H D Schultz

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. doi request reprint Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure
    Karla K V Haack
    Department of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198
    Hypertension 63:1041-9. 2014
  2. doi request reprint Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure
    Noah J Marcus
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Physiol 592:391-408. 2014
  3. pmc Role of the carotid body in the pathophysiology of heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Curr Hypertens Rep 15:356-62. 2013
  4. pmc Role of neurotransmitter gases in the control of the carotid body in heart failure
    Harold D Schultz
    Department of Integrative Cellular Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, United States
    Respir Physiol Neurobiol 184:197-203. 2012
  5. doi request reprint Heart failure and carotid body chemoreception
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
    Adv Exp Med Biol 758:387-95. 2012
  6. pmc Carotid body function in heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Respir Physiol Neurobiol 157:171-85. 2007
  7. pmc The spice of life is at the root of cardiac pain
    Harold D Schultz
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
    J Physiol 551:400. 2003
  8. pmc Angiotensin and carotid body chemoreception in heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Curr Opin Pharmacol 11:144-9. 2011
  9. ncbi request reprint Arterial chemoreceptors and sympathetic nerve activity: implications for hypertension and heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 50:6-13. 2007
  10. ncbi request reprint Chemoreflex function in heart failure
    H D Schultz
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha, NE 68198 4575, USA
    Heart Fail Rev 5:45-56. 2000

