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Species | H D SchultzSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
Role of neurotransmitter gases in the control of the carotid body in heart failureHarold D Schultz
Department of Integrative Cellular Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, United States
Respir Physiol Neurobiol 184:197-203. 2012..This brief review highlights evidence that the alterations in the gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide in the carotid body contribute to the exaggerated carotid body function observed in heart failure...
Heart failure and carotid body chemoreceptionHarold D Schultz
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Adv Exp Med Biol 758:387-95. 2012..This review will focus on recent advances in our understanding of the physiological mechanisms that alter CB function in CHF and their potential translational impact on treatment of CHF...
Arterial chemoreceptors and sympathetic nerve activity: implications for hypertension and heart failureHarold D Schultz
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198-5850, USA
Hypertension 50:6-13. 2007- Chemoreflex function in heart failureH D Schultz
Department of Physiology and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha, NE 68198 4575, USA
Heart Fail Rev 5:45-56. 2000.... - Nitric oxide regulation of autonomic function in heart failureHarold D Schultz
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198, USA
Curr Heart Fail Rep 6:71-80. 2009..This review also emphasizes questions of regulation of NO function in the autonomic nervous system that remain unresolved... - The spice of life is at the root of cardiac painHarold D Schultz
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
J Physiol 551:400. 2003 - Carotid body function in heart failureHarold D Schultz
Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Respir Physiol Neurobiol 157:171-85. 2007..These results underscore the principle that multiple mechanisms involving Ang II and NO at the level of both the CB and CNS represent complementary and perhaps redundant adaptive mechanisms to enhance CB chemoreflex function in CHF... - Angiotensin and carotid body chemoreception in heart failureHarold D Schultz
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Curr Opin Pharmacol 11:144-9. 2011..This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF... - Cardiac vagal chemosensory afferents. Function in pathophysiological statesH D Schultz
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198 4575, USA
Ann N Y Acad Sci 940:59-73. 2001.... - Cardiac sympathetic afferent sensitivity is enhanced in heart failureW Wang
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198 4575, USA
Am J Physiol 277:H812-7. 1999..It is suggested that the cardiac sympathetic chemosensitive afferent sensitivity is significantly enhanced in dogs with HF even though the baseline cardiac sympathetic afferent discharge is elevated... - Exercise training improves peripheral chemoreflex function in heart failure rabbitsYu Long Li
Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, NE 68198, USA
J Appl Physiol 105:782-90. 2008..EXT reverses the alterations in the nNOS-NO and ANG II-AT(1)-receptor pathways in the CB responsible for chemoreceptor sensitization in CHF... - Volume expansion potentiates cardiac sympathetic afferent reflex in dogsW Wang
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198 4575, USA
Am J Physiol Heart Circ Physiol 280:H576-81. 2001..These data suggest that enhancement of the CSAR in congestive heart failure may be mediated by the concomitant cardiac dilation, which accompanies this disease state... - Role of CuZn superoxide dismutase on carotid body function in heart failure rabbitsYanfeng Ding
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Cardiovasc Res 81:678-85. 2009..Here we investigated the role of cytoplasmic SOD [CuZn superoxide dismutase (CuZnSOD)] in the CB on chemoreceptor activity and function in CHF rabbits... - Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbitsYu-Long Li
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
Cardiovasc Res 71:129-38. 2006..CONCLUSIONS: These results indicate that elevation of Ang II and concomitant upregulation of AT1 receptor in the CB contribute to the increased CB chemoreceptor activity and enhanced peripheral chemoreflex function in CHF... - Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbitsYanfeng Ding
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Appl Physiol 105:14-23. 2008..63 +/- 0.04, 0.56 +/- 0.06, and 0.27 +/- 0.03, respectively) rabbits (P < 0.05). These results suggest that a deficiency of NO and CO in the CBs augments peripheral chemoreflex sensitivity to hypoxia in CHF... - Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbitsYu-Long Li
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
