philadelphia, PA 19104, USA
    Rheumatology (Oxford) 42:1093-100. 2003
    ..This work compares the effect of three commonly used corticosteroid preparations in vivo, showing that they behave differently...
  30. ncbi Subintimal Ki-67 as a synovial tissue biomarker for inflammatory arthropathies
    F Pessler
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Ann Rheum Dis 67:162-7. 2008
    ..We evaluated subintimal Ki-67+ cell density as a tissue biomarker for inflammatory arthropathies and compared it to subintimal CD68, a synovial biomarker of RA...
  31. ncbi Detection and initial characterization of synovial lining fragments in synovial fluid
    L Dai
    University of Pennsylvania, USA
    Rheumatology (Oxford) 45:533-7. 2006
    ..We wished to establish a method for the reliable detection of these fragments in joint and bursa effusions and begin to characterize them by histochemical and immunohistochemical methods...
  32. ncbi Does acute synovitis (pseudogout) occur in patients with chronic pyrophosphate arthropathy (pseudo-osteoarthritis)?
    N Schlesinger
    Division of Rheumatology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Clin Exp Rheumatol 27:940-4. 2009
    ..The two most common are: acute synovitis (pseudogout) and chronic pyrophosphate arthropathy ("pseudo-osteoarthritis"). We have conducted a study to examine whether these are overlapping syndromes...
  33. doi Clinical diagnostic criteria for gout: comparison with the gold standard of synovial fluid crystal analysis
    Aarti Malik
    University of Pennsylvania, VA Medical Center, Philadelphia, Pennsylvania, USA
    J Clin Rheumatol 15:22-4. 2009
    ..Several classification or diagnostic criteria sets for gout have been proposed but none validated...
  34. ncbi Sodium magnetic resonance imaging of proteoglycan depletion in an in vivo model of osteoarthritis
    Andrew J Wheaton
    Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    Acad Radiol 11:21-8. 2004
    ..The aim of the study was to investigate the feasibility of using sodium magnetic resonance imaging (MRI) as a noninvasive quantitative technique for measuring proteoglycan (PG) content in an in vivo porcine model of osteoarthritis (OA)...
  35. pmc Gout epidemiology: results from the UK General Practice Research Database, 1990-1999
    T R Mikuls
    Department of Medicine, University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, USA
    Ann Rheum Dis 64:267-72. 2005
    ..To examine the epidemiology of gout and gout treatment in the United Kingdom using a large national practice based population...
  36. ncbi Chlamydial nucleic acids in synovium in osteoarthritis: what are the implications?
    N Olmez
    Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Rheumatol 28:1874-80. 2001
    ..To study whether there is evidence of bacterial DNA in some osteoarthritic (OA) joint tissues, and the clinical implications of finding bacterial DNA in this relatively noninflammatory disease...
  37. ncbi Gout: can management be improved?
    N Schlesinger
    Section of Rheumatology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Curr Opin Rheumatol 13:240-4. 2001
    ..Treatment of gout in transplant recipients brings into focus some of the issues regarding management of gout, because gout is a common problem among transplant patients...
  38. pmc Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis
    H Ralph Schumacher
    Division of Rheumatology, University of Pennsylvania School of Medicine and Department of Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    BMJ 324:1488-92. 2002
    ..To assess the safety and efficacy of etoricoxib, a selective cyclo-oxygenase-2 inhibitor, in comparison with indometacin in the treatment of acute gouty arthritis...
  39. doi Quality of life and disability in patients with treatment-failure gout
    Michael A Becker
    Division of Biological Sciences, Rheumatology Section, University of Chicago, Chicago, IL, USA
    J Rheumatol 36:1041-8. 2009
    ..The relationship between self-reported quality of life and disability and disease severity was evaluated in subjects with treatment-failure gout (n = 110) in a prospective, 52-week, observational study...
  40. ncbi Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
    Daniel O Clegg
    Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    N Engl J Med 354:795-808. 2006
    ..The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis...
  41. ncbi Are there distinctive inflammatory flares after hylan g-f 20 intraarticular injections?