Collaborators

Detail Information

Publications47

  1. doi request reprint Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure
    Karla K V Haack
    Department of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198
    Hypertension 63:1041-9. 2014
    ....
  2. doi request reprint Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure
    Noah J Marcus
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Physiol 592:391-408. 2014
    ..In conclusion, CBD is effective in reducing RSNA, SRC and arrhythmia incidence, while improving breathing stability and cardiac function in pacing-induced CHF rabbits. ..
  3. pmc Role of the carotid body in the pathophysiology of heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Curr Hypertens Rep 15:356-62. 2013
    ..This review will focus on recent advances in our understanding of the pathophysiological mechanisms that alter CB function in CHF and their potential translational impact on treatment of chronic heart failure (CHF). ..
  4. pmc Role of neurotransmitter gases in the control of the carotid body in heart failure
    Harold D Schultz
    Department of Integrative Cellular Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, United States
    Respir Physiol Neurobiol 184:197-203. 2012
    ..This brief review highlights evidence that the alterations in the gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide in the carotid body contribute to the exaggerated carotid body function observed in heart failure...
  5. doi request reprint Heart failure and carotid body chemoreception
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
    Adv Exp Med Biol 758:387-95. 2012
    ..This review will focus on recent advances in our understanding of the physiological mechanisms that alter CB function in CHF and their potential translational impact on treatment of CHF...
  6. pmc Carotid body function in heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Respir Physiol Neurobiol 157:171-85. 2007
    ..These results underscore the principle that multiple mechanisms involving Ang II and NO at the level of both the CB and CNS represent complementary and perhaps redundant adaptive mechanisms to enhance CB chemoreflex function in CHF...
  7. pmc The spice of life is at the root of cardiac pain
    Harold D Schultz
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
    J Physiol 551:400. 2003
  8. pmc Angiotensin and carotid body chemoreception in heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Curr Opin Pharmacol 11:144-9. 2011
    ..This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF...
  9. ncbi request reprint Arterial chemoreceptors and sympathetic nerve activity: implications for hypertension and heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 50:6-13. 2007
  10. ncbi request reprint Chemoreflex function in heart failure
    H D Schultz
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha, NE 68198 4575, USA
    Heart Fail Rev 5:45-56. 2000
    ....
  11. pmc Nitric oxide regulation of autonomic function in heart failure
    Harold D Schultz
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198, USA
    Curr Heart Fail Rep 6:71-80. 2009
    ..This review also emphasizes questions of regulation of NO function in the autonomic nervous system that remain unresolved...
  12. ncbi request reprint Cardiac vagal chemosensory afferents. Function in pathophysiological states
    H D Schultz
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198 4575, USA
    Ann N Y Acad Sci 940:59-73. 2001
    ....
  13. ncbi request reprint Cardiac sympathetic afferent sensitivity is enhanced in heart failure
    W Wang
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198 4575, USA
    Am J Physiol 277:H812-7. 1999
    ..It is suggested that the cardiac sympathetic chemosensitive afferent sensitivity is significantly enhanced in dogs with HF even though the baseline cardiac sympathetic afferent discharge is elevated...
  14. pmc Exercise training improves peripheral chemoreflex function in heart failure rabbits
    Yu Long Li
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, NE 68198, USA
    J Appl Physiol (1985) 105:782-90. 2008
    ..EXT reverses the alterations in the nNOS-NO and ANG II-AT(1)-receptor pathways in the CB responsible for chemoreceptor sensitization in CHF...
  15. ncbi request reprint Volume expansion potentiates cardiac sympathetic afferent reflex in dogs
    W Wang
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198 4575, USA
    Am J Physiol Heart Circ Physiol 280:H576-81. 2001
    ..These data suggest that enhancement of the CSAR in congestive heart failure may be mediated by the concomitant cardiac dilation, which accompanies this disease state...
  16. ncbi request reprint Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits
    Yu Long Li
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Cardiovasc Res 71:129-38. 2006
    ..We investigated whether Angiotensin II (Ang II) modulates peripheral chemoreflex function through carotid body (CB) chemoreceptors in chronic heart failure (CHF)...
  17. pmc Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits
    Yanfeng Ding
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Cardiovasc Res 81:678-85. 2009
    ..Here we investigated the role of cytoplasmic SOD [CuZn superoxide dismutase (CuZnSOD)] in the CB on chemoreceptor activity and function in CHF rabbits...
  18. pmc Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits
    Yanfeng Ding
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol (1985) 105:14-23. 2008
    ..63 +/- 0.04, 0.56 +/- 0.06, and 0.27 +/- 0.03, respectively) rabbits (P < 0.05). These results suggest that a deficiency of NO and CO in the CBs augments peripheral chemoreflex sensitivity to hypoxia in CHF...
  19. ncbi request reprint Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits
    Yu Long Li
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Circ Res 97:260-7. 2005
    ..05). These results indicate that decreased endogenous nNOS activity in the CB plays an important role in the enhanced activity of the CB chemoreceptors and peripheral chemoreflex function in CHF rabbits...
  20. ncbi request reprint Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 45:1173-81. 2005
    ..9+/-0.2 to 3.1+/-0.2%/mm Hg; P<0.01). These results suggest that tonic cardiac sympathetic afferent input plays an important role in the blunted baroreflex associated with CHF, which is mediated by central AT1 receptors...
  21. ncbi request reprint Sympathoexcitation by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Am J Physiol Heart Circ Physiol 288:H2271-9. 2005
    ....
  22. ncbi request reprint Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Circ Res 95:937-44. 2004
    ..These data demonstrate intense radical stress in autonomic areas of the brain in experimental CHF and provide evidence for a tight relationship between Ang II and ROS as contributors to sympathoexcitation in CHF...
  23. ncbi request reprint Vagal neuroeffector mechanisms affecting transpulmonary pressure in the intact rat
    J R Haselton
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198 4575, USA
    J Appl Physiol (1985) 79:1233-41. 1995
    ..Therefore, nonadrenergic noncholinergic systems did not appear to play an independent role in the response of the airways to the activation of the vagus nerves...
  24. ncbi request reprint Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats
    Lie Gao
    Department of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol (1985) 102:37-43. 2007
    ..These results suggest that both the chemical and electrical stimulation of the CSAR augments chemoreceptor reflex and that central ANG II, specially located in the NTS, plays a major role in these reflex interactions...
  25. ncbi request reprint Altered nitric oxide mechanism within the paraventricular nucleus contributes to the augmented carotid body chemoreflex in heart failure
    Maram K Reddy
    Dept of Cellular and Integrative Physiology, Univ of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Heart Circ Physiol 292:H149-57. 2007
    ....