Circ Res 97:260-7. 2005..05). These results indicate that decreased endogenous nNOS activity in the CB plays an important role in the enhanced activity of the CB chemoreceptors and peripheral chemoreflex function in CHF rabbits... - Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failureLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
Hypertension 45:1173-81. 2005..9+/-0.2 to 3.1+/-0.2%/mm Hg; P<0.01). These results suggest that tonic cardiac sympathetic afferent input plays an important role in the blunted baroreflex associated with CHF, which is mediated by central AT1 receptors... - Sympathoexcitation by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLMLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
Am J Physiol Heart Circ Physiol 288:H2271-9. 2005.... - Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidaseLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
Circ Res 95:937-44. 2004..These data demonstrate intense radical stress in autonomic areas of the brain in experimental CHF and provide evidence for a tight relationship between Ang II and ROS as contributors to sympathoexcitation in CHF... - Vagal neuroeffector mechanisms affecting transpulmonary pressure in the intact ratJ R Haselton
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198 4575, USA
J Appl Physiol 79:1233-41. 1995..Therefore, nonadrenergic noncholinergic systems did not appear to play an independent role in the response of the airways to the activation of the vagus nerves... - NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbitsYu Long Li
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Cardiovasc Res 75:546-54. 2007..NADPH oxidase-derived superoxide anion mediates the effects of Ang II in many organs. We investigated whether this signaling pathway may mediate the enhanced peripheral chemoreceptor sensitivity induced by Ang II in CHF rabbits... - Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized ratsLie Gao
Department of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Appl Physiol 102:37-43. 2007..These results suggest that both the chemical and electrical stimulation of the CSAR augments chemoreceptor reflex and that central ANG II, specially located in the NTS, plays a major role in these reflex interactions... - Altered nitric oxide mechanism within the paraventricular nucleus contributes to the augmented carotid body chemoreflex in heart failureMaram K Reddy
Dept of Cellular and Integrative Physiology, Univ of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Am J Physiol Heart Circ Physiol 292:H149-57. 2007.... - Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid body in heart failure: role of angiotensin IIYu-Long Li
Department of Cellular and Integrative Physiology, University of, Nebraska Medical Center, Omaha, NE 68198-5850, USA
J Physiol 575:215-27. 2006..4 versus Kv4.3) in the CB glomus cell may contribute to the suppression of IK and enhanced sensitivity of IK to hypoxia in CHF... - The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxideIrving H Zucker
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198 4575, USA
Prog Biophys Mol Biol 84:217-32. 2004..Lastly, clinical implications of this work are discussed... - Exercise training and sympathetic regulation in experimental heart failureIrving H Zucker
Department of Physiology and Biophysics, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
Exerc Sport Sci Rev 32:107-11. 2004..Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory... - Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channelYu Long Li
Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Cardiovasc Res 79:715-21. 2008..We investigated whether the excitability of AB neurons is depressed in streptozotocin (STZ)-induced T1D rats and whether HCN channels are involved in this depression... - Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbitsYanfeng Ding
Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
Am J Physiol Regul Integr Comp Physiol 298:R303-11. 2010..05). The results suggest that decreased MnSOD in the CB and elevated mitochondrial superoxide levels contribute to the enhanced CB chemoreceptor activity and peripheral chemoreflex function in CHF rabbits... - Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failureLie Gao
Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, 68198 5850, USA
Am J Physiol Heart Circ Physiol 298:H945-55. 2010..3 expression and subsequent decrease in K(+) current, thereby increasing the excitability of neurons in the RVLM. The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling... - Differential role of the paraventricular nucleus of the hypothalamus in modulating the sympathoexcitatory component of peripheral and central chemoreflexesMaram K Reddy
Dept. of Cellular and Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
