HILDEGARD SCHULLER

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
    PLoS ONE 7:e29915. 2012
  2. pmc Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    PLoS ONE 7:e43376. 2012
  3. pmc Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: implications for intervention
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive Knoxville, TN 37996, USA
    Cancer Biomark 13:133-44. 2013
  4. pmc Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia
    Mohammed H Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, 37996, USA
    Cancer Prev Res (Phila) 6:139-48. 2013
  5. ncbi request reprint Regulatory role of the α7nAChR in cancer
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Curr Drug Targets 13:680-7. 2012
  6. ncbi request reprint Gamma-amino butyric acid inhibits the nicotine-imposed stimulatory challenge in xenograft models of non-small cell lung carcinoma
    H A N Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Curr Cancer Drug Targets 12:97-106. 2012
  7. pmc Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7
    Mohammed H Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Mol Cancer Res 10:239-49. 2012
  8. pmc Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Cancer Prev Res (Phila) 5:189-96. 2012
  9. pmc Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 33:191-6. 2012
  10. pmc Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells
    Howard K Plummer
    Molecular Cancer Analysis Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    Respir Res 6:29. 2005

Research Grants

  1. GABA-B-R-mediated prevention of pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2010
  2. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2003
  3. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2004
  4. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2004
  5. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2004
  6. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2005
  7. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2005
  8. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2005
  9. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2006
  10. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006