    Sally Pullman-Mooar
    MCP Hahneman University School of Medicine, Philadelphia, Pennsylvania, USA
    J Rheumatol 29:2611-4. 2002
    ..This survey was designed to examine features of a group of patients with acute painful joint effusions following hylan G-F 20 (Synvisc) knee injections...
  42. ncbi Is there a role for Chlamydia pneumoniae infection in systemic lupus erythematosus and in the associated atherosclerotic cardiovascular disease?
    T Kitumnuaypong
    Rheumatology Department, University of Pennsylvania, USA
    Clin Exp Rheumatol 22:339-42. 2004
    ....
  43. ncbi NFAT transcription factors--new players in the pathogenesis of inflammatory arthropathies?
    F Pessler
    Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, 3405 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Autoimmun Rev 5:106-10. 2006
    ..Specific anti-NFAT drug therapy may add to the pharmacologic armamentarium against rheumatoid arthritis, other inflammatory arthropathies, and related autoimmune disorders...
  44. ncbi Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studies
    S Nalbant
    Department of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Osteoarthritis Cartilage 11:50-4. 2003
    ..It is not yet known which are initiators, promoters or simply results. Thus, we have evaluated some of those potentially important factors in osteoarthritis (OA) as observed sequentially for the first time in synovial fluids...
  45. doi Update on gout and hyperuricemia
    J F Baker
    Department of Medicine, Division of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Clin Pract 64:371-7. 2010
    ..Physicians should consider cardiovascular risk factors in patients with gout and treat them appropriately and aggressively...
  46. ncbi Correlation of T1rho with fixed charge density in cartilage
    Andrew J Wheaton
    Department of Radiology, University of Pennsylvania, Philadelphia, USA
    J Magn Reson Imaging 20:519-25. 2004
    ..To establish the specificity of T1rho with respect to fixed charge density (FCD) as a measure of proteoglycan (PG) content in cartilage during the onset of osteoarthritis (OA)...
  47. pmc Detection of changes in articular cartilage proteoglycan by T(1rho) magnetic resonance imaging
    Andrew J Wheaton
    B1 Stellar Chance Laboratories, Department of Radiology, University of Pennsylvania, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    J Orthop Res 23:102-8. 2005
    ..The effects of IL-1beta, primarily loss of PG, were confirmed by histological and immunochemical findings. The results from this study demonstrate that R(1rho) is able to track proteoglycan content in vivo...
  48. ncbi West meets East in rheumatology
    Lan X Chen
    Rheumatology Division, School of Medicine, University of Pennsylvania Medical Center Presbyterian and VAMC, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Curr Rheumatol Rep 7:251-3. 2005
  49. ncbi Quantitative analysis of immunohistologic features of very early rheumatoid synovitis in disease modifying antirheumatic drug- and corticosteroid-naïve patients
    Jasvinder A Singh
    Division of Rheumatology, University of Minnesota, Minneapolis, MN, USA
    J Rheumatol 31:1281-5. 2004
    ..To describe the immunohistochemical features of very early rheumatoid synovitis in disease modifying antirheumatic drug- and corticosteroid-naïve patients...
  50. ncbi Predictive factors in early arthritis: long-term follow-up
    H Ralph Schumacher
    Rheumatology Division, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, 19104, USA
    Semin Arthritis Rheum 33:264-72. 2004
    ....
  51. ncbi Iyengar yoga for treating symptoms of osteoarthritis of the knees: a pilot study
    Sharon L Kolasinski
    Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Altern Complement Med 11:689-93. 2005
    ..The aim of this pilot study was to assess the feasibility of using yoga in the tradition of B.K.S. Iyengar to treat the symptoms of osteoarthritis of the knee...
  52. ncbi Why I do research
    H Ralph Schumacher
    University of Pennsylvania School of Medicine, and Arthritis Research, Department of Veterans Affairs Medical Center 151 K, University and Woodland Avenues, Philadelphia, PA 19104, USA
    J Clin Rheumatol 11:228-32. 2005
  53. ncbi Gout: can we create an evidence-based systematic approach to diagnosis and management?