  26. pmc NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits
    Yu Long Li
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Cardiovasc Res 75:546-54. 2007
    ..NADPH oxidase-derived superoxide anion mediates the effects of Ang II in many organs. We investigated whether this signaling pathway may mediate the enhanced peripheral chemoreceptor sensitivity induced by Ang II in CHF rabbits...
  27. pmc Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid body in heart failure: role of angiotensin II
    Yu Long Li
    Department of Cellular and Integrative Physiology, University of, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Physiol 575:215-27. 2006
    ..4 versus Kv4.3) in the CB glomus cell may contribute to the suppression of IK and enhanced sensitivity of IK to hypoxia in CHF...
  28. pmc Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide
    Yu Long Li
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Physiol 555:219-29. 2004
    ..This effect is due mainly to the suppression of KCa channel activity caused by decreased availability of NO. In addition, intracellular cGMP is necessary for the KCa channel modulation by NO...
  29. ncbi request reprint The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide
    Irving H Zucker
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198 4575, USA
    Prog Biophys Mol Biol 84:217-32. 2004
    ..Lastly, clinical implications of this work are discussed...
  30. pmc Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure
    Lie Gao
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, 68198 5850, USA
    Am J Physiol Heart Circ Physiol 298:H945-55. 2010
    ..3 expression and subsequent decrease in K(+) current, thereby increasing the excitability of neurons in the RVLM. The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling...
  31. pmc Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbits
    Yanfeng Ding
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Am J Physiol Regul Integr Comp Physiol 298:R303-11. 2010
    ..05). The results suggest that decreased MnSOD in the CB and elevated mitochondrial superoxide levels contribute to the enhanced CB chemoreceptor activity and peripheral chemoreflex function in CHF rabbits...
  32. pmc Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure
    Irving H Zucker
    Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Heart Circ Physiol 297:H1557-66. 2009
    ..Finally, exercise training reduces both central oxidative stress and AT(1)R expression in animals with CHF. These data strongly suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF...
  33. ncbi request reprint Exercise training and sympathetic regulation in experimental heart failure
    Irving H Zucker
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Exerc Sport Sci Rev 32:107-11. 2004
    ..Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory...
  34. ncbi request reprint Differential role of the paraventricular nucleus of the hypothalamus in modulating the sympathoexcitatory component of peripheral and central chemoreflexes
    Maram K Reddy
    Dept of Cellular and Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Regul Integr Comp Physiol 289:R789-97. 2005
    ..These results suggest a selective role of the PVN in processing the sympathoexcitatory and ventilatory component of the peripheral, but not central, chemoreflex...
  35. doi request reprint Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel
    Yu Long Li
    Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Cardiovasc Res 79:715-21. 2008
    ..We investigated whether the excitability of AB neurons is depressed in streptozotocin (STZ)-induced T1D rats and whether HCN channels are involved in this depression...
  36. ncbi request reprint Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathways
    S Y Sun
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Nebraska Medical Center, Omaha, Nebraska 68198-4575, USA
    Am J Physiol Heart Circ Physiol 281:H93-H104. 2001
    ..Our results suggest that induction of the 5-LOX pathway contributes to the enhanced sensitivity of cardiac vagal afferents to AA in the ischemic condition...
  37. ncbi request reprint Amelioration of depressed cardiopulmonary reflex control of sympathetic nerve activity by short-term exercise training in male rabbits with heart failure
    R U Pliquett
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198 4575, USA
    J Appl Physiol 95:1883-8. 2003
    ..normal animals. Ex substantially restored both CP reflex sensitivity and baseline RSNA in CHF animals. Thus Ex beneficially affects reflex regulation in CHF, thereby lowering resting sympathetic nerve activity...
  38. pmc Expression of neuronal nitric oxide synthase in rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currents
    Yu Long Li
    Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neurophysiol 103:3027-33. 2010
    ..These results suggest that a decrease of NO induced by an attenuated nNOS activity lowers the activation of the BK channels but not the protein expression of the BK channel alpha-subunit in the CB glomus cells during CHF...
  39. pmc The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase
    Erin G Rosenbaugh
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Biomaterials 31:5218-26. 2010
    ..Importantly, neither the PEI-PEG polymer alone nor the CuZnSOD nanozyme induced neuronal toxicity. These findings indicate that CuZnSOD nanozyme inhibits AngII intra-neuronal signaling in vitro and in vivo...
  40. ncbi request reprint Gas exchange and lung mechanics during percutaneous transtracheal ventilation in an unparalyzed canine model
    T P Tran
    Department of Surgery, University of Nebraska Medical Center, Omaha 68198 1150, USA
    Acad Emerg Med 5:320-4. 1998
    ..To compare the efficacy of percutaneous transtracheal ventilation (PTV) in the unparalyzed state with that in the paralyzed state using a sedated nonobstructed canine model...
  41. ncbi request reprint Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidase
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Circulation 112:1763-70. 2005
    ..We hypothesized that SIM exerts its beneficial effect on autonomic function in CHF by downregulating central angiotensin II (Ang II) and superoxide mechanisms...
  42. doi request reprint Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure
    Allison C Kleiber
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1863-72. 2008
    ..Thus one mechanism by which ExT alleviates elevated sympathetic outflow in HF may be through normalization of glutamatergic mechanisms within the PVN...
  43. pmc Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current
    Jing Xiang Yin
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Cell Physiol 298:C857-65. 2010
    ..These data indicate that ANG II increases mitochondrial O(2)(.-), which mediates, at least in part, ANG II-induced activation of Ca(2+)/calmodulin kinase II and inhibition of I(Kv) in neurons...
  44. ncbi request reprint Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology
    Yi Fan Li
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Med 112:59-79. 2005
    ....
  45. pmc Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism
    Rui fang Yang
    University of Nebraska Medical Center, Omaha, 68198 5850, USA
    Am J Physiol Cell Physiol 300:C58-64. 2011
    ..These findings indicate that Ang-(1-7) is capable of increasing nNOS-derived NO(ยท) levels, which in turn, activates hyperpolarizing I(Kv) in catecholaminergic neurons...
  46. pmc Role of blood flow in carotid body chemoreflex function in heart failure
    Yanfeng Ding
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Physiol 589:245-58. 2011
    ..A NO donor and AT1-R antagonist reversed CAO-enhanced chemoreflex sensitivity. These results suggest that a reduction of blood flow to the CB is involved in the augmentation of peripheral chemoreflex sensitivity in CHF...
  47. ncbi request reprint Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure
    Irving H Zucker
    J Appl Physiol 102:498; author reply 504-5. 2007