Collaborators

Detail Information

Publications53

  1. pmc Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
    PLoS ONE 7:e29915. 2012
    ....
  2. pmc Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    PLoS ONE 7:e43376. 2012
    ..Our findings identify the targeted inhibition of stress-induced pathways as a promising area for more effective cancer intervention in pancreatic cancer...
  3. pmc Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: implications for intervention
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive Knoxville, TN 37996, USA
    Cancer Biomark 13:133-44. 2013
    ....
  4. pmc Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia
    Mohammed H Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, 37996, USA
    Cancer Prev Res (Phila) 6:139-48. 2013
    ..Moreover, our data identify GABA as a promising agent for the prevention of PDAC in individuals at risk due to chronic alcohol consumption...
  5. ncbi request reprint Regulatory role of the α7nAChR in cancer
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Curr Drug Targets 13:680-7. 2012
    ....
  6. ncbi request reprint Gamma-amino butyric acid inhibits the nicotine-imposed stimulatory challenge in xenograft models of non-small cell lung carcinoma
    H A N Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Curr Cancer Drug Targets 12:97-106. 2012
    ..GABA has potential to lower the risk of NSCLC among smokers and could be used to enhance the clinical outcome of standard cancer intervention strategies...
  7. pmc Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7
    Mohammed H Al-Wadei
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Mol Cancer Res 10:239-49. 2012
    ..Our findings identify this hitherto unknown autocrine catecholamine loop as an important regulatory cascade in pancreatic cancer that may prove a promising new target for cancer intervention...
  8. pmc Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Cancer Prev Res (Phila) 5:189-96. 2012
    ..Treatment with GABA reversed the effects of stress. Our findings suggest that social stress stimulates NSCLC by increasing nAChR-mediated stress neurotransmitter signaling and that GABA is a promising novel agent for NSCLC intervention...
  9. pmc Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 33:191-6. 2012
    ....
  10. pmc Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells
    Howard K Plummer
    Molecular Cancer Analysis Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    Respir Res 6:29. 2005
    ..In the present study, our goal was to determine the extent of alpha7 mRNA and protein expression in the human lung...
  11. pmc Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines
    Howard K Plummer
    Molecular Cancer Analysis Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    BMC Cancer 4:93. 2004
    ..Previously, GIRK channels have been associated with beta-adrenergic signaling...
  12. pmc Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines
    Howard K Plummer
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    BMC Cancer 5:104. 2005
    ..We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer...
  13. ncbi request reprint NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Lung Cancer 49:35-45. 2005
    ..Taken together, these data point to PKA/CREB as novel targets for the development of cancer therapeutics for PAC patients non-responsive to EGFR-specific tyrosine kinase inhibitors...
  14. doi request reprint Neurotransmission and cancer: implications for prevention and therapy
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Anticancer Drugs 19:655-71. 2008
    ..Marker-guided restoration of the physiological balance in stimulatory and inhibitory neurotransmission represents a promising and hitherto neglected strategy for the prevention and therapy of neurotransmitter-responsive cancers...
  15. pmc Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Carcinogenesis 29:1979-85. 2008
    ..Our findings suggest that marker-guided treatment with GABA or a GABA(B)R agonist of individuals with downregulated pulmonary GABA may provide a novel targeted approach for the prevention of PAC in smokers...
  16. pmc GABA B receptor is a novel drug target for pancreatic cancer
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer 112:767-78. 2008
    ..The aim of the study was to investigate if GABA B R inhibits beta-AR signaling in PDAC and pancreatic duct epithelial cells, thus blocking driving forces of cancer progression, such as cell proliferation and cell migration...
  17. pmc Nitrosamines as nicotinic receptor ligands
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Life Sci 80:2274-80. 2007
    ..NNK and nicotine-induced hyperactivity of the alpha7nAChR/RAF/ERK1/2 pathway thus appears to play a crucial role in the development of SCLC in smokers and could be targeted for cancer prevention...
  18. ncbi request reprint Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
    Hildegard M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA
    Nat Rev Cancer 2:455-63. 2002
  19. ncbi request reprint Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Prog Exp Tumor Res 39:45-63. 2007
    ..Collectively, neurotransmitter receptors of the nicotinic and Beta-adrenergic families appear to regulate cellular functions essential for the development and survival of the most common human cancers...
  20. ncbi request reprint Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers
    Hildegard M Schuller
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Lung Cancer 45:11-8. 2004
    ..At the current state of knowledge such chemopreventive treatments should only be used as adjuvant to cancer therapy of cancers that have been fully characterized at the pathology and molecular level...
  21. pmc Neurotransmitter receptors as central regulators of pancreatic cancer
    Hildegard M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Future Oncol 6:221-8. 2010
    ..Accordingly, PDAC intervention strategies should include the diagnosis of unphysiological neurotransmitter levels and aim to restore any imbalance in stimulatory and inhibitory neurotransmitters...
  22. ncbi request reprint Receptor-mediated effects of nicotine and its nitrosated derivative NNK on pulmonary neuroendocrine cells
    Hildegard M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Anat Rec A Discov Mol Cell Evol Biol 270:51-8. 2003
    ....
  23. ncbi request reprint The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    J Cancer Res Clin Oncol 128:525-32. 2002
    ....
  24. ncbi request reprint Co-expression of beta-adrenergic receptors and cyclooxygenase-2 in pulmonary adenocarcinoma
    H M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Int J Oncol 19:445-9. 2001
    ....
  25. doi request reprint Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Nat Rev Cancer 9:195-205. 2009
    ..This novel paradigm necessitates the development of marker-guided cancer intervention strategies that aim to restore the balance between nAChR-mediated stimulatory and inhibitory neurotransmitters and their downstream effectors...
  26. ncbi request reprint Detection of overexpressed COX-2 in precancerous lesions of hamster pancreas and lungs by molecular imaging: implications for early diagnosis and prevention
    Hildegard M Schuller
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    ChemMedChem 1:603-10. 2006
    ..Our data provide proof of principle for the hypothesis that molecular imaging with radiolabeled COX-2 inhibitors can be used for the noninvasive monitoring of overexpressed COX-2 levels...
  27. ncbi request reprint Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines
    Y Cakir
    Experimental Oncology Laboratory, Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Oncol 21:153-7. 2002