    Lan X Chen
    University of Pennsylvannia, Penn Presbyterian Medical Center, Philadelphia, PA 19104 4283, USA
    Best Pract Res Clin Rheumatol 20:673-84. 2006
    ..Lifestyle measures should be addressed. If chronic tophaceous gout is diagnosed, urate lowering should be started without delay. New agents are under development that may help with difficult cases...
  54. ncbi Diagnosing early rheumatoid arthritis (RA). What are the problems and opportunities?
    H R Schumacher
    Department of Rheumatology, University of Pennsylvania Hospital, 3rd Ravdin Building, 34th and Spruce Street, Philadelphia, Pennsylvania, USA
    Clin Exp Rheumatol 21:S15-9. 2003
    ..We review this area, focusing on work from our own research and how this has guided our thinking...
  55. doi Synovial fluid findings in a patient after hylan GF 20 injection
    Jennifer Kwan-Morley
    VA Hospital, Philadelphia, PA, USA
    J Clin Rheumatol 14:120. 2008
  56. ncbi Assessing single joints in arthritis clinical trials
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Rheumatol 34:641-7. 2007
    ..At OMERACT 8, the group developed a research agenda to perform additional validation studies of clinical and functional indices, imaging, synovial histopathology, and soluble biomarkers...
  57. ncbi Current trends in crystal identification
    Lan X Chen
    VA Medical Center, Rheumatology Research 151K, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Rheumatol 18:171-3. 2006
    ..This review is an attempt to keep current in the sparse literature addressing the still underutilized area of crystal identification...
  58. ncbi Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?
    Joshua F Baker
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med 118:816-26. 2005
    ..Trials of SUA-lowering therapy in hyperuricemic patients evaluating the effect on cardiovascular outcomes are justified in high-risk patients...
  59. ncbi Decreased pain and synovial inflammation after etanercept therapy in patients with reactive and undifferentiated arthritis: an open-label trial
    Stephanie D Flagg
    University of Pennsylvania, VA Medical Centers, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 53:613-7. 2005
    ....
  60. ncbi Utility of digital photographs of the hand for assessing the presence of hand osteoarthritis
    A G Stern
    Division of Rheumatology, University of Pennsylvania Medical Center and Philadelphia VAMC, Philadelphia, PA, USA
    Osteoarthritis Cartilage 12:360-5. 2004
    ..Our study evaluated the accuracy, relative to a radiograph, of a digital photograph of the hands for the presence of OA in a particular joint, as well as for the diagnosis of nodal hand OA...
  61. ncbi Yoga-based intervention for carpal tunnel syndrome: a randomized trial
    M S Garfinkel
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    JAMA 280:1601-3. 1998
    ..Carpal tunnel syndrome is a common complication of repetitive activities and causes significant morbidity...
  62. ncbi Update on identification of pathogenic crystals in joint fluid
    Lan X Chen
    VA Medical Center, 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Curr Rheumatol Rep 6:217-20. 2004
    ..Recent advances have included progress in crystal identification on stained slides, attention to aspiration techniques, and arthrocenteses of asymptomatic joints. Challenges remain to increase use and optimize techniques...
  63. ncbi Ultrasonography for assessment of subcutaneous nodules
    Selim Nalbant
    Rheumatology Division of the Hospital of the University of Pennsylvania, Philadelphia, USA
    J Rheumatol 30:1191-5. 2003
    ..To characterize a variety of subcutaneous lesions by their ultrasonographic (US) appearance, and establish these images as a starting point to measure changes with treatments...
  64. ncbi The promise of coxibs: how far have we progressed?
    H Ralph Schumacher
    VA Medical Center, Philadelphia, PA 19104, USA
    J Pain Symptom Manage 23:S1-4. 2002
  65. ncbi Hyperuricemia and incidence of hypertension among men without metabolic syndrome
    Eswar Krishnan
    School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Hypertension 49:298-303. 2007
    ..09; 95% CI: 1.02 to 1.17). We conclude that the hyperuricemia-hypertension risk relationship is present among normotensive middle-aged men without diabetes/glucose intolerance or metabolic syndrome...
  66. ncbi Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch
    Selim Nalbant
    University of Pennsylvania School of Medicine and the Arthritis Center, VA Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Rheumatol 32:1762-4. 2005
    ..To examine the ability of rofecoxib prophylaxis to blunt the effect of monosodium urate (MSU) crystal inflammation induced in the rat subcutaneous air pouch...