Am J Physiol Regul Integr Comp Physiol 289:R789-97. 2005..These results suggest a selective role of the PVN in processing the sympathoexcitatory and ventilatory component of the peripheral, but not central, chemoreflex... - Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failureIrving H Zucker
Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Am J Physiol Heart Circ Physiol 297:H1557-66. 2009..Finally, exercise training reduces both central oxidative stress and AT(1)R expression in animals with CHF. These data strongly suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF... - Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxideYu-Long Li
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
J Physiol 555:219-29. 2004..This effect is due mainly to the suppression of KCa channel activity caused by decreased availability of NO. In addition, intracellular cGMP is necessary for the KCa channel modulation by NO... - Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathwaysS Y Sun
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Nebraska Medical Center, Omaha, Nebraska 68198-4575, USA
Am J Physiol Heart Circ Physiol 281:H93-H104. 2001..Our results suggest that induction of the 5-LOX pathway contributes to the enhanced sensitivity of cardiac vagal afferents to AA in the ischemic condition... - Amelioration of depressed cardiopulmonary reflex control of sympathetic nerve activity by short-term exercise training in male rabbits with heart failureR U Pliquett
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4575, USA
J Appl Physiol 95:1883-8. 2003..normal animals. Ex substantially restored both CP reflex sensitivity and baseline RSNA in CHF animals. Thus Ex beneficially affects reflex regulation in CHF, thereby lowering resting sympathetic nerve activity... - The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutaseErin G Rosenbaugh
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Biomaterials 31:5218-26. 2010..Importantly, neither the PEI-PEG polymer alone nor the CuZnSOD nanozyme induced neuronal toxicity. These findings indicate that CuZnSOD nanozyme inhibits AngII intra-neuronal signaling in vitro and in vivo... - Expression of neuronal nitric oxide synthase in rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currentsYu Long Li
Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Neurophysiol 103:3027-33. 2010..These results suggest that a decrease of NO induced by an attenuated nNOS activity lowers the activation of the BK channels but not the protein expression of the BK channel alpha-subunit in the CB glomus cells during CHF... - Gas exchange and lung mechanics during percutaneous transtracheal ventilation in an unparalyzed canine modelT P Tran
Department of Surgery, University of Nebraska Medical Center, Omaha 68198 1150, USA
Acad Emerg Med 5:320-4. 1998..To compare the efficacy of percutaneous transtracheal ventilation (PTV) in the unparalyzed state with that in the paralyzed state using a sedated nonobstructed canine model... - Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failureAllison C Kleiber
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Am J Physiol Regul Integr Comp Physiol 294:R1863-72. 2008..Thus one mechanism by which ExT alleviates elevated sympathetic outflow in HF may be through normalization of glutamatergic mechanisms within the PVN... - Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technologyYi-Fan Li
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
Methods Mol Med 112:59-79. 2005.... - Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium currentJing Xiang Yin
Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Am J Physiol Cell Physiol 298:C857-65. 2010..These data indicate that ANG II increases mitochondrial O(2)(.-), which mediates, at least in part, ANG II-induced activation of Ca(2+)/calmodulin kinase II and inhibition of I(Kv) in neurons... - Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidaseLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
Circulation 112:1763-70. 2005..These data also demonstrate that SIM improves left ventricular function in pacing-induced CHF rabbits... - Role of blood flow in carotid body chemoreflex function in heart failureYanfeng Ding
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Physiol 589:245-58. 2011..A NO donor and AT1-R antagonist reversed CAO-enhanced chemoreflex sensitivity. These results suggest that a reduction of blood flow to the CB is involved in the augmentation of peripheral chemoreflex sensitivity in CHF... - Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanismRui fang Yang
University of Nebraska Medical Center, Omaha, 68198 5850, USA
Am J Physiol Cell Physiol 300:C58-64. 2011..These findings indicate that Ang-(1-7) is capable of increasing nNOS-derived NO(ยท) levels, which in turn, activates hyperpolarizing I(Kv) in catecholaminergic neurons... - Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failureIrving H Zucker
J Appl Physiol 102:498; author reply 504-5. 2007