    ..Moreover, our findings suggest that cardiovascular disease and adenocarcinomas in a variety of organ systems, including the breast may share common risk factors and benefit from similar preventive and treatment strategies...
  28. ncbi request reprint Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders
    H M Schuller
    Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville 37909 1071, USA
    Eur J Pharmacol 393:265-77. 2000
    ..Similarly, up-regulation of one or several components of this nicotinic receptor pathway in smokers may be an important factor for the development of small cell lung carcinoma...
  29. ncbi request reprint Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells
    B A Jull
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA
    J Cancer Res Clin Oncol 127:707-17. 2001
    ..Furthermore, our data suggest that serotonin uptake inhibitors may protect against the development or be useful in the clinical management of SCLC...
  30. ncbi request reprint Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas
    D L Weddle
    Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Carcinogenesis 22:473-9. 2001
    ....
  31. ncbi request reprint Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines
    H M Schuller
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901 1071
    Biochem Pharmacol 38:3439-42. 1989
    ..This effect was not changed by pre-exposure to cholinergic antagonists. The data suggest a selective uptake of nicotine and the two nitrosamines via nicotinic cholinergic receptors in pulmonary neuroendocrine cells...
  32. ncbi request reprint Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease
    P G Park
    Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville 37909, USA
    Cancer Res 55:3504-8. 1995
    ....
  33. ncbi request reprint Interaction of tobacco-specific toxicants with nicotinic cholinergic regulation of fetal pulmonary neuroendocrine cells: implications for pediatric lung disease
    H K Plummer
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37996, USA
    Exp Lung Res 26:121-35. 2000
    ....
  34. ncbi request reprint Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
    ..We have recently shown that the growth of cell lines derived from human PACs is controlled by beta-adrenergic receptors, and that NNK is a high affinity agonist for this receptor family...
  35. ncbi request reprint 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells
    P K Tithof
    Department of Comparative Medicine, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37996 4500, USA
    Am J Physiol Heart Circ Physiol 281:H1946-54. 2001
    ..These data suggest that NNK causes EC apoptosis by a mechanism that involves beta1- and beta2-adrenergic receptor-mediated release of AA...
  36. ncbi request reprint Regulation of cell proliferation by beta-adrenergic receptors in a human lung adenocarcinoma cell line
    H M Schuller
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901 1071
    Carcinogenesis 10:1753-5. 1989
    ..These findings suggest an important role of beta-adrenergic receptors in the regulation of cell proliferation in lung tumors comprised of this cell type...
  37. ncbi request reprint PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone
    H A N Al-Wadei
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Eur J Cancer 41:2745-53. 2005
    ..Immunoblot analysis revealed increased phosphorylation of ERK1/2 and of the transcription factor CREB in response to dexamethasone. These data suggest that glucocorticoids could have tumour promoting activity on a sub-set of human PAC...
  38. ncbi request reprint Chemoprevention of lung cancer by non-steroidal anti-inflammatory drugs among cigarette smokers
    Randall E Harris
    The Ohio State University College of Medicine and Public Health, Columbus, OH 43210 1240, USA
    Oncol Rep 9:693-5. 2002
    ..22), and for the individual compounds, aspirin (RR, 0.25) and ibuprofen (RR, 0.39). These results combined with the current molecular evidence suggest that regular NSAID intake may prevent tobacco carcinogenesis through COX-2 blockade...
  39. ncbi request reprint Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention
    Hibret A Adissu
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Oncol 24:1467-72. 2004
    ....
  40. ncbi request reprint Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms
    Thomas Masi
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genes Chromosomes Cancer 44:212-7. 2005
    ....
  41. ncbi request reprint Pulmonary fibroblasts stimulate the proliferation of cell lines from human lung adenocarcinomas
    Maria Cekanova
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Anticancer Drugs 17:771-81. 2006
    ..This may contribute to the disappointing clinical responses to anticancer drugs, which have shown promise in tests with lung cancer cell lines...
  42. pmc Cyclic adenosine monophosphate-dependent cell type-specific modulation of mitogenic signaling by retinoids in normal and neoplastic lung cells
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Cancer Detect Prev 30:403-11. 2006
    ..A diet rich in fruit and vegetables has been shown to reduce the lung cancer risk. However, clinical trials with beta-carotene and retinoids have disappointed, resulted in increased mortality from lung cancer and cardiovascular disease...
  43. ncbi request reprint Theophylline stimulates cAMP-mediated signaling associated with growth regulation in human cells from pulmonary adenocarcinoma and small airway epithelia
    A Hussein
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, 37996, USA
    Int J Oncol 27:155-60. 2005
    ....
  44. ncbi request reprint Overexpressed Raf-1 and phosphorylated cyclic adenosine 3'-5'-monophosphatate response element-binding protein are early markers for lung adenocarcinoma
    Maria Cekanova
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer 109:1164-73. 2007
    ....
  45. ncbi request reprint Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Oncol Rep 15:431-5. 2006
    ..These findings suggest that exposure to caffeine may contribute to the prevalence of PAC observed today...
  46. ncbi request reprint Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells
    Mourad Majidi
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Cancer Res 67:6863-71. 2007
    ..This novel cooperation between beta1AR and ERbeta signaling may contribute to the prominence of lung adenocarcinoma in women...
  47. ncbi request reprint Low concentrations of beta-carotene stimulate the proliferation of human pancreatic duct epithelial cells in a PKA-dependent manner
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Cancer Genomics Proteomics 4:35-42. 2007
    ..While some of the preclinical data suggested cancer preventive effects of these agents, they have disappointed in clinical investigations...
  48. ncbi request reprint Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Cancer 118:1370-80. 2006
    ..Our data challenge the widely accepted view that beta-carotene may be useful as a cancer preventive agent...
  49. ncbi request reprint The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors
    Minoo D F Askari
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, 37996, USA
    J Cancer Res Clin Oncol 131:639-48. 2005
    ..The goal of this study was to elucidate the NNK effects on the signal transduction pathways downstream of both beta(1)- and beta(2)-adrenergic receptors in immortalized human pancreatic HPDE6-c7 cells...
  50. ncbi request reprint Ethanol and the tobacco-specific carcinogen, NNK, contribute to signaling in immortalized human pancreatic duct epithelial cells
    Minoo D F Askari
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Pancreas 33:53-62. 2006
    ....
  51. ncbi request reprint Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium
    Alexander Yu Nikitin
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Cancer Res 64:2307-16. 2004
    ....