  67. ncbi Serum uric acid level and risk for peripheral arterial disease: analysis of data from the multiple risk factor intervention trial
    Joshua F Baker
    Department of Medicine, University of Pennsylvania, USA
    Angiology 58:450-7. 2007
    ..A history of gouty arthritis is an independent and statistically significant predictor of incidence of PAD even after adjustment for the effect of underlying hyperuricemia...
  68. ncbi Phase I design and evaluation of an isometric muscle reeducation device for knee osteoarthritis rehabilitation
    Robert J Goldman
    SensorPad Systems, Inc, Norristown, PA, USA
    J Rehabil Res Dev 40:95-107. 2003
    ..All changes were trends. The Isopad helped subjects with knee OA adhere to a supervised isometric program and meet progressive strength targets. The next-generation Isopad will be employed in a home-based program...
  69. ncbi Benefits and harms of doxycycline treatment for Gulf War veterans' illnesses: a randomized, double-blind, placebo-controlled trial
    Sam T Donta
    Veterans Affairs Medical Center, Boston, MA 02130, USA
    Ann Intern Med 141:85-94. 2004
    ....
  70. ncbi Synovial sarcoma of the foot mimicking acute gouty arthritis
    Ying Du
    Division of Rheumatology, Department of Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Rheumatol 32:2006-8. 2005
    ..We describe a case of synovial sarcoma with an unusually acute presentation near the first metatarsophalangeal joint that resembled acute gouty arthritis...
  71. doi Poor validation of medical record ICD-9 diagnoses of gout in a veterans affairs database
    Aarti Malik
    University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA, USA
    J Rheumatol 36:1283-6. 2009
    ..We evaluated whether we can document the accuracy of such diagnoses by review of medical records and then on direct interviews with a subset of patients...
  72. pmc Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis
    Terence Rooney
    Department of Rheumatology, St Vincent s University Hospital, Dublin 4, Ireland
    Ann Rheum Dis 66:1656-60. 2007
    ..To evaluate inter-observer agreement for microscopic measurement of inflammation in synovial tissue using manual quantitative, semiquantitative and computerised digital image analysis...
  73. ncbi Local ice therapy during bouts of acute gouty arthritis
    Naomi Schlesinger
    Department of Medicine and New Jersey Medical School University of Medicine and Dentistry of New Jersey, Newark, USA
    J Rheumatol 29:331-4. 2002
    ..To evaluate the effect of local application of ice on duration and severity of acute gouty arthritis...
  74. ncbi Cytokine and chemokine mRNA produced in synovial tissue chronically infected with Chlamydia trachomatis and C. pneumoniae
    Herve C Gerard
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Rheumatol 29:1827-35. 2002
    ..pneumoniae...
  75. ncbi The management of gout at an academic healthcare center in Beijing: a physician survey
    Weigang Fang
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    J Rheumatol 33:2041-9. 2006
    ....
  76. ncbi Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout
    Michael A Becker
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Arthritis Rheum 52:916-23. 2005
    ..0 mg/dl)...
  77. ncbi Injectable corticosteroids in modern practice
    Brian J Cole
    Rush Cartilage Restoration Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Am Acad Orthop Surg 13:37-46. 2005
    ..The accuracy of injections affects outcomes. Postinjection flare, facial flushing, and skin and fat atrophy are the most common side effects. Systemic complications of injectable corticosteroids are rare...
  78. ncbi Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    Michael A Becker
    University of Chicago Pritzker School of Medicine, Chicago, USA
    N Engl J Med 353:2450-61. 2005
    ..Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout...
  79. ncbi Necessary and discretionary activities in knee osteoarthritis: do they mediate the pain-depression relationship?
    Patricia A Parmelee
    Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA
    Pain Med 8:449-61. 2007
    ..A key focus was the distinction of functional disability in necessary tasks (basic and instrumental activities of daily living) from discretionary, leisure activities...
  80. ncbi Serum urate levels and gout flares: analysis from managed care data
    Chaitanya A Sarawate
    Health Outcomes Research, HealthCore, Inc, 800 Delaware Avenue, Wilmington, DE 19801 1366, USA
    J Clin Rheumatol 12:61-5. 2006
    ..The desired serum urate level (SUA) for prevention of gout attacks is widely recommended to be in the subsaturating range, <6.0 mg/dL...
  81. ncbi A survey of current evaluation and treatment of gout
    Naomi Schlesinger
    Department of Medicine, The School of Public Health, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903 0019, USA
    J Rheumatol 33:2050-2. 2006
    ..To record diagnostic and treatment approaches to gouty arthritis among US rheumatologists...
  82. ncbi Update on gout
    Naomi Schlesinger
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Arthritis Rheum 47:563-5. 2002
  83. ncbi Early arthritis clinics. Much early arthritis is unclassified
    H Ralph Schumacher
    J Rheumatol 29:2258-60. 2002
  84. ncbi Characteristics of chronic gout in Northern Sulawesi, Indonesia
    Cecilia Padang
    Indonesian Rheumatic Centre, Jakarta, Indonesia
    J Rheumatol 33:1813-7. 2006
    ..To identify associations and possible risk factors for gout that may contribute to chronic tophaceous gout in rural and urban districts of North Sulawesi, Indonesia...
  85. ncbi [Decision-making about gout by physicians of China and influencing factors thereof]
    Wei Gang Fang
    Department of General Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 86:1901-5. 2006
    ..To investigate the decision-making about gout by physicians of China and influencing factors thereof...
  86. ncbi Gout and the risk of acute myocardial infarction
    Eswar Krishnan
    University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Arthritis Rheum 54:2688-96. 2006
    ....
  87. ncbi Clinical Images: rheumatoid nodules in synovium
    Cesar Diaz-Torne
    Hospital de Bellvitge, Barcelona, Spain
    Arthritis Rheum 56:2104. 2007
  88. ncbi Multicentric reticulohistiocytosis responding to tumor necrosis factor-alpha inhibition in a renal transplant patient
    Sean E Shannon
    Department of Rheumatology Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, CSB, PO Box 250637, Charleston, SC 29425, USA
    J Rheumatol 32:565-7. 2005
    ..Within 2 months the patient showed dramatic clinical and serologic improvement that was maintained until she stopped treatment secondary to an upper respiratory tract infection. Once treatment was restarted, the symptoms again improved...
  89. ncbi A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease
    Tammy M Martin
    Casey Eye Institute, CE RES, Oregon Health and Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA
    Arthritis Rheum 52:269-74. 2005
    ..We sought to determine whether a unique genetic region could be implicated in a specific manifestation-AAU-of a multisystem, inflammatory, genetically complex disease, AS...
  90. ncbi Gout medication treatment patterns and adherence to standards of care from a managed care perspective
    Chaitanya A Sarawate
    Health Outcomes Research, HealthCore, Inc, 800 Delaware Ave, Fifth Floor, Wilmington, DE 19801 1366, USA
    Mayo Clin Proc 81:925-34. 2006
    ..To determine allopurinol treatment patterns and adherence to published standards of care for patients with gout...
  91. ncbi Misdiagnosis of a chylous cyst as chest wall gouty tophus: a case of true pseudogout
    Leena G Adhikesavan
    Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Arthritis Rheum 56:3854-7. 2007
    ..Chylous cysts of the neck or chest wall can be caused by thoracic duct injury. Chyle contains 4-40 gm/liter of lipids, mostly triglycerides, and these can form birefringent crystals upon drying, leading to a false diagnosis of gout...
  92. doi Synovial biopsy in the evaluation of nonrheumatic systemic diseases causing arthritis
    H Ralph Schumacher
    Curr Opin Rheumatol 20:61-5. 2008
  93. ncbi Chlamydia trachomatis genes whose products are related to energy metabolism are expressed differentially in active vs. persistent infection
    Herve C Gerard
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Gordon H Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Microbes Infect 4:13-22. 2002
    ..Metabolic rate in persistent C. trachomatis is lower than in actively growing cells, as judged from assays for relative chlamydial primary rRNA transcript levels in persistent vs. actively growing cells...