Research Grants27

  1. GABA-B-R-mediated prevention of pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2010
    ..In vitro and in vivo studies proposed under this project will provide a preclinical basis for the use of GABA-ergic agents for the marker-guided prevention of pancreatic cancer in individuals with pancreatic GABA deficiency. ..
  2. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2003
    ..Data generated by these studies will help identify early markers of pancreatic cancer development that provide a basis for the early detection of this deadly malignancy. ..
  3. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2004
    ..Data generated by these studies will help identify early markers of pancreatic cancer development that provide a basis for the early detection of this deadly malignancy. ..
  4. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2004
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  5. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2004
    ....
  6. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ..Data generated by these studies will help identify early markers of pancreatic cancer development that provide a basis for the early detection of this deadly malignancy. ..
  7. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  8. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ....
  9. Transplancental Pancreatic Carcinogenesis by NNK
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ..Data generated by these studies will help identify early markers of pancreatic cancer development that provide a basis for the early detection of this deadly malignancy. ..
  10. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  11. GABA-B-R-mediated prevention of pancreatic cancer
    HILDEGARD SCHULLER; Fiscal Year: 2009
    ..In vitro and in vivo studies proposed under this project will provide a preclinical basis for the use of GABA-ergic agents for the marker-guided prevention of pancreatic cancer in individuals with pancreatic GABA deficiency. ..
  12. The GABA-B receptor is a novel drug target for pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2010
    ..In vitro and in vivo studies proposed under this project will provide a preclinical basis for the use of GABA-ergic agents for the effective therapy and prevention of pancreatic cancer. ..
  13. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2003
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  14. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2003
    ....
  15. TRANSPLACENTAL PANCREATIC CARCINOGENESIS BY NNK
    HILDEGARD SCHULLER; Fiscal Year: 1999
    ..It is proposed that these studies will serve as the basis for developing effective strategies for prevention of cancer in the children of smokers. ..
  16. TRANSPLACENTAL CARCINOGENICITY OF NNK
    HILDEGARD SCHULLER; Fiscal Year: 1990
    ..Results from these studies could provide important experimental bases for epidemiological surveys of cancer risks associated with in utero exposure to tobacco smoke...
  17. TRANSPLACENTAL CARCINOGENICITY OF NNK
    HILDEGARD SCHULLER; Fiscal Year: 1991
    ..Results from these studies could provide important experimental bases for epidemiological surveys of cancer risks associated with in utero exposure to tobacco smoke...
  18. TRANSPLACENTAL CARCINOGENICITY OF NNK
    HILDEGARD SCHULLER; Fiscal Year: 1992
    ..Results from these studies could provide important experimental bases for epidemiological surveys of cancer risks associated with in utero exposure to tobacco smoke...
  19. TRANSPLACENTAL PANCREATIC CARCINOGENESIS BY NNK
    HILDEGARD SCHULLER; Fiscal Year: 2000
    ..It is proposed that these studies will serve as the basis for developing effective strategies for prevention of cancer in the children of smokers. ..
  20. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2002
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  21. The GABA-B receptor is a novel drug target for pancreatic cancer
    HILDEGARD SCHULLER; Fiscal Year: 2009
    ..In vitro and in vivo studies proposed under this project will provide a preclinical basis for the use of GABA-ergic agents for the effective therapy and prevention of pancreatic cancer. ..